Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; 5-Aza, 5-Aza-2′-deoxycytidine; cFLIP, cellular FLICE inhibitory protein; CREB, cAMP response element-binding protein; DEDs, death effector domains; DISC, death-inducing signaling complex; FADD, Fas-Associated protein with Death Domain; HDAc, histone deace
مقالات ISI DISC، مجموعه ای از سیگنال های ناشی از مرگ (ترجمه نشده)
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Quercetin sensitizes pancreatic cancer cells to TRAIL-induced apoptosis through JNK-mediated cFLIP turnover
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; AIF, apoptosis-inducing factor; cFLIP, FLICE-like inhibitory protein; AMPK, AMP-activated protein kinase; DISC, death-inducing signaling complex; FITC, fluorescein isothiocyanate; JNK, c-Jun N-terminal kinase; PDAC, Pancreatic ductal adenocarcinoma; MMP,
Combinatorial treatment of CD95L and gemcitabine in pancreatic cancer cells induces apoptotic and RIP1-mediated necroptotic cell death network
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; bf, bright field; CD95L, CD95 ligand; DD, death domain; DED, death effector domain; DR, death receptor; c-FLIP, cellular FLICE-inhibitory protein; DISC, Death-Inducing Signaling Complex; IP, immunoprecipitation; Nec-1, necrostatin; PI, propidium iodide; R
Fucoidan protects hepatocytes from apoptosis and inhibits invasion of hepatocellular carcinoma by up-regulating p42/44 MAPK-dependent NDRG-1/CAP43
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; BA, bile acid; cDNA, complementary DNA; CXCL, chemokine ligand; DISC, death-inducing signaling complex; DMEM, Dulbecco׳s modified Eagle׳s medium; DNA, deoxyribonucleic acid; ELISA, enzyme-linked immunosorbent assay; FADD, Fas associated death domain; FBS,
RIP1 modulates death receptor mediated apoptosis and autophagy in macrophages
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; Tumor necrosis factor-related apoptosis-inducing ligand; Apoptosis; Autophagy; RIP1; Ubiquitination; Deathc-FLIP, cellular FLICE inhibitory protein; DISC, death-inducing signaling complex; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; LC3, microtubule-
Synergism of PI3K/Akt inhibition and Fas activation on colon cancer cell death
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; AI, Akt inhibitor VIII; CI, combination index; CRC, colorectal cancer cell; DISC, death-inducing signaling complex; DNA, deoxyribonucleic acid; DRI, dose-reduction index; EC50, half maximal effective concentration; Fa, function of effect level; FACS, fluo
PDTC antagonized polysaccharide-induced apoptosis in MCF-7 cells through a caspase-8 mediated Fas pathway
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; CASPASE, cysteine aspartic acid specific protease; DISC, death-inducing signaling complex; FADD, Fas-associated death domain; FBS, phosphate buffered saline; FITC, fluorescein isothiocyanate; NF-κB, nuclear factor kappa B; PDTC, pyrrolidine dithiocarbamat
Targeting c-FLIP in cancer
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; c-FLIP; Death receptors; CancerCDDP, cisplatin; VP16, etoposide; 5-FU, 5-fluorouracil; DISC, death-inducing signaling complex; DcR2, TRAIL-R4 or decoy receptor 2; DR5, TRAIL-R1
Apaf-1 deficiency confers resistance to ultraviolet-induced apoptosis in mouse embryonic fibroblasts by disrupting reactive oxygen species amplification production and mitochondrial pathway
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; Apaf-1, apoptotic protease-activating factor 1; H2DCFDA, 2′,7′-dichlorodihydrofluorescein diacetate; DCF, 2′,7′-dichlorofluorescein; DISC, death-inducing signaling complex; FADD, Fas-associated death domain protein; HE, dihydroethidium; JC-1, 5,5′,6,6′-te
Regulation of death complexes formation in tumor necrosis factor receptor signaling
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; CHX, cycloheximide; cFLIP, cellular FLICE-inhibitory protein; cIAP-1, inhibitors-of-apoptosis 1; DD, death domain; DISC, death-inducing signaling complex; FADD, Fas-associated death domain protein; IP, immunoprecipitation; KOSR, knockout serum replacement
BRE over-expression promotes growth of hepatocellular carcinoma
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; BRE, brain and reproductive organ-expressed; TNFRSF1A, tumor necrosis factor receptor superfamily member 1A; BRCC45, BRCA1/2-containing complex subunit 45; HCC, hepatocellular carcinoma; DEN, diethylnitrosamine; DISC, death-inducing signaling complex; TTR
Physiological significance of selective degradation of p62 by autophagy
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; Autophagy; Ubiquitin; p62; Neighbor of BRCA1 gene 1; TRAF6; Caspase-8; Keap1Atg, autophagy-related; DISC, death-inducing signaling complex; LC3, microtubule-associated protein 1 light chain 3; LIR, LC3-interacting region; LRS, LC3 recognition sequence; Nb
A novel role of microtubular cytoskeleton in the dynamics of caspase-dependent Fas/CD95 death receptor complexes during apoptosis
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; ALL, acute lymphoblastic leukemia; DISC, death-inducing signaling complex; FADD, Fas associated death domain; IP, immunoprecipitation; LatA, latrunculin A; NDZ, nocodazole; PI, propidium iodide; tBid, truncated Bid; TfR, transferrin receptor; TNF, tumor n
Apoptotic effects of mahanine on human leukemic cells are mediated through crosstalk between Apo-1/Fas signaling and the Bid protein and via mitochondrial pathways
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; BSA, bovine serum albumin; DAB, diaminobenzidine; DISC, death-inducing signaling complex; EtOH, ethanol; FCS, fetal calf serum; FITC, fluorescein isothiocyanate; H2DCFDA, 5-(and-6)-chloromethyl-2′7′-dichlorodihydrofluorescein diacetate acetyl ester; HPLC,
Reactive oxygen species, cellular redox systems, and apoptosis
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; AIF, apoptosis-inducing factor; ANT, adenine nucleotide translocase; Apaf-1, apoptotic protease activation factor-1; ASK, apoptosis signal-regulating kinase; cypD, cyclophilin D; DD, death domain; DISC, death-inducing signaling complex; ER, endoplasmic re
Apple procyanidins activate apoptotic signaling pathway in human colon adenocarcinoma cells by a lipid-raft independent mechanism
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; DISC, death-inducing signaling complex; DMSO, dimethylsulfoxide; DR4/DR5, death receptor 4/death receptor 5; FACS, fluorescence-activated cell sorting; HPLC, high performance liquid chromatography; HRP, horseradish peroxidase; MFI, mean fluorescence inten
Homer1 regulates the susceptibility to TRAIL
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; TRAIL, Tumor Necrosis Factor-related Apoptosis-inducing Ligands; DR4/5, death receptor 4/5; TR, TRAIL resistant; DISC, death-inducing signaling complex; mGluRIs, metabotropic glutamate receptorsHomer1; TRAIL; Apoptosis
Calpain activates caspase-8 in neuron-like differentiated PC12 cells via the amyloid-β-peptide and CD95 pathways
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; AD, Alzheimer's disease; α-CD95, anti-CD95 antibody; Aβ, amyloid-β-peptide; APP, amyloid precursor protein; BAPTA, BAPTA-AM (1,2-Bis-(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetraacetoxymethyl ester); DISC, death-inducing signaling complex; DMEM,
Potential mechanism of cell death in the developing rat brain induced by propofol anesthesia
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; BDNF, brain-derived neurotrophic factor; DISC, death-inducing signaling complex; FADD, Fas-associating protein with a death domain; GABA, γ-aminobutyric acid; GAPDH, glyceraldehydes 3-phosphate dehydrogenase; IAP, inhibitor of apoptosis protein; NGF, nerv
Heme oxygenase-1, a critical arbitrator of cell death pathways in lung injury and disease
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; A/R, anoxia/reoxygenation; BR, bilirubin; BV, biliverdin; BVR, biliverdin reductase; COPD, chronic obstructive pulmonary disease; CS, cigarette smoke; CSE, cigarette smoke extract; Cyt-c, cytochrome c; DISC, death-inducing signaling complex; HO-1, heme ox
Bile Salt–Induced Apoptosis Involves NADPH Oxidase Isoform Activation
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; CD95, CD95 receptor, Apo-1/Fas; CD95-Tyr-P, CD95-tyrosine phosphorylation; CFP, cyan fluorescent protein; CM-H2DCFDA, 5-(and-6-)-chloromethyl-2′,7′-dichlorodihydrofluorescein diacetate; DISC, death-inducing signaling complex; DPI, diphenyleneiodonium chlo
Regulation of CD95/APO-1/Fas-induced apoptosis by protein phosphatases
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; DISC, death-inducing signaling complex; PTP, protein tyrosine phosphatase; FAP-1, Fas-associated phosphatase-1; SHP-1, SH2-containing PTP-1 protein; PTP-1B, protein phosphatase-1B; PTEN, phosphatase and tensin homologue; DD, death domain; EGF, epidermal g
Interferon-α induces transient upregulation of c-FLIP through NF-κB activation
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; IFN-α, interferon-alpha; TRAIL, TNF-related apoptosis-inducing ligand; DISC, death-inducing signaling complex; c-FLIP, cellular FLICE inhibitory protein; PKC, protein kinase C; RT–PCR, reverse transcription–polymerase chain reaction; Ab, antibody; ΔΨm, mi
microRNAs and death receptors
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; AIF, Apoptosis Inducing Factor; DISC, death-inducing signaling complex; HMGA2, high mobility group A2; Ltn A, latrunculin A; RISC, RNA-induced silencing complex; tBid, truncated BidApoptosis; Fas; Let-7; Superclusters; TRAIL
TRAIL-induced survival and proliferation of SCLC cells is mediated by ERK and dependent on TRAIL-R2/DR5 expression in the absence of caspase-8
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; DISC, death-inducing signaling complex; ERK1/2, extracellular signal-regulated kinase 1 and 2; FADD, Fas-associated death domain; FLICE, FADD-like ICE; FLIP, FLICE-inhibitory protein; IFN-γ, interferon-γ; MEK, mitogen-activated ERK kinase; NF-κB, nuclear
Glucagon Receptor Signaling Is Essential for Control of Murine Hepatocyte Survival
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; BHK, baby hamster kidney; CHX, cycloheximide; DISC, death-inducing signaling complex; Epac, exchange protein directly activated by cyclic AMP; Gcgr, glucagon receptor; GLP-1, glucagon-like peptide-1; GLP-2, glucagon-like peptide-2; PKA, protein kinase A;
Ferruginol suppresses survival signaling pathways in androgen-independent human prostate cancer cells
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; Natural compound; Ferruginol; Apoptosis; Prostate cancerAIF, apoptosis-inducing factor; Bax, Bcl-2 associated x protein; CDKIs, cyclin-dependent kinase inhibitors; CDKs, cyclin-dependent kinases; DISC, death-inducing signaling complex; ERK, extracellular
Concepts of activated T cell death
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; AICD, activation-induced cell death; ACAD, activated T cell autonomous death; Bcl-2, B cell leukemia-2; BCR, B cell receptor; CD95L, CD95-ligand; DISC, death-inducing signaling complex; FLIP, FLICE-inhibitory protein; HPK1, hematopoietic progenitor kinase
Revival of apoptotic cells that display early-stage dynamic membrane blebbing
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; FADD, Fas-associated death domain protein; DISC, death-inducing signaling complex; cFLIP, cellular FADD-like interleukin-1β converting enzyme-inhibitory protein; PBS, phosphate-buffered salineApoptosis; FADD; Biotechnology; Membrane blebbing; Anti-apoptot
Bile acid-induced TGR5-dependent c-Jun-N terminal kinase activation leads to enhanced caspase 8 activation in hepatocytes
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; TRAIL-R2, tumor necrosis factor related apoptosis inducing ligand receptor 2; FADD, Fas associated death domain; DISC, death-inducing signaling complex; JNK, c-Jun-N terminal kinase; GPCR, G protein-coupled receptor; DC, deoxycholic acid; RT-PCR, reverse
A cytotoxin isolated from Agkistrodon acutus snake venom induces apoptosis via Fas pathway in A549 cells
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; LAAO, l-amino acid oxidase; JNK, c-Jun NH2-terminal kinase; MTT, 3-[4,5-dimethylthiazol-2-yl]-2,3-diphenyltetrazodium bromide; DISC, death-inducing signaling complex; Δψm,, mitochondrial transmembrane potential; DCF, 2′,7′-dichlorofluorescein; DCFH-DA, 2′
High hepatic glutathione stores alleviate Fas-induced apoptosis in mice
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; Bax, Bcl-2-associated x; Bid, BH3 interacting domain death agonist; DISC, death-inducing signaling complex; FADD, Fas-associated protein with death domain; GSH, reduced glutathione; GSSG, oxidized glutathione; MPT, mitochondrial permeability transition; J
Lexatumumab (TRAIL-receptor 2 mAb) induces expression of DR5 and promotes apoptosis in primary and metastatic renal cell carcinoma in a mouse orthotopic model
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; TNF, tumor necrosis factor; TRAIL, TNF-related apoptosis-inducing ligand; RCC, renal cell carcinoma; FADD, Fas-associated protein with death domain; DED, death effector domain; DISC, death-inducing signaling complex; DD, death domain; c-FLIP, cellular FLI
Role of death receptor and mitochondrial pathways in conventional chemotherapy drug induction of apoptosis
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; Casp-8−/−, caspase-8-deficient; DFF45, DNA fragmentation factor 45; DISC, death-inducing signaling complex; mAb, monoclonal antibody; FADD−/−, FADD-deficient; MMP, mitochondrial membrane potential; siRNA, small interfering RNA; TNF, tumor necrosis factor;
Significant inhibition of TRAIL-mediated fibroblast-like synovial cell apoptosis by IFN-γ through JAK/STAT pathway by translational regulation
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; Abs, antibodies; ATA, aurintricarboxylic acid; BSA, bovine serum albumin; cDNA, complementary DNA; CHX, cycloheximide; DcR, decoy receptor; DEVD, Asp-Glu-Val-Asp; DISC, death-inducing signaling complex; DR, death receptor; ΔΨm, disruption of mitochondrial
Activation of caspase-8 triggers anoikis in human neuroblastoma cells
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; ECM, extracellular matrix; DISC, death-inducing signaling complex; TNF-R, tumor necrosis factor receptor; RA, all-trans-retinoic acid; DMEM, Dulbecco modified Eagle's medium; PH, polyHEMA poly(2-hydroxyethyl methacrylate); PL, poly-l-lysine; LM, laminin;
Adenovirus-mediated transfection of caspase-8 sensitizes hepatocellular carcinoma to TRAIL- and chemotherapeutic agent-induced cell death
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; TRAIL, TNF-related apoptosis-induced ligand; TRAIL-R1, TRAIL-receptor 1; TRAIL-R2, TRAIL-receptor 2; DISC, death-inducing signaling complex; HCC, hepatocellular carcinoma; XIAP, X-linked inhibitor of apoptosis proteins; c-FLIP, cellular FLICE/caspase-8-in
Inhibition of transcription factor NF-κB signaling proteins IKKβ and p65 through specific cysteine residues by epoxyquinone A monomer: Correlation with its anti-cancer cell growth activity
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; Ac-DEVD-AMC, N-acetyl-Asp-Glu-Val-Asp-AMC (7-amino-4-methylcoumarin); DHMEQ, dehydroxymethylepoxyquinomicin; DISC, death-inducing signaling complex; DMEM, Dulbecco's modified Eagle's medium; DTT, dithiothreitol; EMSA, electrophoretic mobility shift assay;
Activation of the Proapoptotic Death Receptor DR5 by Oligomeric Peptide and Antibody Agonists
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; Apo2L, apoptosis-inducing ligand 2; CDR, complementarity determining region; CRD, cysteine-rich domain; DcR, decoy receptor; DISC, death-inducing signaling complex; DR, death receptor; ECD, extracellular domain; ELISA, enzyme-linked immunosorbent assay; F
Sustained Phosphorylation of Bid Is a Marker for Resistance to Fas-Induced Apoptosis During Chronic Liver Diseases
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; BDL, bile duct ligation; DISC, death-inducing signaling complex; EGTA, ethylene glycol-bis[β-aminoethyl ether]-N,N,N′,N′-tetraacetic acid; FADD, Fas-associated death domain adaptor protein; HT-1, hereditary tyrosinemia; IAPs, inhibitors of apoptosis prote
Escape from immune- and nonimmune-mediated tumor surveillance
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; β2m, β2-microglobulin; DR, death receptor; DISC, death-inducing signaling complex; FLIP, FLICE-inhibitory protein; HLA, human leukocyte antigen; IAP, inhibitor of apoptosis protein; IFN, interferon; Ig, Immunoglobulin; KIR, killer cell Ig-like receptor; M
The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways
Keywords: DISC، مجموعه ای از سیگنال های ناشی از مرگ; APAF-1, apoptotic protease activating factor-1; CREB, cyclic AMP response element binding protein; DISC, death-inducing signaling complex; DR, death receptor; ER, endoplasmic reticulum; FADD, Fas-associated death domain protein; GSK3, glycogen synthase ki