Keywords: آی تی.; FTIH; first time in human; PP-HOP; pleural pressure-head out plethysmography; WBP; whole body plethysmography; i.t.; intra tracheal; VT; tidal volume; Bpm; breaths per minute; MV; minute volume; ICH; The International Council for Harmonisation of Technica
مقالات ISI آی تی. (ترجمه نشده)
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Keywords: آی تی.; Der p; Dermatophagoides pteronyssinus; Dex; dexamethasone; ELISA; enzyme-linked immunosorbent assay; EMSA; electrophoretic mobility shift assay; FBS; foetal bovine serum; GMCSF; granulocyte-macrophage colony-stimulating factor; GMP; good manufacturing pra
Keywords: آی تی.; Adenoviral dodecahedron; Virus-like particle; Drug delivery, drug resistance, in vivo imaging; Ad Dd; adenoviral dodecahedron; Ad3; adenovirus type 3; BBB; blood-brain barrier; DOX; doxorubicin; FBS; fetal bovine serum; FSC; forward scatter; HCC; hepato
Keywords: آی تی.; DOP; δ opioid receptor; EM-1; endomorphin-1; EM-2; endomorphin-2; i.c.v.; intracerebroventricular; i.p.; intraperitoneal; i.t.; intrathecal; KOP; κ opioid receptor; MOP; μ opioid receptor; MPE; maximum possible effect; s.c.; subcutaneous; Spinal antino
Keywords: آی تی.; BAL; bronchoalveolar lavage; BID; [bis in die] twice a day; CS; chondroitin sulphate; CXCL8; , C-X-C motif chemokine 8/interleukin-8; CXCR1/2; chemokine (C-X-C motif) receptor 1/2; EAU; experimental autoimmune uveitis; ELICO; ELISA-like competition assay;
Keywords: آی تی.; AA; adjuvant arthritis; AVP; arginine vasopressin; CCK; cholecystokinin; CNS; central nervous system; i.c.v.; intracerebroventricular; i.p.; intraperitoneal; i.t.; intrathecal; M. butyricum; Mycobacterium butyricum; NTS; nucleus of the solitary tract; OXT
Keywords: آی تی.; (A-O); atlanto-occipital; bif; bifurcated; CNS; central nervous system; i.t.; intrathecal; s.c.; subcutaneous; Bifurcated; Continuous infusion; Drug delivery; Hindpaw; Mouse; Osmotic pump; Peripheral; Routes of administration; Spinal cord; Surgical me
Keywords: آی تی.; BNP; B-type natriuretic peptide; CQ; chloroquine; DRG; dorsal root ganglia; GRP; gastrin-releasing peptide; GRPR; gastrin-releasing peptide receptor; i.d.; intradermal; i.t.; intrathecal; Npra; B-type natriuretic peptide receptor; NS; nociceptive-specific
Keywords: آی تی.; i.t.; intrathecally; RNS; reactive nitrogen species; ROS; reactive oxygen species; aging; brain regions; carnosine; [3H]-5-HT binding;
Keywords: آی تی.; AMP; adenosine 5â²-monophosphate; ASIC; acid-sensitive ion channel; ATP; adenosine 5â²-triphosphate; CNS; central nervous system; CREB; cyclic AMP responsive element binding protein; DAG; diacylglycerol; ERK; extracellular signal-regulated protein kinas
Keywords: آی تی.; AM; adrenomedullin; BAM22; bovine adrenal medulla 22; CGRP; calcitonin gene-related peptide; CLR; calcitonin receptor-like receptor; DRG; dorsal root ganglion; i.t.; intrathecal; nNOS; nitric oxide synthase; PB; phosphate buffer; PBS; phosphate-buffered s
Keywords: آی تی.; BS; bystander; i.p.; intraperitoneal; i.t.; intratumor; CTL; control; INH; inhibition phase; REC; recovery phase; Chemotherapy; Bystander tumor; Metabolomics; Transcriptomics; Oxidative stress;
Keywords: آی تی.; BBB; blood-brain barrier; CAD; Charged Aerosol Detector; CM; chitosan-microsphere; CP; compritol; CTS; cryptotanshinone; DGLC; Double gradient liquid chromatograph; DH-Ppt; dehydrogynated protopanaxatriol; DSS; danshensu; F; bioavailability; FA; ferulic
Sequential actions of immune effector cells induced by viral activation of dendritic cells to eliminate murine neuroblastoma
Keywords: آی تی.; DCs; dendritic cells; rSeV; recombinant Sendai virus; Ts-rSeV/dF; temperature-sensitive mutant F-defective nontransmissible rSeV; CTLs; cytotoxic T lymphocytes; NK cells; natural killer cells; i.t.; intratumoral injection; i.p.; intraperitoneal injection;
Blockade of analgesic effects following systemic administration of N-methyl-kyotorphin, NMYR and arginine in mice deficient of preproenkephalin or proopiomelanocortin gene
Keywords: آی تی.; NMYR; N-methyl-l-tyrosine-l-arginine; PENK; preproenkephalin; POMC; proopiomelanocortin; Leu-Arg; l-leucine-l-arginine; NMLR; N-methyl-l-Leucine-l-arginine; WT; wild-type; KO; knockout; DAMGO; [D-Ala2, N-Methyl-Phe4, Gly5-ol] enkephalin; MOPr; μ opioid r
Antinociceptive effects of the endogenous cannabinoid peptide agonist VD-hemopressin(β) in mice
Keywords: آی تی.; ANOVA; analysis of variance; AM251; N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3- carboxamide; AM630; 6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3- yl(4-methoxyphenyl)-methanone; AUC; area under the curve; CB1
CB1 cannabinoid receptor agonist mouse VD-hemopressin(α) produced supraspinal analgesic activity in the preclinical models of pain
Keywords: آی تی.; AM251; N-(piperidin-1-yl-5-(4-iodophenyl-1-(2,4-dichlorophenyl-4-methyl-1H-pyrazole-3-carboxamide; AM4113; 5-(4-alkylphenyl-1-(2,4-dichlorophenyl-4-methyl-N-(piperidin-1-yl-1H-pyrazole-3-carboxamide; AM630; 6-iodo-2-methyl-1-[2-(4-morpholinylethyl]-1H-ind
Adipose-derived stem cells decrease pain in a rat model of oxaliplatin-induced neuropathy: Role of VEGF-A modulation
Keywords: آی تی.; Adipose stem cells; Chemotherapy-induced neuropathic pain; VEGF-A; VEGF165b; Bevacizumab; VEGF-R1; Intrathecal; TGF-β1; EGF; CMTMR; 5-(and 6)-(((4-chloromethyl)benzoyl)amino)tetramethylrhodamine; DRG; dorsal root ganglion; i.p.; intraperitoneal; i.t.; in
Evidence of a role for spinal HMGB1 in ischemic stress-induced mechanical allodynia in mice
Keywords: آی تی.; CPSP; central post-stroke pain; HMGB1; high-mobility group box-1; BCAO; bilateral carotid artery occlusion; mAb; monoclonal antibody; LMWH; low-molecular-weight heparin; LPS-RS; lipopolysaccharides from the photosynthetic bacterium Rhodobacter sphaeroides
Research articleThe new HDAC1 inhibitor LG325 ameliorates neuropathic pain in a mouse model
Keywords: آی تی.; CCI; chronic constriction injury; HAT; histone acetyltransferases; HDAC; histone deacetylase; i.t.; intrathecal; PSL; partial sciatic nerve ligation; SNI; spared nerve injury; SNL; spinal nerve ligation; Neuropathic pain; HDAC1, LG325, mechanical allodyni
FTY720 promotes pulmonary fibrosis when administered during the remodelling phase following a bleomycin-induced lung injury
Keywords: آی تی.; Gilenya®; Bleomycin; Leakage; Inflammation; Sphingosine-1-phosphate; Fibrosis; ANOVA; Analysis of variance; BALF; bronchoalveolar lavage fluid; BSA; bovine serum albumin; CTGF; connective tissue growth factor; ELISA; enzyme-linked immunosorbent assay; Gn
ESC-derived thymic epithelial cells expressing MOG prevents EAE by central and peripheral tolerance mechanisms
Keywords: آی تی.; EAE; experimental autoimmune encephalomyelitis; MS; multiple sclerosis; MOG; myelin oligodendrocyte glycoprotein; TEPs; thymic epithelial progenitors; TECs; thymic epithelial cells; ESCs; embryonic stem cells; mESCs; mouse embryonic stem cells; TCR; T cel
Oral treatment with essential oil of Hyptis spicigera Lam. (Lamiaceae) reduces acute pain and inflammation in mice: Potential interactions with transient receptor potential (TRP) ion channels
Keywords: آی تی.; ANOVA; analysis of variance; COX-2; cyclooxygenase 2; ED50; median effective dose; EOHs; essential oil of Hyptis spicigera; GC-MS; gas chromatography-mass spectrometry; i.pl.; intraplanter; i.t.; intrathecal; IL-1β; interleukin 1; iNOS; inducible nitric
World Trade Center (WTC) dust exposure in mice is associated with inflammation, oxidative stress and epigenetic changes in the lung
Keywords: آی تی.; WTC; World Trade Center; i.t.; intratracheal; i.p.; intraperitoneal; HO-1; heme oxygenase-1; COX-2; cyclooxygenase-2; MMP-12; matrix metalloproteinase-12; BAL; bronchoalveolar lavage; PEEP; positive end expiratory pressure; COPD; chronic obstructive pulmo
Research PaperInflammation-induced GluA1 trafficking and membrane insertion of Ca2Â + permeable AMPA receptors in dorsal horn neurons is dependent on spinal tumor necrosis factor, PI3 kinase and protein kinase A
Keywords: آی تی.; AMPA; α-amino-3-hydroy-5-methyl-4-isoxazolepropionic acid; AMPAr; AMPA receptor; EPSC; excitatory post-synaptic current; ETA; Etanercept; i.t.; intrathecal; LTD; long term depression; LTP; long term potentiation; NMDA; N-methyl-D-aspartic acid; NMDAr; NM
TIPS pentacene loaded PEO-PDLLA core-shell nanoparticles have similar cellular uptake dynamics in M1 and M2 macrophages and in corresponding in vivo microenvironments
Keywords: آی تی.; Asthma; LPS; Nanoparticle; Pulmonary drug delivery; Inflammation; PEG; polyethylene glycol; Th1; T helper cell type 1; Th2; T helper cell type 2; AAMs; alternatively activated macrophage; PLGA; poly(lactide-co-glycolide); LiLa; lipid-latex hybrid; PtdSer;
Up-regulation of CXCL1 and CXCR2 contributes to remifentanil-induced hypernociception via modulating spinal NMDA receptor expression and phosphorylation in rats
Keywords: آی تی.; CFA; complete freund's adjuvant; CXCL1; chemokine (C-X-C motif) ligand 1; GAPDH; glyceraldehydes 3-phosphate dehydrogenase; GSK-3β; glycogen synthase kinase-3β; i.t.; intrathecally; i.v.; intravenously; NMDA; N-methyl-d-aspartate; NS; normal saline; P
Blockade of the spinal BDNF-activated JNK pathway prevents the development of antiretroviral-induced neuropathic pain
Keywords: آی تی.; Antiretroviral; Neuropathic pain; JNK; BDNF; Caspase-3; ATF3; activating transcription factor 3; ddC; 2â²,3â²-dideoxycitidine; d4T; 2â²,3â²-didehydro-3â²-deoxythymidin; DRG; dorsal root ganglia; i.p.; intraperitoneal; i.t.; intrathecal; JNK; c-Jun N-
Dermatophagoides pteronyssinus group 2 allergen bound to 8-OH modified adenine reduces the Th2-mediated airway inflammation without inducing a Th17 response and autoimmunity
Keywords: آی تی.; AIT; allergy immunotherapy; BALF; bronchoalveolar lavage fluid; BMDC; bone marrow dendritic cell; DC; dendritic cell; i.t.; intratracheally; MNC; mononuclear cells; nDer p2; natural dermatophagoides pteronyssinus group 2 major allerg; Adjuvants; Vaccines;
Increase of neurofilament-H protein in sensory neurons in antiretroviral neuropathy: Evidence for a neuroprotective response mediated by the RNA-binding protein HuD
Keywords: آی تی.; aODN; antisense oligonucleotide; BDNF; brain derived neurotrophic factor; ddC; 2⿲,3⿲-dideoxycitidine; DMSO; dimethylsulfoxide; DRG; dorsal root ganglia; i.p.; intraperitoneal; i.t.; intrathecal; LFB; luxol fast blue; NF-L; neurofilament light; NF-M; n
Antitumor dendritic cell-based vaccines: lessons from 20Â years of clinical trials and future perspectives
Keywords: آی تی.; APCs; antigen-presenting cells; cDCs; classical DCs; CTLs; cytotoxic T cells; CTLA-4; cytotoxic T-lymphocyte-associated antigen 4; DC; dendritic cell; Dex; dendritic cell-derived exosomes; EMA; European Medicines Agency; FDA; Food and Drug Administratio
Intrathecal administration of rapamycin inhibits the phosphorylation of DRG Nav1.8 and attenuates STZ-induced painful diabetic neuropathy in rats
Keywords: آی تی.; STZ; streptozotocin; PDN; painful diabetic neuropathy; DRG; dorsal root ganglion; mTOR; mammalian target of rapamycin; S6K; ribosomal protein S6 kinase; 4E-BP; eukaryotic initiation factor 4E (eIF4E) binding protein; IR; insulin receptor; IRS-1; insulin r
PEGylation of paclitaxel largely improves its safety and anti-tumor efficacy following pulmonary delivery in a mouse model of lung carcinoma
Keywords: آی تی.; BAL; bronchoalveolar lavage; DLS; dynamic light scattering; DMEM; Dulbecco's Modified Eagle Medium; PBS; phosphate-buffered saline; EPR; enhanced permeability and retention; FBS; fetal bovine serum; HBSS; Hank's balanced salt solution; HPLC; high perfor
Mechanisms involved in the antinociception induced by spinal administration of inosine or guanine in mice
Keywords: آی تی.; A1; adenosine receptor type 1; A2A; adenosine receptor type 2A; A3; adenosine receptor type 3; ADP; adenosine diphosphate; AMP; adenosine monophosphate; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AOPCP; É,β-methyleneadenosine 5â²-diph
Reversal of neurochemical alterations in the spinal dorsal horn and dorsal root ganglia by Mas-related gene (Mrg) receptors in a rat model of spinal nerve injury
Keywords: آی تی.; BAM8-22; bovine adrenal medulla 8-22; CREB; cyclic AMP response element-binding protein; DMEM; Dulbecco's modified Eagle's medium; DRG; dorsal root ganglion or ganglia; ERK; extracellular signal-regulated kinase; GFAP; glial fibrillary acidic protein;
N-acetyl cysteine improves the effects of corticosteroids in a mouse model of chlorine-induced acute lung injury
Keywords: آی تی.; AHR; airway hyperresponsiveness; ALI; acute lung injury; BAL; bronchoalveolar lavage; Cl2; chlorine; ERS; respiratory elastance; DEX; dexamethasone (low-dose); G; tissue resistance; H; tissue elastance; HDEX; dexamethasone (high-dose); i.p.; intraperitone
Research reportBidirectional amygdaloid control of neuropathic hypersensitivity mediated by descending serotonergic pathways acting on spinal 5-HT3 and 5-HT1A receptors
Keywords: آی تی.; CeA; central nucleus of amygdala; i.t.; intrathecal; NMDA; N-methyl-d-aspartate; 8-OH-DPAT; 8-hydroxy-2-dipropylaminotetralin; RVM; rostral ventromedial medulla; Amygdala; Descending pain control; Neuropathic pain; Rostral ventromedial medulla; Serotonerg
Spinal RyR2 pathway regulated by the RNA-binding protein HuD induces pain hypersensitivity in antiretroviral neuropathy
Keywords: آی تی.; aODN; antisense oligonucleotide; CaMKII; Ca2Â +-calmodulin-dependent kinase II; ddC; 2â²,3â²-dideoxycitidine; dODN; degenerate oligonucleotide; ELAV protein; embryonic lethal abnormal vision protein; HIV-SN; HIV-associated sensory neuropathy; i.p.; intr
Spinal sigma-1 receptor activation increases the production of d-serine in astrocytes which contributes to the development of mechanical allodynia in a mouse model of neuropathic pain
Keywords: آی تی.; l-serine O-sulfate potassium salt (PubChem CID: 5951); N-[2-(3,4-dichlorophenyl) ethyl]-N-methyl-2-(dimethylamino) ethylamine dihydro-bromide (PubChem CID: 188,914); d-serine (PubChem CID: 71,077); BD-1047; N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(dime
Involvement of p38 MAPK activation mediated through AT1 receptors on spinal astrocytes and neurons in angiotensin II- and III-induced nociceptive behavior in mice
Keywords: آی تی.; Angiotensin II; Angiotensin III; AT1 receptors; Nociceptive behavior; p38 MAPK; Astrocyte; Neuron; Intrathecal administration; Mice; Ang; angiotensin; AT1; Ang II type 1; AT2; Ang II type 2; i.t.; intrathecal; MAPK; mitogen-activated protein kinase; ACE;
Role of nerve growth factor-tyrosine kinase receptor A signaling in paclitaxel-induced peripheral neuropathy in rats
Keywords: آی تی.; BDNF; brain-derived neurotrophic factor; DH; spinal dorsal horn; DRG; dorsal root ganglia; I.P.; intraperitoneal; I.T.; intrathecal; NEDD4-2; neural precursor cell-expressed developmentally downregulated 4-2; NGF; nerve growth factor; p75NTR; p75 neurotro
Analgesic tolerance and cross-tolerance to the cannabinoid receptors ligands hemopressin, VD-hemopressin(α) and WIN55,212-2 at the supraspinal level in mice
Keywords: آی تی.; AM251; N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide; AM630; 6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl(4-methoxyphenyl)-methanone; CB1; cannabinoid receptor type 1; CB2; cannabinoid receptor t
Astrogliosis as a therapeutic target for neurodegenerative diseases
Keywords: آی تی.; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ATP; adenosine triphosphate; BB14®; nerve growth factor-like peptide; BDNF; brain-derived neurotrophic factor; Ca2+; calcium; CNS; central nervous system; COX-1/2; cyclooxygenase-1/2; EAAC1; ex
Neuropharmacology and analgesiaAntinociceptive effect of botulinum toxin type A on experimental abdominal pain
Keywords: آی تی.; BTX-A; botulinum toxin type A; CNS; central nervous system; CSF; cerebrospinal fluid; GABA; γ-aminobutyric acid; i.c.; intracisternal; i.col.; intracolonic; i.p.; intraperitoneal; i.t.; intrathecal; NGS; normal goat serum; NSAIDs; Non-steroidal anti-infl
Activation of spinal α2 adrenergic receptors induces hyperglycemia in mouse though activating sympathetic outflow
Keywords: آی تی.; I.t.; Intrathecal; I.p.; Intraperitoneal; PTX; Pertussis toxin; 6-OHDA; 6-hydroxydopamine; ADX; Adrenalectomy; ICR; Imprinting control region; PEC; The polyethylene glycol 400; ethanol; sodium carboxymethyl cellulose mixture; Gi; inhibitory G protein; DSP
RHOB influences lung adenocarcinoma metastasis and resistance in a host-sensitive manner
Keywords: آی تی.; GTPase; Non-cell autonomous; Microenvironment; Tumor-stroma; MMP; Chemotherapy; Radiotheraphy; Drug target; ADC; Adenocarcinoma; SQ; squamous cell carcinoma; TP; time to progression; i.c.; intracardiac; i.t.; intratibial; HMS; highly-metastatic subpopulat
The spinal inhibition of N-type voltage-gated calcium channels selectively prevents scratching behavior in mice
Keywords: آی تی.; ANOVA; analysis of variance; EDTA; ethylenediaminetetraacetic acid; GRP; gastrin-releasing peptide; GRPR; gastrin-releasing peptide receptor; i.d.; intradermal; i.t.; intrathecal; MPO; myeloperoxidase; PAR-2; proteinase-activated receptor 2; PBS; phosphat
Agile delivery of protein therapeutics to CNS
Keywords: آی تی.; Aβ; amyloid β; Ab-InsR; antibodies against insulin receptor; Ab-TfR; antibodies against transferrin receptor; AD; Alzheimer's disease; Aerosol OT; bis-(2-ethylhexyl) sulfosucciate; ALS; amyotrophic lateral sclerosis; ApoB; apolipoprotein B; ApoE; apolip
Involvement of μ-opioid receptors in antinociceptive action of botulinum toxin type A
Keywords: آی تی.; Botulinum toxin A; Opioid antagonist; μ-Opioid receptors; Formalin test; Peripheral neuropathy; c-Fos; BTX-A; botulinum toxin type A; SNAP-25; Synaptosomal Associated Protein of 25 kDa; i.pl.; intraplantarly; s.c.; subcutaneously; i.t.; intrathecally; i
Neuromedin U causes biphasic cardiovascular effects and impairs baroreflex function in rostral ventrolateral medulla of spontaneously hypertensive rat
Keywords: آی تی.; AUC; area under the curve; BP; blood pressure; HR; heart rate; i.t.; intrathecal; MAP; mean arterial pressure; NMU; neuromedin U; NMU1; neuromedin U receptor 1; NMU2; neuromedin U receptor 2; NTS; nucleus tractus solitarius; PBS; phosphate buffered saline