
A citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cells
Keywords: MEK; mitogen-activated protein/extracellular signal-regulated kinase; TPA; 12-O-tetradecanoyl phorbol 13-acetate; MMP; matrix metalloproteinase; ERK; extracellular regulated kinases; HEPT; 3,5,6,7,8,3â²,4â²-heptamethoxyflavone; MEM; Eagle's minimum es