کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2514551 1118472 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulation of CD95/APO-1/Fas-induced apoptosis by protein phosphatases
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Regulation of CD95/APO-1/Fas-induced apoptosis by protein phosphatases
چکیده انگلیسی

Triggering the CD95/APO-1/Fas receptor by CD95-L induces the assembly of the death-inducing signaling complex (DISC), which permits initiator caspases activation and progression of a signaling cascade that culminates in cellular apoptosis. Despite the CD95 receptor does not exhibit any kinase activity by itself, phosphorylation/dephosphorylation events seem important to regulate many aspects of CD95-mediated apoptosis. Here, we try to highlight particularly the importance of protein phosphatases in the modulation of the CD95 system.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Pharmacology - Volume 76, Issue 11, 1 December 2008, Pages 1451–1458
نویسندگان
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