TIPS pentacene loaded PEO-PDLLA core-shell nanoparticles have similar cellular uptake dynamics in M1 and M2 macrophages and in corresponding in vivo microenvironments

Nanoparticles are promising drug delivery and bioimaging platforms. However, the cellular uptake dynamics of nanoparticles are not fully understood, especially in the case of macrophages that can differentiate into different M1 or M2 polarization states to tightly regulate inflammation. In this study, the cellular uptake dynamics of nanoparticles were investigated in polarized macrophages and in the context of either acute or allergic lung inflammation. The overall findings of this paper demonstrate that M1 and M2 macrophages display similar cellular uptake dynamics both ex vivo and in vivo under corresponding Th1 and Th2 modulated microenvironments.85