Keywords: IDH; Isocitrate dehydrogenase; TCA; the tricarboxylic acid; a-KG; a-Ketoglutaric acid; D2HG; D-2-Hydroxyglutaric acid; mIDH1; Mutant IDH1; mIDH2; Mutant IDH2; R132H; Arg132 mutation to His; R132C; Arg132 mutation to Cys; R140Q; Arg140 mutation to Gln; WT;