
The value of integrating pre-clinical data to predict nausea and vomiting risk in humans as illustrated by AZD3514, a novel androgen receptor modulator
Keywords: ADR, adverse drug reaction; AE, adverse effect; AR, androgen receptor; AUC, area under the curve; DRF, dose range finding; FITH, first in time in human; GI, gastrointestinal; MTD, maximum tolerated doseNausea; Vomiting; Pre-clinical animal models; Transla