Keywords: فارسیل پیرو فسفات سنتاز; FPPS; farnesyl pyrophosphate synthase; MIR; myocardial ischemia/reperfusion; HR; hyproxia/reoxygenation; ROS; reactive oxygen species; FPP; arnesyl pyrophosphate; GGPP; geranylgeranyl pyrophosphate; SHR; spontaneously hypertensive rats; DMEM; Dulbecco's m
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Keywords: فارسیل پیرو فسفات سنتاز; W. somnifera; Withanolides; Bioreactor; P. indica; Cell suspension cultures; CAS; Cycloaretenol synthase; DW; Dry weight; DXS; 1-deoxy-d-xylulose 5-phosphate synthase; DXR; 1-deoxy-d-xylulose 5-phosphate reductoisomerase; FPPS; Farnesyl pyrophosphate sy
Keywords: فارسیل پیرو فسفات سنتاز; 2-DE; two-dimensional gel electrophoresis; ECL; enhanced chemiluminescence; FBS; fetal bovine serum; FPPS; farnesyl pyrophosphate synthase; IPP; isopentyl diphosphate; LC; liquid chromatography; MALDI-ToF; matrix-assisted laser desorption/ionization-time
Keywords: فارسیل پیرو فسفات سنتاز; FPP; farnesyl pyrophosphate; FPPS; farnesyl pyrophosphate synthase; GPP; geranyl diphosphate; HMG-CoA reductase; 3-hydroxy-3-methylglutaryl-CoA reductase; IPP; isopentenyl diphosphate; MDD; mevalonate 5-diphosphate decarboxylase, also known as mevalonate
Keywords: فارسیل پیرو فسفات سنتاز; ALP; alkaline phosphatase; BP; bisphosphonate; FPPS; farnesyl pyrophosphate synthase; Irf8; interferon regulatory factor 8; MafB; V-maf musculoaponeurotic fibrosarcoma oncogene homolog B; MFI; median fluorescence intensity; ONJ; osteonecrosis of the jaw;
Integrated metabolomic and transcriptomic analyses revealed the distribution of saponins in Panax notoginseng
Keywords: فارسیل پیرو فسفات سنتاز; AACT; acetoacetyl-CoA acyltransferase; DS; dammarenediol-II synthase; DXPS; 1-deoxy-d-xylulose 5-phosphate synthase; DXPR; 1-deoxy-d-xylulose 5-phosphate reductoisomerase; FPS; farnesyl pyrophosphate synthase; FPP; farnesyl diphosphate; GDPS; gerenyl diph
The MEK5/ERK5 mitogen-activated protein kinase cascade is an effector pathway of bone-sustaining bisphosphonates that regulates osteogenic differentiation and mineralization
Keywords: فارسیل پیرو فسفات سنتاز; ANOVA; analysis of variance; ANT; adenine-nucleotide-translocase; ALPL; alkaline phosphatase; Apppl; ATP analogue triphosphoric acid-1-adenosine-5â²yl ester 3-(3-methylbut-3-enyl) ester; BP; bisphosphonate; EC; endothelial cell; eNOS; endothelial nitric
Longitudinal expression patterns of HMGR, FPS, SS, SE and DS and their correlations with saponin contents in green-purple transitional aerial stems of Panax notoginseng
Keywords: فارسیل پیرو فسفات سنتاز; ANOVA; analysis of variance; Ct; cycle threshold value; CYP450; cytochrome P450; DS; dammarenediol synthase gene; DS; dammarenediol synthase; FPS; farnesyl pyrophosphate synthase gene; FPS; farnesyl pyrophosphate synthase; GAPDH; glyceraldehyde phosphate
Isoprenoids and tau pathology in sporadic Alzheimer's disease
Keywords: فارسیل پیرو فسفات سنتاز; Mevalonate pathway; Isoprenoids; Alzheimer's disease; Tau phosphorylation; Farnesyl pyrophosphate synthase; Geranylgeranyl pyrophosphate synthase;
Floral scent: Regulation and role of MYB transcription factors
Keywords: فارسیل پیرو فسفات سنتاز; ACP; acyl-acyl carrier protein; AOS; allege oxide synthase; DMAPP; dimethyl allyl diphosphate; FPP; farnesyl pyrophosphate; FPPS; farnesyl pyrophosphate synthase; GPP; geranyl diphosphate; GGPP; geranylgeranyl diphosphate farnesyl diphosphate; IPP; isop
Molecular characterization and expression analysis of two farnesyl pyrophosphate synthase genes involved in rubber biosynthesis in Hevea brasiliensis
Keywords: فارسیل پیرو فسفات سنتاز; Hevea brasiliensis; Latex; Farnesyl pyrophosphate synthase; Bark tapping; Ethephon; Methyl jasmonate; Tapping panel dryness;
Upregulation of the mevalonate pathway by cholesterol depletion abolishes tolerance to N-bisphosphonate induced Vγ9Vδ2 T cell cytotoxicity in PC-3 prostate cancer cells
Keywords: فارسیل پیرو فسفات سنتاز; ApppI; triphosphoric acid 1-adenosin-5â²-yl ester 3-(3-methylbut-3-enyl) ester; ECL; enhanced chemiluminescence; FPPS; farnesyl pyrophosphate synthase; FOH; farnesol; GGOH; geranylgraniol; HMGR; 3-hydroxy-3-methylglutaryl coenzyme A reductase; HPLC-ESI
The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants
Keywords: فارسیل پیرو فسفات سنتاز; DMAPP; dimethylallyl pyrophosphate; FPP; farnesyl pyrophosphate; FPPS; farnesyl pyrophosphate synthase; GPP; geranyl pyrophosphate; IPP; isopentenyl pyrophosphate; N-BP; nitrogen-containing bisphosphonates; TCEP; tris(2-carboxyethyl)phosphine; RIS; Risedr
New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase
Keywords: فارسیل پیرو فسفات سنتاز; Farnesyl pyrophosphate synthase; Trypanosoma cruzi; Toxoplasma gondii; Bisphosphonates; Antiparasitic agents;
Farsenyl pyrophosphate synthase is a potential molecular drug target of risedronate in Babesia bovis
Keywords: فارسیل پیرو فسفات سنتاز; Babesia bovis; Risedronate; Farnesyl pyrophosphate synthase
Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced cardiac hypertrophy and fibrosis in vivo
Keywords: فارسیل پیرو فسفات سنتاز; Farnesyl pyrophosphate synthase; Alendronate; Angiotensin II; RhoA; Cardiac hypertrophy
Discovery of thienopyrimidine-based inhibitors of the human farnesyl pyrophosphate synthase—Parallel synthesis of analogs via a trimethylsilyl ylidene intermediate
Keywords: فارسیل پیرو فسفات سنتاز; Thienopyrimidine bisphosphonates; Modified Gewald synthesis; 2-(1-(Trimethylsilyl)ethylidene)malononitrile; Farnesyl pyrophosphate synthase
Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site 'capping' phenyls
Keywords: فارسیل پیرو فسفات سنتاز; Nitrogen-containing bisphosphonates; Farnesyl pyrophosphate synthase;
RNA therapeutics targeting osteoclast-mediated excessive bone resorption
Keywords: فارسیل پیرو فسفات سنتاز; 3BP2; c-Abl SH3 domain-binding protein-2; ADAM; a disintegrin and metalloproteinases; Ago; Argonaute; AP-1; activator protein-1; Ckb; brain-type creatine kinase; CNV; choroidal neovascularization; CPA; cation-proton antiporter; CPC; calcium phosphate bone
Bisphosphonates in preclinical bone oncology
Keywords: فارسیل پیرو فسفات سنتاز; ZOL; zoledronic acid; IPP; isopentenyl pyrophosphate; ApppI; triphosphoric acid I-adenosine-5â²-yl ester 3-[3-methylbut-3-enyl] ester; FPPS; farnesyl pyrophosphate synthase; NBP; nitrogen-containing bisphosphonate; PBMC; peripheral blood mononuclear cell
Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells
Keywords: فارسیل پیرو فسفات سنتاز; ApppI; triphosphoric acid 1-adenosin-5â²-yl ester 3-(3-methylbut-3-enyl) ester; DMAPP; dimethylallyl pyrophosphate; ESI; electrospray ionization; FPPS; farnesyl pyrophosphate synthase; IPP; isopentenyl pyrophosphate; HPLC; high-performance liquid chromat
Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase
Keywords: فارسیل پیرو فسفات سنتاز; Trypanosoma cruzi; Chagas’ disease; Farnesyl pyrophosphate synthase; Toxoplasma gondii; Toxoplasmosis
Molecular cloning and expression of Chimonanthus praecox farnesyl pyrophosphate synthase gene and its possible involvement in the biosynthesis of floral volatile sesquiterpenoids
Keywords: فارسیل پیرو فسفات سنتاز; Farnesyl pyrophosphate synthase; Heterologous expression; Sesquiterpenoid biosynthesis; WintersweetCLD, chain length determination; DMAPP, dimethylallyl pyrophosphate; FARM, first Asp-rich motif; FPP, farnesyl pyrophosphate; GC–MS, gas chromatography–mass
Chronic inhibition of farnesyl pyrophosphate synthase improves endothelial function in spontaneously hypertensive rats
Keywords: فارسیل پیرو فسفات سنتاز; Farnesyl pyrophosphate synthase; Alendronate; Endothelium function; Endothelial nitric oxide synthase; Spontaneously hypertensive rat
Rho GTPase signaling and PTH 3-34, but not PTH 1-34, maintain the actin cytoskeleton and antagonize bisphosphonate effects in mouse osteoblastic MC3T3-E1 cells
Keywords: فارسیل پیرو فسفات سنتاز; CA RhoA; Constitutively active RhoA; FPP; Farnesyl pyrophosphate; FPP Synthase; Farnesyl pyrophosphate synthase; GG; Geranylgeranyl group; GGOH; Geranylgeraniol; GGPP; Geranylgeranyl pyrophosphate; GGTase I; Geranylgeranyl transferase I; GGTI-2166; Gerany
New insights into the molecular actions of plant sterols and stanols in cholesterol metabolism
Keywords: فارسیل پیرو فسفات سنتاز; ACAT; acyl-CoA:cholesterol acyltransferase; ABC; adenosine triphosphate-binding cassette transporter; ANXA2-CAV1; annexin 2/caveolin 1; apo; apolipoprotein; CVD; cardiovascular disease; CYP7A1; cytochrome P450 family 7 subfamily A polypeptide 1; FPPS; f
Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase
Keywords: فارسیل پیرو فسفات سنتاز; Bisphosphonate; Geranylgeranyl pyrophosphate synthase; Farnesyl pyrophosphate synthase; Isoprenoid; Mevalonate; Prenylation; Ras; Zoledronate; Digeranyl bisphosphonate
Characterization of the farnesyl pyrophosphate synthase of Trypanosoma cruzi by homology modeling and molecular dynamics
Keywords: فارسیل پیرو فسفات سنتاز; Chagas’ disease; Homology modeling; Molecular dynamics; Bisphosphonates; Farnesyl pyrophosphate synthase
Synthesis and biological evaluation of 1-amino-1,1-bisphosphonates derived from fatty acids against Trypanosoma cruzi targeting farnesyl pyrophosphate synthase
Keywords: فارسیل پیرو فسفات سنتاز; Chagas’ disease; Trypanosoma cruzi; Bisphosphonates; Farnesyl pyrophosphate synthase