کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10816999 1058623 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Myostatin induces p300 degradation to silence cyclin D1 expression through the PI3K/PTEN/Akt pathway
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Myostatin induces p300 degradation to silence cyclin D1 expression through the PI3K/PTEN/Akt pathway
چکیده انگلیسی
Myostatin is a negative regulator of skeletal muscle growth and affects numerous genes expression involved in cell proliferation, differentiation and metabolism. However, the molecular mechanisms underlying myostatin-regulated genes expression remain to be elucidated. In this study, we showed that myostatin blocked the recruitment of p300 to the cyclin D1 promoter, resulting in the silence of cyclin D1 expression. Our data further demonstrated that myostatin decreased the protein level of p300 by inducing p300 degradation via the ubiquitin-proteasome system. In addition, we provided experimental evidence to show that myostatin-induced p300 degradation was mediated by the phosphatidylinositol 3-kinase/PTEN/Akt signaling pathway and this could be antagonized by IGF-1 or insulin. Results presented in this study uncovered an epigenetic control of genes expression in response to myostatin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Signalling - Volume 20, Issue 8, August 2008, Pages 1452-1458
نویسندگان
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