دانلود مقالات ISI درباره DSB، شکست دو رشته + ترجمه فارسی

Cellular responses to targeted genomic sequence modification using single-stranded oligonucleotides and zinc-finger nucleases

Keywords: DSB، شکست دو رشته; bp, base pairs; DSB, double-strand break; compl, complementary; ctr, control; dox, doxycycline; EGFP, enhanced green fluorescent protein; H2AX, variant of histone H2A; HR, homologous recombination; mEGFP, mutated enhanced green fluorescent protein; MMR, m

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Human Transcriptional Coactivator PC4 Stimulates DNA End Joining and Activates DSB Repair Activity

Keywords: DSB، شکست دو رشته; DSB, double-strand break; NHEJ, nonhomologous end joining; BSA, bovine serum albumin; AFM, atomic force microscopy; CTD, C-terminal domain; ssDNA, single-stranded DNA; dsDNA, double-stranded DNA; dNTP, deoxyribonucleotide triphosphate; HMGB1, high-mobilit

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2009 سفارش ترجمه

Loss of epigenetic silencing in tumors preferentially affects primate-specific retroelements

Keywords: DSB، شکست دو رشته; DSB, double-strand break; EIDR, endonuclease-independent DNA repair; ERV, endogenous retrovirus; HERV, human endogenous retrovirus; HNSCC, head and neck squamous cell carcinoma; LINE, long interspersed nuclear element; LTR, long terminal repeat; MaLR, mam

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2009 سفارش ترجمه

Role of the mismatch repair gene, Msh6, in suppressing genome instability and radiation-induced mutations

Keywords: DSB، شکست دو رشته; Aprt, adenine phosphoribosyltransferase; DSB, double-strand break; Hprt, hypoxanthineguanine phosphoribosyltransferase; IR, ionizing radiation; MF, mutant frequency; MMR, mismatch repair; MR, mitotic recombinationLoss of heterozygosity; Mismatch repair; M

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Analysis of Strand Transfer and Template Switching Mechanisms of DNA Gap Repair by Homologous Recombination in Escherichiacoli: Predominance of Strand Transfer

Keywords: DSB، شکست دو رشته; HR, homologous recombination; DSG, daughter strand gap; DSB, double-strand break; BP-G, benzo[a]pyrene–guanine; TLS, translesion DNA synthesis; HJ, Holliday junctionDNA damage; DNA damage tolerance; DNA repair; DNA replication; translesion DNA synthesis

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Endogenous DNA damage clusters in human hematopoietic stem and progenitor cells

Keywords: DSB، شکست دو رشته; AP, abasic (apurinic or apyrimidinic); αT, α-anomeric 2′-thymidine; BSA, bovine serum albumin; DHU, 5,6-dihydrouridine; DSB, double-strand break; HRP, horseradish peroxidase; OxyBase, oxidized base (cluster); OxyPur, oxidized purine; OxyPyr, oxidized pyri

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

In normal human fibroblasts variation in DSB repair capacity cannot be ascribed to radiation-induced changes in the localisation, expression or activity of major NHEJ proteins

Keywords: DSB، شکست دو رشته; BCA, bicinchoninic acid; cpm, counts per minute; CV, coefficient of variation; DSB, double-strand break; ECL, enhanced chemiluminescence; HDR, homology-directed repair; NHEJ, non-homologous end-joining; PCNA, proliferating cell nuclear antigen; PV, pellet

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Depletion of WRN enhances DNA damage in HeLa cells exposed to the benzene metabolite, hydroquinone

Keywords: DSB، شکست دو رشته; DSB, double-strand break; RNAi, RNA interference; siRNA, small interfering RNARNA interference; siRNA; γH2AX; p53; Leukemia; Lymphoma; DNA repair; Strand breaks

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Plasmid expression of mutS, -L and/or -H gene in Escherichia colidam cells results in strains that display reduced mutation frequency

Keywords: DSB، شکست دو رشته; 2-AP, 2-aminopurine; Dam, DNA-adenine methylase; DSB, double-strand break; LB, Luria–Bertani medium; MMRS, mismatch repair system; Rifr, rifampicin-resistantMutS; MutL; MutH; Dam; Mismatch; Mutation frequency

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination

Keywords: DSB، شکست دو رشته; CHO, Chinese hamster ovary; DSB, double-strand break; GJIC, gap-junction-mediated intercellular communication; HPRT, hypoxanthine-guanine phosphoribosyltransferase; HRR, homologous recombinational repair; IR, ionizing radiation; NHEJ, non-homologous end j

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Minimal deletion regions in lung squamous cell carcinoma: Association with abnormality of the DNA double-strand break repair genes and their applications on gene identification and prognostic biomarkers

Keywords: DSB، شکست دو رشته; NSCLC, non-small cell lung cancer; SCC, lung squamous cell carcinoma; FAL, high fractional allelic loss; DSB, double-strand break; TSG, tumor suppressor genes; MDRs, minimal deletion regions; LOH, loss of heterozygosity; RT-PCR, reverse transcriptase-poly

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

DNA polymerase η reduces the γ-H2AX response to psoralen interstrand crosslinks in human cells

Keywords: DSB، شکست دو رشته; BrdU, bromodeoxyuridine; DSB, double-strand break; HMT, 4′-hydroxymethyl-3,4,5′-trimethylpsoralen; ICL, interstrand crosslink; NER, nucleotide excision repair; ssDNA, single-strand DNA; TLS, translesion synthesis; UVA, ultraviolet AInterstrand crosslink;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Insulin-like growth factor-1 attenuates cisplatin-induced γH2AX formation and DNA double-strand breaks repair pathway in non-small cell lung cancer

Keywords: DSB، شکست دو رشته; ATM, ataxia-telangiectasia mutated; ATR, ATM-Rad3-related; DNA-PKcs, DNA-dependent protein kinase catalytic subunit; DSB, double-strand break; HR, homologous recombination-directed DNA repair; IGF-1, insulin-like growth factor-1; IGF-1R, IGR-1 receptor, I

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Age, sex, and race influence single-strand break repair capacity in a human population

Keywords: DSB، شکست دو رشته; AP sites, apurinic/apyrimidinic sites; BER, base excision repair; BMI, body mass index; DSB, double-strand break; DMSO, dimethyl sulfoxide; FBS, fetal bovine serum; NER, nucleotide excision repair; PBMC, peripheral blood mononuclear cells; PBS, phosphate-

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

Characterization of Abasic Endonuclease Activity of Human Ape1 on Alternative Substrates, as Well as Effects of ATP and Sequence Context on AP Site Incision

Keywords: DSB، شکست دو رشته; AP, apurinic/apyrimidinic; Ape1, apurinic/apyrimidinic endonuclease 1; BER, base excision repair; ssDNA, single-stranded DNA; dsDNA, double-stranded DNA; CSR, class switch recombination; DSB, double-strand break; AID, activation-induced cytidine deaminase

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

Two distinctly altered cellular responses to DNA double-strand breaks in human neuroblastoma

Keywords: DSB، شکست دو رشته; Neuroblastoma; DNA double-strand breaks; Chk2; p21; VimentinNB, neuroblastoma; MNA, MYCN amplification; DSB, double-strand break; ATM, ataxia telangiectasia mutated; NSE, neuron-specific enolase; NCS, neocarzinostatin; IR, ionizing radiation

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

Bloom's syndrome workshop focuses on the functional specificities of RecQ helicases

Keywords: DSB، شکست دو رشته; ALT, alternative lengthening of telomeres; BS, Bloom's syndrome; CPT, camptothecin; dsDNA, double-stranded DNA; DSB, double-strand break; ES cells, embryonic stem cells; G4, G quartet; G4P, G4 DNA-forming potential; HR, homologous recombination; HU, hydro

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

Telomerase-dependent and -independent chromosome healing in mouse embryonic stem cells

Keywords: DSB، شکست دو رشته; B/F/B, breakage/fusion/bridge; DSB, double-strand break; ES, embryonic stem; ganr, ganciclovir-resistant; ganr/puror, ganciclovir and puromycin-resistant; HSV-tk, Herpes simplex virus-thymidine kinase; NHEJ, nonhomologous end joining; PCR, polymerase chai

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2008 سفارش ترجمه

Results from the “Technical Workshop on Genotoxicity Biosensing” on the micro-scale fluorometric assay of deoxyribonucleic acid unwinding

Keywords: DSB، شکست دو رشته; ALS, alkali-labile sites; CHO, Chinese hamster ovary cells; DSB, double-strand break; dsDNA, double-stranded DNA; μ-FADU, micro-scale fluorometric analysis of DNA unwinding; FCS, fetal calf serum; PBS, phosphate buffered saline; SSB, single-strand breaks;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

Ionizing radiation induces a Yap1-dependent peroxide stress response in yeast

Keywords: DSB، شکست دو رشته; IR, ionizing radiation; SSB, single-strand break; DSB, double-strand break; GPx, glutathione peroxidase; 2D-PAGE, two-dimensional polyacrylamide gel electrophoresis; ORF, open-reading frame; SD, synthetic defined minimal medium; YPD, yeast peptone dextros

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

Vanadium Induces VL30 Retrotransposition at an Unusually High Level: A Possible Carcinogenesis Mechanism

Keywords: DSB، شکست دو رشته; VL30s, viral-like 30 elements; EGFP, enhanced green fluorescent protein; FACS, fluorescence-activated cell scanning; NAC, N-acetyl-cysteine; DFO, deferoxamine; enRTs, endogenous reverse transcriptases; DSB, double-strand break; ROS, reactive oxygen specie

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

Differential regulation of Ku gene expression in etiolated mung bean hypocotyls by auxins

Keywords: DSB، شکست دو رشته; BAPTA, 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid; C5, lavendustin C; DEB, DNA end-binding; DNA–PK, DNA-dependent protein kinase; DSB, double-strand break; EDTA, N,N,N′N′-ethylenediamine tetraacetic acid; EGTA, ethylene glycol-bis(2-aminoeth

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2007 سفارش ترجمه

Identification of sequences that target BRCA1 to nuclear foci following alkylative DNA damage

Keywords: DSB، شکست دو رشته; ATM, ataxia telangiectasia mutated; ATR, ATM and Rad3 related; DMEM, Dulbecco's modified Eagle's medium; DSB, double-strand break; IR, ionizing radiation; EMS, ethyl methanesulfonate; MMTS, methyl methanethiosulfonate; MMS, methyl methanesulfonate; PBS, p

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2007 سفارش ترجمه

Structure and Function of a Mycobacterial NHEJ DNA Repair Polymerase

Keywords: DSB، شکست دو رشته; DSB, double-strand break; NHEJ, non-homologous end-joining; AEP, archaeo-eukaryotic primaseNHEJ; DNA breaks; ligase D; primase; polymerase

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2007 سفارش ترجمه

Strand-specific Contacts and Divalent Metal Ion Regulate Double-strand Break Formation by the GIY-YIG Homing Endonuclease I-BmoI

Keywords: DSB، شکست دو رشته; DSB, double-strand break; UC, upper complex; LC, lower complex; OP-Cu, 1,10-phenanthroline copperGIY-YIG homing endonuclease; I-BmoI; double-strand break; strand-specific nicking; divalent metal ion

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2007 سفارش ترجمه

Engineered I-CreI Derivatives Cleaving Sequences from the Human XPC Gene can Induce Highly Efficient Gene Correction in Mammalian Cells

Keywords: DSB، شکست دو رشته; DSB, double-strand break; XP, Xeroderma Pigmentosumhoming endonuclease; meganuclease; I-CreI; I-SceI; XPC

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2007 سفارش ترجمه

The Characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 Complex Reveals that Rad50 Negatively Regulates Mre11 Endonucleolytic but not the Exonucleolytic Activity

Keywords: DSB، شکست دو رشته; ATPγS, adenosine 5′-O-(thiotriphosphate); dsDNA, double-stranded DNA; DSB, double-strand break; MRX(N), Mre11/Rad50/Xrs2/Nbs1; ssDNA, single-stranded DNA; TLC, thin-layer chromatographyMRX/N complex; telomeres; G quadruplex DNA; endonuclease; negative reg

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2007 سفارش ترجمه

Traffic safety for the cell: Influence of cyclin-dependent kinase activity on genomic stability

Keywords: DSB، شکست دو رشته; ATM, ataxia–telangiectasia mutated; ATR, ATM and Rad3 related; Cdk, cyclin-dependent kinase; DSB, double-strand break; G2, gap phase 2; H2AX, histone H2 AX; MMR, mismatch repair; S phase, DNA synthesis phaseCdk; Cell cycle; Genomic instability; DNA damage

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

Genomic alterations upon integration of zebrafish L1 elements revealed by the TANT method

Keywords: DSB، شکست دو رشته; DSB, double-strand break; EN, endodeoxyribonuclease; MH, microhomology; LINE, long interspersed nuclear element; RT, reverse transcriptase; SINE, short interspersed nuclear element; TANT, target analysis of nested transposons; TPRT, target-primed reverse

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Highly efficient generation of signal transduction knockout mutants using a fungal strain deficient in the mammalian ku70 ortholog

Keywords: DSB، شکست دو رشته; DSB, Double-Strand Break; HR, Homologous Recombination; NHEJ, Non-Homologous End JoiningSordaria macrospora; Homologous recombination; Development; Pheromone; Receptor

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

Microarray analysis of differentially expressed genes after exposure of normal human fibroblasts to ionizing radiation from an external source and from DNA-incorporated iodine-125 radionuclide

Keywords: DSB، شکست دو رشته; IR, ionizing radiation; HDR, high-dose rate; LDR, low-dose rate; DSB, double-strand break; 125I-IUdR, [125I]-iododeoxyuridine; LET, linear energy transfer; cDNA, DNA complementary to RNA; PBS, phosphate-buffered saline; EMEM, Eagle's Minimum Essential Med

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

The Fanconi anemia pathway limits the severity of mutagenesis

Keywords: DSB، شکست دو رشته; CHO, chinese hamster ovary; DSB, double-strand break; FA, Fanconi anemia; Hprt, hypoxanthine phosphoribosyltransferase; HRR, homologous recombination repair; IR, ionizing radiation; NHEJ, nonhomologous end joining; 6S-Gua, 6-thioguanineSpontaneous mutatio

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

The Human LINE-1 Retrotransposon Creates DNA Double-strand Breaks

Keywords: DSB، شکست دو رشته; LINE; retrotransposition; genetic instability; L1LINE, long interspersed element; DSB, double-strand break; L1, LINE-1 retroelement; ORF, open reading frame; NeoR, neomycin resistance; FOV, fields of view; TPRT, target-primed reverse transcription; EN, en

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Recombinase, chromosomal translocations and lymphoid neoplasia: Targeting mistakes and repair failures

Keywords: DSB، شکست دو رشته; BE, broken end; BL, Burkitt's lymphoma; B-NHL, B-cell Non-Hodgkin's lymphoma; CE, coding end; CJ, coding joint; CSR, class-switch recombination; DSB, double-strand break; NHEJ, non-homologous end-joining; SHM, somatic hypermutation; HJ, hybrid joint; RSS,

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2006 سفارش ترجمه

Transgene structures suggest that multiple mechanisms are involved in T-DNA integration in plants

Keywords: DSB، شکست دو رشته; ds, double-stranded; DSB, double-strand break; DSBR, double-strand break repair; LB, T-DNA left border; NHEJ, non-homologous end-joining; RB, T-DNA right border; ss, single-stranded; SSA, single-strand annealing; SDSA, synthesis-dependent strand annealing

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2006 سفارش ترجمه