Keywords: DSB، شکست دو رشته; BRCA1, breast cancer type 1 susceptibility protein; Cav-1, caveolin 1 protein; cGy, centigray; cNOS, constitutive nitric oxide synthase; c-PTIO, 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide; DSB, double-strand break; E2F4, transcripti
مقالات ISI DSB، شکست دو رشته (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: DSB، شکست دو رشته; ATR, ataxia telangiectasia and Rad3-related protein; SSB, single-strand break; DSB, double-strand break; PI3KK, phosphatidylinositol 3-kinase-related kinase; ATM, ataxia telangiectasia mutated; DNA-PKcs, DNA-dependent protein kinase catalytic subunit; BRC
Keywords: DSB، شکست دو رشته; DNA-PK, DNA-dependent protein kinase; DNA-PKcs, DNA-dependent protein kinase catalytic subunit; DSB, double-strand break; FBS, foetal bovine serum; HR, homologous recombination; IR, ionising radiation; NHEJ, non-homologous end joining; PPARγ, peroxisome p
SNF2H interacts with XRCC1 and is involved in repair of H2O2-induced DNA damage
Keywords: DSB، شکست دو رشته; AP sites, apurinic/apyrimidinic sites; BER, base excision repair; CBB, Coomassie Brilliant Blue; CK2, , casein kinase 2; DSB, double-strand break; OGG1, 8-oxoguanine DNA glycosylase; PAR, poly(ADP-ribose); PARP, poly(ADP-ribose) polymerase; SNF2H, sucrose
Ku antigen displays the AP lyase activity on a certain type of duplex DNA
Keywords: DSB، شکست دو رشته; AP site, apurinic/apyrimidinic site; APE1, apurinic/apyrimidinic endonuclease 1; BER, base excision repair; dRP, deoxyribose phosphate; DSB, double-strand break; Endo III, Escherichia coli endonuclease III; GAPDH, glyceraldehyde-3-phosphate dehydrogenase;
A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy
Keywords: DSB، شکست دو رشته; BLM, Bloom Syndrome; CPT, camptothecin; DNA2, DNA2 nuclease/helicase; DSB, double-strand break; EMSA, electrophoretic mobility shift assay; EXO1, exonuclesae 1; FA, Fanconi anemia; FEN1, flap endonuclease 1; HDR, homology direct repair; HTS, high throughp
Zinc finger nuclease technology: Advances and obstacles in modelling and treating genetic disorders
Keywords: DSB، شکست دو رشته; ZFN, Zinc finger nuclease; DSB, double-strand break; TFIII, transcription factor III; NHEJ, non-homologous end joining; TF, transcription factor; HDR, homology directed repair; HR, homologous recombination; XSCID, human X-linked sever combined immunodefic
Yet another job for Dna2: Checkpoint activation
Keywords: DSB، شکست دو رشته; 9–1–1, human Rad9, Rad1, Hus1 (yeast Ddc1, Rad17, Mec3) checkpoint clamp; ATM, ataxia-telangiectasia mutated; ATR, ATM and Rad3–related; ATRIP, ATR interacting protein; DSB, double-strand break; dsDNA, double-stranded DNA; ssDNA, single-stranded DNA; FEN1
Chromatin dynamics after DNA damage: The legacy of the access–repair–restore model
Keywords: DSB، شکست دو رشته; ARR, access–repair–restore; ASF1, anti-silencing function 1; BRG1, Brahma-related gene 1; CAF-1, chromatin assembly factor-1; CENPA, centromeric protein A; DAXX, death domain-associated protein; DDB2, DNA damage binding protein 2; DSB, double-strand break
Biochemical mechanism of DSB end resection and its regulation
Keywords: DSB، شکست دو رشته; DSB, double-strand break; HR, homologous recombination; NHEJ, nonhomologous end joining; MMEJ, microhomolgy-mediated end joining; MRN, MRE11–RAD50–NBS1 complex; RPA, replication protein AResection; Recombination; Double-strand breaks; Nucleases; Helicases
Sensitization of Pancreatic Cancers to Gemcitabine Chemoradiation by WEE1 Kinase Inhibition Depends on Homologous Recombination Repair 12
Keywords: DSB، شکست دو رشته; DSB, double-strand break; HR, homologous recombination; RER, radiation enhancement ratio; RT, radiation
Multifaceted control of DNA repair pathways by the hypoxic tumor microenvironment
Keywords: DSB، شکست دو رشته; ATM, ataxia telangiectasia mutated; ATR, ataxia telangiectasia and Rad3-related; BER, base excision repair; DSB, double-strand break; H3K4me2, histone H3 lysine 4 dimethylation; H3K4me3, histone H3 lysine 4 trimethylation; H3K9me2, histone H3 lysine 9 dim
A complex microcephaly syndrome in a Pakistani family associated with a novel missense mutation in RBBP8 and a heterozygous deletion in NRXN1
Keywords: DSB، شکست دو رشته; ATR, ataxia–telangiectasia and RAD3-related; BMI, Body mass index; CBC, complete blood count; CNV, copy number variation; DDR, DNA-damage response; DSB, Double-strand break; EGF, epidermal growth factor; ID, intellectual disability; Mb, megabase; MIM, Men
TALEN construction via “Unit Assembly” method and targeted genome modifications in zebrafish
Keywords: DSB، شکست دو رشته; Cas, CRISPR-associated; CRISPR, clustered regularly-interspaced short palindromic repeats; dpf, days post-fertilization; DSB, double-strand break; HR, homologous recombination; NHEJ, non-homologous end-joining; TALE, transcription activator-like effector;
p53-Dependent suppression of genome instability in germ cells
Keywords: DSB، شکست دو رشته; Medaka fish; Microsatellite instability; Radiation; Spermatogonial stem cell; msh2; p53CE, fluorescent capillary electrophoresis; DDR, DNA damage response; DSB, double-strand break; ESTR, expanded simple tandem repeat; HRM, high-resolution melting; MMR, m
Endonucleases: new tools to edit the mouse genome
Keywords: DSB، شکست دو رشته; CRISPR/Cas, clustered regularly interspaced short palindromic repeats/CRISPR-associated; crRNA, CRISPR RNA; DSB, double-strand break; dsDNA, double-strand DNA; ES, embryonic stem; FLASH, fast ligation-based automatable solid-phase high-throughput; gRNA, g
A Preclinical Study Combining the DNA Repair Inhibitor Dbait with Radiotherapy for the Treatment of Melanoma 1
Keywords: DSB، شکست دو رشته; DNA-PK, DNA-dependent kinase; DSB, double-strand break; PARP, poly-adenyl-ribose polymerase; RT, radiation therapy; SSB, single-strand break; TGD, tumor growth delay
PARP-mediated repair, homologous recombination, and back-up non-homologous end joining-like repair of single-strand nicks
Keywords: DSB، شکست دو رشته; DSB, double-strand break; HR, homologous recombination; NHEJ, non-homologous end-joining; TLR, Traffic Light ReporterHomologous recombination; Non-homologous end-joining; PARP; Single-strand nick; Nickase; Gene correction
A recombinase paralog from the hyperthermophilic crenarchaeon Sulfolobus solfataricus enhances SsoRadA ssDNA binding and strand displacement
Keywords: DSB، شکست دو رشته; dsDNA, double-strand DNA; ssDNA, single-strand DNA; Gy, Gray; IR, ionizing radiation; UV, ultraviolet; DSB, double-strand break; HR, homologous recombination; bp, basepairs; EMSA, electrophoretic mobility shift assay; ORF, open reading frameArchaea; Recom
Recombinase-mediated cassette exchange (RMCE) — A rapidly-expanding toolbox for targeted genomic modifications
Keywords: DSB، شکست دو رشته; attB/attP, recombinase-attachment sites within the bacterial and phage genomes; ccc, covalently-closed circular; Cre, cyclization recombinase/causes recombination; DSB, double-strand break; ESC, embryonic stem cell; flexing, Flp-mediated excision; EUCOMM,
SIRT1 as a therapeutic target in inflammaging of the pulmonary disease
Keywords: DSB، شکست دو رشته; AICAR, 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside; AMPK, AMP-activated kinase; ATM, ataxia telangiectasia mutated; CHK2, checkpoint kinase 2; COPD, chronic obstructive pulmonary disease; DDR, DNA damage response; DSB, double-strand break; EGCG, e
Fully functional global genome repair of (6-4) photoproducts and compromised transcription-coupled repair of cyclobutane pyrimidine dimers in condensed mitotic chromatin
Keywords: DSB، شکست دو رشته; CPD, cyclobutane pyrimidine dimer; DHFR, dihydrofolate reductase; DSB, double-strand break; ELISA, enzyme-linked immunosorbent assay; HR, homologous recombination; NHEJ, nonhomologous end joining; 6-4PP, (6-4) pyrimidine–pyrimidone photoproduct; T4 endo V
“Delayed death” phenomenon: A synergistic action of cyclophosphamide and exogenous DNA
Keywords: DSB، شکست دو رشته; CP, cyclophosphamide; ICL, interstrand cross-link; HSC, hematopoietic stem cell; DSB, double-strand break; BMC, bone marrow cellBone marrow cells; Systemic inflammation; Involution of lymphoid organs; Mouse short interspersed elements; Apoptosis
ATR–Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity
Keywords: DSB، شکست دو رشته; 5-FU, 5-fluorouracil; FUTP, fluorouridine triphosphate; FdUTP, fluorodeoxyuridine triphosphate; FdUMP, fluorodeoxyuridine monophosphate; TS, thymidylate synthase; BER, base excision repair; MMR, mismatch repair; DSB, double-strand break; HRR, homologous r
Involvement of MRE11A and XPA gene polymorphisms in the modulation of DNA double-strand break repair activity: A genotype–phenotype correlation study
Keywords: DSB، شکست دو رشته; SNP, single nucleotide polymorphism; PBMC, peripheral blood mononuclear cells; DSB, double-strand break; DSBR, double-strand break repair; IR, ionizing radiation; NER, nucleotide excision repair; LD, linkage disequilibrium; MRN complex, MRE11–RAD50–NBS1 c
Sequences in PSF/SFPQ mediate radioresistance and recruitment of PSF/SFPQ-containing complexes to DNA damage sites in human cells
Keywords: DSB، شکست دو رشته; RRM, RNA recognition motif; PSF, polypyrimidine tract binding protein-associated splicing factor; DSB, double-strand break; DBHS, Drosophila behavior human splicingPSF; Radiation sensitivity; Double-strand break repair; Laser-induced DNA damage
Detection of DNA damage in oocytes of small ovarian follicles following phosphoramide mustard exposures of cultured rodent ovaries in vitro
Keywords: DSB، شکست دو رشته; Ab, antibody; ATM, ataxia-telangiectasia mutated; ATR, ATM-related; CPA, cyclophosphamide; DMSO, dimethyl sulfoxide; DNA-PK, DNA-dependent protein kinases; DSB, double-strand break; IHC, immunohistochemistry; IR, ionizing radiation; PIKK, phosphatidylinos
The DNA damage checkpoint allows recombination between divergent DNA sequences in budding yeast
Keywords: DSB، شکست دو رشته; DDR, DNA damage response; SSA, single-strand annealing; DSB, double-strand break; BIR, break-induced replication; HR, homologous recombination; ssDNA, single-stranded DNA; NHEJ, non-homologous end joining; SDSA, synthesis-dependent strand annealing; TLS,
Physiological consequences of defects in ERCC1–XPF DNA repair endonuclease
Keywords: DSB، شکست دو رشته; CS, Cockayne syndrome; COFS, cerebro-oculo-facio-skeletal syndrome; CPD, cyclopyrimidine dimer; CSR, class switch recombination; DSB, double-strand break; ERCC1, excision repair cross complementation group 1; HR, homologous recombination; ICL, interstrand
Repair of DNA Double-Strand Breaks Induced by Ionizing Radiation Damage Correlates with Upregulation of Homologous Recombination Genes in Sulfolobus solfataricus
Keywords: DSB، شکست دو رشته; archaea; Sulfolobus; radiation; DNA repair kinetics; recombinationssDNA, single-strand DNA; IR, ionizing radiation; DSB, double-strand break; HR, homologous recombination; PFGE, pulsed-field gel electrophoresis; NHEJ, nonhomologous end-joining; qRT-PCR, q
Spatiotemporal analysis of DNA repair using charged particle radiation
Keywords: DSB، شکست دو رشته; RIF, radiation-induced foci; DSB, double-strand break; LET, linear energy transfer (typical unit: keV/μm); HZE, ions with high energy and high atomic number; Amu, atomic mass units; NHEJ, Non-Homologous End Joining; HR, Homologous Recombination; DDR, DNA
Inter-individual variation in DNA double-strand break repair in human fibroblasts before and after exposure to low doses of ionizing radiation
Keywords: DSB، شکست دو رشته; A-T, ataxia-telangiectasia; ATM, ataxia-telangiectasia mutated; ATR, ATM and Rad3-related; LIG, ligase; DSB, double-strand break; FANC, Fanconi anemia; IR, ionizing radiation; NBN, nibrin; NBS, Nijmegen breakage syndrome; NHEJ, nonhomologous end joiningγ-
A single-strand specific lesion drives MMS-induced hyper-mutability at a double-strand break in yeast
Keywords: DSB، شکست دو رشته; LHM, localized hyper-mutability; ssDNA, single-strand DNA; dsDNA, double-strand DNA; MMS, methyl methanesulfonate; DSB, double-strand break; TLS, DNA translesion synthesis; BER, base excision repair; HR, homologous recombination; NER, nucleotide excision
Cooperative biological effects between ionizing radiation and other physical and chemical agents
Keywords: DSB، شکست دو رشته; BER, base excision repair; DSB, double-strand break; ELF EMFs, extremely low-frequency electromagnetic fields; IR, ionizing radiation; MN, micronucleus; NER, nucleotide excision repair; SAR, specific absorption rateCombined exposure; Ionizing radiation; E
Role of oxidatively induced DNA lesions in human pathogenesis
Keywords: DSB، شکست دو رشته; 8-oxo-dG, 8-oxo-2′-deoxyguanosine; BER, base excision repair; DEANO, diethylamine NONOate; DSB, double-strand break; FISH, fluorescent in situ hybridization; Mbp, mega base pair; mtDNA, mitochondrial DNA; NO, nitric oxide; OCDL, oxidative clustered DNA le
Structural Insight into p53 Recognition by the 53BP1 Tandem Tudor Domain
Keywords: DSB، شکست دو رشته; 53BP1, p53 binding protein 1; PDB, Protein Data Bank; DSB, double-strand break; ChIP, chromatin immunoprecipitation; Fmoc, 9-fluorenylmethoxycarbonylTudor domain; methylated p53; 53BP1; structure; cancer
DNA ligase 4 stabilizes the ribosomal DNA array upon fork collapse at the replication fork barrier
Keywords: DSB، شکست دو رشته; ARS, origin of replication; DSB, double-strand break; EM, electron microscopy; ERC, extrachromosomal rDNA circle; HR, homologous recombination; IGS, intergenic spacer; NHEJ, non-homologous end-joining; rDNA, ribosomal DNA; RF, replication fork; RFB, repli
Consequences of ionizing radiation-induced damage in human neural stem cells
Keywords: DSB، شکست دو رشته; hNSCs, human neural stem cells; γ-H2AX, phospho-histone (Ser139) H2AX; DSB, double-strand break; PARP, poly(ADP-ribose) polymerase; PFA, paraformaldehyde; BrdU, bromodeoxyuridine; ROS, reactive oxygen species; RNS, reactive nitrogen species; CM-H2DCF, 5-(
Photoactivated multivitamin preparation induces poly(ADP-ribosyl)ation, a DNA damage response in mammalian cells
Keywords: DSB، شکست دو رشته; TPN, total parenteral nutrition; MVP, multivitamin preparation; AA, ascorbic acid; Rib, riboflavin; ROS, reactive oxygen species; BPD, bronchopulmonary dysplasia; SSB, single-strand break; DSB, double-strand break; PARP, poly(ADP-ribose) polymerase; MVP(−
Cellular pathways for DNA repair and damage tolerance of formaldehyde-induced DNA-protein crosslinks
Keywords: DSB، شکست دو رشته; BER, base excision repair; DPC, DNA-protein crosslink; DSB, double-strand break; NER, nucleotide excision repair; HR, homologous recombination; PFGE, pulsed field gel electrophoresis; SSB, single-strand breakDNA repair; Homologous recombination; Nucleotid
Choreography of recombination proteins during the DNA damage response
Keywords: DSB، شکست دو رشته; DSB, double-strand break; DSBR, double-strand break repair; HR, homologous recombination; IR, ionizing radiation; MMS, methyl methanesulfonate; NHEJ, non-homologous end-joining; RPA, replication protein A; GFP, green fluorescent protein; CFP, cyan fluores
In utero and acute exposure to benzene: Investigation of DNA double-strand breaks and DNA recombination in mice
Keywords: DSB، شکست دو رشته; DSB, double-strand break; GD, gestational day; i.p., intraperitoneal; V(D)J, variable diversity joining; X-gal, 5-bromo-4-chloro-3-indolyl-β-d-galactosideChildhood leukemia; Benzene; DNA double-strand breaks; Micronuclei; Genotoxicity tests
Regulation of rDNA stability by sumoylation
Keywords: DSB، شکست دو رشته; 4-NQO, 4-nitroquinoline 1-oxide; BIR, break-induced repair; DSB, double-strand break; GC, gene conversion; HR, homologous recombination; IR, ionizing radiation; MMS, methyl methanesulfonate; NHEJ, non-homologous end-joining; rDNA, ribosomal DNA; RFB, repl
In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation
Keywords: DSB، شکست دو رشته; Apex1, apurinic/apyrimidinic endonuclease 1; DSB, double-strand break; HRR, homologous recombination repair; IR, ionizing radiation; MEFs, mouse embryonic fibroblasts; NHEJ, non-homologous end-joining; PG, phosphoglycolate; pTyr, phosphotyrosyl; Pnkp, pol
DNA-PKcs and ATM co-regulate DNA double-strand break repair
Keywords: DSB، شکست دو رشته; DSB, double-strand break; HR, homologous recombination; NHEJ, non-homologous end-joining; PIK, phosphotidylinositol-3-kinase; IR, ionizing radiationDNA repair; Homologous recombination; Genome stability
Rag-dependent and Rag-independent mechanisms of Notch1 rearrangement in thymic lymphomas of Atm−/− and scid mice
Keywords: DSB، شکست دو رشته; Atm, ataxia telangiectasia mutated; DSB, double-strand break; IAP, intracisternal A particle; MHEJ, microhomology-mediated end-joining; NHEJ, nonhomologous end-joining; Prkdc, protein kinase, DNA-activated, catalytic subunit; Rag, recombination activating
Dynamic Regulatory Interactions of Rad51, Rad52, and Replication Protein-A in Recombination Intermediates
Keywords: DSB، شکست دو رشته; RPA, replication protein-A; ssDNA, single-stranded DNA; DSB, double-strand break; HR, homologous recombination; SSA, single-strand annealing; dsDNA, double-stranded DNA; DAPI, 4′,6-diamidino-2-phenylindolehomologous recombination; genome integrity; single
DNA Double-Strand Break Formation upon UV-Induced Replication Stress Activates ATM and DNA-PKcs Kinases
Keywords: DSB، شکست دو رشته; ATM, ataxia-telangiectasia mutated; ATR, ataxia-telangiectasia and Rad3 related; DNA-PKcs, DNA-dependent protein kinase catalytic subunit; CPD, cyclobutane pyrimidine dimer; NER, nucleotide excision repair; DSB, double-strand break; ssDNA, single-stranded
Curcumin derivatives: Molecular basis of their anti-cancer activity
Keywords: DSB، شکست دو رشته; bDMC, bis-DemethoxyCurcumin; DAC, diAcetylCurcumin; MIT, microtubule-targeting agents; BrdU, bromodeoxyuridine; PI, propidium iodide; DMSO, dimethylsulfoxide; DSB, double-strand break; FACS, Fluorescence Activated Cell Sorter; ChIP, Chromatin immunoprecip
Radioprotective effects of manganese-containing superoxide dismutase mimics on ataxia–telangiectasia cells
Keywords: DSB، شکست دو رشته; A-T, ataxia–telangiectasia; WT, wild type; SOD, superoxide dismutase; IR, ionizing radiation; DSB, double-strand break; IRIF, irradiation-induced immunofluorescent nuclear focus; MnTM-2-PyP5+, manganese(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)por