Spinal sigma-1 receptor activation increases the production of d-serine in astrocytes which contributes to the development of mechanical allodynia in a mouse model of neuropathic pain

DAAO, d-amino acid oxidase; i.t., intrathecal; LSOS, l-serine O-sulfate potassium salt; NMDA R, N-methyl-d-aspartate receptor; Sig-1R, sigma-1 receptor; Srr, serine racemase.