Keywords: Serine racemase inhibitor; d-Serine; In silico; In vitro;
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Keywords: d-serine; Diabetes; Obesity; Insulin secretion;
Keywords: Prosophyllines and derivatives; Garner's aldehyde; d-serine; Asymmetric catalysis; Chiral auxiliaries;
Keywords: Epileptogenesis; Kindling epileptogenesis; Taurine; Indoleamine 2,3-dioxygenase; d-Serine; Serotonin;
Keywords: Serine racemase; d-Serine; Arc-Luc Tg mice; NMDA receptors; Over-action; In vivo assay;
Keywords: Serine racemase inhibitors; NMDA receptor; In silico screening; d-Serine; Overactivation;
Keywords: Racemases; d-Proline; d-Serine; Inhibition; Substrate-product analogues;
Keywords: Depression; D-serine; L-serine; HVA;
Pharmacokinetics and toxicokinetics of d-serine in rats
Keywords: AUC; area under the plasma concentrationtime curve; AUC0-last; AUC from time 0 to the last point with a quantifiable plasma concentration; AUCip; AUC after intraperitoneal administration; bw; body weight; CLtot; total plasma clearance; Cmax; maximal plasm
Lack of correlation between phonetic magnetic mismatch field and plasma d-serine levels in humans
Keywords: Mismatch negativity (MMN); Speech sounds; d-serine;
Deletion of serine racemase confers D-serine -dependent resilience to chronic social defeat stress
Keywords: Depression; D-Serine; Serine racemase; Stress resilience; BDNF; brain-derived neurotrophic factor; BSA; bovine serum albumin; CSDS; chronic social defeat stress; CSF; cerebrospinal fluid; DG; dentate gyrus; ECL; enhanced chemiluminescence; FST; forced swi
Serine Racemase and D-serine in the Amygdala Are Dynamically Involved in Fear Learning
Keywords: Amygdala; D-serine; Fear conditioning; NMDA receptor; Posttraumatic stress disorder; Serine racemase;
Amino acid analyses of the exosome-eluted fractions from human serum by HPLC with fluorescence detection
Keywords: EVs; extracellular vesicles; HPLC; high-performance liquid chromatography; NBD-F; 4-fluoro-7-nitro-2,1,3-benzoxadiazole; NMDA; N-methyl-D-aspartate; RIPA; radioimmunoprecipitation assay; Exosomes; Human serum; Amino acid; Cystine; d-serine;
Involvement of neuronal and glial activities in control of the extracellular d-serine concentrations by the AMPA glutamate receptor in the mouse medial prefrontal cortex
Keywords: α-Amino-3-hydroxy-5-methyl-4-isoxazolepropioinic acid-type glutamate receptor; Glia; In vivo microdialysis; Medial prefrontal cortex; Neuron; d-Serine; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropioinic acid; AUC; area under curve; HPLC; high-perfo
Human d-amino acid oxidase: The inactive G183R variant
Keywords: ALS; amyotrophic lateral sclerosis; CBIO; 6-chloro-benzo(d)isoxazol-3-ol; CD; circular dichroism; CPZ; chlorpromazine; DAAO; d-amino acid oxidase (EC 1.4.3.3); EYFP; enhanced yellow fluorescent protein; hDAAO; human d-amino acid oxidase; NLS; N-lauroylsar
Age-related vulnerability of pattern separation in C57BL/6J mice
Keywords: Cognitive aging; Pattern separation; Object location; Object feature; D-serine;
d-Serine is a potential biomarker for clinical response in treatment of post-traumatic stress disorder using (R,S)-ketamine infusion and TIMBER psychotherapy: A pilot study
Keywords: PTSD; post-traumatic stress disorder; Ket; (R,S)-ketamine; TIMBER; Trauma Interventions using Mindfulness Based Extinction and Reconsolidation; DSR; d-serine; TM; trauma memory; MB-GET; mindfulness based graded exposure therapy; CBT; cognitive behavioral
Structural basis for potent inhibition of d-amino acid oxidase by thiophene carboxylic acids
Keywords: Flavoenzyme; Schizophrenia; Drug discovery; X-ray crystallography; Molecular dynamics; DAO/DAAO; d-amino acid oxidase; D-Ser; d-serine; SAR; Structure-activity relationship; MD; molecular dynamics; H-bond; hydrogen bond; DOPA; dihydroxyphenylalanine; CPC;
Research articleEffects of pregabalin on spinal d-serine content and NMDA receptor-mediated synaptic transmission in mice with neuropathic pain
Keywords: Pregabalin; d-Serine; NMDAR mediated synaptic current; Spinal superficial dorsal horn; Neuropathic pain; Tight-seal whole-cell recording;
The alteration of serine transporter activity in a cell line model of amyotrophic lateral sclerosis (ALS)
Keywords: Amyotrophic lateral sclerosis (ALS); Motor neuron disease; d-Serine; l-Serine;
Phenylglycine analogs are inhibitors of the neutral amino acid transporters ASCT1 and ASCT2 and enhance NMDA receptor-mediated LTP in rat visual cortex slices
Keywords: D-serine; ASCT1; ASCT2; Phenylglycine; LTP; NMDA;
Spinal D-Serine Increases PKC-Dependent GluN1 Phosphorylation Contributing to the Sigma-1 Receptor-Induced Development of Mechanical Allodynia in a Mouse Model of Neuropathic Pain
Keywords: D-serine; sigma-1 receptor; GluN1 phosphorylation; protein kinase C; neuropathic pain;
CSF d-serine concentrations are similar in Alzheimer's disease, other dementias, and elderly controls
Keywords: Alzheimer's disease; Dementia with Lewy bodies; Frontotemporal dementia; Biological markers; Cerebrospinal fluid; d-serine;
d-Amino acid oxidase inhibitors based on the 5-hydroxy-1,2,4-triazin-6(1H)-one scaffold
Keywords: d-Amino acid oxidase; Flavoenzyme; Pharmacokinetics; Schizophrenia; d-Serine;
Modulation of glycine sites enhances social memory in rats using PQQ combined with d-serine
Keywords: Co-agonist NMDA receptor; Glycine sites; d-serine; PQQ; Schizophrenic;
Endogenous co-agonists of the NMDA receptor modulate contextual fear in trace conditioning
Keywords: NMDA receptor; Glycine modulatory site; D-Serine; Trace conditioning; Contextual conditioning;
The role of D-serine in peripheral tissues
Keywords: D-serine; Serine racemase; NMDA
The inverse link between genetic risk for schizophrenia and migraine through NMDA (N-methyl-D-aspartate) receptor activation via D-serine
Keywords: Migraine; D-serine; Serine-racemase; NMDA hypo-/hyperactivation; Schizophrenia;
Low d-serine levels in schizophrenia: A systematic review and meta-analysis
Keywords: d-Serine; Schizophrenia; N-Methyl-d-aspartate receptor; Meta-analysis;
EphB3 signaling propagates synaptic dysfunction in the traumatic injured brain
Keywords: EphB3 receptors; d-serine; Synapse damage; Synaptic plasticity; Traumatic brain injury;
Restoration of visual performance by d-serine in models of inner and outer retinal dysfunction assessed using sweep VEP measurements in the conscious rat and rabbit
Keywords: Visual evoked potential; Retinal damage; Contrast sensitivity function; d-Serine; LTP; Vision enhancement;
Experimental approaches for elucidating co-agonist regulation of NMDA receptor in motor neurons: Therapeutic implications for amyotrophic lateral sclerosis (ALS)
Keywords: d-Serine; d-Amino acid oxidase (DAO); Amyotrophic lateral sclerosis (ALS); Motor neurons; Glycine
Transition of serine residues to the d-form during the conversion of ovalbumin into heat stable S-ovalbumin
Keywords: d-Amino acid; d-Serine; Ovalbumin; Isomerization; LC–MS/MS
Subchronic pharmacological and chronic genetic NMDA receptor hypofunction differentially regulate the Akt signaling pathway and Arc expression in juvenile and adult mice
Keywords: Schizophrenia; d-Serine; Serine racemase; Tropomyosin receptor kinase B (TrkB); MK801;
Efficacy of Glutamate Modulators in Tic Suppression: A Double-Blind, Randomized Control Trial of D-serine and Riluzole in Tourette Syndrome
Keywords: Tourette syndrome; tics; d-serine; riluzole; glutamate
Correlation of functional GRIN2A gene promoter polymorphisms with schizophrenia and serum d-serine levels
Keywords: NMDArs, N-methyl-d-aspartic acid receptors; d-ser, d-serine; (GT)n, GRIN2A; iGluRs, ionotropic glutamate receptorsGRIN2A; GT; Single nucleotide polymorphism; Schizophrenia; d-Serine
Neuropathic pain depends upon d-serine co-activation of spinal NMDA receptors in rats
Keywords: NMDA; N-methyl-D-aspartate; DAAO; D-aminoacid oxidase; Neuropathic pain; Astrocyte; NMDA receptor; d-Serine;
PEGylated d-serine dehydratase as a d-serine reducing agent
Keywords: d-serine; d-serine dehydratase; PEGylation; d-amino acid; NMDA receptors
Research reportEffects of a glycine transporter-1 inhibitor and D-serine on MK-801-induced immobility in the forced swimming test in rats
Keywords: Forced swimming test; MK-801; Glycine transporter-1 inhibitor; D-serine; Schizophrenia;
Behavioral and cognitive effects of the N-methyl-d-aspartate receptor co-agonist d-serine in healthy humans: Initial findings
Keywords: Behavior; Cognition; N-methyl-d-aspartate receptor; d-serine;
Alterations in the motor cortical and striatal glutamatergic system and d-serine levels in the bilateral 6-hydroxydopamine rat model for Parkinson's disease
Keywords: Bilateral 6-OHDA rat model; Glutamate; Glutamate transporters; d-serine; Motor cortex; Striatum6-OHDA, 6-hydroxydopamine; DA, dopamine; DOPAC, 3,4-dihydroxyphenylacetic acid; IBC, N-isobutyryl-l-cysteine; i.p., intraperitoneally; MPTP, 1-methyl-4-phenyl-1
d-Aspartate: An endogenous NMDA receptor agonist enriched in the developing brain with potential involvement in schizophrenia
Keywords: d-Aspartate; d-Serine; d-Aspartate oxidase; NMDA receptor; Schizophrenia
Spinal sigma-1 receptor activation increases the production of d-serine in astrocytes which contributes to the development of mechanical allodynia in a mouse model of neuropathic pain
Keywords: l-serine O-sulfate potassium salt (PubChem CID: 5951); N-[2-(3,4-dichlorophenyl) ethyl]-N-methyl-2-(dimethylamino) ethylamine dihydro-bromide (PubChem CID: 188,914); d-serine (PubChem CID: 71,077); BD-1047; N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(dime
Short communicationD-serine deficiency attenuates the behavioral and cellular effects induced by the hallucinogenic 5-HT2A receptor agonist DOI
Keywords: NMDA Receptor; D-Serine; Serotonin; 5-HT2A Receptor; Metabotropic glutamate 2 receptor;
Short Communicationd-Serine enhances fear extinction by increasing GluA2-containing AMPA receptor endocytosis
Keywords: d-Serine; AMPA receptors; Extinction;
d-serine prevents cognitive deficits induced by acute stress
Keywords: Stress; d-serine; NMDA receptor; Serine racemase; Prepulse inhibition; Object recognition task; Cognition; NMDAR; N-methyl-d-aspartate receptor; PPI; prepulse inhibition of the acoustic startle response; PFC; prefrontal cortex; LTP; long-term potentiation
Effect of d-serine on spermatogenesis and extracellular signal-regulated protein kinase (ERK) phosphorylation in the testis of the silkworm, Bombyx mori
Keywords: ERK; d-Serine; Signal transduction; Silkworm; Spermatogenesis; Testis
Pathogenic effects of amyotrophic lateral sclerosis-linked mutation in D-amino acid oxidase are mediated by D-serine
Keywords: Amyotrophic lateral sclerosis; Motor neurons; D-serine; D-amino acid oxidase; Autophagy; Apoptosis; N-methyl-D-aspartate receptors;
Astroglial d-serine is the endogenous co-agonist at the presynaptic NMDA receptor in rat entorhinal cortex
Keywords: Entorhinal cortex; Presynaptic NMDA receptor; Glycine; d-Serine; Glutamate release; Astroglia2-AP5, D-2-Amino-5-phosphonopentanoic acid; BsGO, Bacillus subtilis glycine oxidase; CGS15943, (9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine);
Cortical synaptic NMDA receptor deficits in α7 nicotinic acetylcholine receptor gene deletion models: Implications for neuropsychiatric diseases
Keywords: nAChR; nicotinic acetylcholine receptor; NMDAR; N-methyl-d-aspartate receptor; SR; serine racemase; VGLUT1; vesicular glutamate transporter 1; WT; wild-type; α7-KO; α7 nAChR null; α7 nicotinic acetylcholine receptor; Synaptic NMDA receptor; Extrasynapt