Keywords: ACC1; acetylcoenzyme A carboxylase 1; ASIP; agouti signaling protein; BETA2; transcription factor Beta 2; CYP7a1; cytochrome P450, family 7, subfamily a, polypeptide 1; cFOS; transcription factor C-fos; FASN; fatty acid synthase; FOXA2; forkhead box prote
مقالات ISI (ترجمه نشده)
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Keywords: NAFLD; nonalcoholic fatty liver disease; NASH; nonalcoholic steatohepatitis; FC; free cholesterol; VLDL; very low density lipoprotein; LDL; low density lipoprotein; mTOR; mechanistic target of rapamycin signaling; AMPK; AMP-activated protein kinase; TG; t
Keywords: Anthocyanins; Cholesterol; Sterol; Hypercholesterolemia; ABCG5 and 8; ATP binding cassette transporter 5 and 8; ACAT2; acyl CoA:cholesterol acyltransferase2; CYP7A1; cholesterol-7α-hydroxylase; CrA; cranberry anthocyanins; HMG-CoA-R; 3-Hydroxy-3-methylgl
Keywords: Resistin-like molecule; Macrophage; Helminth infection; T helper type 2; Toll-like Receptor 4; ABC; ATP-binding cassette transporter; ADD1; adipocyte determination and differentiation dependent factor 1; ADSF; adipocyte secreted factor; Akt (aka PKB); pro
Keywords: Acadl; acyl-CoA dehydrogenase, long chain; Acadvl; acyl-CoA dehydrogenase, very long chain; Acaca; acetyl-CoA carboxylase alpha; Abcb11; ATP binding cassette subfamily B member 11; Abcg5; ATP binding cassette subfamily G member 5; Abcg8; ATP binding casse
Keywords: BA; bile acids; BSH; bile salt hydrolase; CA; cholic acid; CDCA; chenodeoxycholic acid; DCA; deoxycholic acid; LCA; litocholic acid; MCA; muricholic acid; CYP7A1; cholesterol 7-αhydroxylase; L.; Lactobacillus; B.; Bifidobacterium; EPS; exopolysaccharide;
Keywords: Flavonoids; Quercetin; Plant-derived polyphenol; Cardiovascular action; Bioassay; CVD; Cardiovascular disease; eNOS; endothelial nitric oxide synthase; BcL2; B-cell lymphoma 2; MDA; malonaldehyde; TNFα; tumor necrosis factor α; IL-6; Interleukin 6; PPAR
Keywords: ASBT; apical sodium-dependent bile acid transporter; ASDs; amorphous solid dispersions; BACS; bile acid-CoA synthase; BAT; bile acid-amino acid transferase; BCS; biopharmaceutics classification system; BSH; bile salt hydrolase; C4; 7α-hydroxy-4-cholesten
Keywords: Unfolded Protein Response; Cyp7a1; 7α-Hydroxy-4-Cholesten-3-1; Bile Acid Synthesis; ABC; adenosine triphosphate binding cassette; C4; 7α-hydroxy-4-cholesten-3-1; CYP7A1; cholesterol 7α-hydroxylase; DMEM; Dulbecco's modified Eagle medium; DMSO; dimethyl
Keywords: Estradiol (PubChem CID: 5757); 4-Hydroxyestradiol (PubChem CID: 5282360); 4-Methoxyestradiol (PubChem CID: 68578); 4-Methoxyestrone (PubChem CID: 194066); 4-Hydroxyestradiol; 4-Methoxyestrogen; CYP7A1; Cholesterol; Triglyceride;
Keywords: PBC; primary biliary cholangitis; PSC; primary sclerosing cholangitis; CYP7A1; cholesterol 7a-hydroxylase; CDCA; chenodeoxycholic acid; CA; cholic acid; LCA; lithocholic acid; DCA; deoxycholic acid; mROS; mitochondrial reactive oxygen species; MPT; mitoch
Keywords: DCA; deoxycholic acid; βMCA; β-muricholic acid; CA; cholic acid; CDCA; chenodeoxycholic acid; HDCA; hyodeoxycholic acid; ID; iron depletion; Rif; rifampicin; TUDCA; tauroursodeoxycholic acid; TCDCA; taurochenodeoxycholic acid; TDCA; taurodeoxycholic a
Keywords: Bile Acids; FXR; TGR5; Meta-Inflammation; apo; apolipoprotein; ASBT; apical sodiumâdependent bile acid transporter; BA; bile acid; BAS; bile acid sequestrant; BAT; brown adipose tissue; BSH; bile salt hydrolase; CA; cholic acid; CCK; cholecystokinin; CD
Keywords: ABCB4; ATP-binding cassette transporter B4; ADX; adrenalectomy; ALT/GPT; alanine transaminase/glutamic pyruvic transaminase; ANIT; alpha-naphthylisothiocyanate; APOA4; apolipoprotein A4; BSEP/ABCB11; bile salt efflux pump; CYP7A1; cholesterol 7alpha-hydro
Keywords: ACTB; β-actin; ANOVA; analysis of variance; AP; alkaline phosphatase; BA; bile acids; Brassica; brassicasterol; Campe; campesterol; Chole; cholesterol plus 25-OH-cholesterol; Ctrl; control; CYP7A1; cholesterol-7-α-hydroxylase; DTT; dithiothreitol; EDTA;
Keywords: NAFLD; Non-Alcoholic Fatty Liver Disease; NAFL; Non-Alcoholic Fatty Liver; NASH; Non-Alcoholic SteatoHepatitis; FA; fatty acids; TG; triglycerides; SFA; saturated fatty acids; CYP; cytochrome; HFA; high fatty acids; HCh; high cholesterol; ALT; alanine ami
Keywords: High-fat; Non-alcoholic liver disease; Obesity; Scopoletin; Transcriptome; ALT; alanine aminotransferase; Apoa4; apolipoprotein A-IV; AST; aspartate aminotransferase; β-oxidation; fatty acid β-oxidation; Cdkn1a; cyclin-dependent kinase inhibitor 1A; Cid
Keywords: 5α-cholestanol; Cholesterol; β-sitosterol; Sterol; ABCG5/8; ATP-binding cassette transporters sub-family G member 5 and 8; ACAT2; acyl-CoA: cholesterol acyltransferase 2; CYP7A1; cholesterol-7α-hydroxylase; DC; dihydrocholesterol; HDL-C; high density l
Keywords: TUNEL; terminal deoxynucleotidyl transferase dUTP nick-end labeling; ELISA; enzyme-linked immunosorbent assay; DNA; deoxyribonucleic acid; TNFα; tumor necrosis factor-alpha; Foxa2; forkhead box protein A2; HNF6; hepatocyte nuclear factor 6; C/EBPα; CCAA
Keywords: 24OHC; 24S-Hydroxycholesterol; 27OHC; 27-Hydroxycholesterol; ABC; ATP-binding cassette transporter; ACAT; Acyl-Coa:cholesterol acyltransferase; AD; Alzheimer disease; ApoE; Apolipoprotein E; BACHD; Bacterial artificial chromosome HD; BDNF; Brain-derived n
Keywords: Liver; Nuclear receptor; FXR; SHP; CYP7A1; CYP8B1All-trans retinoic acid (Pubchem CID: 444795)
Keywords: ASBT; apical sodium dependent transporter; AKT; protein kinase B; BSEP; bile salt export protein (ABCB11); CA; cholic acid; CCA; cholangiocarcinoma; CDCA; chenodeoxycholic acid; CYP7A1; cholesterol 7α-hydroxylase; CYP7B1; oxysterol 7α-hydroxylase; CYP27
Keywords: Cholesterol; Oxysterol; CYP46A1; CYP27A1; CYP3A4; CYP39A1; CYP7B1; CH25H; Cholesterol 7α-hydroxylase; Sterol 27-hydroxylase; Cholesterol 24-hydroxylase; Cholesterol 25-hydroxylase; Oxysterol 7α-hydroxylase; 24-hydroxycholesterol 7α-hydroxylase; Epigene
Keywords: CYP7A1; cytochrome P450 family 7 subfamily A polypeptide 1; FXRα; farnesoid X receptor α; HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase; LDLR; low density lipoprotein receptor; PCSK9; proprotein convertase subtilisin/kexin type 9; SREBP2; sterol regul
Keywords: Tomato pomace byproducts; Bile acid; Cholesterol; Hamster; CYP7A1; CYP51;
Oral administration of palatinose vs sucrose improves hyperglycemia in normal C57BL/6J mice
Keywords: Palatinose; Hepatic lipogenesis; Cholesterol homeostasis; C57BL/6J mice; Sucrose; ACC; acetyl-CoA carboxylase; ALT; alanine aminotransferase; AST; serum aspartate aminotransferase; AUC; area under the curve; CYP7A1; cholesterol 7 alpha-hydroxylase; FAS; f
Alisma orientale extract exerts the reversing cholestasis effect by activation of farnesoid X receptor
Keywords: Alisma orientale; Cholestasis; Proteomics; Farnesoid X receptor; AOE; Alisma orientale extract; ANIT; α-naphthylisothiocyanate; FXR; farnesoid X receptor; AST; aspartate aminotransferase; ALT; alanine aminotransferase; TBIL; total bilirubin; TBA; intrahe
Overexpression of transforming growth factor β induced factor homeobox 1 represses NPC1L1 and lowers markers of intestinal cholesterol absorption
Keywords: Cholesterol metabolism; Lipoproteins; Liver; Transcription; Dyslipidemia; ABCA1; ATP-binding cassette transporter A1; ACAT2; acyl-Coenzyme A:cholesterol acyltransferase 2; apo; apolipoprotein; CYP7A1; cholesterol 7α-hydroxylase; HMGCR; 3-hydroxy-3-methyl
Ganoderic Acid A improves high fat diet-induced obesity, lipid accumulation and insulin sensitivity through regulating SREBP pathway
Keywords: Ganoderic Acid A; SREBPs; Obesity; Insulin resistance; Lipid accumulation; ABCA1; ATP-binding cassette transporter 1; ACC; acetyl-CoA carboxylase; ACO; acyl-CoA oxidase; BAT; brown adipose tissue; CPT1; carntine palmitoyltransferase 1; CYP7A1; cholesterol
PMFs-rich Citrus extract prevents the development of non-alcoholic fatty liver disease in C57BL/6J mice induced by a high-fat diet
Keywords: NAFLD; non-alcoholic fatty liver disease; NASH; non-alcoholic steatohepatitis; Nrf2; nuclear factor erythroid-2 related factor 2; DIO; diet -induced obese; TGs; triglycerides; ROS; reactive oxygen species; Keap1; Kelch-like ECH-associated protein 1; NQO1;
The ileum-liver Farnesoid X Receptor signaling axis mediates the compensatory mechanism of 17α-ethynylestradiol-induced cholestasis via increasing hepatic biosynthesis of chenodeoxycholic acids in rats
Keywords: Asbt; apical sodium-dependent bile acids transporter; ALP; alkaline phosphatase; ALT; alanine transaminase; AST; aspartate transaminase; BAs; bile acids; Bsep/BSEP; bile salt export pump; β-MCA; β-muricholic acid; CA; cholic acid; CDCA; chenodeoxycholic
Part A: Temporal and dose-dependent transcriptional responses in the liver of fathead minnows following short term exposure to the polycyclic aromatic hydrocarbon phenanthrene
Keywords: SREBF1; sterol regulatory element binding transcription factor 1; FASN; fatty acid synthase; HSD17B12; hydroxysteroid (17-beta) dehydrogenase 12; ACACA; acetyl-CoA carboxylase alpha; CYB5A; cytochrome b5 type A (microsomal); SLC27A4; solute carrier family
Takeda G Protein-Coupled Receptor 5-Mechanistic Target of Rapamycin Complex 1 Signaling Contributes to the Increment of Glucagon-Like Peptide-1 Production after Roux-en-Y Gastric Bypass
Keywords: BAs; Bile acids; Cyp7a1; Cytochrome P450 family 7 subfamily A member 1; DCA; Deoxycholic acid; FXR; Farnesoid X receptor; GLP-1; Glucagon-like peptide-1; ip; Intraperitoneal; mTOR; mechanistic target of rapamycin; mTORC1; mechanistic target of rapamycin c
Zingiber officinale extract administration diminishes steroyl-CoA desaturase gene expression and activity in hyperlipidemic hamster liver by reducing the oxidative and endoplasmic reticulum stress
Keywords: ATP binding cassette transporter G5/G8; Endoplasmic reticulum stress; Ginger extract; Paraoxonase 1; Stearoyl CoA desaturases; Steatotic liver; ABCG5/G8; ATP-binding cassette sub-family G member 5/8; ACC; acetyl-CoA carboxylase; ATF6α; activating transcr
Ablating both Fabp1 and Scp2/Scpx (TKO) induces hepatic phospholipid and cholesterol accumulation in high fat-fed mice
Keywords: 3αHSD; 3alpha-hydroxysteroid reductase; ABCA1; ATP-binding cassette sub-family A member 1; ABCG1; 4, 5 or 8, ATP-binding cassette sub-family G member 1,4, 5 or 8; ACAT2; acetyl-CoA acetyltransferase (Soat2 gene); ACC1; acetyl-CoA carboxylase (Acaca gene)
Cholesterol 7- alpha hydroxylase gene (CYP7A1) promoter polymorphism rs3808607 as a risk factor for pulmonary tuberculosis in Egypt
Keywords: AFB; acid fast bacillus; MTB; Mycobacterium tuberculosis; PTB; Pulmonary TB; HOMA -IR; homeostatic model assessment of insulin resistance; ROS; reactive oxygen species; CYP7A1; Polymorphism; Pulmonary tuberculosis-lipid profile;
An FXR Agonist Reduces Bile Acid Synthesis Independently of Increases in FGF19 in Healthy Volunteers
Keywords: Liver; CYP7A1; Nuclear Receptor Subfamily 1 Group H Member 4; NR1H4; BA; bile acid; C4; 7α-hydroxy-4-cholesten-3-one; CDCA; chenodeoxycholic acid; CYP7A1; cholesterol 7α-hydroxylase; FGF; fibroblast growth factor; FXR; farnesoid X receptor; LDL; low-den
Cyp7a1 is continuously increased with disrupted Fxr-mediated feedback inhibition in hypercholesterolemic TALLYHO/Jng mice
Keywords: TALLYHO/Jng; Hypercholesterolemia; BAs metabolism; Cyp7a1; Fxr;
EP4 emerges as a novel regulator of bile acid synthesis and its activation protects against hypercholesterolemia
Keywords: EP4; Hypercholesterolemia; Bile acids; CYP7A1; Cholesterol homeostasis;
Supplementation with curcumin inhibits intestinal cholesterol absorption and prevents atherosclerosis in high-fat diet-fed apolipoprotein E knockout mice
Keywords: Atherosclerosis; ApoEâ/â mice; Curcumin; Cholesterol absorption; Niemann-Pick C1-like 1; ABCG5; ATP-binding cassette transporter G5; ACAT2; acyl-CoA/cholesterol acyltransferase 2; ApoE; apolipoprotein E; ApoEâ/â; ApoE knockout; CYP7A1; cholesterol
Nuclear receptor FXR, bile acids and liver damage: Introducing the progressive familial intrahepatic cholestasis with FXR mutations
Keywords: NR; nuclear receptor; FXR; farnesoid X receptor; RXR; retinoid X receptor; PXR; pregnane X receptor; VDR; Vitamin D receptor; TGR5; G protein-coupled bile acid receptor; Lrh1; liver receptor homolog 1; Mdr; multidrug resistance protein; Abcb4; ATP Bindi
E4bp4 regulates carboxylesterase 2 enzymes through repression of the nuclear receptor Rev-erbα in mice
Keywords: bZip; the basic leucine zipper; CAR; constitutive androstane receptor; Ces/CES; mouse and human carboxylesterases; ChIP; chromatin immunoprecipitation assay; Co-IP; co-immunoprecipitation; CYP7A1; cholesterol 7alpha-hydroxylase; DMEM; Dulbecco's modifie
Transhepatic bile acid kinetics in pigs and humans
Keywords: Bile acids; TGR5; Porcine; Postprandial; Portal concentrations; BAs; bile acids; ASBT; apical sodium-dependent bile acid transporter; OST; organic solute transporter; NTCP; taurocholate cotransporting polypeptide; OATP; organic anion transporting polypept
Maternal fructose induces gender-dependent changes in both LXRα promoter methylation and cholesterol metabolism in progeny
Keywords: RCT; Reverse cholesterol transport; LXRα; Liver X-receptor alpha; CpG islands; CG-dinucleotide-rich regions in the gene promoter; HDL; High-density lipoproteins; PPAR; Peroxisome proliferator-activated receptor; SRB-1; Scavenger Receptor class B, member
Intake of stigmasterol and β-sitosterol alters lipid metabolism and alleviates NAFLD in mice fed a high-fat western-style diet
Keywords: ABCA1; ATP binding cassette transporter A1; ABCG5; ATP binding cassette transporter 5; ALT; alanine aminotransferase; ASBT; ileal apical sodium-dependent bile acid transporter; BA; bile acid(s); BSEP; bile salt export pump; CD36; Cluster of Differentiatio
Disruption of TFGβ-SMAD3 pathway by the nuclear receptor SHP mediates the antifibrotic activities of BAR704, a novel highly selective FXR ligand
Keywords: CDCA; chenodeoxycholic acid; CA; cholic acid; DCA; deoxycholic acid; LCA; litocholic acid; BAs; bile acids; BARS; bile acid activated receptors; GPBAR1; G protein coupled bile acid receptor; TGR5; Takeda G protein receptor 5; FXR; farnesoid x-receptor; PX
Nrf2 is crucial for the down-regulation of Cyp7a1 induced by arachidonic acid in Hepg2 cells
Keywords: AA; arachidonic acid; CYP7A1; cholesterol 7α-hydroxylase; FA; fatty acid; HFD; high-fat diet; NAFLD; non-alcoholic fatty liver disease; Nrf2; nuclear factor erythroid-derived 2-like 2; siRNA; small interfering RNA; NAFLD; Nrf2; CYP7A1; HepG2; Arachidonic
LC-MS/MS quantification of 7α-hydroxy-4-cholesten-3-one (C4) in rat and monkey plasma
Keywords: LC-MS/MS; Quantification; 7α-hydroxy-4-cholesten-3-one (C4); Bile acid synthesis; CYP7A1; Biomarker;
Cassia auriculata flower extract attenuates hyperlipidemia in male Wistar rats by regulating the hepatic cholesterol metabolism
Keywords: Et- CAF; ethanolic extract of Cassia auriculata flower; HMGR; HMG-CoA reductase; HMGS; HMGCoA synthase; SREBP-1c; sterol regulatory element binding protein -1c; SREBP-2; sterol regulatory element binding protein- 2; CYP7A1; cholesterol 7 α-hydroxylase; A
Prenatal betaine exposure alleviates corticosterone-induced inhibition of CYP27A1 expression in the liver of juvenile chickens associated with its promoter DNA methylation
Keywords: SREBP; sterol regulator element-binding protein; HMGCR; 3-hydroxy-3-methylglutaryl coenzyme A reductase; CYP7A1; cholesterol-7alpha-hydroxylase; CYP27A1; cholesterol-27alpha-hydroxylase; ACAT1; acetyl-CoA cholesterol acyltransferase 1; LDLR; low density l