دانلود مقالات ISI درباره خراب + ترجمه فارسی

آنالوگهای دوزهای چربی با یک لینک دهنده جدید منجر به فعالیت های آگونیست قوی در گیرنده های مو، دلتا و کاپا می شود

Cyclic biphalin analogues with a novel linker lead to potent agonist activities at mu, delta, and kappa opioid receptors

Keywords: خراب; Biphalin; Opioid receptors; MOR/DOR/KOR agonist; Synergistic analgesic effect; Cyclic peptides; Acm; acetamidomethyl; ACN; acetonitrile; BBB; blood brain barrier; Boc; t-butyloxycarbonyl; BOP; (benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluoro

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2018 سفارش ترجمه

پیشرفت در درک مکانیسم های اثرات جانبی ناشی از داروهای مهارکننده مخدر و افسردگی تنفسی

Progress in understanding mechanisms of opioid-induced gastrointestinal adverse effects and respiratory depression

Keywords: خراب; Opioids; Analgesia; Adverse effects; Mechanisms; Constipation; Nausea; Vomiting; Respiratory depression; 5-HT; 5-hydroxytryptamine; 7TMRs; 7-transmembrane spanning G-protein coupled receptors; AC; adenylyl cyclase; β-arr1; β-arrestin1; β-arr2; β-arres

دانلود رایگان متن کامل مقاله ISI 60 صفحه سال انتشار : 2018 سفارش ترجمه

تأثیر فعال سازی گیرندههای اپتیوپسی دلتا در شناخت فضایی و نوروژنز در موشهای صحرایی ایسکمیک مغزی

Research paperEffect of delta opioid receptor activation on spatial cognition and neurogenesis in cerebral ischemic rats

Keywords: خراب; Delta-opioid receptor; DADLE; Cerebral ischemia; Neurogenesis; Spatial cognition;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

درمان های غیر دارویی برای سکته مغزی: مکانیسم ها و پیامدهای بالینی

Non-pharmaceutical therapies for stroke: Mechanisms and clinical implications

Keywords: خراب; ACP; antegrade cerebral perfusion; AMES; assisted movement with enhanced sensation; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid; BAIPC; bilateral arm ischemic preconditioning; BBB; blood-brain barrier; BCI; Brain-Computer Interface; B

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2014 سفارش ترجمه

Up-regulation of μ-, δ- and κ-opioid receptors in concanavalin A-stimulated rat spleen lymphocytes

Keywords: خراب; Opioids receptors; Up-regulation; Concanavalin A; Rat spleen lymphocytes; G proteins; β-arrestin-1/2; Ab; antibodies; Bt, Bnsp, Bsp; total, non-specific and specific radioligand binding; Con A; Concanavalin A; DAMGO; [(2-D-alanine-2-4-methylphenylalanine

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Induction of oxidative stress by long-term treatment of live HEK293 cells with therapeutic concentration of lithium is associated with down-regulation of δ-opioid receptor amount and function

Keywords: خراب; AAS; atomic absorption spectroscopy; Ab; antibody; BD; bipolar disorder; DADLE; (2-d-alanine-5-d-leucine)-enkephalin = Tyr-d-Ala-Gly-Phe-d-Leu; DCF; 2′,7′-dichlorofluorescein; DCFH-DA; 2′,7′-dichlorofluorescin diacetate (synonym dichlorodihydr

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Can crosstalk between DOR and PARP reduce oxidative stress mediated neurodegeneration?

Keywords: خراب; Oxidative stress (OS); Delta opioid receptor (DOR); Poly (ADP-ribose)-polymerase1 (PARP1); Neuroprotection; Attenuation; OS; Oxidative stress; DOR; Delta opioid receptor; PARP; Poly (ADP-ribose)-polymerase; AD; Alzheimer's disease; PD; Parkinson's disease

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2018 سفارش ترجمه

Site-specific O-glycosylation of N-terminal serine residues by polypeptide GalNAc-transferase 2 modulates human δ-opioid receptor turnover at the plasma membrane

Keywords: خراب; β1AR; β1-adrenergic receptor; DADLE; D-Ala2, D-Leu5-Enkephalin; Endo H; endo-β-N-acetylglucosaminidase H; ER; endoplasmic reticulum; FBS; fetal bovine serum; Gal; galactose; GalNAc; N-acetylgalactosamine; GalNAc-T; GalNAc-transferase; GPCR; G protein-c

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2018 سفارش ترجمه

DADLE enhances viability and anti-inflammatory effect of human MSCs subjected to 'serum free' apoptotic condition in part via the DOR/PI3K/AKT pathway

Keywords: خراب; Cell survival; DADLE; MSCs; PI3K/Akt signaling; Anti-inflammatory cytokines;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Proteomic analysis of protein composition of rat forebrain cortex exposed to morphine for 10 days; comparison with animals exposed to morphine and subsequently nurtured for 20 days in the absence of this drug

Keywords: خراب; ABC; ammonium bicarbonate; ACN; acetonitrile; AC; adenylyl cyclase; CBB; Coomassie Brilliant Blue; CNS; central nervous system; DAMGO; [(2-d-alanine2-4-methylphenylalanine-5-glycineol)-enkefalin]; DADLE; [(2-d-alanine-5-d-leucine)-enkefalin]; 2D-ELFO; t

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Protective effect of delta opioid agonist [d-Ala2, d-Leu5] enkephalin on spinal cord ischemia reperfusion injury by regional perfusion into abdominal aorta in rabbits

Keywords: خراب; DADLE; Spinal cord; Ischemia reperfusion injury; Neuroprotection; Rabbits;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Blood-brain transfer and antinociception of linear and cyclic N-methyl-guanidine and thiourea-enkephalins

Keywords: خراب; Blood-brain barrier (BBB) transport (influx/efflux); Antinociceptive activity; Linear/cyclic enkephalin analogs; In vivo mouse models; AUC; area under the curve; Alloc; allyloxycarbonyl; BBB; blood-brain barrier; Boc; tertButyloxycarbonyl; BSA; bovine

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

[d-Ala2, d-Leu5] encephalin (DADLE) reversibly inhibits cellular transcription in neurons without causing cell injury

Keywords: خراب; DADLE; [d-Ala(2)-d-Leu(5)]-Enkephalin; DOR; delta opioid receptor; CTD; C-terminal domain; OGD; oxygen glucose deprivation; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; DADLE; Neurons; RNA polymerase II; SH-SY5Y; Transcription;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Factors that Restrict the Cell Permeation of Cyclic Prodrugs of an Opioid Peptide, Part 4: Characterization of the Biopharmaceutical and Physicochemical Properties of Two New Cyclic Prodrugs Designed to be Stable to Oxidative Metabolism by Cytochrome P-45

Keywords: خراب; cyclic peptide prodrug; ester prodrug; DADLE; opioid peptide; physicochemical properties; molecular dynamics; structure; permeability; cytrochrome P-450

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Factors that Restrict the Cell Permeation of Cyclic Prodrugs of an Opioid Peptide, Part 3: Synthesis of Analogs Designed to have Improved Stability to Oxidative Metabolism

Keywords: خراب; cyclic peptide prodrug; DADLE; opioid peptide; peptides; metabolism; cytochrome P450; oxidation; structure; synthesis

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Delta opioid peptide [d-Ala2, d-Leu5] enkephalin (DADLE) triggers postconditioning against transient forebrain ischemia

Keywords: خراب; DADLE; Postconditioning; Hippocampus; Transient forebrain ischemia; Akt; Morris water maze

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Astroglial reaction to delta opioid peptide [d-Ala2, d-Leu5] enkephalin confers neuroprotection against global ischemia in the adult rat hippocampus

Keywords: خراب; astrocyte; hippocampus; immunoreactivity; p-Akt; active caspase-3; global ischemia; ACSF; artificial cerebrospinal fluid; DADLE; [d-Ala2, d-Leu5] enkephalin; DOR; delta opioid receptor; GFAP; glial fibrillary acidic protein; SGZ; subgranular zone;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Up-regulation of adenylylcyclases I and II induced by long-term adaptation of rats to morphine fades away 20 days after morphine withdrawal

Keywords: خراب; AC; adenylyl cyclase; β-AR; β-adrenergic receptor; DADLE; [2-d-alanine, 5-d-leucine]enkephalin = Tyr-d-Ala-Gly-Phe-d-Leu; DAMGO; [2-d-alanine, 4-N-methylphenylalanine, 5-glycinol]enkephalin = Tyr-d-Ala-Gly-N-methyl-Phe-Gly-ol; DOR; δ-opioid recepto

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

A comprehensive study on the putative δ-opioid receptor (sub)types using the highly selective δ-antagonist, Tyr-Tic-(2S,3R)-β-MePhe-Phe-OH

Keywords: خراب; Bmax; receptor density; BNTX; 7-benzylidenenaltrexone; DADLE; [d-Ala2,d-Leu5]enkephalin; deltorphin II; Tyr-d-Ala-Phe-Glu-Val-Val-Gly-NH2; DOR-1; δ-opioid receptor; DOR-KO; δ-opioid receptor knock-out; DPDPE; Tyr-c[d-Pen-Gly-Phe-d-Pen]-OH; DSLET; Tyr-d-

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Fluorescence spectroscopy studies of HEK293 cells expressing DOR-Gi1α fusion protein; the effect of cholesterol depletion

Keywords: خراب; β-CDX; β-cyclodextrin; DADLE; D-Ala2-D-Leu5 enkephalin; DMEM; Dulbecco's modified Eagle's medium; DOR; δ-opioid receptor; DOR-Gi1α cells; HEK293 cells stably expressing DOR-Gi1α (Cys351-Ile351) fusion protein; DPH; 1,6-diphenyl-1,3,5-hexatriene; DR

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Effects of intracerebroventricular application of the delta opioid receptor agonist [d-Ala2, d-Leu5] enkephalin on neurological recovery following asphyxial cardiac arrest in rats

Keywords: خراب; global cerebral ischemia; neurological deficit; delta opioid; hippocampus; neuroprotection; ACSF; artificial cerebrospinal fluid; BBB; blood brain barrier; CA; cardiac arrest; CPR; cardiopulmonary resuscitation; DADLE; [d-Ala2, d-Leu5] enkephalin; DOR; de

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

Research ReportDelta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) reduced oxygen-glucose deprivation caused neuronal injury through the MAPK pathway

Keywords: خراب; DADLE; Neuron; Neuroprotection; ERK; P38; JNK;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

δ-Opioid receptors stimulate ERK1/2 activity in NG108-15 hybrid cells by integrin-mediated transactivation of TrkA receptors

Keywords: خراب; DADLE; [d-Ala2, d-Leu5]enkephalin; DOR; δ-opioid receptor; EGF; epidermal growth factor; ERK; extracellular signal-regulated protein kinase; FN; fibronectin; NG108-15 cells; neuroblastoma × glioma (NG108-15) hybrid cells; TrkA; tropomyosin-related kin

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Assessment of the delta opioid agonist DADLE in a rat model of lethal hemorrhage treated by emergency preservation and resuscitation

Keywords: خراب; Hypothermia; Hemorrhage; Shock; Cerebral ischemia; Cardiopulmonary bypass; Suspended animation; DADLE; Delta opioid agonist;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Delta opioid receptors stimulation with [d-Ala2, d-Leu5] enkephalin does not provide neuroprotection in the hippocampus in rats subjected to forebrain ischemia

Keywords: خراب; Delta opioid; DADLE; Forebrain ischemia; Neuroprotection; Hippocampus;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Dose-dependent neuroprotection of delta opioid peptide [d-Ala2, d-Leu5] enkephalin in neuronal death and retarded behavior induced by forebrain ischemia in rats

Keywords: خراب; DADLE; Intracerebroventricular administration; Neuroprotection; Forebrain ischemia; Morris water maze; Rats

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه