Neurostatin blocks glioma cell cycle progression by inhibiting EGFR activation
Keywords: Neurostatin; Gangliosides; EGFR; Cell cycle; Glioma;
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SCFTrCP acts in endosomal sorting of the GH receptor
Keywords: EGFR; epidermal growth factor receptor; EpoR; erythropoietin receptor; ESCRT; endosomal sorting complex required for transport; GHR; growth hormone receptor; MVB; multivesicular body; PrlR; prolactin receptor; RTK; receptor tyrosine kinase; siRNA; small i
Lovastatin Sensitizes Lung Cancer Cells to Ionizing Radiation: Modulation of Molecular Pathways of Radioresistance and Tumor Suppression
Keywords: Lovastatin; Lung cancer; A549 cells; Radiation sensitizer; Apoptosis; Akt; AMPK; Erk; EGFR; Cell cycle; Cleaved caspase 3
Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFκB and AhR and EGFR-ERK pathway
Keywords: AhR; Cytokines; EGFR; Keratinocytes; Plant polyphenols; UVAÂ +Â UVB;
Unknown primary tumors
Keywords: αFP; alpha-fetoprotein; βHCG; human chorionic gonadotropin; CA; cytosine-adenosine; CEA; carcinoembryonic antigen; CK; cytokeratin; EGFR; epidermal growth factor receptor; ECM; extracellular matrix; EANM; European Association of Nuclear Medicine; FFPE;
Targeting PI3K Signaling as a Therapeutic Approach for Colorectal Cancer
Keywords: Colon Cancer; Neoplasm; Signal Transduction; Genetics; Tumor; CRC; colorectal cancer; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; GPCR; G-protein-coupled receptor; IRS1; insulin receptor substrate 1; MEF; murine embryonic fibro
Cigarette smoking, cyclooxygenase-2 pathway and cancer
Keywords: AA; arachidonic acid; PLA2; phospholipase A2; COX; cyclooxygenase; PGE2; prostaglandin E2; TxA2; thromboxane A2; TxB2; thromboxane B2; PGI2; prostacyclin; PGES; prostaglandin E synthase; TxAS; thromboxane synthase; PGIS; prostacyclin synthase; GPCR; G-pro
Recognition, Pathogenesis, and Treatment of Different Stages of Nephropathy in Patients With Type 2 Diabetes Mellitus
Keywords: AACE; American Association of Clinical Endocrinologists; ACCORD; Action to Control Cardiovascular Risk in Diabetes; ACE; angiotensin-converting enzyme; ADA; American Diabetes Association; ARB; angiotensin receptor blocker; BMI; body mass index; CI; confid
Paradigm of kinase-driven pathway downstream of epidermal growth factor receptor/Akt in human lung carcinomas
Keywords: Lung carcinoma; EGFR; Akt; mTOR; p70S6-kinase
DARPP-32 Increases Interactions Between Epidermal Growth Factor Receptor and ERBB3 to Promote Tumor Resistance to Gefitinib
Keywords: Stomach Cancer; Treatment; PI3K; AKT; Drug Resistance; PPP1R1B; Dopamine Signaling; DARPP-32; dopamine and adenosine 3â², 5â²-cyclic monophosphate-regulated phosphoprotein, Mr 32000; EGFR; epidermal growth factor receptor; GSK; glyocogen synthase kina
The multiple roles of amphiregulin in human cancer
Keywords: AREG; amphiregulin; TACE; tumor-necrosis factor-alpha converting enzyme; ADAM; a disintegrin and metalloproteinase; CTF; carboxy-terminal fragment; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; EGFR-TKI; epidermal growth factor rec
Primary resistance to cetuximab in a panel of patient-derived tumour xenograft models: Activation of MET as one mechanism for drug resistance
Keywords: Cetuximab; EGFR; MET; Primary drug resistance; Patient-derived xenografts;
Annexin A6-Linking Ca2+ signaling with cholesterol transport
Keywords: AA; arachidonic acid; AnxA; annexin group A; BCC; breast cancer cells; cav-1; caveolin-1; cPLA2; cytoplasmic phospholipase A2; CHO; Chinese Hamster Ovary; DRM; detergent resistant membranes; EGFR; epidermal growth factor receptor; eNOS; endothelial nitric
Development of Novel Targeted Agents in the Treatment of Metastatic Colorectal Cancer
Keywords: EGFR; MAPK pathway; PI3K/AKT pathway; Targeted therapy
Characterization of Aneuploid Populations with Trisomy 7 and 20 Derived from Diploid Human Colonic Epithelial Cells
Keywords: +7; trisomy 7; +20; trisomy 20; APC; adenomatosis polyposis coli; CIN; chromosomal instability; CRC; colorectal cancer; CT; immortalized with Cdk4 and hTERT; CTRP; HCEC CT with K-RasV12 expression and TP53 knockdown; EGFR; epidermal growth factor receptor
Identification of an Exon 4-Deletion Variant of Epidermal Growth Factor Receptor with Increased Metastasis-Promoting Capacity
Keywords: de4 EGFR; the exon 4 deletion variant of EGFR; EGFR; epidermal growth factor receptor; EGFRvIII; epidermal growth factor receptor variant III; ERK; extracellular signal-regulated kinase; EGFRwt; wild type EGFR;
Animal models relevant to human prostate carcinogenesis underlining the critical implication of prostatic stem/progenitor cells
Keywords: ADT; androgen deprivation therapy; AI; androgen-independent; ALDH; aldehyde dehydrogenase; AR; androgen receptor; ARR2; two androgen-responsive regions; BM; bone marrow; CXCR4; CXC chemokine receptor 4; CK; cytokeratin; ECM; extracellular matrix; EGFR; ep
EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells
Keywords: Stem cell; Midgut; Drosophila; EGFR; Visceral muscle;
Maintenance of EGFR and EGFRvIII expressions in an in vivo and in vitro model of human glioblastoma multiforme
Keywords: EGFR; EGFRvIII; Stem cells; Glioblastoma multiforme
Cysteine/cystine redox signaling in cardiovascular disease
Keywords: AMS; 4-acetamido-4â²-maleimidylstilbene-2,2â²-disulfonic acid; BMI; body mass index; CVD; cardiovascular disease; Cys; cysteine; CySS; cystine; EhCySS; redox state of cysteine/cystine; EhGSSG; redox state of GSH/GSSG; DCF; dichlorofluorescin; Trx; thior
Lineage Tracing Evidence for Transdifferentiation of Acinar to Duct Cells and Plasticity of Human Pancreas
Keywords: Metaplasia; Reprogramming; Exocrine Pancreas; Tissue Engineering; BrdU; 5â²-bromodeoxyuridine; CAII; carbonic anhydrase II; CFTR; cystic fibrosis transmembrane conductance regulator; CK19; cytokeratin 19; CMV; cytomegalovirus promoter; DAPI; 4â²,6-diami
Heat shock proteins in oncology: Diagnostic biomarkers or therapeutic targets?
Keywords: 2 DE; 2D gel electrophoresis; 2DPAGE; 2D polyacrylamide gel electrophoresis; AIF; Apoptosis inducing factor; Apaf-1; Apoptotic protease activating factor 1; APC; Antigen presenting cell; ASK-1; Apoptosis Signal-regulating Kinase 1; Bag; Bcl-2-associated a
Role of Notch and its oncogenic signaling crosstalk in breast cancer
Keywords: 4T1 cells; mouse mammary cancer cell line; ADAM; a disintegrin and metalloprotease; Akt; protein kinase B; ALDH; aldehyde dehydrogenase; ANK; ankyrin; Axin2; the Axin-related protein; BALB/c; an albino, laboratory-bred strain of the house mouse; Bcl-2; B-
Mucins in the pathogenesis of breast cancer: Implications in diagnosis, prognosis and therapy
Keywords: BC; breast cancer; UEH; usual epithelial hyperplasia (also called ductal hyperplasia DH); ADH; atypical ductal hyperplasia; CIS; carcinoma in situ; SRCC; signet ring cell carcinoma; FGF; fibroblast growth factor; EGFR; epidermal growth factor receptor (al
Cardiovascular Risk Factors and Systolic and Diastolic Cardiac Function: A Tissue Doppler and Speckle Tracking Echocardiographic Study
Keywords: Blood pressure; Cholesterol; Obesity; Population; Strain; BMI; Body mass index; EF; Ejection fraction; eGFR; Estimated glomerular filtration rate; HDL; High-density lipoprotein; LV; Left ventricular; pwTD; Pulsed-wave tissue Doppler; RV; Right ventricular
Early Requirement of Rac1 in a Mouse Model of Pancreatic Cancer
Keywords: Genetically Engineered Mice; Ductal Cell; Cytoskeleton; Signaling; ADM; acinar-ductal metaplasia; BrdU; bromodeoxyuridine; CK19; cytokeratin 19; CytD; cytochalasin D; EGFR; epidermal growth factor receptor; LatA; latrunculin A; PanIN; pancreatic intraepit
International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma
Keywords: Lung; Adenocarcinoma; Classification; Histologic; Pathology; Oncology; Pulmonary; Radiology; Computed tomography; Molecular; EGFR; KRAS; EML4-ALK; Gene profiling; Gene amplification; Surgery; Limited resection; Bronchioloalveolar carcinoma; Lepidic; Acina
A Brief Retrospective Report on the Feasibility of Epidermal Growth Factor Receptor and KRAS Mutation Analysis in Transesophageal Ultrasound- and Endobronchial Ultrasound-Guided Fine Needle Cytological Aspirates
Keywords: EBUS; EUS; EGFR; KRAS; Cytology; Mutation analysis; Adenocarcinoma; Lung; NSCLC
NFE2L2 Gene Mutation in Male Japanese Squamous Cell Carcinoma of the Lung
Keywords: NFE2L2; Squamous cell carcinoma; EGFR; Tumor progression; mutation
Side-Effects of Long-Term Administration of Erlotinib in Patients with Non-small Cell Lung Cancer
Keywords: EGFR; Erlotinib; Long term; Side effects; Fatigue
Imidazo[2,1-b]thiazoles: Multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases
Keywords: IGF-1R; EGFR; ErbB2; Kinase; Inhibitor; Imidazo[2,1-b]thiazoles
Serum levels and urinary excretion of salusin-α in renal insufficiency
Keywords: Salusin-α; eGFR; Atherosclerosis; Fractional excretion; Radioimmunoassay; Chronic renal failure
Molecular alterations in uterine serous carcinoma
Keywords: Uterine serous carcinoma; PIK3CA; EGFR; HER-2; Claudin-3; Claudin-4
Frequency of EGFR and KRAS Mutations in Japanese Patients with Lung Adenocarcinoma with Features of the Mucinous Subtype of Bronchioloalveolar Carcinoma
Keywords: EGFR; KRAS; Mucinous BAC; Nonmucinous BAC
Estimated glomerular filtration rate is an independent predictor for mortality of patients with acute heart failure
Keywords: Acute heart failure; eGFR; CKD; BNP
Effects of chronic lithium treatment on renal function
Keywords: Lithium; Kidney; Dialysis; ESRD; eGFR; Renal
Aldosterone as a renal growth factor
Keywords: Aldosterone; Kidney; Protein kinase D; EGFR; Polycystic kidney disease; Mitogen activated protein kinase
Comparison of four antibodies for immunohistochemical evaluation of epidermal growth factor receptor expression in non-small cell lung cancer
Keywords: Non-small cell lung cancer; Lung cancer; Epidermal growth factor receptor; EGFR; Immunohistochemistry; Erlotinib
PTEN mutations and relationship to EGFR, ERBB2, KRAS, and TP53 mutations in non-small cell lung cancers
Keywords: PTEN; EGFR; KRAS; TP53; Non-small cell lung cancer
Reliability of chromogenic in situ hybridization for epidermal growth factor receptor gene copy number detection in non-small-cell lung carcinomas: A comparison with fluorescence in situ hybridization study
Keywords: EGFR; Non-small-cell carcinoma; Fluorescence in situ hybridization; Chromogenic in situ hybridization; Reproducibility
Src Inhibitors in Lung Cancer: Current Status and Future Directions
Keywords: Bosutinib; Dasatinib; EGFR; Saracatinib
Correlation of Epidermal Growth Factor Receptor With Morphological Features of Colorectal Advanced Adenomas: A Pilot Correlative Case Series
Keywords: Colorectal adenomas; Epidermal growth factor receptor; EGFR;
Biologie des cancers bronchopulmonaires
Keywords: cancers pulmonaires; biologie moléculaire; antityrosine-kinases; EGFR; Ras; ALK; adénocarcinomes; résistance; thérapeutiques ciblées; lung cancer; molecular biology; anti-tyrosinekinases; EGFR; Ras; ALK; adenocarcinomas; resistance; targeted therapy;
Platelet reactivity on aspirin, clopidogrel and abciximab in patients with acute coronary syndromes and reduced estimated glomerular filtration rate
Keywords: ACS; acute coronary syndrome; ADPtest; platelet reactivity test with adenosine diphosphate; ASPItest; platelet reactivity test with arachidonic acid; AU; aggregation unit; BMI; body mass index; CABG; coronary artery bypass grafting; CI; confidence interva
The HER3/ErbB3 receptor: A promising target in cancer drug therapy
Keywords: HER; human epidermal growth factor receptor; RTKs; receptor tyrosine kinases; EGFR; epidermal growth factor receptor; IGF-1R; insulin-like growth factor type 1 receptor; IGF; insulin-like growth factor; EGF; epidermal growth factor; TGF-α; transforming
Percutaneous Radio Frequency Ablation of Renal Tumors in Patients With von Hippel-Lindau Disease: Preliminary Results
Keywords: kidney; carcinoma; renal cell; catheter ablation; von Hippel-Lindau disease; treatment failure; CT; computerized tomography; eGFR; estimated GFR; GFR; glomerular filtration rate; NSS; nephron sparing surgery; RCC; renal cell carcinoma; RF; radio frequency
Chronic Kidney Disease Epidemiology Collaboration Versus Modification of Diet in Renal Disease Equations for Renal Function Evaluation in Patients Undergoing Partial Nephrectomy
Keywords: kidney function tests; creatinine; nephrectomy; kidney failure; chronic; CKD; chronic kidney disease; CKD-EPI; Chronic Kidney Disease Epidemiology Collaboration; eGFR; estimated glomerular filtration rate; GFR; glomerular filtration rate; MDRD; Modificati
Histopathological Predictors of Renal Function Decrease After Laparoscopic Radical Nephrectomy
Keywords: kidney; carcinoma; renal cell; nephrectomy; glomerulosclerosis; focal segmental; kidney failure; AS; arteriosclerosis; BSA; body surface area; CAD; coronary artery disease; CG; Cockcroft-Gault; CKD; chronic kidney disease; DM; diabetes mellitus; ESRD; end
Substituted 4-amino-1H-pyrazolo[3,4-d]pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases
Keywords: Multi-targeted kinase inhibitors; IGF1R; EGFR; ErbB2
Serial decline of kidney function as a novel biomarker for the progression of atherothrombotic disease
Keywords: Atherosclerosis; Kidney; Renal disease; eGFR; Coronary artery disease; Coronary; Angiography;