Leukocytes and drug-resistant cancer cells are targets for intracellular delivery by adenoviral dodecahedron

The covalent attachment of doxorubicin to Dd enables efficient drug delivery and significantly enhances cytotoxicity in multidrug resistant cancer cells in vitro. Importantly, the affinity of Dd in human blood ex vivo is highly in favor of leukocytes, independently of their subtypes despite high representation of red blood cells and platelets. Thus, current results demonstrate that Dd is a promising vector targeting leukocytes and drug resistant cancer cells.210