کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1983256 1539866 2016 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bitter taste receptors: Novel insights into the biochemistry and pharmacology
ترجمه فارسی عنوان
گیرنده های طعم دهنده تلخ: بینش جدید در مورد بیوشیمی و فارماکولوژی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
Bitter taste receptors (T2Rs) belong to the super family of G protein-coupled receptors (GPCRs). There are 25 T2Rs expressed in humans, and these interact with a large and diverse group of bitter ligands. T2Rs are expressed in many extra-oral tissues and can perform diverse physiological roles. Structure-function studies led to the identification of similarities and dissimilarities between T2Rs and Class A GPCRs including amino acid conservation and novel motifs. However, the efficacy of most of the T2R ligands is not yet elucidated and the biochemical pharmacology of T2Rs is poorly understood. Recent studies on T2Rs characterized novel ligands including blockers for these receptors that include inverse agonist and antagonists. In this review we discuss the techniques used for elucidating bitter blockers, concept of ligand bias, generic amino acid numbering, the role of cholesterol, and conserved water molecules in the biochemistry and pharmacology of T2Rs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 77, Part B, August 2016, Pages 184-196
نویسندگان
, , , , ,