The use of low dose methotrexate in rheumatoid arthritis—are we entering a new era of therapeutic drug monitoring and pharmacogenomics?
Keywords: DHFR، dihydrofolate reductase; Rheumatoid arthritis; Methotrexate; Methotrexate polyglutamates; PharmacogenomicsACR, American College of Rheumatology; AICAR, amino-imidazole carboxamidoribonucleotide transformylase (ATIC); DHF, dihydrofolate; DHFR, dihydrofolate reductase; DMARDs, dise