Asparagine Deamidation Dependence on Buffer Type, pH, and Temperature
Keywords: انحلال; deamidation; formulation; kinetics; protein formulation; stability; buffer; pH; temperature;
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Process scale separation of an anti-CD22 immunotoxin charge variant
Keywords: انحلال; Moxetumomab pasudotox; Deamidation; Scale-up; Immunotoxin; Charge variant; CD22
Effects of enzymatic modification of wheat protein on the formation of pyrazines and other volatile components in the Maillard reaction
Keywords: انحلال; Wheat gluten; Deamidation; Ammonia; Volatile components; Pyrazines;
Microbial transglutaminase-induced structural and rheological changes of cationic and anionic myofibrillar proteins
Keywords: انحلال; Transglutaminase; Myofibrillar; Isoelectric point; Cross-linking; Deamidation
UHT milk contains multiple forms of αS1-casein that undergo degradative changes during storage
Keywords: انحلال; Two dimensional gel electrophoresis; Casein; Phosphorylation; Deamidation; Alternative splicing;
A Mechanism-Based Kinetic Analysis of Succinimide-Mediated Deamidation, Racemization, and Covalent Adduct Formation in a Model Peptide in Amorphous Lyophiles
Keywords: انحلال; nonreducible aggregates; amorphous solids; chemical stability; deamidation; lyophilization; solid-state kinetics; peptide stability; protein aggregation; solid state stability
Effects of Water and Polymer Content on Covalent Amide-Linked Adduct Formation in Peptide-Containing Amorphous Lyophiles
Keywords: انحلال; amorphous; chemical stability; deamidation; hypromellose; lyophilization; nonreducible aggregates; solid-state stability; peptide stability; phase separation; protein aggregation
Forced Degradation of Therapeutic Proteins
Keywords: انحلال; Comparability studies; Forced degradation (stress testing); Analysis; Deamidation; Oxidation; Protein aggregation; Protein formulation; Protein structure; Proteins Stability;
Amino acids: Chemistry, functionality and selected non-enzymatic post-translational modifications
Keywords: انحلال; Amino acid chemistry; Post-translational modifications; Protein species; Thiol group; Deamidation; Carbonylation;
Pathophysiology of Celiac Disease
Keywords: انحلال; Celiac disease; HLA-DQ2 and HLA-DQ8; Single-nucleotide polymorphisms; Intestinal microbiome; Gluten; Deamidation; Adaptive and innate immunity;
Energy metabolism and ageing regulation: Metabolically driven deamidation of triosephosphate isomerase may contribute to proteostatic dysfunction
Keywords: انحلال; Glycation; Methylglyoxal; Dihydroxyacetone; Deamidation; Triosephosphate isomerase; Glycolysis; Altered proteins; Ageing; Proteotoxicity
Effects of glutaminase deamidation on the structure and solubility of rice glutelin
Keywords: انحلال; Rice glutelin; Glutaminase; Deamidation; Structure; Solubility;
Effects of deamidation on aggregation and emulsifying properties of barley glutelin
Keywords: انحلال; Barley protein; Glutelin; Deamidation; Aggregation; Solubility; Emulsifying property;
Emulsion preparation with modified oat bran: Optimization of the emulsification process for microencapsulation purposes
Keywords: انحلال; Oat bran; Modification; Emulsion; Stability; Homogenization; Deamidation; Microencapsulation
Adsorption of deamidated antibody variants on macroporous and dextran-grafted cation exchangers: I. Adsorption equilibrium
Keywords: انحلال; Monoclonal antibody charge variants; Deamidation; Adsorption isotherm; Ion exchange; Selectivity; Linear gradient elution
Identification and characterization of oxidation and deamidation sites in monoclonal rat/mouse hybrid antibodies
Keywords: انحلال; HPLC, high performance liquid chromatography; LC/MS, liquid chromatography mass spectrometry; ESI, electrospray ionization; MWCO, molecular weight cutoff; FFE, free flow electrophoresis; IEF, isoelectric focusingOxidation; Deamidation; Rat; Mouse; Antibod
Solvent accessibility of βB2-crystallin and local structural changes due to deamidation at the dimer interface
Keywords: انحلال; lens; β-crystallins; deamidation; hydrogen/deuterium exchange with mass spectrometry; 3D structure; MW; molecular weight; SDS-PAGE; sodium dodecyl sulfate - polyacrylamyde gel electrophoresis; 3D; three dimensional; bis-ANS; 4,4â²-Bis (1-anilinonaphth
Aggregation of deamidated human βB2-crystallin and incomplete rescue by α-crystallin chaperone
Keywords: انحلال; lens; β-crystallins; deamidation; α-crystallin chaperone; protein aggregation; cataracts; IPTG; isopropyl α-d-thiogalactoside; PMSF; phenyl-methyl-sulfonyl fluoride; DLS; dynamic light scattering; Rh; hydrodynamic radius; Pd; polydispersity; SAXS; smal
Kinetics of Aspartic Acid Isomerization and Enantiomerization in Model Aspartyl Tripeptides under Forced Conditions
Keywords: انحلال; enantiomerization; isomerization; deamidation; peptides; aspartyl peptide; aspartic acid; isoaspartic acid; kinetics; stability; capillary electrophoresis;
Comparative Evaluation of Disodium Edetate and Diethylenetriaminepentaacetic Acid as Iron Chelators to Prevent Metal -Catalyzed Destabilization of a Therapeutic Monoclonal Antibody
Keywords: انحلال; Protein aggregation; oxidation; deamidation; fragmentation; chelator; monoclonal antibody; protein structure; binding; stability; protein formulation;
Formulation and Immunogenicity of a Potential Multivalent Type III Secretion System-Based Protein Vaccine
Keywords: انحلال; protein formulation; stability; vaccine adjuvants; protein aggregation; fluorescence spectroscopy; adsorption; deamidation; tip proteins; needle proteins; immunogenicity;
Degradation products analysis of an Fc fusion protein using LC/MS methods
Keywords: انحلال; LC/MS; Formulation; Fc fusion protein; Deamidation; Oxidation
Effects of succinylation and deamidation on functional properties of oat protein isolate
Keywords: انحلال; Protein isolate; Succinylation; Deamidation; Functional properties
Characterization of deamidated peptide variants by micro-preparative capillary electrophoresis and mass spectrometry
Keywords: انحلال; Capillary electrophoresis; Liquid chromatrography; Deamidation; Peptides; Nanospray; Mass spectrometry
Raman spectroscopic study of deamidated food proteins
Keywords: انحلال; Deamidation; Soy proteins isolates; Whey protein isolates; Spray-dried egg white; Raman spectroscopy
Human antibody Fc deamidation in vivo
Keywords: انحلال; Posttranslational modification; Deamidation; Critical quality attribute
An improved trypsin digestion method minimizes digestion-induced modifications on proteins
Keywords: انحلال; Trypsin digestion; Posttranslational modification; Deamidation; N-terminal glutamine cyclization; LC/MS; Peptide mapping
Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody
Keywords: انحلال; Charge heterogeneity; Deamidation; Isomerization; Mass spectrometry; Monoclonal antibody
Two-dimensional cartography of equine β-casein variants achieved by isolation of phosphorylation isoforms and control of the deamidation phenomenon
Keywords: انحلال; equine β-casein; deamidation; phosphorylation; two-dimensional cartography
Succinimide formation at Asn 55 in the complementarity determining region of a recombinant monoclonal antibody IgG1 heavy chain
Keywords: انحلال; antibody; deamidation; high performance liquid chromatography (HPLC); mass spectrometry; protein structure;
Lens aging: Effects of crystallins
Keywords: انحلال; Lens crystallin; Aging; Lens opacity; Chaperone; Deamidation; Glycation; Oxidation; Peptide
Evaluation of chemical degradation of a trivalent recombinant protein vaccine against botulinum neurotoxin by LysC peptide mapping and MALDI-TOF mass spectrometry
Keywords: انحلال; botulinum neurotoxin; recombinant vaccine; trivalent vaccine; stability; aluminum salt adjuvant; mass spectrometry; deamidation; oxidation
Stabilization of a polypeptide in non-aqueous solvents
Keywords: انحلال; Peptide stability; Non-aqueous solvent; Deamidation; Zinc stabilization; Dimerization; PACAP
Thermally induced changes in the structure and activity of yeast hexokinase B
Keywords: انحلال; Yeast hexokinase B; Thermoinactivation; Aggregation; Deamidation; Size exclusion-HPLC;
Chemical Degradation of Peptides and Proteins in PLGA: A Review of Reactions and Mechanisms
Keywords: انحلال; PLGA; hydrolysis; deamidation; acylation; peptide stability;
Detection of protein modifications and counterfeit protein pharmaceuticals using isotope tags for relative and absolute quantification and matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry: Studies of insulins
Keywords: انحلال; iTRAQ/MALDI; Insulins; Glu-C; Deamidation; Aggregation; Generic protein drugs; Counterfeit
Dimerization of a PACAP peptide analogue in DMSO via asparagine and aspartic acid residues
Keywords: انحلال; stability; deamidation; dehydration; formulation; mass spectrometry; peptide delivery; peptides; physical characterization; physical stability; HPLC (highâperformance/pressure liquid chromatography);
Tissue transglutaminase catalyzes the deamidation of glutamines in lens βB2- and βB3-crystallins
Keywords: انحلال; lens; crystallin; transglutaminase; deamidation; crosslink; calcium
Heterogeneity of Monoclonal Antibodies
Keywords: انحلال; Structure; Stability; Protein aggregation; Glycosylation; Deamidation; Analytical biochemistry;
The Complex Inter-Relationships Between Protein Flexibility and Stability
Keywords: انحلال; chemical stability; deamidation; formulation; oxidation; physical stability; physicochemical; protein folding/refolding;
Protein A chromatography for antibody purification
Keywords: انحلال; Affinity chromatography; Cleaning-in-place (CIP); Deamidation; Protein A; Protein engineering; Stabilization
Counteracting expression deficiencies by anticipating posttranslational modification of PaHNL5-L1Q-A111G by genetic engineering
Keywords: انحلال; Hydroxynitrile lyase; Posttranslational modification; Engineering; Secretion enhancement; Deamidation; PaHNL; Prunus
Analysis of post-translational modifications in recombinant monoclonal antibody IgG1 by reversed-phase liquid chromatography/mass spectrometry
Keywords: انحلال; RP-HPLC; LC-TOF MS; Antibody; Deamidation; Oxidation; Cyclization; Isomerization; Glycosylation; Peptide mapping
Evaluation of the iCE280 Analyzer as a potential high-throughput tool for formulation development
Keywords: انحلال; Imaged capillary isoelectric focusing; iCE280 Analyzer; Deamidation; Protein; Pegylation
Identification of deamidation and isomerization sites on pharmaceutical recombinant antibody using H218O
Keywords: انحلال; Deamidation; Isomerization; Antibody; 18O; Peptide mapping; High-performance liquid chromatography; Mass spectrometry
The Role of the Cyclic Imide in Alternate Degradation Pathways for AsparagineâContaining Peptides and Proteins
Keywords: انحلال; deamidation; peptides; stability; kinetics; peptide delivery; asparagine; diketopiperazine; isoasparagine;
Influence of pH, buffer species, and storage temperature on physicochemical stability of a humanized monoclonal antibody LA298
Keywords: انحلال; Humanized monoclonal antibody; Degradation; Stability; Protein; HPLC; Deamidation; Solution; Preformulation; Protein aggregation
Deamidation of peptides in aerobic nitric oxide solution by a nitrosative pathway
Keywords: انحلال; Nitric oxide; Deamidation; Amide nitrosation
Characterization of the stability of a fully human monoclonal IgG after prolonged incubation at elevated temperature
Keywords: انحلال; Recombinant monoclonal antibody; Peptide mapping; Deamidation; Pyroglutamate
Thermostabilization of Bacillus amyloliquefaciens α-amylase by chemical cross-linking
Keywords: انحلال; α-Amylase; Chemical cross-linking; Thermostability; Aggregation; Hydrophobicity; Deamidation