The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy

Schematic diagrams reveal URMC-099 affects nanoART endosomal trafficking and HIV-1 progeny virion production. (A) HIV-1 budding, assembly and maturation in macrophage Rab7 and Rab11 endosomal compartments. (B) NanoATV targets endosomal compartment for storage and inhibits viral maturation at the site of viral assembly. (C) URMC-099 boosts nanoATV antiviral activity through increased nanoATV accumulation in macrophage Rab7 and Rab11 endosomal compartments.170