دانلود مقالات ISI درباره فضای طراحی + ترجمه فارسی

In silico robustness testing of a compendial HPLC purity method by using of a multidimensional design space build by chromatography modeling-Case study pramipexole

Keywords: فضای طراحی; HPLC method development; Quality by Design; Design Space; Robustness in routine quality control; Pramipexole;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Development of a liquid chromatographic method for the simultaneous quantification of curcumin, β-arteether, tetrahydrocurcumin and dihydroartemisinin. Application to lipid-based formulations

Keywords: فضای طراحی; Curcumin; β-Arteether; Liquid chromatography; Design space; Accuracy profile;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2014 سفارش ترجمه

Development and validation of an UPLC method for determination of content uniformity in low-dose solid drugs products using the design space approach

Keywords: فضای طراحی; UPLC; Robustness; Response surface; Repeatability; Design space; Finasteride;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Using an innovative Quality-by-Design approach for development of a stability indicating UHPLC method for ebastine in the API and pharmaceutical formulations

Keywords: فضای طراحی; Quality by Design; Design Space; Chromatography modeling software DryLab®4; UHPLC method development; Ebastine;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Application of an innovative design space optimization strategy to the development of LC methods for the simultaneous screening of antibiotics to combat poor quality medicines

Keywords: فضای طراحی; Antibiotics and associated substances; Poor quality medicines; Design of experiments; Design space; Method transfer; Accuracy profile;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Lyophilization Process Design Space

Keywords: فضای طراحی; freeze-drying/lyophilization; quality by design (QbD); process analytical technology (PAT); Design Space; processing; Scale-Up; heat and mass transfer; process validation; primary drying;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Graphical tool for the preliminary design of compact heat exchangers

Keywords: فضای طراحی; Parameter plots; Spiral heat exchangers; Compabloc heat exchangers; Design space; Thermal length; Hydraulic length

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Model-based design space determination of peptide chromatographic purification processes

Keywords: فضای طراحی; Reversed-phase chromatography; Peptide; Design space; Preparative; Sensitivity; Robustness

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Mitigation of chromatography adsorbent lot performance variability through control of buffer solution design space

Keywords: فضای طراحی; Anion exchange chromatography; Chromatography adsorbent lot variability; Design space; Process scale-up

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Application of a Quality by Design Approach to the Cell Culture Process of Monoclonal Antibody Production, Resulting in the Establishment of a Design Space

Keywords: فضای طراحی; antibody; biotechnology; cell culture; design of experiments; design space; failure mode and effects analysis; mathematical models; multivariate analysis; proteins; quality by design;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Fast freeze-drying cycle design and optimization using a PAT based on the measurement of product temperature

Keywords: فضای طراحی; Freeze-drying; Process design; Process Analytical Technology; Monitoring; Design space; Mathematical modeling

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Sizing of standalone photovoltaic thermal (PVT) systems using design space approach

Keywords: فضای طراحی; Design space; Photovoltaic thermal system; Optimum system sizing; Sizing curve;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Ternary isocratic mobile phase optimization utilizing resolution Design Space based on retention time and peak width modeling

Keywords: فضای طراحی; HPLC; Method development; Mobile phase optimization; Retention modeling; Resolution; Design Space

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Implementation of a design space approach for enantiomeric separations in polar organic solvent chromatography

Keywords: فضای طراحی; Design space; Design of experiment; Enantioseparation; HPLC–UV; Polar organic solvent chromatography; SK channels modulators

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Quality by design for wet granulation in pharmaceutical processing: Assessing models for a priori design and scaling

Keywords: فضای طراحی; Wet granulation; Quality by Design; Regime map; Design space; Excipient variability; Scale-up

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Quality by Design approach in the development of a solvent-modified micellar electrokinetic chromatography method: Finding the design space for the determination of amitriptyline and its impurities

Keywords: فضای طراحی; Amitriptyline; Capillary electrophoresis; Design space; Experimental design; Impurities; Quality by Design

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

General procedure to aid the development of continuous pharmaceutical processes using multivariate statistical modeling – An industrial case study

Keywords: فضای طراحی; Latent variable methods; Pharmaceutical development; Continuous processing; Design space; Quality by design; Quality risk assessment; Control strategy

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2013 سفارش ترجمه

Establishing and analyzing the design space in the development of direct compression formulations by gene expression programming

Keywords: فضای طراحی; FDA; Food and Drug Administration; GMP; Good Manufacturing Practice; QbD; quality by design; ICH; International Conference on Harmonization; RSM; Response Surface Methodology; GEP; gene expression programming; MSE; Mean Squared Error; SRM; Structural Risk

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Development of a RP-LC method for a diastereomeric drug valganciclovir hydrochloride by enhanced approach

Keywords: فضای طراحی; Valganciclovir; Design space; Central composite design; Related substances; RP-LC;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

A quality by design study applied to an industrial pharmaceutical fluid bed granulation

Keywords: فضای طراحی; Quality by Design; Process Analytical Technology; Design Space; Multivariate data analysis; Fluid bed granulation

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Interdependence of Drug Substance Physical Properties and Corresponding Quality Control Strategy

Keywords: فضای طراحی; physical property; particle size; drug substance; design space; quality by design; dissolution; multivariate analysis; principle component analysis; solid dosage form; physical characterization;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Combining fundamental knowledge and latent variable techniques to transfer process monitoring models between plants

Keywords: فضای طراحی; Model transfer; Process monitoring; JY-PLS; Quality-by-design; PAT; Scale-up; Design space

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

A quality by design (QbD) case study on liposomes containing hydrophilic API: II. Screening of critical variables, and establishment of design space at laboratory scale

Keywords: فضای طراحی; Liposome; QbD; Tenofovir; Encapsulation efficiency; Plackett-Burman; Central composite design; Response surface method (RSM); Design space;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Pharmaceutical NanotechnologyApplication of quality by design to formulation and processing of protein liposomes

Keywords: فضای طراحی; Liposome; QbD; Superoxide dismutase; Freeze-and-thaw unilamellar vesicles (FAT-ULV); Encapsulation efficiency; D-optimal design; Design space; Risk analysis;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Application of an innovative design space optimization strategy to the development of liquid chromatographic methods to combat potentially counterfeit nonsteroidal anti-inflammatory drugs

Keywords: فضای طراحی; NSAIDs; Substandard and counterfeit drugs; Design of experiments; Design space; Method transfer; Accuracy profile

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Application of Quality by Design to the characterization of the cell culture process of an Fc-Fusion protein

Keywords: فضای طراحی; Cell culture process; Characterization; Quality by Design (QbD); Design of Experiments (DoE); Design space; Fc-Fusion protein

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Quality by design approach for formulation development: A case study of dispersible tablets

Keywords: فضای طراحی; Quality by design; Dispersible tablets; Critical quality attributes; Risk assessment; Design space; Control strategy;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Quality by Design: Multidimensional exploration of the design space in high performance liquid chromatography method development for better robustness before validation

Keywords: فضای طراحی; Robustness; Design space; Validation; Chromatography modeling software; Quality by Design (QbD)

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Development of a Fluid Bed Granulation Design Space Using Critical Quality Attribute Weighted Tolerance Intervals

Keywords: فضای طراحی; fluid bed processing; process analytical technology; multivariate modeling; design space; quality by design;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

A perspective on PSE in pharmaceutical process development and innovation

Keywords: فضای طراحی; ANN; artificial neural network; API; active pharmaceutical ingredient; CAMD; computer-aided molecular design; CFD; computational fluid dynamics; CP; continuous processing; CPM; continuous pharmaceutical manufacturing; CPP; critical process parameter; CQA;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Application of the quality by design approach to the drug substance manufacturing process of an Fc fusion protein: Towards a global multi‐step design space

Keywords: فضای طراحی; Quality by Design; design space; proteins; validation; biotechnology; mathematical models; regulatory science; multivariate analysis;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Arc-elasticity and hierarchical exploration of the neighborhood of solutions in mechanical design

Keywords: فضای طراحی; Optimization; Mechanical design; Arc-elasticity; Design space; Genetic algorithm

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Expanding the term “Design Space” in high performance liquid chromatography (I)

Keywords: فضای طراحی; Quality by Design; Design Space; 3-D computer modeling software; HPLC method development; Snyder–Dolan hydrophobic subtraction model of RPLC phase selectivity

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Optimisation and validation of a fast HPLC method for the quantification of sulindac and its related impurities

Keywords: فضای طراحی; HPLC; Sulindac; Validation; Design space; Sub-2micron column;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Application of a new optimization strategy for the separation of tertiary alkaloids extracted from Strychnos usambarensis leaves

Keywords: فضای طراحی; HPLC-UV; Independent component analysis; Design space; Design of experiment; Strychnos usambarensis

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Performance-Based Quality Specifications: The Relationship Between Process Critical Control Parameters, Critical Quality Attributes, and Clinical Performance

Keywords: فضای طراحی; Monte Carlo; simulations; content uniformity; dissolution; toxicity; risk assessment; quality; quality by design; design space; theophylline;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Application of new methodologies based on design of experiments, independent component analysis and design space for robust optimization in liquid chromatography

Keywords: فضای طراحی; High-performance liquid chromatography; Method development; Separation optimization; Experimental design; Design space; Independent component analysis

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

A new PAT/QbD approach for the determination of blend homogeneity: Combination of on-line NIRS analysis with PC Scores Distance Analysis (PC-SDA)

Keywords: فضای طراحی; PAT; on-line NIRS; NIR-CI; Blending; Design space; QbD

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

An integrated Quality by Design (QbD) approach towards design space definition of a blending unit operation by Discrete Element Method (DEM) simulation

Keywords: فضای طراحی; Quality by Design; Discrete element method; Blending; Double cone mixer; Content uniformity; Design space

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Quality by design approach of a pharmaceutical gel manufacturing process, part 2: Near infrared monitoring of composition and physical parameters

Keywords: فضای طراحی; quality by design; process analytical technologies; design space; analytical chemistry; near‐infrared spectroscopy; partial least squares; multivariate analysis; hydrogel; normal operation conditions;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Quality by design approach of a pharmaceutical gel manufacturing process, part 1: Determination of the design space

Keywords: فضای طراحی; quality by design; process analytical technology; design of experiments; design space; analytical chemistry; viscosity; hydrogel;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Innovative high-performance liquid chromatography method development for the screening of 19 antimalarial drugs based on a generic approach, using design of experiments, independent component analysis and design space

Keywords: فضای طراحی; Antimalarial drugs; Counterfeit; Design of experiments; Design space; Quality by design; Independent component analysis

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Influences of communication structural complexity on operational safety in regional airspace design

Keywords: فضای طراحی; Airspace design; Aircraft proximity; Design space; Communications; Mid-air collision

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Optimization of a pharmaceutical freeze-dried product and its process using an experimental design approach and innovative process analyzers

Keywords: فضای طراحی; Freeze-drying; Optimisation; Spectroscopy; Design space;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Advanced approach to build the design space for the primary drying of a pharmaceutical freeze‐drying process

Keywords: فضای طراحی; freeze drying/lyophilization; processing; mathematical model; dynamic simulation; algorithm; design space; PAT;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Generating sample looks for geometric objects in a visual design language

Keywords: فضای طراحی; Design language; Logic programming; Computer-aided design; Solid modelling; Sample look; Design space

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

A new roadmap for biopharmaceutical drug product development: Integrating development, validation, and quality by design

Keywords: فضای طراحی; quality by design (QbD); process validation; design space; risk assessment; process robustness; protein formulation; unit operations; regulatory science; biotechnology; mixing;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

On the Use of Mathematical Models to Build the Design Space for the Primary Drying Phase of a Pharmaceutical Lyophilization Process

Keywords: فضای طراحی; freeze‐drying; design space; process modeling; dynamic parameters estimation

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2011 سفارش ترجمه

Quality-by-Design (QbD): An integrated process analytical technology (PAT) approach for a dynamic pharmaceutical co-precipitation process characterization and process design space development

Keywords: فضای طراحی; Quality-by-Design (QbD); Process analytical technology (PAT); Co-precipitation; Real-time process monitoring; Critical process variable; Design space

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2011 سفارش ترجمه

A novel multi-dimensional visualization technique for understanding the design parameters of drug formulations

Keywords: فضای طراحی; Design of experiments; Response surface method; Data visualization; Formulation design; Design space; Nasal drug formulations

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه