Keywords: FAS، اسید چرب سنتاز; ABCA1, ATP-binding cassette transporter 1; FAS, fatty acid synthase; HDL, high-density lipoprotein; LDL, low-density lipoprotein; LDLR, low-density lipoprotein receptor; LXR and LXRα, liver X receptor and liver X receptor α; LV, left ventricular; LVEF, le
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Keywords: FAS، اسید چرب سنتاز; MLE, mulberry leaf extract; MLPE, mulberry leaf polyphenolic extract; HFD, high-fat diet; HPLC, high-performance liquid chromatography; NAFLD, non-alcoholic fatty liver disease; FAS, fatty acid synthase; SREBPs, sterol regulatory element binding proteins;
Keywords: FAS، اسید چرب سنتاز; hepatocellular carcinoma; fat diet; IGF; celecoxibAFP, alpha-fetoprotein; CCl4, carbon-tetrachloride; COX-2, cyclooxygenase 2; FAS, fatty acid synthase; FFA, free fatty acid; GH, growth hormone; H&E, Hematoxylin and Eosin stain; HCC, hepatocellular carcin
Keywords: FAS، اسید چرب سنتاز; ATGL, adipose triglyceride lipase; CPT1, carnitine palmitoyltransferase-1; EF1α, elongation factor 1α; FAS, fatty acid synthase; FATP1, fatty acid transporter-1; GHS-R1a, growth hormone secretagogue receptor 1a, ghrelin receptor; GAPDH, glyceraldehyde 3-p
Keywords: FAS، اسید چرب سنتاز; NAFLD, non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis; FGF21, fibroblast growth factor 21; SREBP-1c, sterol regulatory element-binding protein-1c; ACC, acetyl-CoA carboxylase; FAS, fatty acid synthase; SCD1, stearoyl-CoA desaturase
Keywords: FAS، اسید چرب سنتاز; ASC, Adipose-derived stem cells; BAT, Brown adipose tissue; BMI, Body mass index; bHLH, Basic helix–loop–helix; DNA, Deoxyribonucleic acid; DIO, Diet induced obesity; FAS, Fatty acid synthase; FFA, Free fatty acid; GWAS, Genome wide association study; HFD
Keywords: FAS، اسید چرب سنتاز; Prebiotic fiber; Gut microbiota; Obesity; Lipid metabolism; Cholesterol; RatAMPK, AMP-activated protein kinase; C, control; CYP, cholesterol 7-α-hydroxylase; DXA, dual energy x-ray absorptiometry; FAS, fatty acid synthase; HF, high prebiotic fiber; HFHS,
Keywords: FAS، اسید چرب سنتاز; ACC, acetyl CoA carboxylase; ADFI, average daily feed intake; ADG, average daily gain; AO, animal fat; BW, body weight; CP, crude protein; DM, dry matter; FAS, fatty acid synthase; G:F, gain to feed ratio; GE, gross energy; HSL, hormone sensitive lipase;
Keywords: FAS، اسید چرب سنتاز; HIP, haploinsufficiency profiling; HOP, homozygous profiling; MoA, mechanism of action; FAS, fatty acid synthase; Cmpd, compoundChemogenomic profiling; Target identification; Mechanism of action; Yeast; HIP HOP profiling
Keywords: FAS، اسید چرب سنتاز; AKT, protein kinase B; AMPKα, AMP-activated protein kinase-α; ACC, acetyl-CoA carboxylase; ATGL, adipose triglyceride lipase; C/EBPα, CCAAT/enhancer-binding protein α; FAS, fatty acid synthase; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; GLUT 4, gluc
Keywords: FAS، اسید چرب سنتاز; KASIII, 3-Ketoacyl-ACP-Synthase III; HBFA, ω-1 Hydroxy Branched Fatty Acid; FAS, Fatty Acid Synthase; PHB, Polyhydroxybutyrate3-Ketoacyl-ACP Synthase III; Fatty acid synthesis; Bio-based chemicals; Omega-functionalized fatty acids; Substrate diversity; Mi
A trans10-18:1 enriched fraction from beef fed a barley grain-based diet induces lipogenic gene expression and reduces viability of HepG2 cells
Keywords: FAS، اسید چرب سنتاز; ACC, acetyl-CoA carboxylase; Ag+-SPE, silver ion solid phase extraction; BSA, bovine serum albumin; c,, cis; FAS, fatty acid synthase; HMGCR, 3-Hydroxy-3-Methylglutaryl-CoA reductase; HT10, high-t10 fraction; HT11, high-t11 fraction; MUFA, monounsaturated
AMPK is involved in the differential neonatal performance of chicks hatching at different time
Keywords: FAS، اسید چرب سنتاز; ACC, acetyl-CoA carboxylase; AgRP, agouti-related peptide; AMPK, AMP-activated protein kinase; CRH, corticotropin-releasing hormone; GS, glycogen synthase; HIF1α, hypoxia-inducible factor 1-alpha; FAS, fatty acid synthase; FTO, fat mass and obesity-associ
Andrographolide inhibits adipogenesis of 3T3-L1 cells by suppressing C/EBPβ expression and activation
Keywords: FAS، اسید چرب سنتاز; CDK, cyclin-dependent kinase; CREB, cAMP response element-binding protein; C/EBP, CCAAT/enhancer-binding protein; EMSA, electrophoretic mobility shift assay; ERK, extracellular signal-regulated kinases; FAS, fatty acid synthase; GSK, glycogen synthase kin
Anti-obesity effect of Crinum asiaticum var. japonicum Baker extract in high-fat diet-induced and monogenic obese mice
Keywords: FAS، اسید چرب سنتاز; CAE, Crinum asiaticum var. japonicum Baker extract; aP2, adipocyte protein 2; ACC, acetyl CoA carboxylase; C/EBP, CCAAT/enhancer binding protein; FAS, fatty acid synthase; HDL-C, high density lipoprotein-cholesterol; HMGCR, 3-hydroxy-3-methyl-glutaryl-CoA
Defatted safflower seed extract inhibits adipogenesis in 3T3-L1 preadipocytes and improves lipid profiles in C57BL/6J ob/ob mice fed a high-fat diet
Keywords: FAS، اسید چرب سنتاز; ACS, acetyl-CoA synthetase; AMPK, adenosine monophosphate–activated protein kinase; BrdU, bromodeoxyuridine; CSE, defatted safflower (Cathamus tinctorius L.) seed ethanol extract; FABP4, fatty acid binding protein 4; FAS, fatty acid synthase; FATP1, fatty
Ameliorative potential of gingerol: Promising modulation of inflammatory factors and lipid marker enzymes expressions in HFD induced obesity in rats
Keywords: FAS، اسید چرب سنتاز; Antiobesity effect; Gingerol; Ginger; High-fat diet; InsulinHDL, High - Density Lipoprotein; HFD, High-Fat Diet; FAS, Fatty Acid Synthase; ACC, Acetyl Co-A Carboxylase; CPT-1, Carnitine Palmitoyl Transferase-1; HMGR, HMG coA reductase; LCAT, Lecithin Chol
Resistant starch-rich wx/ae brown rice prevents insulin resistance and hypertriglyceridaemia in type 2 diabetic NSY mice
Keywords: FAS، اسید چرب سنتاز; wx/ae rice; Resistant starch; Insulin resistance; Hypertriglyceridaemia; Type 2 diabetesALT, alanine aminotransferase; ANOVA, analysis of variance; AST, aspartate aminotransferase; CYP, cytochrome P450; DS, digestible starch; FAS, fatty acid synthase; FXR
Astaxanthin reduces hepatic lipid accumulations in high-fat-fed C57BL/6J mice via activation of peroxisome proliferator-activated receptor (PPAR) alpha and inhibition of PPAR gamma and Akt
Keywords: FAS، اسید چرب سنتاز; ACC1, acetyl-CoA carboxylase 1; ACOX1, acyl-CoA oxidase 1; Akt, protein kinase B; AX, astaxanthin; CPT1, carnitine palmitoyltransferase 1; FAS, fatty acid synthase; FPLC, fast protein liquid chromatography; GSK-3, glycogen synthase kinase-3; HFD, high-fat
Endoplasmic reticulum stress and dysregulation of calcium homeostasis mediate Cu-induced alteration in hepatic lipid metabolism of javelin goby Synechogobius hasta
Keywords: FAS، اسید چرب سنتاز; ACC, acetyl-CoA carboxylase; ATF6, activating transcription factor 6; 2-APB, 2-aminoethyldiphenyl borate; CRT, calreticulin; DMSO, dimethyl sulfoxide; eIF2α, eukaryotic translation initiation factor 2 alpha; FAS, fatty acid synthase; FBS, fetal bovine ser
The Nutrient-Dependent O-GlcNAc Modification Controls the Expression of Liver Fatty Acid Synthase
Keywords: FAS، اسید چرب سنتاز; HCD, high-carbohydrate diet; FAS, fatty acid synthase; HBP, hexosamine biosynthesis pathway; PTM, post-translational modification; OGT, O-GlcNAc transferase; OGA, O-GlcNAcase; ChREBP, carbohydrate responsive element-binding protein; LXR, liver X receptor;
Triiodothyronine enhances accumulation of intracellular lipids in adipocytes through thyroid hormone receptor α via direct and indirect mechanisms
Keywords: FAS، اسید چرب سنتاز; T3; TRα; FAS; SREBP-1c; HSL; 3T3-L1PPARγ, peroxisome proliferator-activated receptor γ; C/EBP, CCAAT/enhancer binding protein; SREBP, sterol regulatory element-binding protein; ACC, acetyl-CoA carboxylase; FAS, fatty acid synthase; TG, triglyceride; ATGL,
MicroRNAs and oncogenic transcriptional regulatory networks controlling metabolic reprogramming in cancers
Keywords: FAS، اسید چرب سنتاز; ACC, acetyl-CoA carboxylase; ACL, ATP-citrate lyase; BRCA1, breast cancer type 1 susceptibility protein; c-MYC, V-myc avian myelocytomatosis viral oncogene homolog; FAS, fatty acid synthase; FH, fumarate hydratase; G6PD, glucose-6-phosphate dehydrogenase;
Irisin ameliorates hepatic glucose/lipid metabolism and enhances cell survival in insulin-resistant human HepG2 cells through adenosine monophosphate-activated protein kinase signaling
Keywords: FAS، اسید چرب سنتاز; ACC, acetyl-CoA-carboxylase; AMPK, adenosine monophosphate-activated protein kinase; BrdU, bromodeoxyuridine; CaMKKβ, Ca2+/calmodulin-dependent protein kinase kinase β; ERK, extracellular signal-regulated kinase; FAS, fatty acid synthase; FNDC5, fibronect
Anti-lipidaemic and anti-inflammatory effect of açai (Euterpe oleracea Martius) polyphenols on 3T3-L1 adipocytes
Keywords: FAS، اسید چرب سنتاز; aP2, adipocyte fatty acid-binding protein 2; C/ebp, CCAAT/enhancer-binding protein; DCFH-DA, 2,7-dichlorofluorescein diacetate; DMSO, dimethyl sulphoxide; FAS, fatty acid synthase; FATP1, fatty acid transport proteins; FBS, foetal bovine serum; H2O2, hydr
JAK and STAT members of yellow catfish Pelteobagrus fulvidraco and their roles in leptin affecting lipid metabolism
Keywords: FAS، اسید چرب سنتاز; ACC, acetyl-CoA carboxylase; B2M, beta-2-microglobulin; CPT I, carnitine palmitoyl transferase I; FAS, fatty acid synthase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; HPRT, hypoxanthine-guanine phosphoribosyl transferase; HSL, hormone-sensitive lipa
New insights into the posttranslational regulation of human cytosolic thioredoxin by S-palmitoylation
Keywords: FAS، اسید چرب سنتاز; Posttranslational modification; Thioredoxin; PTP1B; S-palmitoylation; InsulinACSL, long-chain acyl-CoA synthetase; 2-BP, 2-bromopalmitate; FAS, fatty acid synthase; Gluc-N, glucosamine; GSNO, S-nitroso-glutathione; HAM, hydroxylamine; pNPP, para-Nitrophen
Dietary methimazole-induced hypothyroidism reduces hepatic lipid deposition by down-regulating lipogenesis and up-regulating lipolysis in Pelteobagrus fulvidraco
Keywords: FAS، اسید چرب سنتاز; ACC, acetyl-CoA carboxylase; CPT 1, carnitine palmitoyltransferase 1; CF, condition factor; FAS, fatty acid synthase; FCR, feed conversion rate; G6PD, glucose 6-phosphate dehydrogenase; HSI, hepatosomatic index; HSL, hormone-sensitive lipase; ICDH, isocit
Fermented soy bean extract suppresses differentiation of 3T3-L1 preadipocytes and facilitates its glucose utilization
Keywords: FAS، اسید چرب سنتاز; ACC, acetyl-CoA carboxylase; AP2, activating protein 2; BTD-1, soy bean extract fermented by Bacillus subtilis MORI; CPT I, carnitine palmitoyltransferase I; C/EBPα, CCAAT element binding protein α; DNJ, 1-deoxynorigimycin; FAS, fatty acid synthase; GLUT4
ChREBP and LXRα mediate synergistically lipogenesis induced by glucose in porcine adipocytes
Keywords: FAS، اسید چرب سنتاز; ChREBP, carbohydrate response element binding protein; ChoRE, carbohydrate response element; LXRs, liver X receptors; LXRα, liver X receptor alpha; SREBP-1c, sterol regulatory element-binding protein 1c; FAS, fatty acid synthase; ACC1, acetyl-CoA carboxyl
Anti-adipogenic effect of erucin in early stage of adipogenesis by regulating Ras activity in 3T3-L1 preadipocytes
Keywords: FAS، اسید چرب سنتاز; AMPK, AMP-activated protein kinase; BCS, bovine calf serum; C/EBP, CCAAT/enhancer-binding protein; ERK, extracellular signal-regulated kinase; FACS, fluorescence activated cell sorting; FAS, fatty acid synthase; FBS, fetal bovine serum; GSK3β, glycogen sy
Upregulation of miR-125b by estrogen protects against non-alcoholic fatty liver in female mice
Keywords: FAS، اسید چرب سنتاز; NAFLD, non-alcoholic fatty liver disease; ChIP, chromatin immunoprecipitation; HFD, high-fat diet; ALT, alanine aminotransferase; AST, aspartate aminotransferase; FFA, free fatty acid; FAS, fatty acid synthase; SCD1, stearoyl coenzyme A desaturase 1; SREB
A dipeptidyl peptidase-IV inhibitor improves hepatic steatosis and insulin resistance by AMPK-dependent and JNK-dependent inhibition of LECT2 expression
Keywords: FAS، اسید چرب سنتاز; ACC, acetyl-CoA carboxylase; DM, diabetes mellitus; DPP4, dipeptidyl peptidase-4; FAS, fatty acid synthase; FFA, free fatty acids; GLP-1, glucagon-like peptide; JNK, c-Jun N-terminal kinase; LECT2, leukocyte cell-derived chemotaxin 2; LPS, lipopolysacchar
Differential effects of dietary copper deficiency and excess on lipid metabolism in yellow catfish Pelteobagrus fulvidraco
Keywords: FAS، اسید چرب سنتاز; ACC, acetyl-CoA carboxylase; ATGL, adipose triacylglyceride lipase; CF, condition factor; Cu, copper; FAS, fatty acid synthase; FBW, final mean body weight; G6PD, glucose 6-phosphate dehydrogenase; HSI, hepatosomatic index; HSL, hormone-sensitive lipase;
Possible involvement of glucocorticoids in 5α-dihydrotestosterone-induced PCOS-like metabolic disturbances in the rat visceral adipose tissue
Keywords: FAS، اسید چرب سنتاز; 11βHSD1, 11 beta-hydroxysteroid dehydrogenase type 1; ATGL, adipose tissue triglyceride lipase; CD36, cluster of differentiation 36; CL, corpora lutea; CORT, corticosterone; DHT, 5α-dihydrotestosterone; FAS, fatty acid synthase; H6PDH, hexose-6-phosphate
Translocator protein (18 kDa) as a pharmacological target in adipocytes to regulate glucose homeostasis
Keywords: FAS، اسید چرب سنتاز; TSPO, translocator protein; T2DM, type 2 diabetes mellitus; SREBP-1c, sterol regulatory element binding protein-1c; HSL, hormone-sensitive lipase; WAT, white adipose tissues; IL-6, interleukin-6; FAS, fatty acid synthase; ATGL, adipose triglyceride lipase
Piperazine derivatives: Synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase and SAR studies
Keywords: FAS، اسید چرب سنتاز; Mycobacterium tuberculosis; Tuberculosis; Enoyl-ACP reductase; InhA inhibition; PiperazinesTB, tuberculosis; M. tuberculosis, Mycobacterium tuberculosis; MDR-TB, multidrug-resistant tuberculosis; HIV, human immunodeficiency virus; FAS, fatty acid synthase
BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humans
Keywords: FAS، اسید چرب سنتاز; ACC, acetyl-CoA carboxylase; ACPD, 2-acetyl-1,3-cyclopentanedione; aPKC, atypical protein kinase C; Akt, protein kinase B; BMI, body mass index; DIO, diet-induced obesity; FAS, fatty acid synthase; FoxO1, forkhead box O1; GAPDH, glyceraldehyde-phosphate d
Metabolic reprogramming of the heart through stearoyl-CoA desaturase
Keywords: FAS، اسید چرب سنتاز; AMPK, AMP-activated protein kinase; CD36, fatty acid translocase CD36; CPT1, carnitine palmitoyltransferase; CVD, cardiovascular disease; DAG, diacylglycerol; DAGL, diacylglycerol lipase; FA, fatty acid; FAS, fatty acid synthase; FATP, fatty acid transpor
TRC8 downregulation contributes to the development of non-alcoholic steatohepatitis by exacerbating hepatic endoplasmic reticulum stress
Keywords: FAS، اسید چرب سنتاز; Adv, adenovirus; CHX, cycloheximide; Dgat1, DAG acyltransferase; ER, endoplasmic reticulum; FAS, fatty acid synthase; FBS, fetal bovine serum; GST, glutathione-s-transferase; HA, hemagglutinin; HFD, high-fat diet; KO, knockout; MCD, methionine and choline
Insulin and insulin-like growth factor-1 can modulate the phosphoinositide-3-kinase/Akt/FoxO1 pathway in SZ95 sebocytes in vitro
Keywords: FAS، اسید چرب سنتاز; High glycaemic load diet; Acne; IGF-1; Insulin; FoxO1; SebocytesACS, Acyl-CoA synthetase; ANOVA, analysis of variance; AR, androgen receptor; DAPI, 4, 6-diamidino-2-phenylindole, dihydro-chloride; ECL, Enhanced chemiluminescence; FAS, Fatty acid synthase;
Inhibition of fatty acid synthase induces pro-survival Akt and ERK signaling in K-Ras-driven cancer cells
Keywords: FAS، اسید چرب سنتاز; FAS, fatty acid synthase; IGF-1R, insulin-like growth factor-1 receptor; mTORC2, mammalian/mechanistic target of rapamycin complex 2; PI3K, phosphatidylinositol 3-kinaseFatty acid synthase; K-Ras; Akt; ERK
Hepatitis B virus X protein mutant HBxΔ127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT
Keywords: FAS، اسید چرب سنتاز; HBV, hepatitis B virus; HBx, hepatitis B virus X protein; HCC, hepatocellular carcinoma; hTERT, human telomerase reverse transcriptase; PCNA, proliferating cell nuclear antigen; 5-LOX, 5-lipoxygenases; FAS, fatty acid synthase; RCC, renal cell carcinoma;
Regulation of insulin on lipid metabolism in freshly isolated hepatocytes from yellow catfish (Pelteobagrus fulvidraco)
Keywords: FAS، اسید چرب سنتاز; CPT, carnitine palmitoyl transferase; DMSO, dimethyl sulphoxide; FAS, fatty acid synthase; FBS, fetal bovine serum; G6PD, glucose-6-phosphate dehydrogenase; MTT, 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazoliumbromide; PBS, phosphate buffered saline;
Growth performance, lipid deposition and hepatic lipid metabolism related gene expression in juvenile turbot (Scophthalmus maximus L.) fed diets with various fish oil substitution levels by soybean oil
Keywords: FAS، اسید چرب سنتاز; LPL, lipoprotein lipase; CPT I, carnitine palmitoyltransferase I; PPARα, peroxisome proliferator-activated receptor alpha; LXR, liver X receptor; FAS, fatty acid synthase; SREBP-1, sterol regulatory element-binding protein 1; MTP, microsomal triacylglycer
Betaine attenuates hepatic steatosis by reducing methylation of the MTTP promoter and elevating genomic methylation in mice fed a high-fat diet
Keywords: FAS، اسید چرب سنتاز; FAS, fatty acid synthase; ACC, acetyl-CoA carboxylase; PPARα, peroxisomal proliferator-activated receptor alpha; ACOX, acyl-CoA oxidase; MTTP, microsomal triglyceride transfer protein; ApoB, apolipoprotein B; SAM, S-adenosylmethionine; SAH, S-adenosylhomo
Oleanolic acid supplement attenuates liquid fructose-induced adipose tissue insulin resistance through the insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt signaling pathway in rats
Keywords: FAS، اسید چرب سنتاز; ACC, acetyl-CoA carboxylase; Adipo-IR, adipose tissue insulin resistance; AUC, area under the curve; FAS, fatty acid synthase; HOMA-IR, the homeostasis model assessment of insulin resistance; IRS, insulin receptor substrate; NEFA, non-esterified fatty aci
Effects of dietary arachidonic acid (ARA) on lipid metabolism and health status of juvenile grass carp, Ctenopharyngodon idellus
Keywords: FAS، اسید چرب سنتاز; A/G, albumin/globulin; ALT, alanine aminotransferase; ARA, arachidonic acid; AST, aspartate aminotransferase; ELO, fatty acid elongase; FAD, fatty acid desaturase; FAS, fatty acid synthase; FCR, feed conversion ratio; GLO, globulin; GLU, glucose; HIS, hep
Viola mandshurica ethanolic extract prevents high-fat-diet-induced obesity in mice by activating AMP-activated protein kinase
Keywords: FAS، اسید چرب سنتاز; ACC, acetyl-coA carboxylase; ALT, alanine aminotransferase; AMP, adenosine monophosphate; AMPK, AMP-activated protein kinase; AST, aspartate aminotransferase; aP2, adipocyte protein 2; BUN, blood urea nitrogen; FAS, fatty acid synthase; GAPDH, glyceraldeh
SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis
Keywords: FAS، اسید چرب سنتاز; ACC, acetyl CoA carboxylase; ALT, alanine aminotransferase; AMPK, AMP-activated protein kinase; CPT-1, carnitine palmitoyltrasnferase-1; FAS, fatty acid synthase; FFA, free fatty acid; HFD, high-fat diet; LKB1, liver kinase B1; MB, methylene blue; LXRα, l