Keywords: حلقه داخل سلولی; ATP; adenosine triphosphate; CBX; carbenoxolone; C-terminus; carboxyl-terminus; CNS; central nervous system; EL; extracellular loop; Gly0; core glycosylation; Gly1; high mannose glycosylation; Gly2; complex glycosylation; ICL; intracellular loop; N2a; Neu
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Keywords: حلقه داخل سلولی; AC; adenylate cyclase; Actn4; α-Actinin-4; ARF6; ADP-ribosylation factor 6; ATD; amino terminal domain; CAIN; calcineurin inhibitor protein; CaM; calmodulin; CaMKII; Ca2+/calmodulin-dependent protein kinase II; Cbln1; cerebellin 1 precursor; CC; coiled-c
Keywords: حلقه داخل سلولی; 2-APB; 2-aminoethoxydiphenyl borate;; ATP; adenosine triphosphate; CT; C-terminal tail; Cx(s); connexin(s); dsRNA; double-stranded RNA; EL(s); extracellular loop(s); GA; glycyrrhetinic acid; GABA; γ-amino butyric acid; GJ(s); gap junction(s); GJIC; gap j
Keywords: حلقه داخل سلولی; GPCRs; G protein-coupled receptors; T2Rs; bitter taste receptors; CAMs; constitutive active mutants; TM; transmembrane; PLCβ2; phospholipase Cβ2; IP3; inositol-1,4,5-triphosphate; ECL; extracellular loop; ICL; intracellular loop; G protein-coupled recep
Keywords: حلقه داخل سلولی; DAT; dopamine transporter; NET; norepinephrine transporter; SERT; serotonin transporter; TM; transmembrane domain; EL; extracellular loop; IL; intracellular loop; o.w.w.; original wet weight; BCIP/NBT; 5-bromo-4-chloro-3-indolyl phosphate/nitro blue; CFT;
G protein-coupled receptor kinases: Past, present and future
Keywords: حلقه داخل سلولی; αN-helix; N-terminal α-helical domain; α2AAR; α2A-adrenergic receptor; AST; active site tether; βAR; β-adrenergic receptor; β2AR; β2-adrenergic receptor; βARK; β-adrenergic receptor kinase; CLBD; C-terminal lipid binding domain; EM; electron mic
Melanocortin-4 receptor in swamp eel (Monopterus albus): Cloning, tissue distribution, and pharmacology
Keywords: حلقه داخل سلولی; ACTH; Adrenocorticotropic hormone; AgRP; Agouti-related protein; α-MSH; α-melanocyte-stimulating hormone; BSA; bovine serum albumin; cAMP; 3â²,5â²-cyclic adenosine monophosphate; CNS; central nervous system; DMEM; Dulbecco's Modified Eagle Medium; ECL
Functional characterization of the dual allatostatin-A receptors in mosquitoes
Keywords: حلقه داخل سلولی; AstA; allatostatin-A; N-terminus; amino-terminus; AstAR; AstA receptor; C-terminus; carboxy-terminus; cDNA; complementary deoxyribonucleic acid; CHO; chinese hamster oocyte; ECL; extracellular loop; EC50; Half maximal effective concentration; ICL; intrace
Designer Approaches for G Protein-Coupled Receptor Modulation for Cardiovascular Disease
Keywords: حلقه داخل سلولی; biased ligands; G protein-coupled receptor kinases; G protein-coupled receptors; AR; adrenergic receptor; AT1R; angiotensin II type 1A receptor; CRF; corticotropin-releasing factor; EGFR; epidermal growth factor receptor; ERK1/2; extracellular signal-
W1038 near D-loop of NBD2 is a focal point for inter-domain communication in multidrug transporter Cdr1 of Candida albicans
Keywords: حلقه داخل سلولی; ABC; ATP-binding cassette; TMD; transmembrane domain; NBD; nucleotide binding domain; TMH; transmembrane helix; ICL; intracellular loop; Cdr1p; Candida drug resistance 1 protein; Pdr5p; pleiotropic drug resistance 5 protein; TAP; transporter associated wi
Assessing GPCR homology models constructed from templates of various transmembrane sequence identities: Binding mode prediction and docking enrichment
Keywords: حلقه داخل سلولی; A2AAR; adenosine receptor A2A; AUC; area under curve; β2AR; beta 2 adrenergic receptor; D3R; dopamine receptor D3; δOR; delta-opioid receptor; ECL; extracellular loop; GPCR; G protein-coupled receptor; H1R; histamine receptor H1; ICL; intracellular loop
Attachment of a 'molecular spring' restores drug-stimulated ATPase activity to P-glycoprotein lacking both Q loop glutamines
Keywords: حلقه داخل سلولی; P-glycoprotein; ABC protein; Disulfide cross-linking; Molecular spring; Drug-stimulated ATPase activity; ABC; ATP-binding cassette; P-gp; P-glycoprotein; NBD; nucleotide-binding domain; HEK; human embryonic kidney; TM; transmembrane; TMD; transmembrane do
Interactions and cooperativity between P-glycoprotein structural domains determined by thermal unfolding provides insights into its solution structure and function
Keywords: حلقه داخل سلولی; AMPPCP; β, γ-methylene ATP; CD; circular dichroism; CU; cooperative unit; CFTR; cystic fibrosis transmembrane conductance regulator; DDM; n-dodecyl-β-d-maltopyranoside; ÎHc; calorimetric enthalpy; DLS; dynamic light scattering; DMNG; decyl maltose neo
MC1R signaling. Intracellular partners and pathophysiological implications
Keywords: حلقه داخل سلولی; AC; adenylyl cyclase; ACTH; adrenocorticotropic hormone; ARRB; β-arrestin; ASIP; agouti signal protein; CBD103; dog β-defensin-3; CREB; cAMP responsive-element binding protein; EDN1; endothelin 1; ER; endoplasmic reticulum; ERK; extracellular signal-reg
P-glycoprotein ATPase activity requires lipids to activate a switch at the first transmission interface
Keywords: حلقه داخل سلولی; P-glycoprotein; ABC protein; Disulfide cross-linking; Switch; Transmission interface; ATPase activity; ABC; ATP-binding cassette; P-gp; P-glycoprotein; NBD; nucleotide-binding domain; HEK; human embryonic kidney; TM; transmembrane; TMD; transmembrane doma
A promiscuous recognition mechanism between GPR17 and SDF-1: Molecular insights
Keywords: حلقه داخل سلولی; SDF-1; stromal cell-derived factor 1; GPCR; G protein-coupled receptor; CNS; central nervous system; NS; nervous system; DRG; dorsal root ganglion; OPC; oligodendrocyte precursor cell; MS; multiple sclerosis; PDB; Protein Data Bank; TM; transmembrane; EL;
New paradigms in GPCR drug discovery
Keywords: حلقه داخل سلولی; cAMP; 3â²,5â²-cyclic adenosine monophosphate; ADP; adenosine 5â²- diphosphate; GPCR; G protein-coupled receptor; TM; transmembrane helix; ERK; extracellular signal-regulated kinase; T4L; T-4 lysozyme; BRIL; thermostabilized apocytochrome b562; StaRs; s
Heterotypic gap junctions at glutamatergic mixed synapses are abundant in goldfish brain
Keywords: حلقه داخل سلولی; CE; club ending (size of terminal and state of myelination not determinable); CNS; central nervous system; CT; carboxy terminus; Cx34.7; connexin34.7; Cx35; connexin35; Cx36; connexin36; Cx45; connexin45; Cx57; connexin57; DR-FRIL; double-replica FRIL; DR
8-(2-Furyl)adenine derivatives as A2A adenosine receptor ligands
Keywords: حلقه داخل سلولی; Purinergic receptors; Adenosine receptors; Adenosine receptor antagonists; Adenine derivatives; Purine derivatives; Molecular modelling; AR; adenosine receptor; GPCR; G protein-coupled receptor; CNS; central nervous system; DMF; dimethylformamide; NBS; N-
The COOH-terminus of TM4SF5 in hepatoma cell lines regulates c-Src to form invasive protrusions via EGFR Tyr845 phosphorylation
Keywords: حلقه داخل سلولی; ICL; intracellular loop; SYF; c-Src-, Fyn-, and Yes-negative mouse embryonic fibroblasts; SYF++; c-Src-reconstituted SYF cells; SFKs; c-Src family kinases; TERM; tetraspanin-enriched microdomain; TM4SF5; Transmembrane 4 L6 family member 5; TM4SF5ÎC; COOH
Capturing of the free cysteine residue in the ligand-binding site by affinity labeling of the ORL1 nociceptin receptor
Keywords: حلقه داخل سلولی; Ac-RYYRIK-NH2; the one-letter amino acid code denotes Ac-Arg-Tyr-Tyr-Arg-Ile-Lys-NH2; BSA; bovine serum albumin; DMEM; Dulbecco's modified Eagle's medium; DMF; N,N-dimethylformamide; EC50; the concentration for the half maximal effective concentration
Expression, purification and NMR characterization of the cyclic recombinant form of the third intracellular loop of the vasopressin type 2 receptor
Keywords: حلقه داخل سلولی; G-protein coupled receptor; Vasopressin receptor subtype 2; Intracellular loop; Affinity purification; Nuclear magnetic resonance
Affinity of aporphines for the human 5-HT2A receptor: Insights from homology modeling and molecular docking studies
Keywords: حلقه داخل سلولی; Nantenine; Aporphine; Serotonin; MDMA; 5-HT2A; 5-HT; 5-hydroxytryptamine, serotonin; AcOH; acetic acid; Boc; tert-butoxycarbonyl; BLAST; Basic Local Alignment Search Tool; BRho; bovine rhodopsin; CDI; 1,1â²-carbonyldiimidazole; D; aspartic acid; DCM; dic
Role of third intracellular loop of the melanocortin 4 receptor in the regulation of constitutive activity
Keywords: حلقه داخل سلولی; Melanocortin; Melanocortin 4 receptor; Constitutive activity; G protein; Intracellular loop; Obesity; Mutation
Structural domains determining signalling characteristics of the CRH-receptor type 1 variant R1β and response to PKC phosphorylation
Keywords: حلقه داخل سلولی; CRH receptor; PKC; Desensitization; β-arrestin; Phosphorylation; Intracellular loop
Heterooligomerization of human dopamine receptor 2 and somatostatin receptor 2
Keywords: حلقه داخل سلولی; C-tail; carboxy-terminal tail; DA; dopamine; DR; dopamine receptor; hD2R; human dopamine receptor 2; FSK; forskolin; GPCR; G-protein-coupled receptor; HA; hemoagglutinin; ICL; intracellular loop; pbFRET; photobleaching fluorescence resonance energy transf
Design and synthesis of cyclic and linear peptide-agarose tools for baiting interacting protein partners of GPCRs
Keywords: حلقه داخل سلولی; G-protein-coupled receptors; Intracellular loop; Peptide synthesis; Ligation; Proteomics