دانلود مقالات ISI درباره Fen1 + ترجمه فارسی

اثرات پیش بینی شده تغییرات در ماشین آلات تعمیرات پایه در سرطان کولورکتال پراکنده

Prognostic impact of changes in base excision repair machinery in sporadic colorectal cancer

Keywords: CRC; colorectal cancer; TNM; tumor-node-metastasis; APC; adenomatous polyposis coli; BER; base excision repair; dRP; deoxyrbose phosphate; AP site; apurinic/abasic site; SN-BER; single-nucleotide base excision repair; LP-BER; long-patch base excision repa

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

گلیوبلاستوما و مقاومت شیمیایی به عوامل آلکالنیده: درگیری آپوپتوز، اتوفایگی و پاسخ پروتئینی باز

Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response

Keywords: ABCB1; ATP-binding cassette sub-family B member 1; ABCG; ATP-binding cassette drug efflux transporters; ACD; autophagic cell death; AKT; alpha serine/threonine protein kinase; ALDH; aldehyde dehydrogenase; AMPK; AMP-activated protein kinase; AP; apurinic/

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

افزونگی در تعمیر ریبونوکلئوتید: رقابت، جبران و همکاری

Redundancy in ribonucleotide excision repair: Competition, compensation, and cooperation

Keywords: nt; nucleotide; dNTP; deoxyribonucleoside triphosphate; rNTP; ribonucleoside triphosphate; pol; DNA polymerase; RNase H; ribonuclease H; Top1; topoisomerase 1; Fen1; flap endonuclease 1; PCNA; proliferating cell nuclear antigen; Exo1; exonuclease 1; Cho;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

یک روش جدید برای نظارت بر استخراج پروتئین های مربوط به ضایعه عملکردی در سلول های زنده

A novel method for monitoring functional lesion-specific recruitment of repair proteins in live cells

Keywords: AP-site; abasic site; BER; base excision repair; APE1; apurinic apyrimidinic endonuclease 1; Polβ; DNA polymerase β; LIG1; DNA ligase 1; FEN1; flap endonuclease 1; DNA-protein interaction; Base excision repair; Abasic sites; Repair intermediate; Co-lo

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

ابزار مایعات اشعه برای تصحیح تعمیر پایه برش و تعمیر مجدد یک رشته

Micro-irradiation tools to visualize base excision repair and single-strand break repair

Keywords: DIQ; 1,5-dihydroxyisoquinoline; 4-AN; 4-amino-1,8-naphthalimide; 6,4PPs; 6,4-photoproducts; 8-oxodG; 8-oxo-2′-deoxyguanosine; OGG1; 8-oxoguanine glycosylase 1; APE1; AP-endonuclease; ATM; ataxia telangiectasia-mutated gene; BER; base excision repair; BR

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

نقش مکانیزم های مرتبط با سرطان زایی در کاتاراکتوژنز و پیامدهای آن برای کاتاراکتوژنز تابش یونیزه

Role of carcinogenesis related mechanisms in cataractogenesis and its implications for ionizing radiation cataractogenesis

Keywords: Crystalline lens; Ionizing radiation; DNA repair factors; Nontargeted effects; Inflammation; Tumor suppressors; A-bomb; atomic-bomb; Acvr1; activin A type 1 receptor; AP; apurinic/apyrimidinic; APE1; apurinic/apyrimidinic endonuclease 1; AQP; aquaporin; A

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Proteins of the retinoblastoma pathway, FEN1 and MGMT are novel potential prognostic biomarkers in pancreatic adenocarcinoma

Keywords: Rb; retinoblastoma-associated protein-1; CDK4/6; cyclin-dependent kinases 4 and 6; MGMT; O6-methylguanine-DNA-alkyltranferase; FEN1; flap endonuclease-1; PDAC; pancreatic ductal adenocarcinoma; DFS; disease-free survival; RFS; relapse-free survival; OS; o

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Synergistic antitumor effect of combined paclitaxel with FEN1 inhibitor in cervical cancer cells

Keywords: Paclitaxel; FEN1; Cervical cancer; Chemotherapeutic drug;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

A cardiac glycoside HTF-1 isolated from Helleborus thibetanus Franch displays potent in vitro anti-cancer activity via caspase-9, MAPK and PI3K-Akt-mTOR pathways

Keywords: Cardiac glycoside; Anti-Cancer; Helleborus thibetanus Franch.; Apoptosis; ERK and JNK pathways; PI3K-Akt-mTOR pathway; CGs; cardiac glycosides; FEN1; flap endonuclease 1; PARP; (poly (ADP-ribose) polymerase; MAPK; mitogen-activated protein kinase; ERK1/2;

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2018 سفارش ترجمه

Formation and processing of DNA damage substrates for the hNEIL enzymes

Keywords: AP; abasic site; APE1; apurinic/apyrimidinic endonuclease; Asc; ascorbate; BER; base excision repair; DHT; 5,6-dihydro-2′-deoxythymidine; DHU; 5,6-dihydro-2′-deoxyuridine; dsDNA; double-stranded DNA; ESCODD; European Standards Committee on Oxidative D

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2017 سفارش ترجمه

Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA

Keywords: BER; base excision repair; DFCS; disease-free carotid segments; MI; myocardial infarction; ROS; reactive oxygen species; TDG; thymine DNA glycosylase; OGG1; 8-oxoguanine DNA glycosylase 1; NTH; Nth-like DNA glycosylase 1; SMUG1; single-strand-selective mo

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2016 سفارش ترجمه

Cancer TARGETases: DSB repair as a pharmacological target

Keywords: DSB repair; Genome instability; Cancer; Kinases; Helicases; Nucleases; ALT; alternative telomere lengthening; AML; acute myeloid leukemia; A-T; ataxia-telangiectasia; ATM; ataxia-telangiectasia mutated; ATP; adenosine triphosphate; ATR; ataxia-tel

دانلود رایگان متن کامل مقاله ISI 110 صفحه سال انتشار : 2016 سفارش ترجمه

BRCA1: Beyond double-strand break repair

Keywords: BRCA1; Base-excision repair; 8oxoG; 8-oxo-guanine; 8oxodG; 8-hydroxy-2′-deoxyguanosine; AP; apurinic/apyrimidinic; APE1 (or APE1/REF1); AP-endonuclease (redox effector factor-1); ATR; ataxia telangiectasia and Rad3 related; ATM; ataxia telangiectasia mu

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Yet another job for Dna2: Checkpoint activation

Keywords: 9–1–1, human Rad9, Rad1, Hus1 (yeast Ddc1, Rad17, Mec3) checkpoint clamp; ATM, ataxia-telangiectasia mutated; ATR, ATM and Rad3–related; ATRIP, ATR interacting protein; DSB, double-strand break; dsDNA, double-stranded DNA; ssDNA, single-stranded DNA; FEN1

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Regulation of the human Suv3 helicase on DNA by inorganic cofactors

Keywords: Helicase; Cofactor; Nucleotide; Divalent cations; DNA binding protein; bp; basepair; BSA; bovine serum albumin; dNTP; deoxynucleoside triphosphate; dsDNA; double stranded DNA; Dss1p; deletion of Suv3 suppressor 1; FEN1; flap endonuclease 1; mtDNA; mitocho

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Primer removal during mammalian mitochondrial DNA replication

Keywords: mtDNA; RNA primer; RNase H1; FEN1; DNA2; MGME1;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer

Keywords: FEN1; Breast cancer; Prognostic factor; Predictive factor; Drug target;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights

Keywords: HDAC inhibitor; DNA damage response; DNA repair; Cell cycle checkpoints; Apoptosis; Rational combinations; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; APAF-1; apoptotic protease activating factor 1; ASK1; apoptosis signal-regulating ki

دانلود رایگان متن کامل مقاله ISI 78 صفحه سال انتشار : 2014 سفارش ترجمه

Role of oxidative DNA damage in mitochondrial dysfunction and Huntington's disease pathogenesis

Keywords: AP; apurinic/apyrimidinic; ARE; antioxidant response element; ATM; ataxia telangiectasia mutated kinase; ATR; Rad3-related kinase; BER; base excision repair; FEN1; flap endonuclease 1; HD; Huntington's disease; MMR; mismatch repair; Nrf2; NF-E2-related

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

DNA repair mechanisms in dividing and non-dividing cells

Keywords: DNA repair; Neural cells; Neurological disorder; Dividing and non-dividing; Endogenous DNA damage; AOA1; ataxia with ocular motor apraxia 1; AP; apurinic/apyrimidinic; APE1; AP endonuclease 1; APTX; aprataxin; ATM; ataxia telangiectasia mutated; CPDs; cyc

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2013 سفارش ترجمه

Dynamics of enzymatic interactions during short flap human Okazaki fragment processing by two forms of human DNA polymerase δ

Keywords: Pol; DNA polymerase; Fen1; flap endonuclease 1; PCNA; proliferating cell nuclear antigen; RFC; replication factor C; AP site; apurinic/apyrimidinic site; DNA polymerase δ; DNA replication; Okazaki fragment; Lagging strand; Fen1; Flap endonuclease 1;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

p300/CBP acetyl transferases interact with and acetylate the nucleotide excision repair factor XPG

Keywords: APE1; AP-endonuclease 1; BER; base excision repair; CBP; CREB-binding protein; CPD; cyclobutane pyrimidine dimers; FEN1; flap endonuclease 1; HAT; histone acetyltransferase; HDAC1; histone deacetylase 1; KAT; lysine acetyltransferase; MPG; methylpurine DN

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Incidence and persistence of 8-oxo-7,8-dihydroguanine within a hairpin intermediate exacerbates a toxic oxidation cycle associated with trinucleotide repeat expansion

Keywords: 8-oxoG; 8-oxo-7,8-dihydroguanine; AP; apurinic; APE1; apurinic endonuclease 1; BER; base excision repair; BSA; bovine serum albumin; DMT; dimethoxytrityl; EDTA; ethylenediaminetetraacetic acid; FEN1; flap endonuclease 1; HD; Huntington's disease; hOGG1; h

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

HMGB1: Roles in base excision repair and related function

Keywords: HMGB1; DNA binding; DNA bending; Base excision repair; AP endonuclease; FEN1; Trinucleotide repeat expansion

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

Roles of Werner syndrome protein in protection of genome integrity

Keywords: γ-H2AX; phosphorylated histone H2AX; 4-NQO; 4-nitroquinoline 1-oxide; 5-OHdC; 5-hydroxycytidine; 5-OHU; 5-hydroxyuracil; 8-oxodA; 8-oxoadenine; 8-oxodG; 8-oxoguanine; ALT; alternative lengthening of telomeres; APE1; apurinic/apyrimidinic endonuclease 1;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2010 سفارش ترجمه

Evidence for a role of FEN1 in maintaining mitochondrial DNA integrity

Keywords: Mitochondria; Mitochondrial DNA; FEN1; Mitochondrial base excision repair

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Huntingtin triplet-repeat locus is stable under long-term Fen1 knockdown in human cells

Keywords: RNAi; Huntingtin; PCR; Fen1

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Effect of polyamine deficiency on proteins involved in Okazaki fragment maturation

Keywords: DNA ligase I; FEN1; human breast cancer; DENSPM; CGP 48664; AdoMetDC; S-adenosylmethionine decarboxylase; BASE; BioArray Software Environment; BAC; bacterial artificial chromosome; CGP 48664; 4-amidinoindan-1-one 2′-amidinohydrazone; DENSPM; N1,N11-diet

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

The rate of base excision repair of uracil is controlled by the initiating glycosylase

Keywords: BER; base excision repair; cccDNA; covalently closed circular DNA; dRP; deoxyribosephosphate; FEN1; flap endonuclease 1; Lig I; DNA ligase I; Lig III; DNA ligase III; LP; long patch; MBD4; methyl-binding domain 4; nAP; nicked abasic site; PARP; poly-(ADP-

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2008 سفارش ترجمه

Analyses of the interaction of WRNIP1 with Werner syndrome protein (WRN) in vitro and in the cell

Keywords: WRN; Mgs1; WRNIP1; RecQ; FEN1; DT40; Polδ

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2006 سفارش ترجمه

The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors

Keywords: FEN1; Endonuclease; Cancer; DNA repair;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2005 سفارش ترجمه

Structure and transcription promoter activity of mouse flap endonuclease 1 gene: Alternative splicing and bidirectional promoter

Keywords: 5′ RACE; rapid amplification of 5′ cDNA ends; CSB; conserved sequence block; EBS; Ets-binding site; EST; expressed sequence tag; FEN1; flap endonuclease 1; RT; reverse transcription; PCR; polymerase chain reaction; Bidirectional gene organization; Luc

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

DNA repair fidelity of base excision repair pathways in human cell extracts

Keywords: BER; base excision repair; AP site; apurinic/apyrimidinic site, abasic site; RAP; reduced abasic site; APE1; apurinic/apyrimidinic endonuclease 1; Pol β; DNA polymerase β; UDG; uracil-DNA glycosylase; XRCC1; X-ray repair cross-complementing protein-1;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه