Keywords: حلقه خارج سلولی; AC-42; 4-(4-Butyl-1-piperidinyl)-1-(2-methylphenyl)-1-butanone hydrochloride; ACh; acetylcholine; AM; allosteric modulator; BQCA; Benzyl quinolone carboxylic acid; ECL; extracellular loop; FRET; Förster resonance energy transfer; F-V curve; Function -
مقالات ISI حلقه خارج سلولی (ترجمه نشده)
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Keywords: حلقه خارج سلولی; ATP; adenosine triphosphate; CBX; carbenoxolone; C-terminus; carboxyl-terminus; CNS; central nervous system; EL; extracellular loop; Gly0; core glycosylation; Gly1; high mannose glycosylation; Gly2; complex glycosylation; ICL; intracellular loop; N2a; Neu
Keywords: حلقه خارج سلولی; aPKC; atypical protein kinase; ECL; extracellular loop; FD4; 4Â kDa FITC-dextran; FD10; 10Â kDa FITC-dextran; FD40; 40Â kDa FITC-dextran; JAM; junctional adhesion molecules; Par; partitioning defective; SC; stratum corneum; SG; stratum granulosum; TER; tr
Keywords: حلقه خارج سلولی; GPCRs; G protein-coupled receptors; T2Rs; bitter taste receptors; CAMs; constitutive active mutants; TM; transmembrane; PLCβ2; phospholipase Cβ2; IP3; inositol-1,4,5-triphosphate; ECL; extracellular loop; ICL; intracellular loop; G protein-coupled recep
Keywords: حلقه خارج سلولی; Cx; connexin; Vj; transjunctional voltage; NT; amino terminal domain; CT; carboxyl terminal domain; CL; cytoplasmic loop; EL; extracellular loop; TM; transmembrane helix; EM; electron microscopy; Cx32*Cx43E1; Cx32 chimera in which the EL1 of Cx32 is repla
Keywords: حلقه خارج سلولی; DAT; dopamine transporter; NET; norepinephrine transporter; SERT; serotonin transporter; TM; transmembrane domain; EL; extracellular loop; IL; intracellular loop; o.w.w.; original wet weight; BCIP/NBT; 5-bromo-4-chloro-3-indolyl phosphate/nitro blue; CFT;
Keywords: حلقه خارج سلولی; OR; odorant receptor; Orco; odorant receptor co-receptor; ECL; extracellular loop; AgamOR; Anopheles gambiae OR; CquiOR; Culex quinquefasciatus OR; BmorOR; Bombyx mori OR; wt; wild type; TM; transmembrane; Extracellular loop; AgamOR10; CquiOR10; BmorOR1;
Plasticity of the ligand binding pocket in the bitter taste receptor T2R7
Keywords: حلقه خارج سلولی; Bitter taste receptor (T2R); Extracellular loop; Bitter agonists; Homology modeling; Mutagenesis;
An incretin-based tri-agonist promotes superior insulin secretion from murine pancreatic islets via PLC activation
Keywords: حلقه خارج سلولی; Tri-agonist; Signaling cascade; Pancreatic islets; Insulin secretion; G proteins; TRP channels; AC; Adenylyl cyclase; cAMP; Cyclic adenosine monophosphate; ECL; Extracellular loop; EPAC; Exchange protein directly activated by cAMP; FCS; Fetal calf serum;
Melanocortin-4 receptor in swamp eel (Monopterus albus): Cloning, tissue distribution, and pharmacology
Keywords: حلقه خارج سلولی; ACTH; Adrenocorticotropic hormone; AgRP; Agouti-related protein; α-MSH; α-melanocyte-stimulating hormone; BSA; bovine serum albumin; cAMP; 3â²,5â²-cyclic adenosine monophosphate; CNS; central nervous system; DMEM; Dulbecco's Modified Eagle Medium; ECL
Functional characterization of the dual allatostatin-A receptors in mosquitoes
Keywords: حلقه خارج سلولی; AstA; allatostatin-A; N-terminus; amino-terminus; AstAR; AstA receptor; C-terminus; carboxy-terminus; cDNA; complementary deoxyribonucleic acid; CHO; chinese hamster oocyte; ECL; extracellular loop; EC50; Half maximal effective concentration; ICL; intrace
The aminopyridine-3,5-dicarbonitrile core for the design of new non-nucleoside-like agonists of the human adenosine A2B receptor
Keywords: حلقه خارج سلولی; G protein-coupled receptors; Adenosine A2B receptor agonists; Aminopyridine-3,5-dicarbonitriles; Ligand-adenosine receptor modelling studies; ABMECA; N6-(4-aminobenzyl)N-methylcarboxamidoadenosine; Ado; Adenosine; AR; adenosine receptor; CHO; Chinese hams
Focusing on claudin-5: A promising candidate in the regulation of BBB to treat ischemic stroke
Keywords: حلقه خارج سلولی; 5α-DHP; 5α-dihydroprogestrone; ABC; ATP-binding cassette; AF6; ALL-1-fused gene from chromosome 6; ALL; acute lymphoblastic leukemia; AMPAR; amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor; Ang-1; angiopoietin-1; AP-1; activator protein-1; BBB;
Membrane cholesterol modulates STEAP2 conformation during dynamic intracellular trafficking processes leading to broad subcellular distribution
Keywords: حلقه خارج سلولی; BSA; bovine serum albumin; DIC; differential interference contrast; ER; endoplasmic reticulum; FAD; flavin adenine dinucleotide; GFP; green fluorescent protein; HEK; human embryonic kidney; mAb; monoclonal antibody; MOPS; 3-(N-morpholino)propanesulfonic a
Assessing GPCR homology models constructed from templates of various transmembrane sequence identities: Binding mode prediction and docking enrichment
Keywords: حلقه خارج سلولی; A2AAR; adenosine receptor A2A; AUC; area under curve; β2AR; beta 2 adrenergic receptor; D3R; dopamine receptor D3; δOR; delta-opioid receptor; ECL; extracellular loop; GPCR; G protein-coupled receptor; H1R; histamine receptor H1; ICL; intracellular loop
Muscarinic receptor oligomerization
Keywords: حلقه خارج سلولی; Muscarinic acetylcholine receptor; Quaternary structure; Dimerization; Oligomerization; Ligand regulation; BRET; bioluminescence resonance energy transfer; CNO; clozapine-N-oxide; EL; extracellular loop; FCS; fluorescence correlation spectroscopy; FRET; f
A monoclonal antibody raised against a thermo-stabilised β1-adrenoceptor interacts with extracellular loop 2 and acts as a negative allosteric modulator of a sub-set of β1-adrenoceptors expressed in stable cell lines
Keywords: حلقه خارج سلولی; Alprenolol (Pubchem CID: 2119); CGP 12177 (Pubchem CID: 2687); CGP 20712A (Pubchem CID: 2685); Cimaterol (Pubchem CID: 2755); Furimazine (Pubchem CID: 219083); Hoechst 33342 (Pubchem CID: 1464); IBMX (Pubchem CID: 3758); ICI 118551 (Pubchem CID: 5484725);
Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor
Keywords: حلقه خارج سلولی; ACh; acetylcholine; mAChR; muscarinic acetylcholine receptor; GPCR; G protein-coupled receptor; AD; Alzheimer's disease; PAM; positive allosteric modulator; NAM; negative allosteric modulator; TM; transmembrane domain; ECL; extracellular loop; CHO; Chin
Understanding the common themes and diverse roles of the second extracellular loop (ECL2) of the GPCR super-family
Keywords: حلقه خارج سلولی; GPCR; Extracellular loop; Ligand-binding; Receptor activation; Signalling; Family B;
Reprint of Pharmacological and molecular characterization of the positive allosteric modulators of metabotropic glutamate receptor 2
Keywords: حلقه خارج سلولی; Metabotropic glutamate receptor; mGlu2; mGlu3; mGluR; Negative allosteric modulators; Positive allosteric modulators; LY354740; LY487379; ECL; extracellular loop; FLIPR; Fluorometric Imaging Plate Reader; GPCR; G-protein coupled receptor; mGluR; metabotro
The key residue within the second extracellular loop of human EP3 involved in selectively turning down PGE2- and retaining PGE1-mediated signaling in live cells
Keywords: حلقه خارج سلولی; EP selectivity; G protein-coupled receptor (GPCR); Prostaglandin; Prostaglandin E1; Prostaglandin E2; Receptor regulation; AA; arachidonic acid; COX-1 and -2; cyclooxygenase-1 and -2, respectively; cPGES; cytosolic PGES; DGLA; dihomo-γ-linolenic acid; EP
A promiscuous recognition mechanism between GPR17 and SDF-1: Molecular insights
Keywords: حلقه خارج سلولی; SDF-1; stromal cell-derived factor 1; GPCR; G protein-coupled receptor; CNS; central nervous system; NS; nervous system; DRG; dorsal root ganglion; OPC; oligodendrocyte precursor cell; MS; multiple sclerosis; PDB; Protein Data Bank; TM; transmembrane; EL;
The cataract related mutation N188T in human connexin46 (hCx46) revealed a critical role for residue N188 in the docking process of gap junction channels
Keywords: حلقه خارج سلولی; CI; confidence interval; CL; cytoplasmic loop; Cx; connexin; DOPE; discrete optimized protein energy; E1Â +Â E2; extracellular loop; ER; end oplasmic reticulum; HB; hydrogen bond; hCx; human connexin; LY; Lucifer yellow; MD; molecular dynamics; NS; not si
Design, synthesis, pharmacological characterization of a fluorescent agonist of the P2Y14 receptor
Keywords: حلقه خارج سلولی; DXQJLXWZLNCEJX-VBCGWZPHSA-N; BODIPY; boron-dipyrromethene; cAMP; 3â²,5â²-cyclic adenosine monophosphate; CHO; Chinese hamster ovary; COMU; [[(Z)-(1-cyano-2-ethoxy-2-oxoethylidene)amino]oxy-morpholin-4-ylmethylidene]-dimethylazanium hexafluorophosphate;
Clathrin-dependent endocytosis of claudin-2 by DFYSP peptide causes lysosomal damage in lung adenocarcinoma A549 cells
Keywords: حلقه خارج سلولی; CQ; chloroquine; DAPI; 4â²,6-diamidino-2-phenylindole; ECL; extracellular loop; MβCD; methyl-β-cyclodextrin; MDC; monodancylcadaverine; NSCLC; non-small cell lung cancer; TJs; tight junctions; TUNEL; TdT-mediated dUTP-biotin nick end labeling; WST-1; t
Conserved disulfide bond is not essential for the adenosine A2A receptor: Extracellular cysteines influence receptor distribution within the cell and ligand-binding recognition
Keywords: حلقه خارج سلولی; GPCRs; G protein-coupled receptors; ARs; adenosine receptors; ECL; extracellular loop; DTT; dithiothreitol; CFP; cyan fluorescent protein; A2AR; A2A receptor; WT; wild type; ER; endoplasmic reticulum; M; plasma membrane; HR; Hausdorff ratio; HEK cells; hu
Emerging opportunities for allosteric modulation of G-protein coupled receptors
Keywords: حلقه خارج سلولی; GPCR; G-protein coupled receptor; Ã2-AR; Ã2-adrenoceptor; Ã1-AR; Ã1-adrenoceptor; A2a-AR; A2a- adenosine receptor; CXCR4; CXCR4 chemokine receptor; D3R; dopamine 3 receptor; H1R; histamine 1 receptor; M2R; M2 muscarinic receptor; M3R; M3 muscarinic re
8-(2-Furyl)adenine derivatives as A2A adenosine receptor ligands
Keywords: حلقه خارج سلولی; Purinergic receptors; Adenosine receptors; Adenosine receptor antagonists; Adenine derivatives; Purine derivatives; Molecular modelling; AR; adenosine receptor; GPCR; G protein-coupled receptor; CNS; central nervous system; DMF; dimethylformamide; NBS; N-
Design, synthesis, and binding mode prediction of 2-pyridone-based selective CB2 receptor agonists
Keywords: حلقه خارج سلولی; IPCYPXCGYWGJEK-UHFFFAOYSA-N; cAMP; 3â²,5â²-cyclic adenosine monophosphate; CB; cannabinoid; CHO; Chinese hamster ovary; CNS; central nervous system; DCM; dichloromethane; DMF; N,N-dimethylformamide; DPPA; diphenylphosphonic azide; ECL; extracellular loo
Characterization of α2B-adrenoceptor ligand binding in the presence of Muscarinic toxin α and delineation of structural features of receptor binding selectivity
Keywords: حلقه خارج سلولی; α2-Adrenoceptor; Chimeric receptor; Extracellular loop; Ligand binding; Mamba snake; Muscarinic toxin;
Role of a conserved glycine triplet in the NSS amino acid transporter KAAT1
Keywords: حلقه خارج سلولی; KAAT1; K+-coupled amino acid transporter 1; CuPh; Cu(II)(1,10-phenanthroline)3; DTT; dithiothreitol; TMA; tetramethylammonium; EL; extracellular loop; TM; transmembrane domain; Structure-function; Site-directed mutagenesis; Cross-linking; Cation interacti
Structural and functional analysis of extracellular loop 4 of the Nhe1 isoform of the Na+/H+ exchanger
Keywords: حلقه خارج سلولی; CHO; Chinese hamster ovary; EL; extracellular loop; HA; hemagglutinin; NHE1; Na+/H+ exchanger type 1 isoform; MTSES; ([2-Sulfonatoethyl]methanethiosulfonate); MTSET; ([2-(Trimethylammonium)ethyl] methanethiosulfonate); TM; transmembrane segment; Cation co
Determination of different putative allosteric binding pockets at the lutropin receptor by using diverse drug-like low molecular weight ligands
Keywords: حلقه خارج سلولی; 7-TM; seven transmembrane; A2AR; adenosine A2A receptor; A3R; adenosine A3 receptor; BSA; bovine serum albumin; cAMP; cyclic adenosine-5â²-monophosphate; CHO; Chinese Hamster Ovary; CHOhLHr_luc; human LH receptor and luciferase reporter gene transfected
Affinity of aporphines for the human 5-HT2A receptor: Insights from homology modeling and molecular docking studies
Keywords: حلقه خارج سلولی; Nantenine; Aporphine; Serotonin; MDMA; 5-HT2A; 5-HT; 5-hydroxytryptamine, serotonin; AcOH; acetic acid; Boc; tert-butoxycarbonyl; BLAST; Basic Local Alignment Search Tool; BRho; bovine rhodopsin; CDI; 1,1â²-carbonyldiimidazole; D; aspartic acid; DCM; dic
Structure and function of G protein-coupled receptors using NMR spectroscopy
Keywords: حلقه خارج سلولی; Membrane proteins; Magic angle spinning; Structure; CL; cytoplasmic loop; cryo-EM; cryogenic electron microscopy; C-terminus; carboxy terminus; DARR; dipolar-assisted rotational resonance; DDM; dodecyl-β-d-maltoside; DNA; deoxyribonucleic acid; DNP; dyna
Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39
Keywords: حلقه خارج سلولی; GPR39; G protein-coupled receptor 39; 7TM; seven transmembrane domain; ECL; extracellular loop; IP; inositol phosphate; ELISA; enzyme-linked immunosorbent assay; G protein-coupled receptor; GPR39; Metal ion; Zn2+ binding site;
Extracellular loop 3 (ECL3) and ECL3-proximal transmembrane domains VI and VII of the mesotocin and vasotocin receptors confer differential ligand selectivity and signaling activity
Keywords: حلقه خارج سلولی; Mesotocin; Vasotocin; Oxytocin; Arginine vasopressin; Receptor; Ligand selectivity; Extracellular loop; Transmembrane domain
Structure and function of claudins
Keywords: حلقه خارج سلولی; Tight junction; Transmembrane protein; Claudin; Extracellular loop; Cell–cell contact; Paracellular pore; Structural model; Epithelial and endothelial barriers
Soluble chemokine CCR5 receptor is present in human plasma
Keywords: حلقه خارج سلولی; sCCR5; soluble chemokine receptor CCR5; HIV; human immunodeficiency virus; mAb; monoclonal antibody; ECL; extracellular loop; PBMC; peripheral blood mononuclear cells; RT-PCR; reverse trascriptase-polymerase chain reaction; M-MLV RT; moloney murine leukem
Origin of the prolactin-releasing hormone (PRLH) receptors: Evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution
Keywords: حلقه خارج سلولی; PRLH; prolactin-releasing hormone; PRLHR; PRLH receptor; NPYR; neuropeptide Y receptor; GPCR; G-protein-coupled receptor; ACTH; adrenocorticotropin; TM; transmembrane region; EL; extracellular loop; HMM; Hidden Markov Model; LG; linkage group; PRH; prolac