Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; AEA, anandamide; AG, 2-arachidonoyl glycerol; CB1, cannabinoid receptor 1; CB2, cannabinoid receptor 2; CB receptor, cannabinoid receptor; FAAH, fatty acid amide hydrolase; NM, nitrogen mustard; OEA, oleyolethanolamide; PEA, palmitoylethanolamide; PPARα,
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Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; AEA, arachidonoyl ethanolamide; 2-AG, 2-arachidonoylglycerol; CB1, cannabinoid receptor 1; CB2, cannabinoid receptor 2; FAAH, fatty acid amide hydrolase; FLS, fibroblastlike synoviocyte; IFN, interferon; IL, interleukin; MMP, matrix metalloproteinase; RA,
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; AEA, anandamide; CB1R, cannabinoid receptor CB1; DAB, 3,3′-diaminobenzidine; DAGL, diacylglycerol lipase enzyme; dLGN, dorsal lateral geniculate nucleus; eCB, endocannabinoid; ERG, electroretinogram; FAAH, fatty acid amide hydrolase; GABA, GABAergic cell;
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; 2-AG, 2-arachidonoylglycerol; AEA, N-arachidonoylethanolamide, anandamide; BA, basal nucleus of the amygdala; ECs, endocannabinoids; Ent, entorhinal cortex; FAAH, fatty acid amide hydrolase; Hip, hippocampus; KA, kainic acid; LFP, local field potential; M
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; ACTH, adrenocorticotropic hormone; AEA, N-arachidonylethanolamine; CB1, cannabinoid type 1 receptor; CORT, corticosterone; CRH, corticotropin-releasing hormone; CRHR1, CRH receptor type 1; CRH-OE, CRH overexpressing mice; FAAH, fatty acid amide hydrolase;
Distinct neuronal activation patterns are associated with PCP-induced social withdrawal and its reversal by the endocannabinoid-enhancing drug URB597
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; AEA, anandamide; BNST, bed nucleus of the stria terminalis; BLA, basolateral amygdala; CeA, central amygdala; CPu, caudate putamen; FAAH, fatty acid amide hydrolase; MDT, mediodorsal thalamus; PAG, periaqueductal gray; PCP, phencyclidine; ROI, region of i
Endocannabinoid-mediated improvement on a test of aversive memory in a mouse model of fragile X syndrome
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; Fragile X syndrome; FAAH; Passive avoidance; Propofol; Fmr1 KO mice; Memory2-AG, 2-arachidonoylglycerol; CB1, cannabinoid receptor-1; eCB, endocannabinoid; FAAH, fatty acid amide hydrolase; FMRP, fragile X mental retardation protein; Fmr1, fragile X menta
Lipopolysaccharide suppresses carboxylesterase 2g activity and 2-arachidonoylglycerol hydrolysis: A possible mechanism to regulate inflammation
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; 2-AG, 2-arachidonoylglycerol; AA, arachidonic acid; ABPP, activity-based protein profiling; AEA, arachidonylethanolamide (anandamide); Ces, carboxylesterase; FAAH, fatty acid amide hydrolase; IL, interleukin; LPS, lipopolysaccharide; MAGL, monoacylglycero
Palmitoylethanolamide (PEA)—‘Promiscuous’ anti-inflammatory and analgesic molecule at the interface between nutrition and pharma
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; n-3 LC-PUFA, (n-3) long chain polyunsaturated fatty acid; 2-AG, 2-arachidonoyl-glycerol; AEA, arachidonoylethanolamide (anandamide); CB (receptor), cannabinoid (receptor); GPCR, G-protein coupled receptor; FAAH, fatty acid amide hydrolase; PPAR, peroxisom
Role of anorectic N-acylethanolamines in intestinal physiology and satiety control with respect to dietary fat
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; AEA, anandamide; 2-AG, 2-arachidonoyl glycerol; CCK, cholescystokinin; EPEA, eicosapentaenoylethanolamide; DHEA, docosahexaenoylethanolamide; FAAH, fatty acid amide hydrolase; GLP-1, glucagon-like peptide-1; LEA, linoleoylethanolamide; NAAA, N-acylethanol
JZL184 is anti-hyperalgesic in a murine model of cisplatin-induced peripheral neuropathy
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; AEA, anandamide; 2-AG, 2-arachidonoyl-sn-glycerol; CB, cannabinoid; d, deuterated; DRG, dorsal root ganglion; EC50, concentration of drug that evokes 50% of a maximum response; FAAH, fatty acid amide hydrolase; IC50, concentration of drug that reduces the
Cannabinoid receptor antagonists and fatty acids alter endocannabinoid system gene expression and COX activity
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; CB1, cannabinoid receptor 1; CB2, cannabinoid receptor 2; NAPE-PLD, N-acyl phosphatidylethanolamine phospholipase D; FAAH, fatty acid amide hydrolase; DAGL-α, diacylglycerol lipase α; DAGL-ß, diacylglycerol lipase β; NF-κB, nuclear factor kappa-light-chai
Brain regional cannabinoid CB1 receptor signalling and alternative enzymatic pathways for 2-arachidonoylglycerol generation in brain sections of diacylglycerol lipase deficient mice
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; 2-AG, 2-arachidonoylglycerol; AEA, N-arachidonoylethanolamide/anandamide; BSA, bovine serum albumin; DAGL, diacylglycerol lipase; eCB, endocannabinoid; FAAH, fatty acid amide hydrolase; KO, knockout; LC/MS/MS, liquid chromatography/tandem mass spectrometr
Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; FAAH, fatty acid amide hydrolase; EC, endogenous cannabinoid; AEA, arachidonoylethanolamide; CB1, cannabinoid 1; CB2, cannabinoid 2; SAR, Structure–activity relationship; DMPK, drug metabolism and pharmacokinetics; PK, pharmacokinetics; PD, pharmacodynami
Structure–affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; ES, endocannabinoid system; CB, cannabinoid; MAGL, monoacylglycerol lipase; FAAH, fatty acid amide hydrolase; TRPA1, transient potential ankirin type-1 receptor; THC, (−)-Δ9-tetrahydrocannabinol; eCBs, endocannabinoids; AEA, anandamide; 2-AG, 2-arachidono
The effects of cannabidiol on the antigen-induced contraction of airways smooth muscle in the guinea-pig
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; Airway obstruction; Cannabinoids; Guinea-pig bronchi; Sensory nerves; Mast cellsAUC, area under the curve; CBD, (−)-cannabidiol; Cdyn, dynamic compliance; Δ9-THC, (−)-Δ9-tetrahydrocannabinol; FAAH, fatty acid amide hydrolase; NKA, neurokinin A; OVA, ovalb
Astroglial CB1 cannabinoid receptors regulate leptin signaling in mouse brain astrocytes ★
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; CB1, type-1 cannabinoid receptor; Cx, cerebral cortex; FAAH, fatty acid amide hydrolase; GFAP, glial fibrillary acidic protein; MGL, monoacylglycerol lipase; ObR, leptin receptor; ObRb, long-isoform leptin receptor; P-STAT3, Tyr705-phosphorylated form of
Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; FAAH, fatty acid amide hydrolase; EC, endogenous cannabinoid; AEA, arachidonoylethanolamide; CB1, cannabinoid 1; CB2, cannabinoid 2; SAR, structure–activity relationship; DMPK, drug metabolism and pharmacokinetics; Troc, 2,2,2-trichloroethoxy carbonylFatt
Identification of receptors and enzymes for endocannabinoids in NSC-34 cells: Relevance for in vitro studies with cannabinoids in motor neuron diseases
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; ALS, amyotrophic lateral sclerosis; CB1 receptor, cannabinoid receptor type 1; CB2 receptor, cannabinoid receptor type 2; DAGL, diacylglycerol-lipase; FAAH, fatty acid amide hydrolase; MAGL, monoacylglycerol-lipase; NAPE-PLD, N-arachidonoylphosphatidyleth
Chronic, noninvasive glucocorticoid administration suppresses limbic endocannabinoid signaling in mice
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; CB1; cannabinoid; 2-AG; anandamide; stress; corticosteroneAEA, anandamide; CB1, cannabinoid type 1; CB2, cannabinoid type 2; CORT, corticosterone; Ct, cycle threshold value; ECS, endocannabinoid system; FAAH, fatty acid amide hydrolase; HPA, hypothalamic
New insights on endocannabinoid transmission in psychomotor disorders
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; AEA, anandamide; 2-AG, 2-Arachidonoyl Glycerol; CSF, Cerebrospinal Fluid; DSE, Depolarization-induced Suppression of Excitation; DSI, Depolarization-induced Suppression of Inhibition; EC, Endocannabinoid; FAAH, Fatty Acid Amide Hydrolase; MSN, Medium Spin
Assay and inhibition of diacylglycerol lipase activity
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; AA, arachidonic acid; 2-AG, 2-arachidonoylglycerol; DAGL, diacylglycerol lipase; FAAH, fatty acid amide hydrolase; FRET, fluorescence resonance energy transfer; MAGL, monoacylglycerol lipase; NBD, nitrobenzoxadiazole; [14C]SAG, [1″-14C]1-stearoyl-2-arachi
Effect of delta-9-tetrahydrocannabinol on behavioral despair and on pre- and postsynaptic serotonergic transmission
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; 5-HT, 5-hydroxytryptamine, serotonin; CB1R, cannabinoid CB1 receptor; Delta-9-THC, (-)-trans-delta(9)-tetrahydrocannabinol; DR, dorsal raphe; FAAH, fatty acid amide hydrolase; MAGL, monoacylglycerol lipase; FST, forced swim test; OFT, open field test; WAY
Enhancement of the behavioral effects of endogenous and exogenous cannabinoid agonists by phenylmethyl sulfonyl fluoride
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; THC; Anandamide; CP 55; 940; FAAH; Drug discrimination; Cannabinoid; PMSF2-AG, 2-arachidonoyl glycerol; AEA, anandamide; FAAH, fatty acid amide hydrolase; MAGL, monoacylglycerol lipase; PMSF, phenylmethyl sulfonyl fluoride; THC, Δ9-tetrahydrocannabinol
Cannabinoid modulation of noradrenergic circuits: Implications for psychiatric disorders
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; AR, adrenergic receptor; CB1r, cannabinoid type 1 receptor; ∆9-THC, ∆9-tetrahydrohydrocannabinol; FAAH, fatty acid amide hydrolase; LC, locus coeruleus; MAO, monoamine oxidase; NE, norepinephrine; NET, norepinephrine transporter; Acb, nucleus accumbens; N
Endocannabinoid signaling, glucocorticoid-mediated negative feedback, and regulation of the hypothalamic-pituitary-adrenal axis
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; stress; hpa axis; 2-AG; CB1; cannabinoid; anandamideACTH, adrenocorticotropic hormone; AEA, N-arachidonylethanolamine; BNST, bed nucleus of the stria terminalis; CRH, corticotropin releasing hormone; DAG, diacylglycerol; FAAH, Fatty acid amide hydrolase;
N-Acylethanolamines and related compounds: Aspects of metabolism and functions
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; DDM, n-dodecyl-β-d-maltoside; FAAH, fatty acid amide hydrolase; LPE, lyso-phosphatidylethanolamine; NAE, N-acylethanolamine; NAPE, N-acylphosphatidylethanolamine; PAL, phenylalanine ammonia lyase; PE, phosphatidylethanolamine; ROS, reactive oxygen species
Analysis of the discriminative inhibition of mammalian digestive lipases by 3-phenyl substituted 1,3,4-oxadiazol-2(3H)-ones
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; Enzyme; Enzyme inhibition; Lipases; Oxadiazolone; In silico molecular dockingAchE, acetylcholinesterase; DAG, diacylglycerol; DGL, dog gastric lipase; FAAH, fatty acid amide hydrolase; FFA, free fatty acid; GPLRP2, guinea pig pancreatic lipase-related pro
Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 2. Discovery of 7-azaspiro[3.5]nonane urea PF-04862853, an orally efficacious inhibitor of fatty acid amide hydrolase (FAAH) for pain
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; FAAH, fatty acid amide hydrolase; AEA, anandamide; ABPP, activity-based protein profiling; CFA, complete Freund’s adjuvant; MED, minimum efficacious dose; SAR, structure–activity relationship; CNS, central nervous system; PK, pharmacokineticFatty acid ami
Pharmacological elevation of anandamide impairs short-term memory by altering the neurophysiology in the hippocampus
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; Delayed-non-match-to-sample; Electrophysiology; Endocannabinoid; Hippocampus; Short-term memory; Single-unit recording; Ensemble code2-AG, 2-Arachidonyl glycerol; DNMS, Delayed-non-match-to-sample; FAAH, Fatty acid amide hydrolase; STM, Short-Term Memory;
Neurochemical basis of cannabis addiction
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; THC; reward; tolerance; CB1 receptor; dopamine; opioidCRF, corticotrophin-releasing factor; DA, dopamine; DAMGO, D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin; FAAH, fatty acid amide hydrolase; [35S]-GTP gamma S, [35S]-guanylyl-5'-O-(gamma-thio)-triphosphate
Investigation of CNR1 and FAAH endocannabinoid gene polymorphisms in bipolar disorder and major depression
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; AEA, arachidonoylethanolamide; 2-AG, 2-arachidonoylglycerol; ANOVA, analysis of variance; BD, bipolar disorder; BMI, body mass index; FAAH, fatty acid amide hydrolase; MD, major depression; SCID-IP, Structured Clinical Interview for DSM IV-Patient Edition
Analysis of gene expression pattern reveals potential targets of dietary oleoylethanolamide in reducing body fat gain in C3H mice
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; ACO, acyl-CoA oxidase; FAAH, fatty acid amide hydrolase; FAT/CD36, fatty acid transporter/cluster of differentiation 36; FIAF, fasting-induced adipocyte factor; GPR119, G-protein-coupled receptor 119; PPAR, peroxisome proliferator-activated receptorOleoyl
Lauroylethanolamide is a potent competitive inhibitor of lipoxygenase activity
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; FAAH, fatty acid amide hydrolase; FFA, free fatty acid; FFA 12:0, lauric acid; FFA 18:2, linoleic acid; FFA 18:3, α-linolenic acid; JA, jasmonic acid; KO, knockout; LOX, lipoxygenase; NAE, N-acylethanolamine; NAE 12:0, N-lauroylethanolamide; NAE 18:2, N-l
Transient receptor potential vanilloid 1 channels control acetylcholine/2-arachidonoylglicerol coupling in the striatum
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; anandamide; CB1 receptors; endocannabinoids; IPSC; muscarinic receptors; vanilloid receptorsAch, acetylcholine; AEA, anandamide; DAGL, diacylglycerol lipase; FAAH, fatty acid amide hydrolase; IPSC, inhibitory postsynaptic current; LTD, long-term depressio
Hydrolysis of 2-arachidonoylglycerol in Tetrahymena thermophila. Identification and partial characterization of a Monoacylglycerol Lipase-like enzyme
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; AEA, N-arachidonoylethanolamine/anandamide; 2-AG, 2-arachidonoylglycerol; AA, arachidonic acid; 2-OG, 2-oleoylglycerol; NAE, N-acylethanolamines; AcG, acylglycerols; FAAH, Fatty Acid Amide Hydrolase; MAGL, Monoacylglycerol Lipase; NAPE, N-arachidonoylphos
Methylation and acetylation of 15-hydroxyanandamide modulate its interaction with the endocannabinoid system
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; Anandamide; 2-Arachidonoylglycerol; Fatty acid amide hydrolase; Natural inhibitorsAEA, anandamide; 2-AG, 2-arachidonoylglycerol; FAAH, fatty acid amide hydrolase; HAEAs, hydroxyanandamides; ECS, endocannabinoid system; AMT, anandamide membrane transport;
Validation and application of an LC–MS/MS method for quantitation of three fatty acid ethanolamides as biomarkers for fatty acid hydrolase inhibition in human plasma
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; AEA, arachidonyl ethanolamide; FAAH, fatty acid amide hydrolase; HPLC, high performance liquid chromatography; HQC, high QC; J&J, Johnson and Johnson; LC-MS/MS, liquid chromatography tandem mass spectrometry; LLE, liquid–liquid extraction; LLOQ, lower lim
Tuberoinfundibular peptide of 39 residues (TIP39) signaling modulates acute and tonic nociception
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; BLA, basolateral amygdaloid nucleus; CB1, cannabinoid receptor 1; FAAH, fatty acid amide hydrolase; HYWH, Histidine3-Tyrosine4-Tryptophan5-Histidine6-TIP39; icv, intracerebroventricular; ip, intraperitoneal; MPL, medial paralemniscal nucleus; PAG, periaqu
Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; FAAH, fatty acid amide hydrolase; Azetidine; Urea; Inhibitor;
Temporal changes in mouse brain fatty acid amide hydrolase activity
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; anandamide; endocannabinoid; FAAH; circadianAEA, anandamide; CB1R, cannabinoid receptor 1; EDTA, ethylenediaminetetraacetic acid; FAAH, fatty acid amide hydrolase; NAE, N-acylethanolamines; PAG, periaqueductal gray; PBST, phosphate-buffered saline+Tween;
N-acylethanolamines, anandamide and food intake
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; Acyl-S-CoA, acylated coenzyme A (thioester); CB1, cannabinoid receptor-1; FAAH, fatty acid amide hydrolase; FAAH-2, fatty acid amide hydrolase-2; FATP1, fatty acid transport protein 1; GDE1, glycerophospho diester phosphodiesterase-1; GP-NAE, glycerophosp
Biology of endocannabinoid synthesis system
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; Abh4, α/β-hydrolase 4; 2-AG, 2-arachidonoylglycerol; CB1 (or 2), cannabinoid receptor type 1 (or 2); DAGL, diacylglycerol lipase; FAAH, fatty acid amide hydrolase; GP-NAE, glycerophospho-NAE; LPS, lipopolysaccharide; MAGL, monoacylglycerol lipase; 1-mGluR
N-arachidonylglycine causes ROS production and cytochrome c release in liver mitochondria
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; AA, arachidonic acid; CCCP, carbonyl cyanide-3 chlorophenylhydrazone; CsA, cyclosporin A; DCFH, dichlorofluorescin; FFA, free fatty acids; FAAH, fatty acid amide hydrolase; MPT, mitochondrial permeability transition; MPTP, mitochondrial permeability trans
Effect of synthetic and natural phospholipids on N-acylphosphatidylethanolamine-hydrolyzing phospholipase D activity
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; AEA, N-arachidonoylethanolamine or anandamide; CB1, cannabinoid receptor type-1; FAAH, fatty acid amide hydrolase; GP-NAE, sn-glycero-3-phospho(N-acyl)ethanolamine; NAE, N-acylethanolamine; NAPE, N-acylated ethanolamine phospholipid; NAPE-PLD, NAPE-hydrol
Ontogenetic expression of the vanilloid receptors TRPV1 and TRPV2 in the rat retina
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; AMCA, aminomethylcoumarin; DAPI, diamidino-2-phenylindole; FAAH, fatty acid amide hydrolase; FITC, fluorescein isothiocyanate; GCL, ganglion cell layer; GFAP, glial fibrillary acidic protein; INL, inner nuclear layer; IPL, inner plexiform layer; NGF, nerv
The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; Endocannabinoid; N-Arachidonoylethanolamine; 2-Arachidonoylglycerol; Fatty acid amide hydrolase; Monoglyceride lipaseAEA, N-arachidonoylethanolamine, anandamide; 2-AG, 2-arachidonoylglycerol; FAAH, fatty acid amide hydrolase; MGL, monoglyceride lipase
Effect of social isolation on CB1 and D2 receptor and fatty acid amide hydrolase expression in rats
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; cannabinoid; social isolation; dopamine; fatty acid amide hydrolase; schizophreniaAEA, anandamide; FAAH, fatty acid amide hydrolase; HEK, human embryonic kidney; PBS, phosphate-buffered saline; PPI, prepulse inhibition; 2-AG, 2-arachidonylglycerol; Δ9-THC
Endocannabinoids, metabolic regulation, and the role of diet
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; AEA, N-arachidonoyl ethanolamine; 2-AG, 2-arachidonoylglycerol; FAAH, fatty acid amide hydrolase; TBI, traumatic brain injuryEndocannabinoids; Endocannabinoid receptors; Bone; Cardiovascular; Energy metabolism; Dietary fats; Metabolic regulation; Review
Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: Effect of high fat diets
Keywords: FAAH، اسید آمید هیدرولاز اسید چرب; AEA, arachidonoylethanolamide (anandamide); 2-AG, 2-arachidonoylglycerol; CB1, cannabinoid receptor type 1; CB2, cannabinoid receptor type 2; DAGL, diacylglycerol lipase; EC, endocannabinoid; FAAH, fatty acid amide hydrolase; HFD, high fat diet; STD, stan