Keywords: CAP; cationic antimicrobial peptide; TM; transmembrane; PPI; protein-protein interaction; Fmoc; Fluorenylmethyloxycarbonyl chloride; DMF; dimethylformamide; DCM; dichloromethane; DIEA; diisopropylethylamine; HATU; 1-[bis(dimethylamino)methylene]-1H-1,2,3-
مقالات ISI (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: QPA; quaternary protoberberine alkaloid; TF; transcriptional factor; UC; ulcerative colitis; IEC-6; intestinal epithelial cell-6; XBP1; X-box-binding protein 1; MIC; minimal inhibitory concentration; SAR; structure-activity relationship; SASP; Sulfasalazi
Keywords: SI; supporting information; NBD-Cl; 4-chloro-7-nitrobenzofurazan; NBD-OH; 4-hydroxy-7-nitrobenzofurazan; DIC; N,Nâ²-diisopropylcarbodiimide; DMAP; 4-dimethylaminopyridine; DIEA; N,N-diisopropylethylamine; HATU; 1-[bis(dimethylamino)methylene]-1H-1,2,3-tr
Keywords: ABD3; albumin-binding domain 3; ACN; acetonitrile; AUC; area under the curve; BA; bioavailability; cAMP; cyclic adenosine monophosphate; CHO; Chinese hamster ovary; DIEA; diisopropyl ethylene diamine; Cmax; peak plasma concentration; CLp; plasma clearance
Keywords: AF-1; activation function-1; AF-2; activation function-2; AP-1; activator protein 1; dppp; 1,3-bis(diphenylphosphino)propane; DEX; dexamethasone; DIEA; N,N-diisopropylethylamine; FKBP5; FK506-binding protein 5; GR; glucocorticoid receptor; GRE; glucocorti
A unique red-emitting two-photon fluorescent probe with tumor-specificity for imaging in living cells and tissues
Keywords: HOBT; 1-hydroxybenzotriazole; EDC; N-(3-dimethylaminopropyl)-N'-ethylcarbod-iimide hydrochloride; DIEA; ethyldiisopropylamine; DMF; dimethylformamide; Red-emitting two-photon fluorescent probe; High-definition three-dimensional imaging; Tumor-specific ima
Metal coordinated pyrrole-based macrocycles as contrast agents for magnetic resonance imaging technologies: Synthesis and applications
Keywords: AAV9; adeno-associated serotype 9 viral vector; BODIPY; boron-dipyrromethene; BSA; bovine serum albumin; C60; Buckminsterfullerene; CCMV; cowpea chlorotic mottle virus; CD; β-cyclodextrin; Cell line H1299; human non-small cell lung carcinoma cell line; C
Keywords: AM251; 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(1-piperidyl)pyrazo-le-3-carboxamide; BSA; bovine serum albumin; DAMGO; [d-Ala2, N-MePhe4, Gly-ol]-enkephalin; DIEA; diisopropylethylamine; DMF; dimethylformamide; EGTA; ethylene glycol-bis(2-amino
Keywords: BBB; blood-brain barrier; Boc; tert-butyloxycarbonyl; cAMP; cyclic adenosine monophosphate; CNS; central nervous system; DAMGO; H-Tyr-d-Ala-Gly-NMePhe-Gly-ol; DCM; dichloromethane; DIEA; N,N-diisopropylethylamine; DOR; δ-opioid receptor; DPDPE; Tyr-c(d
Keywords: Cyclic peptides; Microwave assisted synthesis; Lactam-bridge cyclic peptides; SHU9119; MTII; MWA-SPPS; microwave-assisted solid phase peptide synthesis; MBHA; methylbenzhydryl; MCR; melanocortin receptors; NDP; [Nle4, DPhe7]-αMSH; MTII; melanotan-II; RP-
Keywords: Dab; dabsyl moiety; TCTU; O-(6-chlorobenzotriazol-1-yl)-N,N,Nâ²,Nâ²-tetramethyluronium tetrafluoroborate, Fmoc, fluorenylomethyloxycarbonyl group; DIEA; diisopropylethylamine; SPPS; solid-phase peptide synthesis.; Isotopic labeling; Quantitative proteom
Keywords: Ac; acetyl; ACTH; adrenocorticotropic hormone; Alloc; allyloxycarbonyl; Boc; t-butoxycarbonyl; BSA; bovine serum albumin; DIC; N,Nâ²,-diisopropylcarbodiimide; DIEA; diisopropylethylamine; DMEM; Dulbecco's Modified Eagle Medium; DMF; N,N-dimethylformami
Keywords: BSA; bovine serum albumin; Cl-HOBt; 6-chloro-1-hydroxybenzotriazole; CuAAC; copper(I)-catalyzed azide-alkyne cycloaddition; DCM; dichloromethane; DIC; diisopropyl carbodiimide; DIEA; diisopropylethylamine; DMEM; Dulbecco's Modified Eagle Medium; DMF; N,
Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile
Keywords: BA; bioavailability; RAAS; renin-angiotensin-aldosterone system; BP; blood pressure; Ang I; angiotensin I; ACE; Angiotensin-converting enzyme; Ang II; angiotensin II; AT1; Ang II type I receptor; DRI; direct renin inhibitor; TPSA; topological polar surfac
Evaluation of a novel GRPR antagonist for prostate cancer PET imaging: [64Cu]-DOTHA2-PEG-RM26
Keywords: BBN; bombesin; BFCs; bifunctional chelates; BSA; bovine serum albumin; CB-TE2A; 4,11-bis(carboxymethyl)-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane; CH3CN; acetonitrile; C-NE3TA; 4-carboxymethyl-7-[2-(carboxymethyl-amino)-3-(4-nitro-phenyl)-propyl]-[1,4,7]t
Development of novel oxazolo[5,4-d]pyrimidines as competitive CB2 neutral antagonists based on scaffold hopping
Keywords: Cannabinoid; CB2 receptor; Neutral antagonist; oxazolo[5,4-d]pyrimidine; Boc; tert-butyloxycarbonyl; cAMP; cyclic adenosine monophosphate; CHO; Chinese hamster ovary cells; CHO-CB2; Chinese hamster ovary cells expressing CB2 receptors; CHO-WT; Chinese ham
New insights about the peculiar role of the 28-38 C-terminal segment and some selected residues in PACAP for signaling and neuroprotection
Keywords: ACN; acetonitrile; BBB; bloodbrain barrier; Bip; biphenylalanine; Boc; tert-butoxycarbonyl; BOP; (benzotriazol-1-yloxy)tris(dimethylamino) phosphonium hexafluorophosphate; BRET; bioluminescence resonance energy transfer; CHO cells; Chinese hamster ovary c
Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease
Keywords: PK; pharmacokinetics; DMF; N,N,-dimethylfornamide; DCM; dichloromethane; CDI; carbonyl diimidazole; TLC; thin layer chromatography; EDCI; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; HOBt; N-hydroxybenzotriazole; DIEA; diisopropylethylamine; DTT; dithio
Acylguanidine derivatives of zanamivir and oseltamivir: Potential orally available prodrugs against influenza viruses
Keywords: Acylguanidine; Zanamivir; Oseltamivir; Neuraminidase inhibitor; Influenza; Arg; arginine; Boc; tert-butoxycarbonyl; (Boc)2O; di(tert-butyl) dicarbonate; CC50; half maximal cytotoxicity concentration; CPE; cytopathic effect; DIEA; diisopropyl ethylamine; D
N-Thiazolylamide-based free fatty-acid 2 receptor agonists: Discovery, lead optimization and demonstration of off-target effect in a diabetes model
Keywords: AUCu; unbound area-under-the-curve; (S)-BINAP; (S)-(-)-(1,1â²-binaphthalene-2,2â²-diyl)bis(diphenylphosphine); CLu; unbound systemic clearance rate; Compd; compound; DIEA; N,N-diisopropyl ethylamine, EtOAc, ethyl acetate; FFA2 receptor; free fatty acid-
Formation of platinum (II) as a six member ring for sustained polymeric delivery
Keywords: Hyaluronic acid; Cisplatin chemotherapy; Lysine; Homo-lysine; Five-membered ring; Six-membered ring; HA; hyaluronic acid; PPG; photoremovable protecting group; pHP; p-hydroxyphenacyl; Fmoc; fluorenylmethoxy-carbonyl; HATU; 2-(1H-7-azabenzotriazol-1-yl)-1,
Design, synthesis and biological activity of 3-oxoamino-benzenesulfonamides as selective and reversible LSD1 inhibitors
Keywords: LSD1; Inhibitors; Selective; Reversible; Docking; DCM; dichloromethane; TBSCl; tert-butyldimethylsilyl chloride; TBAF; tetrabutylammonium fluoride; rt; room temperature; DMF; N,N-dimethylformamide; THF; tetrahydrofuran; DIEA; N,N-diisopropylethylamine;
Substituted α-mercaptoketones, new types of specific neprilysin inhibitors
Keywords: BTFA; boron trifluoroacetate; DIEA; diisopropylethylamine; EtOH; ethanol; HPLC; High Performance Liquid Chromatography; LC/MS; Liquid Chromatography/Mass Spectroscopy; LDA; lithium diisopropyl amide; NEP; neprilysin; NMM; N-methylmorpholine; PMBSH; para-m
Calcium phosphate-polymer hybrid nanoparticles for enhanced triple negative breast cancer treatment via co-delivery of paclitaxel and miR-221/222 inhibitors
Keywords: miR; micro RNA; miRi; micro RNA inhibitor; pac; paclitaxel; ER; estrogen receptor; PR; progesterone receptor; HER2/neu; epidermal growth factor receptor 2; TNBC; triple-negative breast cancer; PLGA; poly(d,l-lactide-co-glycolide); PEG; poly(ethylene-glyco
Comparison of extracellular Cys/Trp motif between Schizosaccharomyces pombe Ctr4 and Ctr5
Keywords: Ctr; copper transporter; BCA; bicinchoninic acid; Fmoc; 9-fluorenylmethyloxycarbonyl; NMP; N-methylpyrrolidone; HBTU; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate; HOBt; 1-hydroxybenzotriazol; DIEA; N,N-diisopropylethylamine; DM
Insights into amyloid-like aggregation of H2 region of the C-terminal domain of nucleophosmin
Keywords: TIS; Triisopropylsilane; TFA; Trifluoroacetic acid; DMF; Dimethylformamide; HBTU; 1-H-Benzotriazolium, 1-[bis(dimethylamino)methylene]-Hexafluorophosphate(1-),3 oxide; HOBt; N-hydroxybenzotriazole; DIEA; Di-isopropylethylamine; Fmoc; Fluorenylmethoxycarbo
Determining the best recipient vessel site for autologous microsurgical breast reconstruction with DIEP flaps: An anatomical study
Keywords: Autologous breast reconstruction; DIEP flap; Microsurgery; Anatomical study; Vessel diameter; DIEP; deep inferior epigastric artery perforator; DIEA; deep inferior epigastric artery; DIEV; deep inferior epigastric vein; ITA; internal thoracic artery; ITV;
Design and optimization of purine derivatives as in vivo active PDE10A inhibitors
Keywords: DIEA; N,N-diisopropylethylamine; DME; dimethoxyethane; DMF; N,N-dimethylformamide; EDC; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; HOBt; 1-hydroxybenzotriazole; rt; room temperature; TEA; triethylamine; THF; tetrahydrofuran; Phosphodiesterase; PDE10A;
New amphiphilic neamine conjugates bearing a metal binding motif active against MDR E. aerogenes Gram-negative bacteria
Keywords: Antibacterial activity; Gram-negative bacteria; Metal-binding groups; Membrane permeability; Multidrug resistant bacteria; Neamine derivatives; HOAt; 1-hydroxy-7azabenzotriazole; HATU; 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium-3-o
Effect of TLR ligands co-encapsulated with multiepitopic antigen in nanoliposomes targeted to human DCs via Fc receptor for cancer vaccines
Keywords: AAA; amino acid analysis; C18; octadecylsilica; DIEA; N,N-diisopropyl-ethylamine; DIPCDI; N,N'-Diisopropylcarbodiimide; DMF; N,N-dimethylformamide; DMSO; dimethyl sulfoxide Fmoc, 9-fluorenylmethoxycarbonyl; HOAt; 1-hydroxy-7-azabenzotriazole (3-hydroxy-
Modulating hydrogen-bond basicity within the context of protein-ligand binding: A case study with thrombin inhibitors that reveals a dominating role for desolvation
Keywords: Thrombin; Protein-ligand binding; Desolvation; Bioisosterism; Hydrogen bond; Cooperativity; Nonadditivity; B3LYP/6-31Gâ; Bn; benzyl; tert-Bu; tertiary butyl; DCM; dichloromethane; DIEA; diisopropylethylamine; DMF; dimethylformamide; EDCI.HCl; 1-ethyl-3-
Role of individual disulfide bridges in the conformation and activity of spinoxin (α-KTx6.13), a potassium channel toxin from Heterometrus spinifer scorpion venom
Keywords: Scorpion toxin; Voltage-gated potassium channel; Synthetic analog; Disulfide bond formation; Cysteine-stabilized α/β scaffold; Acm; acetamidomethyl; CSαβ scaffold; cysteine-stabilized α/β scaffold; DCM; dichloromethane; DIEA; N,N-diisopropylethylami
Isolation and characterization of a structurally unique β-hairpin venom peptide from the predatory ant Anochetus emarginatus
Keywords: RP-HPLC; reversed phase-high performance liquid chromatography; LC; liquid chromatography; MS; mass spectrometry; ACN; acetonitrile; TFA; trifluoroacetic acid; MALDI; matrix-assisted laser desorption/ionization; TOF; time-of-flight; FA; ferulic acid; DTT;
Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors
Keywords: AcOH; acetic acid; Ang I; angiotensin I; Ang II; angiotensin II; AUC; area under the blood concentration-time curve; C5min; concentration in plasma 5Â min after administration; CLtotal; total clearance; Cmax; maximum concentration in plasma; DIEA; N,N-d
Molecular interaction of δ-conopeptide EVIA with voltage-gated Na+ channels
Keywords: COSY; correlation spectroscopy; DG; distance geometry; DIEA; N,N-diisopropylethylamine; Fmoc; 9-fluorenylmethoxycarbonyl; GSH; glutathione reduced; GSSG; glutathione oxidized; HBTU; O-(benzotriazol-1-yl)-N,N,Nâ²,Nâ²-tetramethyl-uronium-hexafluorophospha
An update on the stereoselective synthesis of γ-amino acids
Keywords: ABO; 2,7,8-trioxabicyclo[3.2.1]octane; Ac; acetyl; ACPECA; 4-aminocyclopent-2-ene-1-carboxylic acid; AHPPA; 4-amino-3-hydroxy-5-phenylpentanoic acid; AMCP; 2-(aminomethyl)-cyclopentanecarboxylic acid; APCH; 2-(1-aminopropyl)cyclohexanecarboxylic acid; APT
A novel synthetic luteinizing hormone-releasing hormone (LHRH) analogue coupled with modified β-cyclodextrin: Insight into its intramolecular interactions
Keywords: BOP; benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphonium hexafluorophosphate; CLTR-Cl; 2-chlorotrityl chloride; DCC; N,Nâ²-dicyclohexylcarbodiimide; DMA; dimethylacetamide; DIC; N,Nâ²-diisopropylcarbodiimide; DIEA; diisopropylethylamine; DMF; N,N-di
PEGylation of the peptide Bac7(1-35) reduces renal clearance while retaining antibacterial activity and bacterial cell penetration capacity
Keywords: Antimicrobial peptide; Proline-rich; PEGylation; Antibacterial activity; Cell penetrating; Optical imaging; Boc2O; Di-t-butyl dicarbonate; Et2O; ethyl ether; CFU; colony forming unit; Cmc; S-carboxymethyl-cysteine; DIEA; N,N-Diisopropylethylamine; HCTU; 2
Blood-brain transfer and antinociception of linear and cyclic N-methyl-guanidine and thiourea-enkephalins
Keywords: Blood-brain barrier (BBB) transport (influx/efflux); Antinociceptive activity; Linear/cyclic enkephalin analogs; In vivo mouse models; AUC; area under the curve; Alloc; allyloxycarbonyl; BBB; blood-brain barrier; Boc; tertButyloxycarbonyl; BSA; bovine
Binding cooperativity between a ligand carbonyl group and a hydrophobic side chain can be enhanced by additional H-bonds in a distance dependent manner: A case study with thrombin inhibitors
Keywords: Cooperativity; Protein-ligand binding; Ligand binding affinity; Scoring functions; B-factor; Thrombin; Non-additivity; Me; methyl; Bn; benzyl; Boc; tert-butoxycarbonyl; ÎGË; standard Gibbs free energy; Ki; inhibition constant; EDCI; 1-(3-dimethylaminopr
Optimization of a novel series of N-phenylindoline-5-sulfonamide-based acyl CoA:monoacylglycerol acyltransferase-2 inhibitors: Mitigation of CYP3A4 time-dependent inhibition and phototoxic liabilities
Keywords: ACAT; acyl CoA:cholesterol acyltransferase; ADME; absorption, distribution, metabolism and excretion; APCI; atomospheric pressure chemical ionization; CM; chylomicron; dba; dibenzylideneacetone; CYP; cytochrome P450; DDI; drug-drug interaction; DGAT; ac
Microwave-assisted guanidinylation in solid phase peptide synthesis: comparison of various reagents
Keywords: Boc; tert-butyloxycarbonyl; Dab; 2,4-diaminobutyric acid; Dap; 2,3-diaminopropionic acid; Dap(g); 3-guanidino-2-aminopropionic acid; DIC; 1,3-diisopropylcarbodiimide; DIEA; diisopropylethylamine; hArg(g); 2,6-diguanidinohexanoic acid; MW; microwave; TBTU;
Synthetically modified l-histidine-rich peptidomimetics exhibit potent activity against Cryptococcus neoformans
Keywords: AA; amino acid; Boc; tert-butoxycarbonyl; DIC; 1,3-diisopropylcarbodiimide; DIEA; N,N-diisopropylethylamine; EYPC; egg yolk l-a-phosphatidylcholine; DMF; N,N-dimethylformamide; EYPG; egg yolk l-a-phosphatidyl-dl-glycerol; TBTU; O-(benzotriazol-1-yl)-N,N,N
Synthesis of IB-01212 by multiple N-methylations of peptide bonds
Keywords: Me2Leu; N,N-dimethylleucine; MeLeu; N-methylleucine; MePhe; N-methylphenylalanine; MSNT; 1-(mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole; NMI; 1-methylimidazole; DIEA; N,N-diisopropylethylamine; Cbz; benzyloxycarbonyl; Depsipeptide; Macrolactonization; N
G-quadruplex DNA recognition by nucleophosmin: New insights from protein dissection
Keywords: TIS; Triisopropylsilane; TFA; Trifluoroacetic acid; DMF; Dimethylformamide; DCM; Dichloromethane; HBTU; 1-H-Benzotriazolium, 1-[bis(dimethylamino)methylene]-hexafluorophosphate(1-), 3 oxide; HOBt; N-hydroxybenzotriazole; DIEA; Di-isopropylethylamine; Fmoc
Gadolinium-based contrast agents targeted to amyloid aggregates for the early diagnosis of Alzheimer's disease by MRI
Keywords: Alzheimer's disease; Amyloid; Gadolinium; DOTA; Pyridine containing TriAza (PCTA); Magnetic resonance imaging (MRI); BAT; bis-amine-bis-thiol; BTA; 2-(4-N-methylaminophenyl)benzothiazole; CA; contrast agent; CMC; critic micelle concentration; CV; cone vol
Discovery and optimization of novel small-molecule HIV-1 entry inhibitors using field-based virtual screening and bioisosteric replacement
Keywords: ADME; absorption, distribution, metabolism, and excretion; AMLV; amphotropic murine leukemia virus; BBB; blood-brain barrier; BIF; bioisostere factor; CNS; central nervous system; DCM; dichloromethane; DiEA; diisopropylethylamine; DIPEA; N,N-diisopropyl
Radiochemical and radiobiological assessment of a pyridyl-S-cysteine functionalized bombesin derivative labeled with the 99mTc(CO)3+ core
Keywords: Boc; t-butyloxycarbonyl; BSA; bovine serum albumin; Cys; cysteine; DIEA; N,N-diisopropylethylamine; DIC; diisopropylcarbamide; DMEM; Dulbecco's modified Eagle medium; DMF; dimethylformamide; EDTA; ethylenediaminetetraacetic acid; ESI-MS; electrospray io
New generation of efficient peptide-based vectors, NickFects, for the delivery of nucleic acids
Keywords: CPP; cell-penetrating peptide; CR; charge ratio; DLS; dynamic light scattering; DIEA; diisopropylethylamine; EGFP; enhanced green fluorescent protein; HBTU; O-benzotriazole-N,N,Nâ²,Nâ²-tetramethyl-uronium-hexafluoro-phosphate; HOBT; hydroxybenzotriazole
Conotoxin truncation as a post-translational modification to increase the pharmacological diversity within the milked venom of Conus magus
Keywords: Conotoxins; N-terminal modification; Milked venom; Post-translational modification; α-Conotoxin; Mass spectrometry; API; Atmospheric pressure ionization; Arg(Pbf); N-alpha-9-fluorenylmethoxycarbonyl-N-g-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-l