Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; DILI, Drug-induced liver injury; ADRs, Adverse drug reactions; HDS, Herbal and/or dietary supplement; APAP, N-acetyl-P-aminophenol; ALF, Acute liver failure; NSAIDs, Non-steroidal anti-inflammatory drugs; AMC, Amoxicillin–clavulanate; INH, Isoniazid; ALT,
مقالات ISI DILI، آسیب کبدی ناشی از مواد مخدر (ترجمه نشده)
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Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; ALF, acute liver failure; APAP, N-acetyl-p-aminophenol/acetaminophen/paracetamol; DILI, drug-induced liver injury; ESC, embryonic stem cells; hHEP, primary human hepatocytes; hSKP, human skin-derived precursors; hSKP-HPC, hSKP-derived hepatic progenitor c
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; AR, adverse reaction; BBW, black box warning; CCL2, chemokine (C-C motif) ligand 2; CXCL8, chemokine (C-X-C motif) ligand 8; DAMP, damage-associated molecular pattern; DILI, drug-induced liver injury; DMSO, dimethyl sulfoxide; FBS, fetal bovine serum; FDA
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; CAM, Complementary and Alternative Medicine; DILI, drug-induced liver injury; LFT, liver function test; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; TB, total bilirubin; γ-GTP, γ-glutamyl transpeptidase; HBs,
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; AOC, area over the curve; BBR, benzbromarone; CsA, cyclosporin A; CYP, cytochrome P450; DRLM, dexamethasone-treated Sprague–Dawley rat liver microsome; DILI, Drug-induced liver injury; G6P, glucose 6-phosphate; G6PDH, glucose-6-phosphate dehydrogenase; mt
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; Tocotrienol; Tocopherol; Antioxidant; Drug-induced liver injuryα-TP, α-tocopherol; α-T3, α-tocotrienol; T3, tocotrienol; TP, tocopherol; DILI, drug-induced liver injury; APAP, acetaminophen; H2O2, hydrogen peroxide; PCNA, proliferating cell nuclear antige
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; ANN, artificial neural networks; BSEP, bile salt export pump; DILI, drug-induced liver injury; ECFC_6, extended connectivity functional class fingerprints of maximum diameter 6; hERG, human ether-a-go-go-related gene; HIAT, hepatocyte imaging assay techno
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; DILI, drug-induced liver injury; EBV, Epstein–Barr virus; CMV, cytomegalovirus; HIV, human immunodeficiency virus; HSV, herpes simplex virus; HAV, hepatitis A virus; HBsAg, hepatitis B surface antigen; HBcAb, hepatitis B core antibody; HCV, hepatitis C vi
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; Non-infectious liver disease; Alcoholic liver disease; Autoimmune liver disease; Drug-induced liver injury; Non-alcoholic fatty liver diseaseAILD, autoimmune liver disease; ALD, alcoholic liver disease; DILI, drug-induced liver injury; HBV, hepatitis B vi
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; DILI, drug-induced liver injury; DMEM, Dulbecco's modified Eagle medium; DMSO, dimethylsulfoxide; ERK, extracellular signal-regulated kinase; FBS, fetal bovine serum; HE, hematoxylin–eosin; LDH, lactate dehydrogenase; PDGF-βR, platelet-derived growth fact
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; APAP, acetaminophen; DILI, drug-induced liver injury; CA, Caffeic acid; ALT/AST, alanine/aspartate aminotransferases; MPO, myeloperoxidase; GSH, glutathione; ROS, reactive oxygen species; Nrf2, nuclear factor erythroid 2-related factor 2; HO-1, heme oxyge
Necrotic cell death and suppression of T-cell immunity characterized acute liver failure due to drug-induced liver injury
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; ALF, acute liver failure; ALI, acute liver injury; AIH, autoimmune hepatitis; AIH-ALF, AIH-induced ALF; AIH-ALI, AIH-induced ALI; DILI, drug-induced liver injury; DILI-ALF, DILI-induced ALF; DILI-ALI, DILI-induced ALI; HAV, hepatitis A virus; HCV, hepatit
MicroRNA-mediated Th2 bias in methimazole-induced acute liver injury in mice
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; ALT, alanine aminotransferase; BSO, L-buthionine-S,R-sulfoximine; DILI, drug-induced liver injury; ELISA, enzyme-linked immunosorbent assay; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GATA3, GATA binding protein 3; GSH, glutathione; GSSG, oxidized g
Inhibition of bile salt transport by drugs associated with liver injury in primary hepatocytes from human, monkey, dog, rat, and mouse
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; Bile salt export pump; BSEP; ABCB11; Drug-induced liver injury; DILI; Bile salts; Hepatocytes; Species differenceBSEP, bile salt export pump; CA, cholic acid; CDCA, chenodeoxycholic acid; DILI, drug-induced liver injury; GCA, glycocholic acid; GCDCA, glyc
Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; APAP; Mouse Model; Gene Regulation; Pharmacologic TreatmentALF, acute liver failure; AMPK, adenosine monophosphate-activated protein kinase; APAP, acetaminophen; CCl4, carbon tetrachloride; D-GalN, D-galactosamine; DILI, drug-induced liver injury; IP, int
Small-molecule modulators of PXR and CAR
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; AF-2, activation function 2; CAR, constitutive androstane receptor; CYP, cytochrome P450; DBD, DNA-binding domain; DDI, drug–drug interactions; DEHP, di(2-ethylhexyl) phthalate; DILI, drug-induced liver injury; DR4, direct repeat separated by 4 nucleotide
Application of lipid peroxidation products as biomarkers for flutamide-induced oxidative stress in vitro
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; 15R-PD2, 15R-prostaglandin D2; DHN-MA, 1,4-dihydroxynonene mercapturic acid; Dihydro-keto PE2, 13,14-dihydro-15-keto prostaglandin E2; DILI, drug-induced liver injury; HNE, 4-hydroxy-2(E)-nonenal; HNE-MA, HNE mercapturic acid; HRP, horseradish peroxidase;
Bridging the gap between old and new concepts in drug-induced liver injury
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; APAP, acetaminophen; 2-APB, 2-aminoethoxydiphenyl borate; Cx32, connexin 32; CYP2E1, cytochrome P450 2E1; DILI, drug-induced liver injury; MPT, membrane permeability transition; NAC, N-acetylcysteine; NAPQI, N-acetyl-p-benzoquinone imine; OXPHOS, oxidativ
Drug-induced severe adverse reaction enhanced by human herpes virus-6 reactivation
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; ADR, adverse drug reaction; DIHS, drug-induced hypersensitivity syndrome; DILI, drug-induced liver injury; DRESS, drug reaction with eosinophilia and systemic symptoms; HCMV, human cytomegalovirus; HHV, human herpes virus; HSR, hypersensitivity reactions;
MicroRNAs in Liver Disease: Bench to Bedside
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; microRNA; liver; miR-122; up-regulation; down-regulationmiRs/miRNA, microRNA; HBV, hepatitis B virus; HCV, hepatitis C virus; HCC, hepatocellular carcinoma; DILI, drug-induced liver injury; IFN, interferon; NAFLD, non-alcoholic fatty liver disease; NASH,
A high content screening assay to predict human drug-induced liver injury during drug discovery
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; AC50, activity concentration 50%; ALT, alanine transferase; Cmax, maximum total concentration in plasma; CCCP, carbonyl cyanide m-chlorophenyl hydrazine; DILI, drug-induced liver injury; DMSO, dimethyl sulfoxide; FBS, fetal bovine serum; HCS, high content
Hepatotoxicity Related to Anti-tuberculosis Drugs: Mechanisms and Management
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; drug-induced liver injury; hepatotoxicity; tuberculosis; genetic; pathogenesisTB, tuberculosis; WHO, World Health Organization; DILI, drug-induced liver injury; ALT, alanine transaminase; AST, aspartate transaminase; ULN, upper limit of normal range; FDA,
Genetic and immune predictors for hypersensitivity syndrome to antiepileptic drugs
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; ADR, adverse drug reaction; AED, antiepileptic drug; CBZ, carbamazepine; DIHS, drug-induced hypersensitivity syndrome; DILI, drug-induced liver injury; DRESS, drug rash with eosinophilia and systemic symptoms; Fas, CD95, APO-I; HLA, human leukocyte antige
An integrated reactive metabolite evaluation approach to assess and reduce safety risk during drug discovery and development
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; APAP, acetaminophen; ARE, antioxidant response element; Clint,cb2, intrinsic clearance of covalent binding; CYP, cytochrome P450; DILI, drug-induced liver injury; Ephx1, microsomal epoxide hydrolase; Gclc, glutamate cysteine ligase; GSH, glutathione; GstA
Outcomes in patients with Mycobacterium abscessus pulmonary disease treated with long-term injectable drugs
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; Atypical mycobacteria; Lung diseases; Mycobacterium abscessus; Treatment outcomeATS, American Thoracic Society; DILI, drug-induced liver injury; NTM, nontuberculous mycobacteria; MAC, Mycobacterium avium-intracellulare complex; TB, tuberculosis; AFB, acid
Clinical course and outcomes of drug-induced liver injury: Nimesulide as the first implicated medication
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; ADR, adverse drug reaction; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; DILI, drug-induced liver injury; NAFLD, non-alcoholic fatty liver disease; NSAIDs, non-steroidal anti-inflammatory drugs; OLT, orthotopi
Pathologic role of stressed-induced glucocorticoids in drug-induced liver injury in mice
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; APAP, acetaminophen; AILI, acetaminophen-induced liver injury; GC, glucocorticoid; GCR, glucocorticoid receptor; ConA, concanavalin A; CCl4, carbon tetrachloride; DILI, drug-induced liver injury; NAPQI, N-acetyl-p-benzoquinone imine; H&E, hematoxylin and
Involvement of natural killer T cells in halothane-induced liver injury in mice
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; DILI, drug-induced liver injury; HILI, halothane-induced liver injury; NKT, natural killer T; IL, interleukin; IFN, interferon; TNF, tumor necrosis factor; α-GalCer, alpha-galactosylceramide; i.p., intraperitoneally; KCs, Kupffer cells; i.v., intravenousl
Cell based approaches for evaluation of drug-induced liver injury
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; DILI, drug-induced liver injury; BSEP/Bsep, bile salt export pump; CLF, cholyl-lysylfluorescein; THLE-CYP, SV40 large T antigen immortalised human liver epithelial cells transfected with individual cytochrome P450 enzymesDrug-induced liver injury; Reactiv
The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; DILI, drug-induced liver injury; APAP, acetaminophen; AILI, acetaminophen-induced liver injury; NAPQI, N-acetyl-p-benzoquinone imine; GSH, glutathione; MIF, migration inhibitory factor; IFN, interferon; TNF, tumor necrosis factor; IL, interleukin; COX, cy
Assessment of candidate biomarkers of drug-induced hepatobiliary injury in preclinical toxicity studies
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; DILI, drug-induced liver injury; GGT, γ-glutamyltransferase; NGAL, neutrophil gelatinase-associated lipocalin; PON1, paraoxonase; 2D-PAGE, two-dimensional polyacryl
Use of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; BEI, biliary excretion index; DILI, drug-induced liver injury; HBSS, Hanks’ balanced salts solution; in vitro Clbiliary, in vitro biliary clearance; LDH, lactate dehydrogenase; SCH, sandwich-cultured hepatocytesSandwich-cultured hepatocytes; Hepatobiliary
Risk Factors for Idiosyncratic Drug-Induced Liver Injury
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; HLA; Amoxicillin-Clavulanate; Hy's Law; DILIanti-TB, antituberculosis; BSEP, bile salt export pump; DILI, drug-induced liver injury; IL, interleukin; MnSOD, manganese superoxide dismutase; MRP, multidrug resistance protein; NAT2, N-acetyltransferase 2; OR
IP-10 protects while MIP-2 promotes experimental anesthetic hapten - induced hepatitis
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; CYP2E1; Trifluoroacetyl chloride; TFA; DILI; MIP-2; IP-10; KC chemokinesAIH, autoimmune hepatitis; CYP2E1, cytochrome P450 2E1; DILI, drug-induced liver injury; IP-10, interferon gamma inducible protein-10; KC, keratinocyte-derived chemokine; KLH, keyhole
Synergistic drug–cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; APAP, acetaminophen; Cmax, average plasma maximum drug concentration; CM-H2DCFDA, 5-(and-6)-chloromethyl-2′7′-dichlorodihydrofluorescein diacetate acetyl ester; TMRM, tetramethyl rhodamine ester; DILI, drug-induced liver injury; DRAQ5, 1,5-bis{[2-(di-meth
Troglitazone-induced hepatic mitochondrial proteome expression dynamics in heterozygous Sod2+/− mice: Two-stage oxidative injury
Keywords: DILI، آسیب کبدی ناشی از مواد مخدر; ACO2, aconitase-2 (mitochondrial form); 2D-DIGE, two-dimensional difference gel electrophoresis; DILI, drug-induced liver injury; ETC, electron transport chain; SOD, superoxide dismutase.Troglitazone; Idiosyncratic drug toxicity; Drug-induced liver injury