Synergistic immunomopharmacological effects of N-alkylamides in Echinacea purpurea herbal extracts
Keywords: Echinacea; Herbal medicines; FAAH; Anandamide; N-alkylamides; Synergism
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TRPV1 channels facilitate glutamate transmission in the striatum
Keywords: Anandamide; Capsaicin; EPSC; FAAH; IPSC; Protein kinase C; TRPV1
The biosynthesis of N-arachidonoyl dopamine (NADA), a putative endocannabinoid and endovanilloid, via conjugation of arachidonic acid with dopamine
Keywords: NADA; Dopamine; TH; FAAH; BiosynthesisNADA, N-arachidonoyl dopamine; NA-tyrosine, N-arachidonoyl tyrosine; NA-DOPA, N-arachidonoyl-l-DOPA; NAGly, N-arachidonoyl glycine; AM404, N-arachidonoyl phenolamine; TH, tyrosine hydroxylase; AADC, l-amino acid decar
A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity
Keywords: 1,2-Diamines; Endocannabinoids; Fatty acid amide hydrolase; FAAH; Inhibitor; Monoacyglycerol lipase; MGL
Endocannabinoids affect the reproductive functions in teleosts and amphibians
Keywords: CB1; FAAH; GnRH-I; Double IFL; Immunohistochemistry;
Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH)
Keywords: FAAH; Fatty acid amide hydrolase; Pain; Endocannabinoid
Type-1 cannabinoid receptors colocalize with caveolin-1 in neuronal cells
Keywords: Caveolin; Cholesterol; Endocannabinoids; G protein-coupled receptors; Lipid rafts; Neurodegeneration; Signal transduction; Trafficking; AEA; anandamide (arachidonoylethanolamide); 2-AG; 2-arachidonoylglycerol; CAV1; caveolin-1; CB1/2R; type 1/2 cannabinoi
Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase
Keywords: FAAH; Fatty acid amide hydrolase; Anandamide; Time dependant inhibition; Urea; Piperazine; Thiadiazole; Lipid; CB1; CB2
Glial expression of cannabinoid CB2 receptors and fatty acid amide hydrolase are beta amyloid-linked events in Down's syndrome
Keywords: cannabinoids; inflammation; amyloid; immunohistochemistry; AA; arachidonic acid; Aβ; β-amyloid; AD; Alzheimer's disease; AEA; arachidonoylethanolamide (anandamide); DS; Down's syndrome; ECS; endocannabinoid system; FAAH; fatty acid amide hydrolase;
Fatty acid amide hydrolase inhibition enhances the anti-allodynic actions of endocannabinoids in a model of acute pain adapted for the mouse
Keywords: fatty acid amide hydrolase; FAAH; endocannabinoid; allodynia; nociception; thermal injuryAEA, N-arachidonylethanolamide (anandamide); CB-1, cannabinoid-1 receptor; CB-2, cannabinoid-2 receptor; CDEX, 2-hydroxypropyl-β-cyclodextrin; FAAH, fatty acid amide
Regional distribution and effects of postmortal delay on endocannabinoid content of the human brain
Keywords: anandamide; 2-arachidonoylglycerol; brain microdissection; neurosurgical dissections; AEA; anandamide; FAAH; fatty acid amide hydrolase; MGL; monoacylglyceride lipase; 2-AG; 2-arachidonoylglycerol;
Fatty Acid Amide Hydrolase Inhibition Heightens Anandamide Signaling Without Producing Reinforcing Effects in Primates
Keywords: Anandamide; FAAH; reinstatement; self-administration; URB597; 2-arachidonoylglycerol
Regulation of endocannabinoid signaling by stress: Implications for stress-related affective disorders
Keywords: Cannabinoid; Anandamide; 2-AG; FAAH; Stress; Hypothalamus; Depression; Antidepressant; Habituation; Prefrontal cortex; Adaptation
A diacylglycerol lipase-CB2 cannabinoid pathway regulates adult subventricular zone neurogenesis in an age-dependent manner
Keywords: Neurogenesis; Diacylglycerol lipase; 2-arachidonlyglycerol; Endocannabinoid; CB1; CB2; Fatty acid amide hydrolase; FAAH
The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition
Keywords: Endogenous cannabinoids; Anandamide; FAAH; URB597; WIN 55,212-2; Conditioned place preferences; Anxiety; Locomotor activity; Rats;
Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH)
Keywords: Carboxylesterase; Esterase; Fatty acid amide hydrolase; FAAH; Trifluoromethyl ketone; TFK; Inhibitor; Kinetics; Sulfur; Benzil; Ab initio calculations; Intramolecular hydrogen bond
Novel inhibitors of fatty acid amide hydrolase
Keywords: Fatty acid amide hydrolase; FAAH; Enzyme; Inhibitor; Bisarylimidazole; Pain; SR141716A; Anandamide; Hargreaves test; Chung model; Formalin test; Persistent; Neuropathic; Antineuropathic; Gabapentin; Morphine; Cannabinoid receptor
The expression of receptors for endocannabinoids in human and rodent skeletal muscle
Keywords: CB1; CB2; TRPV1; FAAH; Skeletal muscle; RT-PCR
Inhibition of microglial fatty acid amide hydrolase modulates LPS stimulated release of inflammatory mediators
Keywords: FAAH; Fatty acid amide hydrolase; Fatty acid amide; Endocannabinoid; Microglia; Cannabinoid receptor; iNOS; Nitric oxide; Cyclo-oxygenase 2; Prostaglandin E2; TNF; URB597
Antidepressant-like Activity of the Fatty Acid Amide Hydrolase Inhibitor URB597 in a Rat Model of Chronic Mild Stress
Keywords: Anandamide; chronic mild stress; depression; FAAH; URB597
Dysregulation of the endogenous cannabinoid system in adult rats prenatally treated with the cannabinoid agonist WIN 55,212-2
Keywords: Prenatal; Cannabinoid CB1 receptor; GTPγS binding; [3H]CP 55,940 binding; Endocannabinoid; Anandamide; FAAH; NAPE-PLD
Severe deficiency of the fatty acid amide hydrolase (FAAH) activity segregates with the Huntington's disease mutation in peripheral lymphocytes
Keywords: Endocannabinoid; Enzyme inhibition; FAAH; Huntington's disease; Lymphocyte;
Development of highly sensitive fluorescent assays for fatty acid amide hydrolase
Keywords: FAAH; Aminopyridines; Fluorescence; Sensitivity; Quantum yields; Substrates
Rapid screening for potentially relevant polymorphisms in the human fatty acid amide hydrolase gene using Pyrosequencing™
Keywords: FAAH; Single nucleotide polymorphism (SNP); Pyrosequencing™ assays
Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets
Keywords: FAAH; Inhibitor; ABPP; MudPIT; Carboxylesterase
Binding mode of new (thio)hydantoin inhibitors of fatty acid amide hydrolase: Comparison with two original compounds, OL-92 and JP104
Keywords: FAAH; Molecular modeling; (thio)Hydantoin; Crystallography; Binding mode
Role of the basolateral nucleus of the amygdala in endocannabinoid-mediated stress-induced analgesia
Keywords: 2-AG; Anandamide; Antinociception; FAAH; MGL; Periaqueductal gray
Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice
Keywords: AChE; acetylcholinesterase; 2-AG; 2-arachidonoylglycerol; BDPO; benzodioxaphosphorin oxide; CB1; cannabinoid receptor; CPO; chlorpyrifos oxon; DFP; diisopropyl fluorophosphate; DMSO; dimethyl sulfoxide; EOPF; ethyl octylphosphonofluoridate; FAAH; fatty ac
A role for vanilloid receptor 1 (TRPV1) and endocannabinnoid signalling in the regulation of spontaneous and L-DOPA induced locomotion in normal and reserpine-treated rats
Keywords: Dopamine; Cannabinoids; FAAH; AMT; Parkinson's disease; Basal ganglia
Increased ethanol consumption and preference and decreased ethanol sensitivity in female FAAH knockout mice
Keywords: FAAH; Knockout mice; CB1 receptors; Limbic forebrain; Ethanol-drinking behavior; Sensitivity; Endocannabinoids
Further Insights into the Regulation of Human FAAH by Progesterone and Leptin
Keywords: Anandamide; Apoptosis; FAAH; Immune cells; Leptin; Neuroimmune axis; Neurons; Progesterone;
CB1 receptor knockout mice show similar behavioral modifications to wild-type mice when enkephalin catabolism is inhibited
Keywords: CMS; chronic unpredictable mild stress; FAAH; fatty acid amide hydrolase; RB101; {N-[(R,S)-2-benzyl-3[(S)(2-amino-4-methyl-thio)-butyldithio]-1-oxo-propyl]-l-phenyl-alanine benzyl ester}; THC; delta-9-tetrahydrocannabinol; Neural basis of behavior; Neurop
Involvement of the cannabimimetic compound, N-palmitoyl-ethanolamine, in inflammatory and neuropathic conditions: Review of the available pre-clinical data, and first human studies
Keywords: Cannabinoid; Vanilloid; Receptor; FAAH; Entourage; Pain; Inflammation; NAE; N-acyl-ethanolamine; PEA; N-palmitoyl-ethanolamine; OEA; N-oleoyl-ethanolamine; SEA; N-stearoyl-ethanolamine; AEA; N-arachidonoyl-ethanolamine; FAAH; fatty acid amide hydrolase; T
Fatty Acid Amide Hydrolase Controls Mouse Intestinal Motility In Vivo
Keywords: 2-AG; 2-arachidonylglycerol; AA-5-HT; N-arachidonoylserotonin; DMSO; dimethyl sulfoxide; FAAH; fatty acid amide hydrolase; I-RTX; 5'-iodoresiniferatoxin; PEA; palmitoylethanolamide; PIP; palmitoylisopropylamide; RT-PCR; reverse-transcription polymerase
Cisplatin increases brain 2-arachidonoylglycerol (2-AG) and concomitantly reduces intestinal 2-AG and anandamide levels in the least shrew
Keywords: Cisplatin; Emesis; 2-AG; Anandamide; Brain; Intestine; AA-5-HT; URB597; OMDM1; VDM11; Uptake inhibitor; FAAH inhibitor; 2-AG; 2-arachidonoylglycerol; AA; arachidonic acid; AA-5-HT; arachidonoylserotonin; PG; prostaglandin; FAAH; fatty acid amide hydrolase
Redistribution of CB1 cannabinoid receptors during evolution of cholinergic basal forebrain territories and their cortical projection areas: A comparison between the gray mouse lemur (Microcebus murinus, primates) and rat
Keywords: endocannabinoid; cholinergic system; mapping; primate; BSA; bovine serum albumin; CB1R; CB1 cannabinoid receptor; CCK; cholecystokinin-8; ChAT; choline-acetyltransferase; Cy; carbocyanine; FAAH; fatty-acid amide hydrolase; ir; immunoreactive; L; layer; NC
Differential Expression of Cannabinoid Receptors in the Human Colon: Cannabinoids Promote Epithelial Wound Healing
Keywords: AEA; anandamide; DNBS; dinitrobenzene sulphonic acid; ERK; extracellular-regulated kinase; FAAH; fatty acid amide hydrolase; GSK; glycogen synthase kinase; LPA; lysophosphatidic acid; MAPK; mitogen-activated protein kinase; NE; noladin ether; PI3K; phosph
Anandamide transport: A critical review
Keywords: Anandamide; BSA; Diffusion; Transport; Uptake; FAAH;