Keywords: Capsaicin; Amitriptyline; Forced swimming test; TRPV1; Depression; Palvanil; Ami; Amitriptyline; Cap; capsaicin; CNS; central nervous system; ED50; dose required to achieve 50% of the maximal effect; EPM; elevated plus maze; FDB; flexor digitorium brevis;
مقالات ISI (ترجمه نشده)
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Keywords: Epilepsy; Seizure disorder; Cannabis; Marijuana; Tetrahydrocannabinol; Cannabidiol; CBD; cannabidiol; CBDA; cannabidiolic acid; CBN; cannabinol; ED50; effective dose in 50%; THC; tetrahydrocannabinol; THCA; tetrahydrocannabinolic acid; THCV; tetrahydrocan
Keywords: ACh; acetylcholine; AFD; African descent; AUC; area under the curve; CAU; Caucasian; COXib; cyclooxygenase inhibition; ED50; half-maximal effective dose; IQR; interquartile range; LDU; laser Doppler units; MAP; mean arterial pressure; Mdn; median; NFCI; n
Keywords: Esterase inhibition; Detoxification; Organophosphorus; Soil aggregates; Andisol; ED50;
Keywords: AgNPs; Phosphatase; Urease; Soil respiration; Substrate-induced respiration; ED50;
Keywords: ACN; acetonitrile; br; broad; Cbz; N-benzyloxycarbonyl; DMAP; 4-dimethylaminopyridine; DMSO; dimethyl sulfoxide; ED50; median effective dose; HPLC; high performance liquid chromatography; LC-MS/MS; liquid chromatography tandem mass spectrometry; MeOH; met
Keywords: CB1R; cannabinoid receptor 1; BW; body weight; DIO; diet-induced obesity; ED50; the dose where the predicted effect reaches 50%; Emax; the dose where the predicted effect reaches 100%; LED; least statistically effective dose; USV; ultrasonic vocalization;
Keywords: Scorpion; Venom; Neurotoxin; Neuropeptide; Ion channels; AC50; toxin concentration for activation to 50%; Cav; voltage-gated calcium channel; EC50; half maximal effective concentration; ED50; median effective dose; ER; endoplasmic reticulum; IC50; half ma
Keywords: ARE; antioxidant response element; C.L.; confidence limit; CS50; current strength required to induce seizure response in 50% of mice; DMSO; dimethyl sulfoxide; ED50; median effective dose; ip; intraperitoneally; IS; internal standard; iv; intravenously; L
Keywords: neonatology; pharmacology; AUC; Area under the curve; cFTOE; Cerebral fractional tissue oxygen extraction; cMABP; Mean arterial blood pressure corrected for postmenstrual age; ED50; Effective dose for 50% of patients; HR; Heart rate; ICS; Intubation condi
Keywords: CAM; Complementary and Alternative Medicine; GI50; growth inhibition 50%; ED50; effective dose; IC50; inhibitory concentration 50%; EtOH; ethanol extract; Hex; hexane extract; EtOAc; ethylacetate extract; MeOH; methanol extract; DCM; Dichloromethane; PE;
Keywords: BBB; blood-brain barrier; Boc; tert-butyloxycarbonyl; cAMP; cyclic adenosine monophosphate; CNS; central nervous system; DAMGO; H-Tyr-d-Ala-Gly-NMePhe-Gly-ol; DCM; dichloromethane; DIEA; N,N-diisopropylethylamine; DOR; δ-opioid receptor; DPDPE; Tyr-c(d
Keywords: AED; antiepileptic drug; AUC; area under the plasma concentration vs time curve; CBZ; carbamazepine; ED50; dose that inhibits maximal response by 50%; FDA; Food and Drug Administration; GBP; gabapentin; ILAE; International League against Epilepsy; LTG; la
Keywords: Androctonus mauretanicus; Buthus occitanus; Scorpion venom; Antivenom; Polyclonal; Scorpion toxin; ED50; Chick biventer cervicis method; Myotoxicity; Neurotoxicity; Lethality;
Keywords: Propolis; Analgesics; Flavonoids; Formononetin; Inflammation.; ASA; acetylsalicylic acid; CI 95%; 95% confidence interval; Dexa; dexamethasone; ED50; median effective dose; FOR; formononetin; HERP; hydroalcoholic extract of red propolis; IL; interleukin;
Keywords: Pediatric medical countermeasure research; Anthrax vaccine; Presidential Ethics Committee; Children; AE; adverse events; AVA; anthrax vaccine adsorbed; BARDA; Biomedical Advanced Research and Development Authority; CDC; Centers for Disease Control and Pre
Keywords: nAChR; nicotinic acetylcholine receptor; ED50; effective dose giving 50% maximal response; 5I-A85380; 3-[(2S)-2-azetidylmethoxy]-5-iodopyridine; HEPES; 4-(2-hydroxyethyl)piperazine-1-ethanesulonic acid.; Nicotinic acetylcholine receptor; Beta4 null mutant
Keywords: Bacillus anthracis; Anthrax; Anthrax Vaccine Adsorbed; AVA; Biothrax; Correlates of protection; Clinical trial; Non-clinical trial; Animal model; AE; adverse events; AUC; area under the receiving operator characteristic curve; AVA; Anthrax Vaccine Adsorbe
Keywords: CI; combination index; ED50; 50% effective dose; ELISA; enzyme linked immunosorbent assay; HMGB1; high mobility group box 1; IFN-γ; interferon-gamma; IL; interleukin; LTB4; leukotrienes B4; LPS; lipopolysaccharide; MLA; methyllycaconitine; PGE2; prostagl
Keywords: AcAlaPNA; N-Acetyl-l-alanyl-p-nitroanilide; AChE; acetylcholinesterase; APH; acylpeptide hydrolase; αNB; alpha-naphthyl butyrate; BChE; butyrylcholinesterase; BTC; S-butyrylthiocholine iodide; CBDP; [2-(o-cresyl)-4H-1,3,2-benzodioxaphosphoran-2-one]; CES
Keywords: Biotoxin; Bioterrorism; Biological warfare agent; BW; Biological warfare; CW; chemical weapons; BWAs; Biological warfare agents; BoNTs; Clostridium botulinum neurotoxins; LD50; median lethal dose; PBT; pentavalent botulinum toxoid; SEB; Staphylococus aure
Comparative immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine and 4vHPV vaccine administered according to two- or three-dose schedules in girls aged 9-14â¯years: Results to month 36 from a randomized trial
Keywords: 2D; 2-dose; 3D; 3-dose; AAHS; aluminum hydroxyphosphate sulphate; AE; adverse event; ANOVA; analysis of variance; AS04; Adjuvant System containing 50 µg 3-O-desacyl-4â²-monophosphoryl lipid A (MPL) adsorbed on aluminum salt (500 µg Al3+); ATP; accordin
Preclinical assessment of utility of M6S for multimodal acute and chronic pain treatment in diabetic neuropathy
Keywords: δ-OR; delta-opioid receptor; DPN; diabetic polyneuropathy; ED50; half-effective drug dose; Emax; maximally effective drug dose; HPT; hot plate threshold; κ-OR; kappa opioid receptor; M6S; morphine-6-O-sulfate; MPE; maximum possible effect; μ-OR; mu-opi
Development of a new approach of immunotherapy against scorpion envenoming: Avian IgYs an alternative to equine IgGs
Keywords: Aah; Androctonus australis hector; ED50; median effective dose; FCA; Freund's complete adjuvant; FIA; Freund's incomplete adjuvant; Fab; Fragment antigen binding; IgY; yolk immunoglobulin; IgG; Immunoglobulin G; LD50; median lethal dose; NMRI; Naval Medic
Proteomics, functional characterization and antivenom neutralization of the venom of Pakistani Russell's viper (Daboia russelii) from the wild
Keywords: Daboia russelii sochureki; Venomics; Procoagulant; Western Russell's viper; ED50; Potency;
Anti-Deinagkistrodon acutus venom properties of ethanolic root extract from Cynanchum paniculatum (Bunge) kitag and its GC-MS analysis
Keywords: CK; creatine kinase; CPER; ethanolic root extract of C. paniculatum; DAV; Deinagkistrodon acutus venom; ED50; effective dose 50; GC-MS; gas chromatography-mass spectrometry; i.m.; intra-muscularly; i.p.; intraperitoneally; i. pl.; intraplantarly; LD50;
An appraisal on synthetic and pharmaceutical perspectives of pyrazolo[4,3-d]pyrimidine scaffold
Keywords: A. flavus; Aspergillus flavus; C. albicans; Candida albicans; cAMP; cyclic adenosine monophosphate; CDK; cyclin-dependent kinase; CNS; central nervous system; COX; cyclooxygenase; CRF; corticotropin-releasing hormone; CRK; cdc2-related kinase; CYC6; cycli
Evaluating the broad-spectrum efficacy of the acetylcholinesterase oximes reactivators MMB4 DMS, HLö-7 DMS, and 2-PAM Cl against phorate oxon, sarin, and VX in the Hartley guinea pig
Keywords: HED; ED50; Protective ratio; MMB4 DMS; HLö-7 DMS; Phorate-oxon;
Antinociceptive effects of the endogenous cannabinoid peptide agonist VD-hemopressin(β) in mice
Keywords: ANOVA; analysis of variance; AM251; N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3- carboxamide; AM630; 6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3- yl(4-methoxyphenyl)-methanone; AUC; area under the curve; CB1
The long-term effect of maternal dietary protein restriction on 5-HT1A receptor function and behavioral responses to stress in adulthood
Keywords: 5-HT; serotonin; PND; postnatal day; ED50; dose of drug that is pharmacologically effective for 50% of the population; Emax; concentration that produces the maximum possible response for that agonist; 8-OH-DPAT; 8-Hydroxy-2-(dipropylamino)tetralin hydrobr
Antihypertensive responses of vasoactive androgens in an in vivo experimental model of preeclampsia
Keywords: DHEA; dehydroepiandrosterone; TES; testosterone; 5α-DHT; 5α-dihydrotestosterone; 5β-DHT; 5β-dihydrotestosterone; BP; blood pressure; PT; treated pregnant; NP; normal pregnant; HR; heart rate; MAP; mean arterial blood pressure; Phe; phenylephrine; AR;
Potential therapeutic applications of the genus Annona: Local and traditional uses and pharmacology
Keywords: ABTS; 2,2-Azinobis-3-Ethylbenzothizoline-6-Sulphonate; ACGs; Acetogenins; AEF; Acetogenin-Enriched Fraction; ATP; Adenosine Triphosphate; COX; Cyclooxygenase; CYP; Cytochrome P450; DNA; Deoxyribonucleic Acid; DPPH; 1,1-Diphenyl-2-Picrylhydrazyl; EC50; Eff
Ethnomedical uses and pharmacological activities of most prevalent species of genus Piper in Panama: A review
Keywords: ED50; effective dose concentration; GI100; 100% growth inhibition; IC50; half maximal inhibitory concentration; LC50; 50% lethal concentration; MIC; minimum inhibitory concentration; MAR; maximum amount required; Piper spp.; Ethnomedicine; Genus Piper; Pa
Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship
Keywords: Cefiderocol; Siderophore; Siderophore cephalosporin; Multi-drug resistant Gram-negative pathogens; ESBL; extended-spectrum β-lactamase; MDR; multi-drug resistant; PG; protecting group; ACLE·HCl; (7-amino-3-chloromethyl-3-cephem-4-carboxylate p-methoxybe
In vitro and in vivo experimental models employed in the discovery and development of antiepileptic drugs for pharmacoresistant epilepsy
Keywords: CNS; central nervous system; COX; cyclooxygenase; EEG; electroencephalography; ED50; median effective dose; MAM; methylazoxymethanol; MES; maximal electroshock; MRP; multidrug resistance-associated protein; PTZ; pentylenetetrazole; scPTZ; subcutaneous pen
Logit-log evaluation of planar yeast estrogen screens
Keywords: HPTLC; Planar yeast estrogen screen (pYES); Logit-log plot; Estradiol equivalents; Dose-response curves; ED50;
Simultaneous in-vivo receptor occupancy assays for serotonin 1A, 2A, and dopamine 2 receptors with the use of non-radiolabelled tracers: Proposed method in screening antipsychotics
Keywords: ED50; Effective dose producing 50% receptor occupancy; g; Gram; i.v.; Intravenous; p.o.; Per oral; Kg; Kilogram; min; Minute; mL; Millilitre; mg; Milligram; μg; Microgram; ng; Nanogram; rpm; Rotations per minute; RO; Receptor Occupancy; CNS; Central nerv
Oral treatment with essential oil of Hyptis spicigera Lam. (Lamiaceae) reduces acute pain and inflammation in mice: Potential interactions with transient receptor potential (TRP) ion channels
Keywords: ANOVA; analysis of variance; COX-2; cyclooxygenase 2; ED50; median effective dose; EOHs; essential oil of Hyptis spicigera; GC-MS; gas chromatography-mass spectrometry; i.pl.; intraplanter; i.t.; intrathecal; IL-1β; interleukin 1; iNOS; inducible nitric
Concurrent bullatine A enhances morphine antinociception and inhibits morphine antinociceptive tolerance by indirect activation of spinal κ-opioid receptors
Keywords: ANOVA; analysis of variance; CFA; complete Freund's adjuvant; ED50; half-effective dose; Emax; maximum effect; GNTI; 5'-guanidinonaltrindole; HPLC; high performance liquid chromatography; LPS; lipopolysaccharides; NMDA; N-methyl-D-aspartate; STZ; strept
sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain
Keywords: SPD; sec-butylpropylacetamide; VPA; valproic acid; CAPs; compound action potentials; AED; antiepileptic drugs; SNL; spinal nerve ligation; PK; pharmacokinetic; PD; pharmacodynamic; VFF; von-Frey filaments; MC; methyl cellulose; TPE; time to peak effect; A
Toxicity of Cry1A toxins from Bacillus thuringiensis to CF1 cells does not involve activation of adenylate cyclase/PKA signaling pathway
Keywords: Bacillus thuringiensis; CF1 cell line; Cry toxins; Mechanism of action; AC/PKA pathway; MAPK p38; Bt; Bacillus thuringiensis; 3d-Cry; three domain Cry toxins; APN; aminopeptidase N; ALP; alkaline phosphatase; PKA; protein kinase A; AC; adenylate cyclase;
Synergistic antipruritic effects of gamma aminobutyric acid AÂ and B agonists in a mouse model of atopic dermatitis
Keywords: Atopic dermatitis; baclofen; chronic itch; GABA; GABAergic progenitor cell transplants; muscimol; pruritogens; AD; Atopic dermatitis; CQ; Chloroquine; ED50; Median effective dose; GABA; Gamma aminobutyric acid; GAD; Glutamic acid decarboxylase; GFP; Green
Toxic elements and associations with hematology, plasma biochemistry, and protein electrophoresis in nesting loggerhead sea turtles (Caretta caretta) from Casey Key, Florida
Keywords: Electrophoresis; Heavy metal; Keratin; Inorganic contaminant; Marine turtle; Toxicology; α; alpha; A:G; albumin:globulin ratio; ALKP; alkaline phosphatase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; AU; absorbance unit; β; beta; BDL
Antinociceptive activity and mechanism of action of hydroalcoholic extract and dichloromethane fraction of Amphilophium crucigerum seeds in mice
Keywords: ALT; alanine aminotransferase; ANOVA; analysis of variance; AST; aspartate aminotransferase; BSA; bovine serum albumin; Ca2+); calcium; CFA; complete Freund's adjuvant; Crd; crude extract; Dcm; dichloromethane fraction; DMSO; dimethyl sulfoxide; ED50; eff
Anti-inflammatory and associated analgesic activities of HPLC standardized alcoholic extract of known ayurvedic plant Schleichera oleosa
Keywords: COX; Cyclooxygenase; ED50; Median effective dose; HPLC; High performance liquid chromatography; HTAB; Hexadecyl-trimethyl-ammonium bromide; MDA; Malondialdehyde; MPO; Myeloperoxidase; NaNO2; Sodium nitrite; NO; Nitric oxide; OECD; Organization for economi
PEGylation of the GALA Peptide Enhances the Lung-Targeting Activity of Nanocarriers That Contain Encapsulated siRNA
Keywords: biomaterials; DNA/oligonucleotide delivery; endothelial; gene delivery; nanoparticles; nanotechnology; PEGylation; siRNA; ED50; 50% effective dose concentration; GALA; GALA peptide (WEAALAEALAEALAEHLAEALAEALEALAA); GALA/Chol; cholesteryl conjugate of GALA
Therapeutic journey of 2,4-thiazolidinediones as a versatile scaffold: An insight into structure activity relationship
Keywords: Thiazolidinedione; PPARγ; Antihyperglycemic; Anticancer; Antimicrobial; AI-2; Auto inducer-2; ATP; Adenosine triphosphate; ALR; Aldose reductase; COX; Cyclooxygenase; EC50; Half maximal effective concentration; ED50; Median effective dose; FFAR1; Free fa
Is sunitinib a Narrow Therapeutic Index Drug? - A systematic review and in vitro toxicology-analysis of Sunitinib vs. Imatinib in cells from different tissues
Keywords: Apoptosis; Drug safety; Imatinib; Narrow Therapeutic Index Drug (NTID); Receptor tyrosine kinase (RTK); Sunitinib; Toxicity; Tyrosine kinase inhibitor (TKI); Cell viability; ALL; acute lymphoblastic leukemia; AUC; area under the curve; b.i.d.; twice daily
Methylglyoxal mediates streptozotocin-induced diabetic neuropathic pain via activation of the peripheral TRPA1 and Nav1.8 channels
Keywords: Methylglyoxal; Diabetic neuropathic pain; TRPA1; Nav1.8; Methylglyoxal scavengers; AGE; advanced glycation end-product; TRPA1; transient receptor potential channel ankyrin 1; AMPK; AMP-activated protein kinase; DMSO; dimethyl sulfoxide; PEG400; polyethyle
Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity
Keywords: ANOVA; analysis of variance; ATF-1; activating transcription factor-1; CCL-2; chemokine ligand 2; CCL-8; chemokine ligand 8; CCL-18; chemokine ligand 18; CCR-1; chemokine receptor 1; CRBN; cereblon; CRE; cAMP responsive element; CREB; cAMP responsive elem