Keywords: FPPS; farnesyl pyrophosphate synthase; MIR; myocardial ischemia/reperfusion; HR; hyproxia/reoxygenation; ROS; reactive oxygen species; FPP; arnesyl pyrophosphate; GGPP; geranylgeranyl pyrophosphate; SHR; spontaneously hypertensive rats; DMEM; Dulbecco's m
مقالات ISI (ترجمه نشده)
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Keywords: CCD; carotenoid cleavage dioxygenase; CHYB; β-carotene hydroxylase; DAFB; days after full bloom; DMAPP; dimethylallyl diphosphate; FPP; farnesyl diphosphate; FPPS; farnesyl diphosphate synthase; FW; fresh weight; GGPP; geranylgeranyl diphosphate; GGPS; g
Keywords: W. somnifera; Withanolides; Bioreactor; P. indica; Cell suspension cultures; CAS; Cycloaretenol synthase; DW; Dry weight; DXS; 1-deoxy-d-xylulose 5-phosphate synthase; DXR; 1-deoxy-d-xylulose 5-phosphate reductoisomerase; FPPS; Farnesyl pyrophosphate sy
Keywords: 2-DE; two-dimensional gel electrophoresis; ECL; enhanced chemiluminescence; FBS; fetal bovine serum; FPPS; farnesyl pyrophosphate synthase; IPP; isopentyl diphosphate; LC; liquid chromatography; MALDI-ToF; matrix-assisted laser desorption/ionization-time
Keywords: FPP; farnesyl pyrophosphate; FPPS; farnesyl pyrophosphate synthase; GPP; geranyl diphosphate; HMG-CoA reductase; 3-hydroxy-3-methylglutaryl-CoA reductase; IPP; isopentenyl diphosphate; MDD; mevalonate 5-diphosphate decarboxylase, also known as mevalonate
Keywords: ALP; alkaline phosphatase; BP; bisphosphonate; FPPS; farnesyl pyrophosphate synthase; Irf8; interferon regulatory factor 8; MafB; V-maf musculoaponeurotic fibrosarcoma oncogene homolog B; MFI; median fluorescence intensity; ONJ; osteonecrosis of the jaw;
Keywords: ABC; ATP-binding cassette; ADH; alcohol dehydrogenase; ADR; adrenodoxin reductase; ADX; adrenodoxin; ARE2; sterol acyltransferase; ARV1; mediator of sterol homeostasis; BTS1; GGPP synthase; CPR; cytochrome P450 reductase; CRT; carotenogenic (genes); CYP;
Engineering metabolic pathways in Amycolatopsis japonicum for the optimization of the precursor supply for heterologous brasilicardin congeners production
Keywords: Norcardia terpenica IFM0406; Mevalonate pathway; Isoprenoids; Prenyltransferases; Aact; acetoacetyl CoA thiolase; BraA; brasilicardin A; BraB; brasilicardin B; BraC; brasilicardin C; BraD; brasilicardin D; BraC-agl; brasilicardin C aglycon; BraD-agl; bras
FPPS mediates TGF-β1-induced non-small cell lung cancer cell invasion and the EMT process via the RhoA/Rock1 pathway
Keywords: FPPS; TGF-β1; Non-small cell lung cancer; EMT; RhoA/Rock1;
Structural characterization of a lepidopteran type-II farnesyl diphosphate synthase from the spruce budworm, Choristoneura fumiferana: Implications for inhibitor design
Keywords: Farnesyl diphosphate synthase; FPPS; Bisphosphonate; Crystal structure; Juvenile hormone; Lepidoptera;
Phototrophic production of heterologous diterpenoids and a hydroxy-functionalized derivative from Chlamydomonas reinhardtii
Keywords: cdm; cell dry mass; IPP; isopentenyl pyrophosphate; DMAPP; dimethylallyl pyrophosphate; FPPs; farnesyl pyrophosphate (synthase); GGPP; geranylgeranyl pyrophosphate; TAP; Tris acetate phosphate medium; YFP; mVenus yellow fluorescent protein; CFP; mCerulean
Floral scent: Regulation and role of MYB transcription factors
Keywords: ACP; acyl-acyl carrier protein; AOS; allege oxide synthase; DMAPP; dimethyl allyl diphosphate; FPP; farnesyl pyrophosphate; FPPS; farnesyl pyrophosphate synthase; GPP; geranyl diphosphate; GGPP; geranylgeranyl diphosphate farnesyl diphosphate; IPP; isop
Upregulation of the mevalonate pathway by cholesterol depletion abolishes tolerance to N-bisphosphonate induced Vγ9Vδ2 T cell cytotoxicity in PC-3 prostate cancer cells
Keywords: ApppI; triphosphoric acid 1-adenosin-5â²-yl ester 3-(3-methylbut-3-enyl) ester; ECL; enhanced chemiluminescence; FPPS; farnesyl pyrophosphate synthase; FOH; farnesol; GGOH; geranylgraniol; HMGR; 3-hydroxy-3-methylglutaryl coenzyme A reductase; HPLC-ESI
Production of dammarane-type sapogenins in rice by expressing the dammarenediol-II synthase gene from Panax ginseng C.A. Mey
Keywords: DS; Dammarenediol-II synthase; T-DNA; Transfer-DNA; HPLC; High performance liquid chromatography; PPD; 20 (S)-Protopanaxadiol; PPT; 20 (S)-Protopanaxatriol; DAD; Dammarenediol-II; ESI; Electrospray ionization; EIC; Extracted ion chromatogram; PSY; Phyto
The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants
Keywords: DMAPP; dimethylallyl pyrophosphate; FPP; farnesyl pyrophosphate; FPPS; farnesyl pyrophosphate synthase; GPP; geranyl pyrophosphate; IPP; isopentenyl pyrophosphate; N-BP; nitrogen-containing bisphosphonates; TCEP; tris(2-carboxyethyl)phosphine; RIS; Risedr
Upregulation of endogenous farnesyl diphosphate synthase overcomes the inhibitory effect of bisphosphonate on protein prenylation in Hela cells
Keywords: BMD; bone mineral density; FPPS; farnesyl diphosphate synthase; HMG CoA reductase; 3-hydroxy 3-methyl-glutaryl CoA reductase; LDS; lipoprotein deficient serum; N-BP; nitrogen-containing bisphosphonate; SREBP; sterol regulatory element binding protein; ZOL
RNA therapeutics targeting osteoclast-mediated excessive bone resorption
Keywords: 3BP2; c-Abl SH3 domain-binding protein-2; ADAM; a disintegrin and metalloproteinases; Ago; Argonaute; AP-1; activator protein-1; Ckb; brain-type creatine kinase; CNV; choroidal neovascularization; CPA; cation-proton antiporter; CPC; calcium phosphate bone
Bisphosphonates in preclinical bone oncology
Keywords: ZOL; zoledronic acid; IPP; isopentenyl pyrophosphate; ApppI; triphosphoric acid I-adenosine-5â²-yl ester 3-[3-methylbut-3-enyl] ester; FPPS; farnesyl pyrophosphate synthase; NBP; nitrogen-containing bisphosphonate; PBMC; peripheral blood mononuclear cell
Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells
Keywords: ApppI; triphosphoric acid 1-adenosin-5â²-yl ester 3-(3-methylbut-3-enyl) ester; DMAPP; dimethylallyl pyrophosphate; ESI; electrospray ionization; FPPS; farnesyl pyrophosphate synthase; IPP; isopentenyl pyrophosphate; HPLC; high-performance liquid chromat
Nitrogen-containing bisphosphonates can inhibit angiogenesis in vivo without the involvement of farnesyl pyrophosphate synthase
Keywords: IPP, isopentenyl pyrophosphate; ApppI, triphosphoric acid 1-adenosin-5′-yl ester 3-(3-methylbut-3-enyl) ester; FPPS, farnesyl pyrophosphate synthaseBisphosphonate; Risedronate; Zoledronate; FPPS; Angiogenesis
The relationship between the chemistry and biological activity of the bisphosphonates
Keywords: Bisphosphonates; FPPS; Osteoclasts; Bone resorption; Osteoporosis; Hydroxyapatite;
Different reaction mechanisms for cis- and trans-prenyltransferases
Keywords: IPP; isopentenyl diphosphate; FPP; farnesyl diphosphate; GPP; geranyl diphosphate; FPPs; farnesyl diphosphate synthase; OPPs; octaprenyl diphosphate synthase; UPPs; undecaprenyl diphosphate synthase; UPP; undecaprenyl diphosphate; TLC; thin layer chromato
Localization of enzymes of artemisinin biosynthesis to the apical cells of glandular secretory trichomes of Artemisia annua L.
Keywords: AAR; artemisinic aldehyde Î11(13) reductase; ADS; amorpha-4,11-diene synthase; CYP71AV1; amorpha-4,11-diene hydroxylase; DXR; 1-deoxy-d-xylulose-5-phosphate reductoisomerase; FPP; farnesyl diphosphate; FPPS; farnesyl diphosphate synthase; GST; glandular
New insights into the molecular actions of plant sterols and stanols in cholesterol metabolism
Keywords: ACAT; acyl-CoA:cholesterol acyltransferase; ABC; adenosine triphosphate-binding cassette transporter; ANXA2-CAV1; annexin 2/caveolin 1; apo; apolipoprotein; CVD; cardiovascular disease; CYP7A1; cytochrome P450 family 7 subfamily A polypeptide 1; FPPS; f
Cloning and characterization of isoprenyl diphosphate synthases with farnesyl diphosphate and geranylgeranyl diphosphate synthase activity from Norway spruce (Picea abies) and their relation to induced oleoresin formation
Keywords: TRD; traumatic resin duct; IPP; isopentenyl diphosphate; DMAPP; dimethylallyl diphosphate; GPP; geranyl diphosphate; FPP; farnesyl diphosphate; GGPP; geranylgeranyl diphosphate; IDS; isoprenyl diphosphate synthase; FPPS; farnesyl diphosphate synthase; GGP