دانلود مقالات ISI درباره DHFR، dihydrofolate reductase + ترجمه فارسی

به سوی درک وضعیت غیرمستقیم ترکیبات دارویی: تاثیرات انرژی مجدد داخل سلول مجتمع پس از اتصال

Towards understanding the unbound state of drug compounds: Implications for the intramolecular reorganization energy upon binding

Keywords: DHFR، dihydrofolate reductase; ACE, angiotensin converting enzyme; DHFR, dihydrofolate reductase; Diel, distance-dependent dielectric; FF, force field; GB, generalized Born solvation model; GlobMin_Diel, global energy minimum obtained with a distant-dependent dielectric constant; GlobM

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2016 سفارش ترجمه

سینامات انولین به عنوان وسیله ای برای تحویل داروهای کولون

Cinnamate of inulin as a vehicle for delivery of colonic drugs

Keywords: DHFR، dihydrofolate reductase; FSCN, cinnamoylated fructose; DHFR, dihydrofolate reductase; INCN, cinnamoylated inulin; MTX, methotrexate; TLC, thin layer chromatography; XTT, 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilideInulin; Cinnamoylated inulin; Inulinase

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

کنترل خاصیت سوبسترا آنزیم دی هیدروفلات ردوکتاز موش با استفاده از یک مجموعه گسترده از اسید آمینه

Manipulating the substrate specificity of murine dihydrofolate reductase enzyme using an expanded set of amino acids

Keywords: DHFR، dihydrofolate reductase; 2Nal, L-2-naphthylalanine; AFWK, phenylalanine/tryptophan/lysine triple auxotrophic E. coli; DHF, dihydrofolate; DHFR, dihydrofolate reductase; FOL, folate; LB, Luria-Broth; Lys, lysine; NADPH, nicotinamide adenine dinucleotide phosphate; mDHFR, murine di

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Engineering mammalian cell factories with SINEUP noncoding RNAs to improve translation of secreted proteins

Keywords: DHFR، dihydrofolate reductase; CHO, Chinese hamster ovary; DHFR, dihydrofolate reductase; GFP, green fluorescent protein; GS, glutamine synthetase; lncRNA, long noncoding RNA; MAb, monoclonal antibody; PBS, phosphate buffered salineCell factory; CHO cell; Serum-free; Long noncoding RNA

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Development and validation of a turbulent flow chromatography and tandem mass spectrometry method for the quantitation of methotrexate and its metabolites 7-hydroxy methotrexate and DAMPA in serum

Keywords: DHFR، dihydrofolate reductase; 7-OH MTX, 7-hydroxy methotrexate; ALL, acute lymphocytic leukemia; CLIA, Clinical Laboratory Improvement Amendments; CPDG2, carboxypeptidase-G2; DAMPA, 4-amino-4-deoxy-N10-methylpteroic acid; DHFR, dihydrofolate reductase; FPIA, fluorescence polarization

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Expanding the tool box for genetic manipulation of Trypanosoma cruzi

Keywords: DHFR، dihydrofolate reductase; SL, splice leader; nt, nucleotide; HR, homologous recombination; SM, selectable marker; GOI, gene of interest; TetR, tetracycline repressor; DHFR, dihydrofolate reductase; DDD, dihydrofolate reductase destabilization domain; ddFKBP, destabilization domain

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Identification of a novel GPR81-selective agonist that suppresses lipolysis in mice without cutaneous flushing

Keywords: DHFR، dihydrofolate reductase; BSA, bovine serum albumin; CHO, Chinese hamster ovary; CRE, cAMP response elements; dhfr, dihydrofolate reductase; Compound 1, N-(5-acetamido-4-(2-thienyl)-1,3-thiazol-2-yl)-4-methylbenzamide; Compound 2, 4-methyl-N-(5-(2-(4-methylpiperazin-1-yl)-2-oxoeth

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Ligand-based discovery of N-(1,3-dioxo-1H,3H-benzo[de]isochromen-5-yl)-carboxamide and sulfonamide derivatives as thymidylate synthase A inhibitors

Keywords: DHFR، dihydrofolate reductase; DHFR, dihydrofolate reductase; DMSO, dimethylsulfoxide; dTMP, 2′-deoxythymidine-5′-monophosphate; dUMP, 2′-deoxyuridine-5′-monophosphate; EcTS, Escherichia coli TS; hTS, human TS; IC50, concentration of inhibitor required for inhibition of 50% of target e

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Regulation of CEP131 gene expression by SP1

Keywords: DHFR، dihydrofolate reductase; EMSA, electrophoretic mobility shift assay; ChIP, chromatin immuno-precipitation; CEP131, centrosomal protein of 131 kDa; SP1, specificity protein 1; DHFR, dihydrofolate reductase; PARP-1, poly (ADP-ribose) polymerase-1; CPAP, centrosomal P4.1-associated

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

The isolation of CHO cells with a site conferring a high and reproducible transgene amplification rate

Keywords: DHFR، dihydrofolate reductase; Fluctuation analysis; Gene amplification; Recombinant protein; CHO cells; DG44; dhfrCHO, Chinese hamster ovary; DHFR, dihydrofolate reductase; MTX, methotrexate; ADA, adenosine deaminase; dCF, deoxycoformycin; SEAP, secreted embryonic alkaline phosphatase

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

The effect of folate-related SNPs on clinicopathological features, response to neoadjuvant treatment and survival in pre- and postmenopausal breast cancer patients

Keywords: DHFR، dihydrofolate reductase; BMI, body mass index; 95% CI, confidence intervals; CMF, cyclophosphamide, methotrexate and 5-fluorouracil; DNMT3b, DNA methyltransferase; DHFR, dihydrofolate reductase; ER, estrogen receptor; FAC, 5-fluorouracil, adriamycin and cyclophosphamide; HER2, hu

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Drugging the undruggable: Transcription therapy for cancer

Keywords: DHFR، dihydrofolate reductase; AR, androgen receptor; DHFR, dihydrofolate reductase; DNMT, DNA methyltransferase; ER, estrogen receptor; HDAC, histone deacetylase; HMT, histone methyltransferase; HTS, high-throughput screening; MDR1, multidrug resistance protein 1; ODN, oligodeoxynucle

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Fully functional global genome repair of (6-4) photoproducts and compromised transcription-coupled repair of cyclobutane pyrimidine dimers in condensed mitotic chromatin

Keywords: DHFR، dihydrofolate reductase; CPD, cyclobutane pyrimidine dimer; DHFR, dihydrofolate reductase; DSB, double-strand break; ELISA, enzyme-linked immunosorbent assay; HR, homologous recombination; NHEJ, nonhomologous end joining; 6-4PP, (6-4) pyrimidine–pyrimidone photoproduct; T4 endo V

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways

Keywords: DHFR، dihydrofolate reductase; Acyl-HSL, Acyl-homoserine lactone; BLA, β-lactamase; bPBP, Bacterial periplasmic binding protein; CFP, Cyan fluorescent protein; Dex, Dexamethosome; DHFR, Dihydrofolate reductase; ER, Estrogen receptor; FRET, Fluorescence resonance energy transfer; GFP, G

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

GnRH-III based multifunctional drug delivery systems containing daunorubicin and methotrexate

Keywords: DHFR، dihydrofolate reductase; Targeted cancer chemotherapy; Multifunctional drug delivery systems; GnRH-III; Daunorubicin; Methotrexate; Cytostatic effectAc, acetyl; Aoa, aminooxyacetyl; Dau, daunorubicin; DHFR, dihydrofolate reductase; Dox, doxorubicin; ESI, electrospray ionization;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Recognition of an ERAD-L substrate analyzed by site-specific in vivo photocrosslinking

Keywords: DHFR، dihydrofolate reductase; CPY, carboxypeptidase Y; DHFR, dihydrofolate reductase; ER, endoplasmic reticulum; ERAD, endoplasmic reticulum-associated degradation; HA, hemagglutinin; sCPY, short carboxypeptidase YER-associated degradation; Misfolded proteins; Hrd3p; Yos9p; Der1p; End

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Development of a fluorescently labeled thermostable DHFR for studying conformational changes associated with inhibitor binding

Keywords: DHFR، dihydrofolate reductase; Bs, Bacillus stearothermophilus; DHFR, dihydrofolate reductase; THF, tetrahydrofolate; MTX, methotrexate; TMP, trimethoprim; MDCC, N-[2-(1-maleimidyl)ethyl]-7-(diethylamino)coumarin-3-carboxamideProtein–ligand interactions; Dihydrofolate reductase; Confor

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed

Keywords: DHFR، dihydrofolate reductase; Pemetrexed; SHMT; Antifolate; Pleural mesotheliomaSHMT, serine hydroxymethyltransferase; THF, tetrahydrofolate; H4PteGlu, tetrahydropteroylglutamate; TS, thymidylate synthase; DHFR, dihydrofolate reductase; dTMP, 2′-deoxythymidine monophosphate

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Underexpression of miR-224 in methotrexate resistant human colon cancer cells

Keywords: DHFR، dihydrofolate reductase; MTX, methotrexate; DHFR, dihydrofolate reductase; miR and miRNA, microRNA; CRC, colorectal carcinoma; PDAC, pancreatic ductal adenocarcinoma; APRT, adenine phosphoribosyltransferase; CDS2, CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Microsecond Subdomain Folding in Dihydrofolate Reductase

Keywords: DHFR، dihydrofolate reductase; DHFR, dihydrofolate reductase; DLD, discontinuous loop subdomain (residues 1−37 and 107−159); ABD, adenosine binding subdomain (residues 38−106); CF, continuous flow; SAXS, small-angle X-ray scattering; FRET, Förster resonance energy transfer; IAEDANS, 5-

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2011 سفارش ترجمه

The N-Terminal Unstructured Domain of Yeast ODC Functions as a Transplantable and Replaceable Ubiquitin-Independent Degron

Keywords: DHFR، dihydrofolate reductase; antizyme; ODC; polyamines; proteasome; ubiquitinODC, ornithine decarboxylase; OAZ, ODC antizyme; CP, core particle; RP, regulatory particle; AZ, antizyme; ODS, ODC degradation signal; DHFR, dihydrofolate reductase; MBP, maltose-binding protein; SD, synthe

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2011 سفارش ترجمه

Probing the roles of conserved arginine-44 of Escherichia coli dihydrofolate reductase in its function and stability by systematic sequence perturbation analysis

Keywords: DHFR، dihydrofolate reductase; Amino acid indices; Catalytic activity; Dihydrofolate reductase; Sequence perturbation analysis; Stability; Systematic amino acid substitutionsAA index, amino acid index; CD, circular dichroism; DHF, dihydrofolate; DHFR, dihydrofolate reductase; Kd, equil

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Thermodynamic and NMR analysis of inhibitor binding to dihydrofolate reductase

Keywords: DHFR، dihydrofolate reductase; DHF, 7,8-dihydrofolate; DHFR, dihydrofolate reductase; HSQC, heteronuclear single-quantum correlation; ITC, isothermal titration calorimetry; Kd, dissociation constant; NMR, nuclear magnetic resonance; NADP+, nicotinamide adenine dinucleotide phosphate; N

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors

Keywords: DHFR، dihydrofolate reductase; TS, thymidylate synthase; dTMP, 2′-deoxythymidine-5′-monophosphate; dUMP, 2′-deoxyuridine-5′-monophosphate; DHFR, dihydrofolate reductase; dTDP, 2′-deoxythymidine-5′-diphosphate; dTTP, 2′-deoxythymidine-5′-triphosphate; MTX, methotrexate; GARFT, glycinami

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1—evidence for direct and indirect antioxidant actions of bilirubin

Keywords: DHFR، dihydrofolate reductase; AT-II, angiotensin-II; BR, bilirubin; BSA, bovin serum albumin; BV, biliverdin; BVR, biliverdin reductase; DHE, dihydroethidine; DHFR, dihydrofolate reductase; DHR, dihydrorhodamine 123; ECL, enhanced chemiluminescence; GCH-1, GTP-cyclohydrolase-1; 2-HE,

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Design, synthesis, biological evaluation and computational investigation of novel inhibitors of dihydrofolate reductase of opportunistic pathogens

Keywords: DHFR، dihydrofolate reductase; pc, Pneumocystis carinii; tg, Toxoplasma gondii; DHFR, dihydrofolate reductase; HIV, human immunodeficiency virus; ma, Mycobacterium aviumDihydrofolate reductase; 2,4-Diaminopyrimidine; Docking; MM-GBSA

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

RCC1 Uses a Conformationally Diverse Loop Region to Interact with the Nucleosome: A Model for the RCC1–Nucleosome Complex

Keywords: DHFR، dihydrofolate reductase; RCC1, regulator of chromosome condensation 1; Ran, Ras-related nuclear; GEF, guanine-exchange factor; GST, glutathione S-transferase; GSH, glutathione; LANA, latency-associated nuclear antigen; DHFR, dihydrofolate reductase; TEV, tobacco etch virus; BSA,

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

Degradation of FAT10 by the 26S proteasome is independent of ubiquitylation but relies on NUB1L

Keywords: DHFR، dihydrofolate reductase; AZ, antizyme; DHFR, dihydrofolate reductase; NUB1L, NEDD8 ultimate buster 1-long; ODC, ornithine decarboxylaseUbiquitin; FAT10; 26S proteasome; NUB1L; Degradation

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

Protein folding does not prevent the nonclassical export of FGF1 and S100A13

Keywords: DHFR، dihydrofolate reductase; FGF1; S100A13; Nonclassical release; Protein folding; Dihydrofolate reductase; AminopterinAP, aminopterin; DHFR, dihydrofolate reductase; ER, endoplasmic reticulum; FGF, fibroblast growth factor; IL1, interleukin 1; MTS, mitochondrial transport sequence;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Methotrexate in Pediatric Osteosarcoma: Response and Toxicity in Relation to Genetic Polymorphisms and Dihydrofolate Reductase and Reduced Folate Carrier 1 Expression

Keywords: DHFR، dihydrofolate reductase; DHFR, Dihydrofolate reductase; GAPDH, Glyceraldehyde-3-phosphate dehydrogenase mRNA; HD-MTX, High-dose methotrexate; MTHFR, 5,10-Methylenetetrahydrofolate reductase; MTR, Methionine synthase; MTX, Methotrexate; OR, Odds ratios; RFC1, Reduced folate carrie

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Protein complementation assays: Approaches for the in vivo analysis of protein interactions

Keywords: DHFR، dihydrofolate reductase; BIFC, bimolecular fluorescence complementation; PCA, protein-fragment complementation assay; GFP, green fluorescent protein; FP, fluorescent protein; DHFR, dihydrofolate reductase; PPI, protein–protein interaction; RET, resonance energy transfer; BIFC-RET

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis

Keywords: DHFR، dihydrofolate reductase; MTX, methotrexate; 7-OHMTX, 7-hydroxymethotrexate; IC50, the drug concentration inhibiting cell growth by 50%; DHFR, dihydrofolate reductase; TS, thymidylate synthase; RFC, reduced folate carrier; FPGS, folylpolyglutamate synthetase; FPGH, folylpolyglutam

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Identification of a dominant CD4 T cell epitope in the membrane lipoprotein Tul4 from Francisella tularensis LVS

Keywords: DHFR، dihydrofolate reductase; DHFR, dihydrofolate reductase; 6× His, 6× histidine; APC, antigen presenting cell; bp, base pairs; aa, amino acids; LVS, live vaccine strain; PCR, polymerase chain reaction; ISCOM, immunostimulating complexes; B6, C57Bl/6JFrancisella tularensis; Tul4; Epi

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Involvement of sphingosine-1-phosphate and S1P1 in angiogenesis: Analyses using a new S1P1 antagonist of non-sphingosine-1-phosphate analog

Keywords: DHFR، dihydrofolate reductase; bFGF, basic fibroblast growth factor; CHO, Chinese hamster ovary; CL2, chemical lead 2; dhfr, dihydrofolate reductase; Edg-1/S1P1, endothelial differentiation gene-1; FBS, fetal bovine serum; FLIPR, fluorometric imaging plate reader; HEK293, human embryon

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Charged Amino Acids in a Preprotein Inhibit SecA-Dependent Protein Translocation

Keywords: DHFR، dihydrofolate reductase; PMF, proton motive force; TMS, transmembrane segments; IMV, inner membrane vesicle; DHFR, dihydrofolate reductase; Mtx, methotrexate; AMP-PNP, adenosine 5′-(β,γ-imido)triphosphate; ATP-γ-S, adenosine 5′-[γ-thio]triphosphate; BSA, bovine serum albuminSecA;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Stabilization of multimeric enzymes: Strategies to prevent subunit dissociation

Keywords: DHFR، dihydrofolate reductase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GDH, glutamate dehydrogenase; DHFR, dihydrofolate reductase; MDH, malate dehydrogenase; CaMDH, malate dehydrogenase from Chloroflexus aurantiacus; Avd, avidin; TIM, triosephosphate isomerase; ADH, alcohol d

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2009 سفارش ترجمه

Mutational ‘hot-spots’ in mammalian, bacterial and protozoal dihydrofolate reductases associated with antifolate resistance: Sequence and structural comparison

Keywords: DHFR، dihydrofolate reductase; DHFR, dihydrofolate reductase; MTX, methotrexate; TMP, trimethoprim; CYC, cycloguanil; PYR, pyrimethamine; NADPH, nicotinamide adenine dinucleotide phosphate (reduced form); DHF, 7,8-dihydrofolate; THF, 5,6,7,8-tetrahydrofolate; PMTX, pemetrexed; TMTX, tr

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2009 سفارش ترجمه

Development of a chemical screening system using aqueorin-fused protein

Keywords: DHFR، dihydrofolate reductase; AQ, aequorin; GFP, green fluorescent protein; MTX, methotrexate; DHFR, dihydrofolate reductase; RI, radioisotope; GMA, glycidyl methacrylate; STR, streptomycin; PNC, penicillin; SDS–PAGE, sodium dodecyl sulfate–polyacrylamide gel electrophoresis; IPTG, is

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Cloning and characterization of Plasmodium vivax serine hydroxymethyltransferase

Keywords: DHFR، dihydrofolate reductase; Pf, Plasmodium falciparum; Pv, P. vivax; DHFR, dihydrofolate reductase; TS, thymidylate synthase; SHMT, serine hydroxymethyltransferase; PLP, pyridoxal phosphate; c, cytosol; mt, mitochondria; bp, base pairPlasmodium vivax; Serine hydroxymethyltransferase

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

The wheat germ cell-free based screening of protein substrates of calcium/calmodulin-dependent protein kinase II delta

Keywords: DHFR، dihydrofolate reductase; CaMKIId, calcium/calmodulin-dependent protein kinase II delta; DHFR, dihydrofolate reductase; 2-DE, two-dimensional gel electrophoresis; MALDI-TOF-MS, matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry; bls, biotin ligation site

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Effects of pressure on enzyme function of Escherichia coli dihydrofolate reductase

Keywords: DHFR، dihydrofolate reductase; DHFR, dihydrofolate reductase; DHF, dihydrofolate; NADPH, nicotinamide adenine dinucleotide phosphate (reduced form); NADPD, [4′(R)-2H]NADPH; THF, tetrahydrofolateDihydrofolate reductase; Enzyme activity; High pressure; Volume change

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

AT1-receptor blockade by telmisartan upregulates GTP-cyclohydrolase I and protects eNOS in diabetic rats

Keywords: DHFR، dihydrofolate reductase; ACh, acetylcholine; DHE, dihydroethidine; DHFR, dihydrofolate reductase; DPI, diphenyleneiodonium; ECL, enhanced chemiluminescence; eNOS, endothelial ⋅NO synthase (type 3); GCH-I, GTP-cyclohydrolase I; GTN, glyceryl trinitrate (nitroglycerin); L-012, 8-am

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Kinetic Folding of Haloferax volcanii and Escherichia coli Dihydrofolate Reductases: Haloadaptation by Unfolded State Destabilization at High Ionic Strength

Keywords: DHFR، dihydrofolate reductase; DHFR, dihydrofolate reductase; ecDHFR, Escherichia coli DHFR; hvDHFR1, Haloferax volcanii DHFR encoded by the hdrA gene; SF, stopped flow; FL, fluorescence; ANS, 1-anilinonaphthalene-8-sulfonic acid; EDTA, ethylenediaminetetraacetic acid; N, native; U, un

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه

Transcriptional regulation of aldo-keto reductase 1C1 in HT29 human colon cancer cells resistant to methotrexate: Role in the cell cycle and apoptosis

Keywords: DHFR، dihydrofolate reductase; AKR1C1, aldo-keto reductase 1 member C1; MTX, methotrexate; DHFR, dihydrofolate reductase; Sp1, specificity protein 1; APRT, adenine phosphoribosyltransferaseMethotrexate; AKR1C1; Transcriptional regulation; Sp1 binding; DHFR; Drug-resistance

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2008 سفارش ترجمه

Methotrexate regulates the expression of glucocorticoid receptor alpha and beta isoforms in normal human peripheral mononuclear cells and human lymphocyte cell lines in vitro

Keywords: DHFR، dihydrofolate reductase; DHFR, dihydrofolate reductase; MTX, methotrexate; GC, glucocorticoids; PBMC, peripheral blood mononuclear cells; GCR, glucocorticoid receptor; DMPX, 3,7-dimethyl-1-propargilxanthine; ICQ, immunocytochemistry; DEX, dexamethasone; LPS, lipopolysaccarideAuto

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

Characterisation of recombinant CHO cell lines by investigation of protein productivities and genetic parameters

Keywords: DHFR، dihydrofolate reductase; CHO, Chinese Hamster Ovary; dhfr, dihydrofolate reductase; EpoFc, erythropoietin-huIgG1Fc fusion protein; GCN, gene copy number; MCB, master cell bank; MTX, methotrexate; OPD, orthophenylenediamine; qp, specific productivity; qPCR, quantitative PCR; RT, r

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

Bacterial Sec-translocase Unfolds and Translocates a Class of Folded Protein Domains

Keywords: DHFR، dihydrofolate reductase; AFM, atomic-force microscopy; DHFR, dihydrofolate reductase; IMV, inner membrane vesicle; PMF, proton motive forceprotein translocation; folding; SecA; SecY

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2007 سفارش ترجمه

Allosteric Communication in Dihydrofolate Reductase: Signaling Network and Pathways for Closed to Occluded Transition and Back

Keywords: DHFR، dihydrofolate reductase; DHFR, dihydrofolate reductase; MD, molecular dynamics; CS, closed state; OS, occluded state; DHF, 7,8 dihydrofolate; THF, 5,6,7,8 tetrahydrofolate; NADPH, nicotinamide adenine dinucleotide phosphate; SCA, statistical coupling analysis; SOP, self-organized

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2007 سفارش ترجمه

The Crystal Structure of the Bifunctional Deaminase/Reductase RibD of the Riboflavin Biosynthetic Pathway in Escherichia coli: Implications for the Reductive Mechanism

Keywords: DHFR، dihydrofolate reductase; RP5, ribose-5-phosphate; DHFR, dihydrofolate reductase; EC, E.coli; Bc, B.subtilis; MjaRED, M.jannaschii reductasebi-functional deaminase/reductase; riboflavin biosynthesis; 3D-structure comparison; NADPH; hydride transfer

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2007 سفارش ترجمه

In search of cyclooxygenase inhibitors, anti-Mycobacterium tuberculosis and anti-malarial drugs from Thai flora and microbes

Keywords: DHFR، dihydrofolate reductase; Malaria; Tuberculosis; Cyclooxygenase; Inflammation; Fungi; Bioactive compounds; ThailandAA, arachidonic acid; COX, cyclooxygenase; DDT, dichloro-diphenyl-trichloroethane; DHFR, dihydrofolate reductase; GI, gastrointestinal; HIV, human immunodeficiency vi

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2007 سفارش ترجمه