Irving Page Lecture: 5-HT2A serotonin receptor biology: Interacting proteins, kinases and paradoxical regulation

► The historical aspects of 5-HT2A receptor signaling is reviewed. ► The role of various interacting proteins and 5-HT2A receptor functional selectivity is highlighted. ► Models for paradoxical regulation of 5-HT2A receptors are highlighted. ► Future directions for research are suggested.