Keywords: RA; rheumatoid arthritis; RF; rheumatoid factor; ACPA; anti-citrullinated protein antibodies; AA; arachidonic acid; PG; prostaglandins; LT; leukotrienes; TX; thromboxanes; LX; lipoxins; NSAID; non steroidal anti-inflammatory drugs; COXIB; COX-2 selective
مقالات ISI (ترجمه نشده)
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Keywords: CT; controlled trial; cysLT; cysteinyl leukotrienes; EAACI; European Academy of Allergy and Clinical Immunology; ECP; eosinophilic cationic protein; eNO; exhaled nitric oxide; FEV1; forced expiratory volume at one second; ITT; intention-to-treat; MS; medi
Keywords: Aspirin-exacerbated respiratory disease (AERD); Asthma; Aspirin (acetylsalicylic acid, ASA); Chronic rhinosinusitis with nasal polyps; Nonsteroidal antiinflammatory drugs (NSAID); Hypersensitivity; Intolerance; AERD; aspirin-exacerbated respiratory diseas
Keywords: Sleep disordered breathing; Obstructive sleep apnea; Cysteinyl leukotrienes; Leukotriene E4; Adenotonsillar hypertrophy; Adenotonsillectomy;
Keywords: RPKM; reads per kilobase of transcript per million mapped reads; FGF; fibroblast growth factor; ETS; E26 transformation-specific or E-twenty-six; LTs; leukotrienes; ALOX5; arachidonate 5-lipoxygenase; LTA4; leukotriene A4; LTB4; leukotriene B4; LTC4; leuk
Keywords: Cysteinyl leukotrienes; Adhesion molecules; Retinal angiogenesis; Oxidative stress
Keywords: ICS; inhaled corticosteroid; Cys-LTs; cysteinyl leukotrienes; EBC; exhaled breath condensate; PEF; peak expiratory flow rate; FEV1; forced expiratory volume in first second; ELISA; enzyme linked immunoassay; FP; fluticasone propionate; P; oral prednisone;
Keywords: Aspirin-exacerbated respiratory disease; Pathogenesis; Cysteinyl leukotrienes; Prostaglandins; Mast cell; Platelet-leukocyte aggregates;
Keywords: Adhesion molecule; Beta2-adrenergic agonist; Chemokine; Cysteinyl leukotrienes; EosinophilsANOVA, analysis of variance; cAMP, cyclic adenosine 3′,5′-monophosphate; CXCR, CXC chemokine receptor; cysLT, cysteinyl leukotriene; EDN, eosinophil-derived neuroto
Increased expression of CysLT2 receptors in the lung of asthmatic mice and role in allergic responses
Keywords: Cysteinyl leukotrienes; CysLT2 receptors; CysLT1 receptors; Airway remodeling; Eosinophil;
A new spin on mast cells and cysteinyl leukotrienes: Leukotriene E4 activates mast cells in vivo
Keywords: Cysteinyl leukotrienes; mast cells; cyclooxygenase products; asthma;
Potential role of leukotriene receptor antagonists in reducing cardiovascular and cerbrovascular risk: A systematic review of human clinical trials and in vivo animal studies
Keywords: AA; arachidonic acid; CV; Cardiovascular; CysLTs; cysteinyl leukotrienes; CysLTR; cysteinyl leukotrienes receptor; LT; leukotrienes; LTRA; leukotrienes receptor antagonist; Leukotriene receptor antagonist; Montelukast; Cardiovascular event; Cysteinyl leuk
Cysteinyl leukotriene receptor 1 regulates glucose-stimulated insulin secretion (GSIS)
Keywords: Type 2 diabetes mellitus; Glucose-stimulated insulin secretion; Cysteinyl leukotrienes; Montelukast; Arf6;
Lipid mediator Leukotriene D4-induces airway epithelial cells proliferation through EGFR/ERK1/2 pathway
Keywords: Cysteinyl leukotrienes; Leukotriene D4; Airway epithelial cells; Proliferation; EGF;
Edaravone, a free radical scavenger, protects neuronal cells' mitochondria from ischemia by inactivating another new critical factor of the 5-lipoxygenase pathway affecting the arachidonic acid metabolism
Keywords: 5-LOX; 5-lipoxygenase; MCAO; middle cerebral artery occlusion; OGD; oxygen glucose deprivation; OGD-R; OGD-reperfusion; CysLTs; cysteinyl leukotrienes; MTT; 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide; ROS; reactive oxygen species; E
The inhibition of 5-Lipoxygenase (5-LO) products leukotriene B4 (LTB4) and cysteinyl leukotrienes (cysLTs) modulates the inflammatory response and improves cutaneous wound healing
Keywords: Repair; Inflammation; Lipid mediators; Skin; Cysteinyl leukotrienes; Leukotriene B4;
The G protein-coupled receptors deorphanization landscape
Keywords: GPCRs; G protein-coupled receptors; GRK; GPCR kinase; IUPHAR; International Union of Basic and Clinical Pharmacology; BPS; British Pharmacological Society; CTR; Calcitonin receptor; CLR; CT Receptor-like; RAMP; Receptor Activity-Modifying Proteins; β2AR;
Leukotriene E4 induces airflow obstruction and mast cell activation through the cysteinyl leukotriene type 1 receptor
Keywords: Asthma; cysteinyl leukotrienes; receptors; bronchoconstriction; mast cells; sputum cells; leukotrienes; mass spectrometry; lipid mediators in urine; AERD; Aspirin-exacerbated respiratory disease; CysLT; Cysteinyl leukotriene; CysLT1; Cysteinyl leukotriene
Cysteinyl leukotriene receptor 1 expression identifies a subset of neutrophils during the antiviral response that contributes to postviral atopic airway disease
Keywords: Asthma; viral infection; nasal lavage; neutrophils; cysteinyl leukotrienes; BAL; Bronchoalveolar lavage; cDC; Conventional dendritic cell; CysLT; Cysteinyl leukotriene; CysLTR; Cysteinyl leukotriene receptor; FDR; False discovery rate; LT; Leukotriene; PI
Leukotriene receptor antagonist attenuated airway inflammation and hyperresponsiveness in a double-stranded RNA-induced asthma exacerbation model
Keywords: Asthma; Cysteinyl leukotrienes; Double-stranded RNA; Leukotriene receptor antagonist; Virus; Ach; acetylcholine; AHR; airway hyperresponsiveness; ASM; airway smooth muscle; BAL; bronchoalveolar lavage; BALF; bronchoalveolar lavage fluid; CCL; Chemokine (C
CysLT2 receptor activation is involved in LTC4-induced lung air-trapping in guinea pigs
Keywords: Cysteinyl leukotrienes; CysLT2 receptors; CysLT1 receptors; Asthma; Air-trapping; Bronchoconstriction;
A new CysLT1 and CysLT2 receptors-mediated anaphylaxis guinea pig model
Keywords: Cysteinyl leukotrienes; CysLT2 receptors; CysLT1 receptors; Asthma; Anaphylaxis; ONO-6950;
Full length articleProlonged, acute suppression of cysteinyl leukotriene to reduce capsular contracture around silicone implants
Keywords: Cysteinyl leukotrienes; Fibrosis; Fibroblast; Montelukast; Myofibroblasts; Silicone implants; TGF-β;
The selective cysteinyl leukotriene receptor 1 (CysLT1R) antagonist montelukast regulates extracellular matrix remodeling
Keywords: Cysteinyl leukotrienes; Montelukast; Tenon fibroblasts; Transforming growth factor-β1; Wound healing;
Montelukast Does not Maintain Symptom Remission After Topical Steroid Therapy for Eosinophilic Esophagitis
Keywords: Inflammation; Swallow; Drug; Treatment; Clinical Trial; Cyst LT; cysteinyl leukotrienes; EoE; eosinophilic esophagitis; eos; eosinophil; ITT; intention to treat; hpf; high-power field; PPI; proton pump inhibitor;
Development of smart cell-free and cell-based assay systems for investigation of leukotriene C4 synthase activity and evaluation of inhibitors
Keywords: 5-LOX; 5-Lipoxygenase; AA; Arachidonic acid; FLAP; 5-Lipoxygenase-activating protein; GSH; Glutathione; LT; Leukotriene; LTA4H; Leukotriene A4 hydrolase; cys-LTs; Cysteinyl leukotrienes; MAPEG; Membrane-associated protein in eicosanoid and glutathione met
Aspirin provocation increases 8-iso-PGE2 in exhaled breath condensate of aspirin-hypersensitive asthmatics
Keywords: Aspirin exacerbated respiratory disease; Aspirin challenge; Exhaled breath condensate; Isoprostanes; Cysteinyl leukotrienes;
Mechanisms of allergy and clinical immunologyProstaglandin D2: AÂ dominant mediator of aspirin-exacerbated respiratory disease
Keywords: Aspirin-exacerbated respiratory disease; Samter triad; nasal polyps; asthma; prostaglandin D2; thromboxane; aspirin desensitization; cysteinyl leukotrienes; urinary eicosanoids; eosinophils; AA; Arachidonic acid; AERD; Aspirin-exacerbated respiratory dise
Expression of CysLT2 receptors in asthma lung, and their possible role in bronchoconstriction
Keywords: Airway smooth muscle; Anti-asthma drugs; CysLT receptors; Cysteinyl leukotrienes; Leukotriene receptor antagonistCysLT, cysteinyl leukotriene; ICS, inhaled corticosteroids; LABA, long-acting β2 receptor agonist
n-3 Polyunsaturated fatty acids inhibit Fc ε receptor I-mediated mast cell activation
Keywords: AA; arachidonic acid; ANOVA; analysis of variance; β-hex; β-hexosaminidase; BMMC; bone marrow-derived mast cells; CCL2; chemokine (C-C motif) ligand 2; cys-LT; cysteinyl leukotrienes; DHA; docosahexaenoic acid; DNP; 2,4-dinitrophenol; DPA; docosapentaen
Research ReportCysLT2 receptor mediates lipopolysaccharide-induced microglial inflammation and consequent neurotoxicity in vitro
Keywords: AV; Annexin V; BV-2 cells; murine microglial cell line; CM; conditioned medium; CysLTR; cysteinyl leukotriene receptor; CysLTs; cysteinyl leukotrienes; DAPI; 4â²,6-diamidino-2-phenylindole; DMEM; Dulbecco׳s modified Eagle׳s medium; ELISA; enzyme-linked
HAMI 3379, a CysLT2R antagonist, dose- and time-dependently attenuates brain injury and inhibits microglial inflammation after focal cerebral ischemia in rats
Keywords: Blood-brain barrier; BBB; CSF; cerebrospinal fluid; CysLT1R; cysteinyl leukotriene receptor 1; CysLT2R; cysteinyl leukotriene receptor 2; CysLTs; cysteinyl leukotrienes; DMSO; dimethyl sulfoxide; GFAP; glial fibrillary acidic protein; Iba-1; ionized cal
Montelukast suppresses epithelial to mesenchymal transition of bronchial epithelial cells induced by eosinophils
Keywords: Airway remodeling; Asthma; Cysteinyl leukotrienes; Epithelial to mesenchymal transition; Eosinophils; Montelukast;
Functional characterization of histamine H4 receptor on human mast cells
Keywords: LAD-2; Laboratory of allergic diseases 2; HMC-1; Human mast cell line-1; MCP-1/CCl2; Monocyte chemo attractant protein-1; H4R; Histamine H4 receptor; MC; Mast cells; LTB4; Leukotriene B4; CyLTs; Cysteinyl leukotrienes; cAMP; Cyclic AMP; RANTES; Regulated
Vascular endothelial growth factor and cysteinyl leukotrienes in sputum supernatant of patients with asthma
Keywords: Asthma; VEGF; Cysteinyl leukotrienes; Inflammation; Angiogenesis; Vascular remodeling;
Effect of allergy and inflammation on eicosanoid gene expression in CFTR deficiency
Keywords: LTs; leukotrienes; LTB4; leukotriene B4; cysLTs; cysteinyl leukotrienes; PLA2; phospholipase A2; sPLA2; secretory PLA2; cPLA2; group IV PLA2; HPETEs; hydroperoxyeicosatetraenoic acids; HETEs; hydroxyeicosatetraenoic acids; CF; cystic fibrosis; Af; Aspergi
Immunomagnetic molecular probe with UHPLC–MS/MS: A promising way for reliable bronchial asthma diagnostics based on quantification of cysteinyl leukotrienes
Keywords: Cysteinyl leukotrienes; Immunomagnetic separation; UHPLC–MS; Bronchial asthma; Biological matrices
Interleukin-13 enhanced Ca2+ oscillations in airway smooth muscle cells
Keywords: Airway smooth muscle cells; Asthma; Ca2+ oscillation; Interleukin-13; Leukotriene D4; 2-APB; 2-aminoethoxydiphenyl borate; ASMCs; airway smooth muscle cells; CICR; calcium induced calcium release; Cys-LTs; cysteinyl leukotrienes; CysLT1R; cysteinyl leukot
Transplantation/ImmunologyIschemic preconditioning decreased leukotriene C4 formation by depressing leukotriene C4 synthase expression and activity during hepatic I/R injury in rats
Keywords: Ischemia preconditioning; Cysteinyl leukotrienes; Leukotriene C4 synthase; Ischemic reperfusion injury; Liver;
Human TH2 cells respond to cysteinyl leukotrienes through selective expression of cysteinyl leukotriene receptor 1
Keywords: Human; TH1; TH2; cysteinyl leukotrienes; chemotaxis; CYSLTR1; cysteinyl leukotriene receptor 1 protein; LTD4; cAMP; Cyclic AMP; CysLT; Cysteinyl leukotriene; CysLT1; Cysteinyl leukotriene receptor 1 protein; CYSLTR1; Cysteinyl leukotriene receptor 1 gene/
Cellular and Molecular NeuroscienceResearch PaperThe new P2Y-like receptor G protein-coupled receptor 17 mediates acute neuronal injury and late microgliosis after focal cerebral ischemia in rats
Keywords: GPR17; cerebral ischemia; neuronal injury; microgliosis; RNA interference; ANOVA; analysis of variance; CysLTs; cysteinyl leukotrienes; CysLT1 receptor; cysteinyl leukotriene receptor 1; CysLT2 receptor; cysteinyl leukotriene receptor 2; ECA; external car
Pathogenesis of airway inflammation in bronchial asthma
Keywords: Bronchial asthma; Eosinophils; IL-5; Cysteinyl leukotrienes; Mast cells; Neutrophils;
The increasing challenge of discovering asthma drugs
Keywords: ACQ; asthma control questionnaire; AHR; airway hyper-responsiveness; AQLQ; asthma quality-of-life questionnaire; BALF; bronchoalveolar lavage fluid; bn; billion; cysLT; cysteinyl leukotrienes; DZ; dizygotic; EAR; early airway response; FDA; Food and Drug
Asthma translational medicine: Report card
Keywords: ACQ; asthma control questionnaire; AHR; airway hyper-responsiveness; AP-1; activator protein 1; APC; antigen-presenting cell; AQLQ; asthma quality-of-life questionnaire; BALF; bronchoalveolar lavage fluid; CTLA-4; cytotoxic T lymphocyte-associated antigen
Proteome changes of human bronchial epithelial cells in response to pro-inflammatory mediator leukotriene E4 and pro-remodelling factor TGF-β1
Keywords: Bronchial epithelial cells; Cysteinyl leukotrienes; Transforming growth factor-β1; Proteomics; Airway inflammation; Airway remodelling
Urine Concentrations of Cysteinyl Leukotrienes in Children With Obstructive Sleep-Disordered Breathing
Keywords: adenoidal hypertrophy; cysteinyl leukotrienes; montelukast; obstructive sleep-disordered breathing; sleep apnea; tonsillar hypertrophy; BMI; body mass index; CysLT; cysteinyl leukotriene; lnCysLT; natural logarithm of cysteinyl leukotriene concentration i
Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals
Keywords: 5-Lipoxygenase pathway; Ischemic cerebrovascular disease; Transient ischemic attack; Ischemic stroke; Ischemic heart disease; Asthma; Chronic obstructive pulmonary disease; Cysteinyl leukotrienes; Leukotriene C4 synthase
Lipid bodies in oxidized LDL-induced foam cells are leukotriene-synthesizing organelles: a MCP-1/CCL2 regulated phenomenon
Keywords: ADRP; adipose differentiation related protein; AA; arachidonic acid; CCR2; CC chemokine receptor 2; COXs; cyclooxygenases; cPLA2; cytosolic phospholipase A2; cysLTs; cysteinyl leukotrienes; ERK; extracellular signal-regulated kinase; FLAP; five lipoxygena
Corticosteroids as inhibitors of cysteinyl leukotriene metabolic and signaling pathways
Keywords: Cysteinyl leukotrienes; corticosteroids; IL-4CCS, Corticosteroid; CysLT, Cysteinyl leukotriene; CysLT1R, Cysteinyl leukotriene receptor 1; CysLT2R, Cysteinyl leukotriene receptor 2; 5-LO, 5-Lipoxygenase; LT, Leukotriene; LTC4S, Leukotriene C4 synthase
Exposure to tobacco smoke increases leukotriene E4–related albuterol usage and response to montelukast
Keywords: Asthma; children; cysteinyl leukotrienes; LTE4; FENO; montelukastCysLT, Cysteinyl leukotriene; ETS, Environmental tobacco smoke; FENO, Fractional exhaled nitric oxide; GEE, Generalized estimating equation; ICS, Inhaled corticosteroid; IQR, Interquartile r