Keywords: انتخابی کارکردی; Brain development; Functional selectivity; Language network; Sentence processing; Verbal working memory;
مقالات ISI انتخابی کارکردی (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: انتخابی کارکردی; GPCRs; Opioid binding; Receptor; Molecular dynamics; Allosteric modulators; Virtual screening; Functional selectivity; Dimerization;
ReviewNew Concepts in Dopamine D2 Receptor Biased Signaling and Implications for Schizophrenia Therapy
Keywords: انتخابی کارکردی; Antipsychotics; Arrestin; Dopamine; Functional selectivity; Schizophrenia; System bias;
β-Arrestin biased dopamine D2 receptor partial agonists: Synthesis and pharmacological evaluation
Keywords: انتخابی کارکردی; GPCR; Dopamine receptor; Ligand bias; Functional selectivity; β-Arrestin; G protein;
RGS proteins destroy spare receptors: Effects of GPCR-interacting proteins and signal deamplification on measurements of GPCR agonist potency
Keywords: انتخابی کارکردی; Agonist potency; Receptor conformation; G protein-mediated signaling; GPCR-interacting proteins (GIPs); Regulator of G protein signaling proteins (RGS proteins); Functional selectivity;
In vivo veritas, the next frontier for functionally selective GPCR ligands
Keywords: انتخابی کارکردی; GPCR, G protein coupled receptors; βArr1, beta-arrestin 1; βArr2, beta arrestin 2; D2R, D2 dopamine receptor; GSK3, glycogen synthase kinase 3G protein coupled receptor; Functional selectivity; Animal models; Beta-arrestin; Cell signaling
Recent updates on GPCR biased agonism
Keywords: انتخابی کارکردی; GPCR; 7TMR; Functional selectivity;
Practical guide for calculating and representing biased signaling by GPCR ligands: A stepwise approach
Keywords: انتخابی کارکردی; Bias; Quantification; Texture; Efficacy; Functional selectivity; Drug development;
Biased agonism: An emerging paradigm in GPCR drug discovery
Keywords: انتخابی کارکردی; Biased ligand; Functional selectivity; GPCR; Drug discovery;
Delineating biased ligand efficacy at 7TM receptors from an experimental perspective
Keywords: انتخابی کارکردی; G protein coupled receptor; Functional selectivity; Bias factor; Resonance energy transfert; β-arrestin; II messengers
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2
Keywords: انتخابی کارکردی; 5-HT; 5-hydroxytryptamine; cAMP; 3â²,5â²-cyclic adenosine monophosphate; ERK1/2; extracellular signal-regulated kinases 1/2; GPCR; G protein-coupled receptor; LogEC50; logarithm of agonist concentration that induces half-maximal response; Emax; maximal
Structure and function of serotonin G protein-coupled receptors
Keywords: انتخابی کارکردی; Serotonin; GPCR; 5-HT1B; 5-HT2B; Functional selectivity; β-Arrestin5-HT, 5-hydroxytryptamine, serotonin; GPCR, G protein-coupled receptor; CNS, central nervous system; GI, gastrointestinal; IP3, inositol triphosphate; DAG, diacylglycerol; GRK, G protein r
Noribogaine is a G-protein biased κ-opioid receptor agonist
Keywords: انتخابی کارکردی; Noribogaine; Mu opioid receptor; Kappa opioid receptor; Biased agonist; Functional selectivity; Addiction; Narcotic; Analgesia; G-protein pathway; Beta-arrestin pathway; Computational simulation; Ibogaine; 18-MC; GPCR; G protein-coupled receptor; OPRM; μ
Opioid Selective Antinociception Following Microinjection Into the Periaqueductal Gray of the Rat
Keywords: انتخابی کارکردی; Functional selectivity; analgesia; oxycodone; methadone; buprenorphine
Biased ligands at G-protein-coupled receptors: promise and progress
Keywords: انتخابی کارکردی; angiotensin; opioid; β-arrestin; functional selectivity; TRV027; TRV130
SKF-83959 is not a highly-biased functionally selective D1 dopamine receptor ligand with activity at phospholipase C
Keywords: انتخابی کارکردی; SKF-83959; Dopamine D1 receptor; Dopamine D5 receptor; Phospholipase C; Adenylate cyclase; Partial agonist; Functional selectivity; Ligand bias; Rat striatum;
Analysis of the histamine H2-receptor in human monocytes
Keywords: انتخابی کارکردی; Histamine H2-receptor; Functional selectivity; MonocyteAC, adenylyl cyclase; AM, amthamine; AML, acute myeloid leukemia; ATP, adenosine 5′-triphosphate; [Ca2+]i, intracellular calcium concentration; cAMP, adenosine-3′,5′-cyclic monophosphate; DC, dendriti
Visual change detection recruits auditory cortices in early deafness
Keywords: انتخابی کارکردی; Deafness; Cross-modal plasticity; MisMatch Negativity; Functional selectivity;
Functional selectivity of G-protein-coupled receptors: From recombinant systems to native human cells
Keywords: انتخابی کارکردی; G-protein-coupled receptor; Beta-adrenergic receptors; Histamine receptors; Functional selectivity; Receptor models; Dichloroisoproterenol; Dimaprit; Dobutamine; Ephedrine; Epinephrine; Fenoterol; Histamine; Isoproterenol; Norepinephrine; Salbutamol;
Support for 5-HT2C receptor functional selectivity in vivo utilizing structurally diverse, selective 5-HT2C receptor ligands and the 2,5-dimethoxy-4-iodoamphetamine elicited head-twitch response model
Keywords: انتخابی کارکردی; Head-twitch response; DOI; Hallucinogen; C57Bl/6J; Mouse serotonin 2C receptor; Mouse serotonin 2A receptor; Functional selectivity;
Functional selectivity induced by mGlu4 receptor positive allosteric modulation and concomitant activation of Gq coupled receptors
Keywords: انتخابی کارکردی; Glutamate; Histamine; Receptor; Allosteric modulator; Functional selectivity; mGlu receptor; metabotropic glutamate receptor; CHO; Chinese Hamster Ovary; DHFR(â); Dihydrofolate Reductase; DMSO; Dimethyl Sulfoxide; GPCR; G-Protein-Coupled Receptor; 7TMR;
Irving Page Lecture: 5-HT2A serotonin receptor biology: Interacting proteins, kinases and paradoxical regulation
Keywords: انتخابی کارکردی; PDZ domain; Functional selectivity; Antipsychotic; Psychoactive; RSK2; Caveolin;
When simple agonism is not enough: Emerging modalities of GPCR ligands
Keywords: انتخابی کارکردی; G protein-coupled receptor; Functional selectivity; Allosterism; Ago-allosterism; Dualsteric ligand; Super-agonism;
The N-terminal domain of human hemokinin-1 influences functional selectivity property for tachykinin receptor neurokinin-1
Keywords: انتخابی کارکردی; cAMP, cyclic adenosine monophosphate; NF-κB, nuclear factor kappa B; ERK1/2, extracellular regulated protein kinases1/2Hemokinin-1; Functional selectivity; Neurokinin-1 receptor; ERK1/2; NF-κB
The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics
Keywords: انتخابی کارکردی; Opioid; G protein-coupled receptor; Mu opioid receptor; Antinociception; Withdrawal; Functional selectivity
Characterizing and predicting the functional and conformational diversity of seven-transmembrane proteins
Keywords: انتخابی کارکردی; G protein-coupled receptors; GPCRs; Conformational ensemble; Functional selectivity; Protein structure prediction; Transmembrane helix topology
Allosteric modulation of G protein-coupled receptors: A pharmacological perspective
Keywords: انتخابی کارکردی; Allosteric modulator; Drug discovery; Functional selectivity; G protein-coupled receptor; Stimulus-bias; Structure–function
Endocrine PharmacologyAbsence of somatostatin SST2 receptor internalization in vivo after intravenous SOM230 application in the AR42J animal tumor model
Keywords: انتخابی کارکردی; Somatostatin receptor; Internalization; Tumor targeting; SOM230; Octreotide; Functional selectivity; Desensitization;
Functionally selective cannabinoid receptor signalling: Therapeutic implications and opportunities
Keywords: انتخابی کارکردی; Cannabinoid receptors; Functional selectivity; G protein-coupled receptors; Cell signalling
Physiological and pharmacological implications of beta-arrestin regulation
Keywords: انتخابی کارکردی; G protein coupled receptors; Seven transmembrane spanning receptors; GRK; Beta-arrestin; Functional selectivity; Knockout mouse models; Drug discovery; Receptor regulation; PhysiologyΔ9-THC, Δ9-tetrahydrocannabinol; DOI, 2,5-dimethoxy-4-iodoamphetamine; C
Concomitant activation of adenylyl cyclase suppresses the opposite influences of CB1 cannabinoid receptor agonists on tyrosine hydroxylase expression
Keywords: انتخابی کارکردی; Functional selectivity; Forskolin; Gene reporter; Tyrosine hydroxylase; Cell signalling
Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells
Keywords: انتخابی کارکردی; 5-HT2 receptor; Gq protein; Calcium release; Functional selectivity; Hallucinogen
Reciprocal influences of CB1 cannabinoid receptor agonists on ERK and JNK signalling in N1E-115 cells
Keywords: انتخابی کارکردی; Functional selectivity; Cannabinoid receptor; Tyrosine hydroxylase; MAPK; Drug efficacy; G Protein coupled receptor
Unique agonist-bound cannabinoid CB1 receptor conformations indicate agonist specificity in signaling
Keywords: انتخابی کارکردی; Trafficking; G proteins; PWR spectroscopy; Functional selectivity
RNA editing of the serotonin 5HT2C receptor and its effects on cell signalling, pharmacology and brain function
Keywords: انتخابی کارکردی; Serotonin; G protein-coupled receptor; RNA editing; Functional selectivity; Stimulus trafficking; Cell signaling; Central nervous system; Receptor theory
Functional selectivity of dopamine D1 receptor agonists in regulating the fate of internalized receptors
Keywords: انتخابی کارکردی; D1 dopamine receptors; Receptor internalization; Receptor recycling; Adenylate cyclase; Functional selectivity; A-77636; Dinapsoline; DopaminecAMP, cyclic AMP (adenosine 3′,5′-cyclic monophosphate); A-77636, (1R,3S)-3-(1′adamantyl)-1-aminomethyl-3,4-dihyd
The novel antidyskinetic drug sarizotan elicits different functional responses at human D2-like dopamine receptors
Keywords: انتخابی کارکردی; Parkinson's disease; Dyskinesia; GIRK channels; Adenylyl cyclase; Sarizotan; Signaling; Functional selectivity; Dopamine receptors; AtT-20 neuroendocrine cells; Partial agonists; Electrophysiology