Keywords: DHFR، dihydrofolate reductase; ACE, angiotensin converting enzyme; DHFR, dihydrofolate reductase; Diel, distance-dependent dielectric; FF, force field; GB, generalized Born solvation model; GlobMin_Diel, global energy minimum obtained with a distant-dependent dielectric constant; GlobM
مقالات ISI DHFR، dihydrofolate reductase (ترجمه نشده)
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Keywords: DHFR، dihydrofolate reductase; FSCN, cinnamoylated fructose; DHFR, dihydrofolate reductase; INCN, cinnamoylated inulin; MTX, methotrexate; TLC, thin layer chromatography; XTT, 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilideInulin; Cinnamoylated inulin; Inulinase
Keywords: DHFR، dihydrofolate reductase; 2Nal, L-2-naphthylalanine; AFWK, phenylalanine/tryptophan/lysine triple auxotrophic E. coli; DHF, dihydrofolate; DHFR, dihydrofolate reductase; FOL, folate; LB, Luria-Broth; Lys, lysine; NADPH, nicotinamide adenine dinucleotide phosphate; mDHFR, murine di
Engineering mammalian cell factories with SINEUP noncoding RNAs to improve translation of secreted proteins
Keywords: DHFR، dihydrofolate reductase; CHO, Chinese hamster ovary; DHFR, dihydrofolate reductase; GFP, green fluorescent protein; GS, glutamine synthetase; lncRNA, long noncoding RNA; MAb, monoclonal antibody; PBS, phosphate buffered salineCell factory; CHO cell; Serum-free; Long noncoding RNA
Development and validation of a turbulent flow chromatography and tandem mass spectrometry method for the quantitation of methotrexate and its metabolites 7-hydroxy methotrexate and DAMPA in serum
Keywords: DHFR، dihydrofolate reductase; 7-OH MTX, 7-hydroxy methotrexate; ALL, acute lymphocytic leukemia; CLIA, Clinical Laboratory Improvement Amendments; CPDG2, carboxypeptidase-G2; DAMPA, 4-amino-4-deoxy-N10-methylpteroic acid; DHFR, dihydrofolate reductase; FPIA, fluorescence polarization
Expanding the tool box for genetic manipulation of Trypanosoma cruzi
Keywords: DHFR، dihydrofolate reductase; SL, splice leader; nt, nucleotide; HR, homologous recombination; SM, selectable marker; GOI, gene of interest; TetR, tetracycline repressor; DHFR, dihydrofolate reductase; DDD, dihydrofolate reductase destabilization domain; ddFKBP, destabilization domain
Identification of a novel GPR81-selective agonist that suppresses lipolysis in mice without cutaneous flushing
Keywords: DHFR، dihydrofolate reductase; BSA, bovine serum albumin; CHO, Chinese hamster ovary; CRE, cAMP response elements; dhfr, dihydrofolate reductase; Compound 1, N-(5-acetamido-4-(2-thienyl)-1,3-thiazol-2-yl)-4-methylbenzamide; Compound 2, 4-methyl-N-(5-(2-(4-methylpiperazin-1-yl)-2-oxoeth
Ligand-based discovery of N-(1,3-dioxo-1H,3H-benzo[de]isochromen-5-yl)-carboxamide and sulfonamide derivatives as thymidylate synthase A inhibitors
Keywords: DHFR، dihydrofolate reductase; DHFR, dihydrofolate reductase; DMSO, dimethylsulfoxide; dTMP, 2′-deoxythymidine-5′-monophosphate; dUMP, 2′-deoxyuridine-5′-monophosphate; EcTS, Escherichia coli TS; hTS, human TS; IC50, concentration of inhibitor required for inhibition of 50% of target e
Regulation of CEP131 gene expression by SP1
Keywords: DHFR، dihydrofolate reductase; EMSA, electrophoretic mobility shift assay; ChIP, chromatin immuno-precipitation; CEP131, centrosomal protein of 131 kDa; SP1, specificity protein 1; DHFR, dihydrofolate reductase; PARP-1, poly (ADP-ribose) polymerase-1; CPAP, centrosomal P4.1-associated
The isolation of CHO cells with a site conferring a high and reproducible transgene amplification rate
Keywords: DHFR، dihydrofolate reductase; Fluctuation analysis; Gene amplification; Recombinant protein; CHO cells; DG44; dhfrCHO, Chinese hamster ovary; DHFR, dihydrofolate reductase; MTX, methotrexate; ADA, adenosine deaminase; dCF, deoxycoformycin; SEAP, secreted embryonic alkaline phosphatase
The effect of folate-related SNPs on clinicopathological features, response to neoadjuvant treatment and survival in pre- and postmenopausal breast cancer patients
Keywords: DHFR، dihydrofolate reductase; BMI, body mass index; 95% CI, confidence intervals; CMF, cyclophosphamide, methotrexate and 5-fluorouracil; DNMT3b, DNA methyltransferase; DHFR, dihydrofolate reductase; ER, estrogen receptor; FAC, 5-fluorouracil, adriamycin and cyclophosphamide; HER2, hu
Drugging the undruggable: Transcription therapy for cancer
Keywords: DHFR، dihydrofolate reductase; AR, androgen receptor; DHFR, dihydrofolate reductase; DNMT, DNA methyltransferase; ER, estrogen receptor; HDAC, histone deacetylase; HMT, histone methyltransferase; HTS, high-throughput screening; MDR1, multidrug resistance protein 1; ODN, oligodeoxynucle
Fully functional global genome repair of (6-4) photoproducts and compromised transcription-coupled repair of cyclobutane pyrimidine dimers in condensed mitotic chromatin
Keywords: DHFR، dihydrofolate reductase; CPD, cyclobutane pyrimidine dimer; DHFR, dihydrofolate reductase; DSB, double-strand break; ELISA, enzyme-linked immunosorbent assay; HR, homologous recombination; NHEJ, nonhomologous end joining; 6-4PP, (6-4) pyrimidine–pyrimidone photoproduct; T4 endo V
Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways
Keywords: DHFR، dihydrofolate reductase; Acyl-HSL, Acyl-homoserine lactone; BLA, β-lactamase; bPBP, Bacterial periplasmic binding protein; CFP, Cyan fluorescent protein; Dex, Dexamethosome; DHFR, Dihydrofolate reductase; ER, Estrogen receptor; FRET, Fluorescence resonance energy transfer; GFP, G
GnRH-III based multifunctional drug delivery systems containing daunorubicin and methotrexate
Keywords: DHFR، dihydrofolate reductase; Targeted cancer chemotherapy; Multifunctional drug delivery systems; GnRH-III; Daunorubicin; Methotrexate; Cytostatic effectAc, acetyl; Aoa, aminooxyacetyl; Dau, daunorubicin; DHFR, dihydrofolate reductase; Dox, doxorubicin; ESI, electrospray ionization;
Recognition of an ERAD-L substrate analyzed by site-specific in vivo photocrosslinking
Keywords: DHFR، dihydrofolate reductase; CPY, carboxypeptidase Y; DHFR, dihydrofolate reductase; ER, endoplasmic reticulum; ERAD, endoplasmic reticulum-associated degradation; HA, hemagglutinin; sCPY, short carboxypeptidase YER-associated degradation; Misfolded proteins; Hrd3p; Yos9p; Der1p; End
Development of a fluorescently labeled thermostable DHFR for studying conformational changes associated with inhibitor binding
Keywords: DHFR، dihydrofolate reductase; Bs, Bacillus stearothermophilus; DHFR, dihydrofolate reductase; THF, tetrahydrofolate; MTX, methotrexate; TMP, trimethoprim; MDCC, N-[2-(1-maleimidyl)ethyl]-7-(diethylamino)coumarin-3-carboxamideProtein–ligand interactions; Dihydrofolate reductase; Confor
In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed
Keywords: DHFR، dihydrofolate reductase; Pemetrexed; SHMT; Antifolate; Pleural mesotheliomaSHMT, serine hydroxymethyltransferase; THF, tetrahydrofolate; H4PteGlu, tetrahydropteroylglutamate; TS, thymidylate synthase; DHFR, dihydrofolate reductase; dTMP, 2′-deoxythymidine monophosphate
Underexpression of miR-224 in methotrexate resistant human colon cancer cells
Keywords: DHFR، dihydrofolate reductase; MTX, methotrexate; DHFR, dihydrofolate reductase; miR and miRNA, microRNA; CRC, colorectal carcinoma; PDAC, pancreatic ductal adenocarcinoma; APRT, adenine phosphoribosyltransferase; CDS2, CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
Microsecond Subdomain Folding in Dihydrofolate Reductase
Keywords: DHFR، dihydrofolate reductase; DHFR, dihydrofolate reductase; DLD, discontinuous loop subdomain (residues 1−37 and 107−159); ABD, adenosine binding subdomain (residues 38−106); CF, continuous flow; SAXS, small-angle X-ray scattering; FRET, Förster resonance energy transfer; IAEDANS, 5-
The N-Terminal Unstructured Domain of Yeast ODC Functions as a Transplantable and Replaceable Ubiquitin-Independent Degron
Keywords: DHFR، dihydrofolate reductase; antizyme; ODC; polyamines; proteasome; ubiquitinODC, ornithine decarboxylase; OAZ, ODC antizyme; CP, core particle; RP, regulatory particle; AZ, antizyme; ODS, ODC degradation signal; DHFR, dihydrofolate reductase; MBP, maltose-binding protein; SD, synthe
Probing the roles of conserved arginine-44 of Escherichia coli dihydrofolate reductase in its function and stability by systematic sequence perturbation analysis
Keywords: DHFR، dihydrofolate reductase; Amino acid indices; Catalytic activity; Dihydrofolate reductase; Sequence perturbation analysis; Stability; Systematic amino acid substitutionsAA index, amino acid index; CD, circular dichroism; DHF, dihydrofolate; DHFR, dihydrofolate reductase; Kd, equil
Thermodynamic and NMR analysis of inhibitor binding to dihydrofolate reductase
Keywords: DHFR، dihydrofolate reductase; DHF, 7,8-dihydrofolate; DHFR, dihydrofolate reductase; HSQC, heteronuclear single-quantum correlation; ITC, isothermal titration calorimetry; Kd, dissociation constant; NMR, nuclear magnetic resonance; NADP+, nicotinamide adenine dinucleotide phosphate; N
2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors
Keywords: DHFR، dihydrofolate reductase; TS, thymidylate synthase; dTMP, 2′-deoxythymidine-5′-monophosphate; dUMP, 2′-deoxyuridine-5′-monophosphate; DHFR, dihydrofolate reductase; dTDP, 2′-deoxythymidine-5′-diphosphate; dTTP, 2′-deoxythymidine-5′-triphosphate; MTX, methotrexate; GARFT, glycinami
Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1—evidence for direct and indirect antioxidant actions of bilirubin
Keywords: DHFR، dihydrofolate reductase; AT-II, angiotensin-II; BR, bilirubin; BSA, bovin serum albumin; BV, biliverdin; BVR, biliverdin reductase; DHE, dihydroethidine; DHFR, dihydrofolate reductase; DHR, dihydrorhodamine 123; ECL, enhanced chemiluminescence; GCH-1, GTP-cyclohydrolase-1; 2-HE,
Design, synthesis, biological evaluation and computational investigation of novel inhibitors of dihydrofolate reductase of opportunistic pathogens
Keywords: DHFR، dihydrofolate reductase; pc, Pneumocystis carinii; tg, Toxoplasma gondii; DHFR, dihydrofolate reductase; HIV, human immunodeficiency virus; ma, Mycobacterium aviumDihydrofolate reductase; 2,4-Diaminopyrimidine; Docking; MM-GBSA
RCC1 Uses a Conformationally Diverse Loop Region to Interact with the Nucleosome: A Model for the RCC1–Nucleosome Complex
Keywords: DHFR، dihydrofolate reductase; RCC1, regulator of chromosome condensation 1; Ran, Ras-related nuclear; GEF, guanine-exchange factor; GST, glutathione S-transferase; GSH, glutathione; LANA, latency-associated nuclear antigen; DHFR, dihydrofolate reductase; TEV, tobacco etch virus; BSA,
Degradation of FAT10 by the 26S proteasome is independent of ubiquitylation but relies on NUB1L
Keywords: DHFR، dihydrofolate reductase; AZ, antizyme; DHFR, dihydrofolate reductase; NUB1L, NEDD8 ultimate buster 1-long; ODC, ornithine decarboxylaseUbiquitin; FAT10; 26S proteasome; NUB1L; Degradation
Protein folding does not prevent the nonclassical export of FGF1 and S100A13
Keywords: DHFR، dihydrofolate reductase; FGF1; S100A13; Nonclassical release; Protein folding; Dihydrofolate reductase; AminopterinAP, aminopterin; DHFR, dihydrofolate reductase; ER, endoplasmic reticulum; FGF, fibroblast growth factor; IL1, interleukin 1; MTS, mitochondrial transport sequence;
Methotrexate in Pediatric Osteosarcoma: Response and Toxicity in Relation to Genetic Polymorphisms and Dihydrofolate Reductase and Reduced Folate Carrier 1 Expression
Keywords: DHFR، dihydrofolate reductase; DHFR, Dihydrofolate reductase; GAPDH, Glyceraldehyde-3-phosphate dehydrogenase mRNA; HD-MTX, High-dose methotrexate; MTHFR, 5,10-Methylenetetrahydrofolate reductase; MTR, Methionine synthase; MTX, Methotrexate; OR, Odds ratios; RFC1, Reduced folate carrie
Protein complementation assays: Approaches for the in vivo analysis of protein interactions
Keywords: DHFR، dihydrofolate reductase; BIFC, bimolecular fluorescence complementation; PCA, protein-fragment complementation assay; GFP, green fluorescent protein; FP, fluorescent protein; DHFR, dihydrofolate reductase; PPI, protein–protein interaction; RET, resonance energy transfer; BIFC-RET
Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis
Keywords: DHFR، dihydrofolate reductase; MTX, methotrexate; 7-OHMTX, 7-hydroxymethotrexate; IC50, the drug concentration inhibiting cell growth by 50%; DHFR, dihydrofolate reductase; TS, thymidylate synthase; RFC, reduced folate carrier; FPGS, folylpolyglutamate synthetase; FPGH, folylpolyglutam
Identification of a dominant CD4 T cell epitope in the membrane lipoprotein Tul4 from Francisella tularensis LVS
Keywords: DHFR، dihydrofolate reductase; DHFR, dihydrofolate reductase; 6× His, 6× histidine; APC, antigen presenting cell; bp, base pairs; aa, amino acids; LVS, live vaccine strain; PCR, polymerase chain reaction; ISCOM, immunostimulating complexes; B6, C57Bl/6JFrancisella tularensis; Tul4; Epi
Involvement of sphingosine-1-phosphate and S1P1 in angiogenesis: Analyses using a new S1P1 antagonist of non-sphingosine-1-phosphate analog
Keywords: DHFR، dihydrofolate reductase; bFGF, basic fibroblast growth factor; CHO, Chinese hamster ovary; CL2, chemical lead 2; dhfr, dihydrofolate reductase; Edg-1/S1P1, endothelial differentiation gene-1; FBS, fetal bovine serum; FLIPR, fluorometric imaging plate reader; HEK293, human embryon
Charged Amino Acids in a Preprotein Inhibit SecA-Dependent Protein Translocation
Keywords: DHFR، dihydrofolate reductase; PMF, proton motive force; TMS, transmembrane segments; IMV, inner membrane vesicle; DHFR, dihydrofolate reductase; Mtx, methotrexate; AMP-PNP, adenosine 5′-(β,γ-imido)triphosphate; ATP-γ-S, adenosine 5′-[γ-thio]triphosphate; BSA, bovine serum albuminSecA;
Stabilization of multimeric enzymes: Strategies to prevent subunit dissociation
Keywords: DHFR، dihydrofolate reductase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GDH, glutamate dehydrogenase; DHFR, dihydrofolate reductase; MDH, malate dehydrogenase; CaMDH, malate dehydrogenase from Chloroflexus aurantiacus; Avd, avidin; TIM, triosephosphate isomerase; ADH, alcohol d
Mutational ‘hot-spots’ in mammalian, bacterial and protozoal dihydrofolate reductases associated with antifolate resistance: Sequence and structural comparison
Keywords: DHFR، dihydrofolate reductase; DHFR, dihydrofolate reductase; MTX, methotrexate; TMP, trimethoprim; CYC, cycloguanil; PYR, pyrimethamine; NADPH, nicotinamide adenine dinucleotide phosphate (reduced form); DHF, 7,8-dihydrofolate; THF, 5,6,7,8-tetrahydrofolate; PMTX, pemetrexed; TMTX, tr
Development of a chemical screening system using aqueorin-fused protein
Keywords: DHFR، dihydrofolate reductase; AQ, aequorin; GFP, green fluorescent protein; MTX, methotrexate; DHFR, dihydrofolate reductase; RI, radioisotope; GMA, glycidyl methacrylate; STR, streptomycin; PNC, penicillin; SDS–PAGE, sodium dodecyl sulfate–polyacrylamide gel electrophoresis; IPTG, is
Cloning and characterization of Plasmodium vivax serine hydroxymethyltransferase
Keywords: DHFR، dihydrofolate reductase; Pf, Plasmodium falciparum; Pv, P. vivax; DHFR, dihydrofolate reductase; TS, thymidylate synthase; SHMT, serine hydroxymethyltransferase; PLP, pyridoxal phosphate; c, cytosol; mt, mitochondria; bp, base pairPlasmodium vivax; Serine hydroxymethyltransferase
The wheat germ cell-free based screening of protein substrates of calcium/calmodulin-dependent protein kinase II delta
Keywords: DHFR، dihydrofolate reductase; CaMKIId, calcium/calmodulin-dependent protein kinase II delta; DHFR, dihydrofolate reductase; 2-DE, two-dimensional gel electrophoresis; MALDI-TOF-MS, matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry; bls, biotin ligation site
Effects of pressure on enzyme function of Escherichia coli dihydrofolate reductase
Keywords: DHFR، dihydrofolate reductase; DHFR, dihydrofolate reductase; DHF, dihydrofolate; NADPH, nicotinamide adenine dinucleotide phosphate (reduced form); NADPD, [4′(R)-2H]NADPH; THF, tetrahydrofolateDihydrofolate reductase; Enzyme activity; High pressure; Volume change
AT1-receptor blockade by telmisartan upregulates GTP-cyclohydrolase I and protects eNOS in diabetic rats
Keywords: DHFR، dihydrofolate reductase; ACh, acetylcholine; DHE, dihydroethidine; DHFR, dihydrofolate reductase; DPI, diphenyleneiodonium; ECL, enhanced chemiluminescence; eNOS, endothelial ⋅NO synthase (type 3); GCH-I, GTP-cyclohydrolase I; GTN, glyceryl trinitrate (nitroglycerin); L-012, 8-am
Kinetic Folding of Haloferax volcanii and Escherichia coli Dihydrofolate Reductases: Haloadaptation by Unfolded State Destabilization at High Ionic Strength
Keywords: DHFR، dihydrofolate reductase; DHFR, dihydrofolate reductase; ecDHFR, Escherichia coli DHFR; hvDHFR1, Haloferax volcanii DHFR encoded by the hdrA gene; SF, stopped flow; FL, fluorescence; ANS, 1-anilinonaphthalene-8-sulfonic acid; EDTA, ethylenediaminetetraacetic acid; N, native; U, un
Transcriptional regulation of aldo-keto reductase 1C1 in HT29 human colon cancer cells resistant to methotrexate: Role in the cell cycle and apoptosis
Keywords: DHFR، dihydrofolate reductase; AKR1C1, aldo-keto reductase 1 member C1; MTX, methotrexate; DHFR, dihydrofolate reductase; Sp1, specificity protein 1; APRT, adenine phosphoribosyltransferaseMethotrexate; AKR1C1; Transcriptional regulation; Sp1 binding; DHFR; Drug-resistance
Methotrexate regulates the expression of glucocorticoid receptor alpha and beta isoforms in normal human peripheral mononuclear cells and human lymphocyte cell lines in vitro
Keywords: DHFR، dihydrofolate reductase; DHFR, dihydrofolate reductase; MTX, methotrexate; GC, glucocorticoids; PBMC, peripheral blood mononuclear cells; GCR, glucocorticoid receptor; DMPX, 3,7-dimethyl-1-propargilxanthine; ICQ, immunocytochemistry; DEX, dexamethasone; LPS, lipopolysaccarideAuto
Characterisation of recombinant CHO cell lines by investigation of protein productivities and genetic parameters
Keywords: DHFR، dihydrofolate reductase; CHO, Chinese Hamster Ovary; dhfr, dihydrofolate reductase; EpoFc, erythropoietin-huIgG1Fc fusion protein; GCN, gene copy number; MCB, master cell bank; MTX, methotrexate; OPD, orthophenylenediamine; qp, specific productivity; qPCR, quantitative PCR; RT, r
Bacterial Sec-translocase Unfolds and Translocates a Class of Folded Protein Domains
Keywords: DHFR، dihydrofolate reductase; AFM, atomic-force microscopy; DHFR, dihydrofolate reductase; IMV, inner membrane vesicle; PMF, proton motive forceprotein translocation; folding; SecA; SecY
Allosteric Communication in Dihydrofolate Reductase: Signaling Network and Pathways for Closed to Occluded Transition and Back
Keywords: DHFR، dihydrofolate reductase; DHFR, dihydrofolate reductase; MD, molecular dynamics; CS, closed state; OS, occluded state; DHF, 7,8 dihydrofolate; THF, 5,6,7,8 tetrahydrofolate; NADPH, nicotinamide adenine dinucleotide phosphate; SCA, statistical coupling analysis; SOP, self-organized
The Crystal Structure of the Bifunctional Deaminase/Reductase RibD of the Riboflavin Biosynthetic Pathway in Escherichia coli: Implications for the Reductive Mechanism
Keywords: DHFR، dihydrofolate reductase; RP5, ribose-5-phosphate; DHFR, dihydrofolate reductase; EC, E.coli; Bc, B.subtilis; MjaRED, M.jannaschii reductasebi-functional deaminase/reductase; riboflavin biosynthesis; 3D-structure comparison; NADPH; hydride transfer
In search of cyclooxygenase inhibitors, anti-Mycobacterium tuberculosis and anti-malarial drugs from Thai flora and microbes
Keywords: DHFR، dihydrofolate reductase; Malaria; Tuberculosis; Cyclooxygenase; Inflammation; Fungi; Bioactive compounds; ThailandAA, arachidonic acid; COX, cyclooxygenase; DDT, dichloro-diphenyl-trichloroethane; DHFR, dihydrofolate reductase; GI, gastrointestinal; HIV, human immunodeficiency vi