Keywords: aPKC; atypical protein kinase C; CBP; CREB binding protein; ChREBP; carbohydrate response element-binding protein; CREB; cAMP response element-binding protein; CRTC2; CREB-regulated transcription coactivator 2; FA; fatty acid; GIPR; glucose-dependent insu
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Keywords: AKT; protein kinase B; Ang II; angiotensin II; BRDN; bilateral renal denervation; BUN; blood urine nitrogen; Cr; creatinine; G6Pase; glucose-6-phosphatase; HFD; high-fat diet; HOMA-IR; homeostasis-model assessment of insulin resistance; HPLC; high-pressur
Keywords: T1DM; Type 1 diabetes mellitus; EDS; Search E-Resources; IGF1; insulin-like growth factor 1; NOD; non-obese diabetic; G6Pase; glucose-6-phosphatase; HGF; hepatocyte growth factor; SCID; severe combined immunodeficiency; BTC; betacellulin; Ngn3; Neurogenin
Keywords: Metabolic diseases; Lipids; Glycogen; Fenofibrate; AST; aspartate transaminase; ALT; alanine transaminase; CKD; Chronic Kidney Disease; EMT; epithelial-mesenchymal transition; G6P; glucose-6 phosphate; G6Pase; glucose-6 phosphatase; GSDI; Glycogen Storage
Keywords: Arctic charr; Compensatory growth; Fasting; Glucose metabolism; miRNAs; Protein metabolism; g6pase; glucose 6-phosphatase; HSI; hepatosomatic index; ISI; intestinal somatic index; miRNA; microRNA; Mafbx; muscle atrophy F-box protein; Murf1; muscle RING-fi
Keywords: Dihydrocapsiate; HFD; Obesity; Glucose intolerance; Hepatic steatosis; ACOX1; Acyl-CoA oxidase 1; ADIPO; adiponectin; AIN; American Institute of Nutrition; ANOVA; 1-way analysis of variance; BAT; brown adipose tissue; BMI; body mass index; C/EBPβ; CCAAT/
Keywords: A-type EGCG dimer; Lead; Liver; Insulin resistance; ER stress; Apoptosis; AEd; A-type dimeric epigallocatechin-3-gallate; AKT; phosphorylated protein kinase B; CHOP; C/EBP homologous protein; EGCG; epigallocatechin-3-gallate; G6Pase; cytoplasmic glucose-6
Keywords: ANOVA; analysis of variance; AUC; area under the curve; BCAAs; branched-chain amino acids; BG; blood glucose; BW; body weight; C/EBPβ; CCAAT/enhancer binding protein; ELISA; enzyme-linked immunosorbent assay; G6P; glucose-6-phosphate; G6Pase; glucose-6-p
Keywords: AKT/PKB; protein kinase B; APPL1; adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; EEA1; early endosomal antigen 1; EGF; epidermal growth factor;; G6Pase; glucose-6-phosphatase;; LDL; low-density lipoprotein;; LDLR;
Keywords: AMPK; 5â² adenosine monophosphate-activated protein kinase; AGE; advanced glycation end-product; BP; blood pressure; CE; cinnamon extracts; CP; cinnamon polyphenols; DM; diabetes mellitus; eNOS; endothelial nitric oxide synthase; FBG; fasting blood gluco
Keywords: Synergy; Ferulic acid; Metformin; Anti-diabetic agents; AMPK, PI-3K; Akt; protein kinase B; AMPK; AMP-activated protein kinase; DM; Diabetes mellitus; G6Pase; glucose-6-phosphatase; IRS; Insulin receptor substrate; LD50; lethal dose 50%; PDK-1; 3-phosphoi
Keywords: ATP; adenosine triphosphate; Ca2+; Â calcium; CamK; calmodulin-dependent kinase; ChREBP; carbohydrate response element binding protein; CypD; cylophilin D; DGAT2; diacylglycerol acyltransferase 2; ER; endoplasmic reticulum; FOXO1; Forkhead box O1; G6P; gl
Keywords: ACC; acetyl-CoA carboxylase; ApoB; apolipoprotein B; ApoCII; apolipoprotein C-II; APPL-1; adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and a leucine zipper motif; CD36; fatty acid translocase; CETP; cholesteryl est
Keywords: ALT; alanine transaminase; AST; aspartate transaminase; FBG; fasting blood glucose; GCK; glucokinase; G6Pase; glucose-6-phosphatase; HMGCR; 3-hydroxy-3-methyl-glutaryl-CoA reductase; LBEO; lemon balm essential oil; PPAR; peroxisome proliferator-activated
Keywords: Glycerol; BALB/cHeA; Gluconeogenesis; Glycogenic amino acid; ALT; alanine amino transferase; ATGL; adipocyte triglyceride lipase; BCAA; branched chain amino acids; DHAP; dihydroxyacetone phosphate; FoxO; forkhead box O; GPD; glycerol-3-phosphate dehydroge
Keywords: High-fat; Non-alcoholic liver disease; Obesity; Scopoletin; Transcriptome; ALT; alanine aminotransferase; Apoa4; apolipoprotein A-IV; AST; aspartate aminotransferase; β-oxidation; fatty acid β-oxidation; Cdkn1a; cyclin-dependent kinase inhibitor 1A; Cid
Keywords: Budesonide (PubChem CID: 5281004); Dexamethasone (PubChem CID: 5743); Hydrocortisone (PubChem CID: 5754); Prednisolone (PubChem CID: 5755); APC; allophycocyanin; BrdU; bromodeoxyuridine; CD; Crohn's disease; CFU; colony forming units; CXCL1; chemokine (
Keywords: GLUT; Glucose transporter; T1DM; Type-1 diabetes mellitus; T2DM; Type-2 diabetes mellitus; PKB/Akt; protein kinase B; GSK-3; glycogen synthase kinase-3; PGC-1α; peroxisome proliferator-activated receptor gamma coactivator-1α; FOXO; forkhead box O; VLDL;
Keywords: ABCB; ATP-binding cassette sub-family B; Apo; apolipoprotein; ASBT; apical sodium dependent bile acid transporter; BDL; bile duct ligation; BSEP; bile salt export pump; CA; cholic acid; CDCA; chenodeoxycholic acid; C/EBP; CCAAT-enhancer-binding protein; C
Keywords: AGE-RAGE; advanced glycation end products; AI; atherogenic index; AMPK; AMP-activated protein kinase; Ara; arabinose; Bax; pro-apoptotic Bcl2-associated X; Bcl-2; B-cell leukaemia/lymphoma 2; BG; blood glucose; CAT; catalase; Fuc; fucose; FBG; fasting blo
Keywords: ACOX; peroxisomal acyl-coenzyme A oxidase 1; BDNF; Brain-derived neurotrophic factor; BM; bardoxolone methyl; CDDO-Im; 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole; FAS; fatty acid synthase; FOXO1; Forkhead box protein O1; HF; high fat; LC; l
Keywords: Food timing; Leptin; Ghrelin; Adiponectin; Feeding behavior; Metabolic syndrome; ACC; acetyl CoA carboxylase; AdipoRS; adiponectin receptors; AgRP; agouti-related protein; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; AST; aspartate a
Keywords: n-3; omega-3; n-6; omega-6; PUFA; polyunsaturated fatty acids; PEPCK; phosphoenolpyruvate carboxykinase; G6Pase; glucose 6 phosphatase; ACC; acetyl-CoA carboxylase; FAS; fatty acid synthase; PMP-70; 70-kDa peroxisomal membrane protein; ACOX1; acyl-CoA oxi
Keywords: AgRP; agouti-related peptide; AIF; apoptosis-inducing factor; AMPK; AMP-activated protein kinase; CaMKII; calcium/calmodulin dependent protein kinase II; Cox6a2; cytochrome c oxidase subunit VI peptide 2a; CPT-1; carnitine palmitoyltransferase 1; ETC; ele
Keywords: ATIC; allylisothiocyanate; GLUT4; glucose transporter 4; mtDNA; mitochondrial DNA; FFA; free fatty acid; OCR; Oxygen consumption rate; DMEM; Dulbecco's Modified Eagle's medium; FBS; fetal bovine serum; 2-NBDG; 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amin
Keywords: ACPase; acid phosphatase; AKI; acute renal injury; ALP; alkaline phosphatase; BBM; brush border membrane; BBMV; brush border membrane vesicles; BUN; blood urea nitrogen; CP; cisplatin; CPFXO; cisplatin-flaxseed oil; FXO; flaxseed oil; FBPase; fructose-1,6
TSPA as a novel ATF6α translocation inducer efficiently ameliorates insulin sensitivity restoration and glucose homeostasis in db/db mice
Keywords: ATF6α; ER stress; Insulin resistance; TSPA; T2DM; Akt; protein kinase B; ATF6; activating transcription factor 6; CHOP; C/EBP-homologous protein; CNX; calnexin; CRT; calreticulin; CREB; cAMP response element binding protein; ER; Endoplasmic reticulum; ER
AMPK activation by pterostilbene contributes to suppression of hepatic gluconeogenic gene expression and glucose production in H4IIE cells
Keywords: Pterostilbene; PPAR-α; AMPK; PEPCK; G6Pase; Gluconeogenesis;
Impairment of bisphenol F on the glucose metabolism of zebrafish larvae
Keywords: BPF; bisphenol F; BPA; bisphenol A; BPS; bisphenol S; IR; insulin receptor; IRS; insulin receptor substrate; PEPCK; phosphoenolpyruvate carboxykinase; DMSO; dimethyl sulfoxide; hpf; hour past fertilization; PCR; polymerase chain reaction; PEPCK-M; mitocho
The CAR agonist TCPOBOP inhibits lipogenesis and promotes fibrosis in the mammary gland of adolescent female mice
Keywords: ACC; acetyl-CoA carboxylase; α-SMA; alpha-smooth muscle actin; CAR; constitutive androstane receptor; FAS; fatty acid synthase; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; G6pase; glucose-6-phosphatase; Gon-WAT; gonadal white adipose tissue; H&E; he
Coordinated regulation of hepatic FoxO1, PGC-1α and SREBP-1c facilitates insulin action and resistance
Keywords: aPKC; atypical protein kinase C; ACC; acetyl-CoA carboxylase; ACPD; 2-acetyl-cyclopentane-1,3-dione; AMPK; AMP-activated protein kinase; Akt; protein kinase B; FAS; fatty acid synthase; FoxO1; forkhead homeobox class O1 protein; G6Pase; glucose-6-phosphat
Root bark extracts of Myrianthus arboreus P. Beauv. (Cecropiaceae) exhibit anti-diabetic potential by modulating hepatocyte glucose homeostasis
Keywords: AMPK; AMP-activated protein kinase; Alk; alkaloid extract; AQ; aqueous fraction; CREB; c-AMP-regulator element-binding protein; Dic; dicloromethane extract; EtOH; ethanol extract; G6Pase; glucose-6-Phosphatase; GS; glycogen Synthase; GSK-3; glycogen Synth
Bisphenol S exposure impairs glucose homeostasis in male zebrafish (Danio rerio)
Keywords: BPS; bisphenol S; BPA; bisphenol A; FBG; fasting blood glucose; IRs; insulin receptors; IRS/PI3K/Akt; insulin receptor substrates/phosphotidylinositol 3-kinase/Akt; GP; glycogen phosphorylase; PEPCK; phosphoenolpyruvate carboxykinase; G6Pase; glucose-6-ph
Treatment of Dendropanax morbifera leaves extract improves diabetic phenotype and inhibits diabetes induced retinal degeneration in db/db mice
Keywords: Dendropanax morbifera; Type 2 diabetes mellitus; Retinal degeneration; Db/db mice; Glucose transporter; AMP-activated protein kinase; DLE; Dendropanax morbifera leaves extract; IGT; Impaired glucose tolerance; GK; glucokinase; PEPCK; phosphoenolpyruvate c
Effects of Ginsenoside Rg3 on fatigue resistance and SIRT1 in aged rats
Keywords: Rg3; Ginsenoside Rg3; Rg3 group; Rg3-treated normal group; POFS; postoperative fatigue syndrome; POFS group; postoperative fatigue syndrome model group; POFSâ+âRg3 group; Rg3-treated postoperative fatigue syndrome model group; OFT; the open field test
Transcriptomic analysis of Momordica charantia polysaccharide on streptozotocin-induced diabetic rats
Keywords: M. charantia; Momordica charantia; RNA-seq; RNA sequencing; T2DM; Type 2 diabetes mellitus; IR; insulin resistance; PPAR; peroxisome proliferator-activated receptor; FBG; fasting blood glucose; G6Pase; glucose-6-phosphatase; PEPCK; phosphoenol pyruvate ca
High-fat diet alters PAS kinase regulation by fasting and feeding in liver
Keywords: ACC; acetyl CoA carboxylase; Akt/PKB; protein kinase B; CHREBP; carbohydrate-responsive element-binding protein; CPT1-A; carnitine palmitoyltransferase 1A; DAPI; 4,6-diamidino-2-phenylindole; FAS; fatty acid synthase; FOXO1; forkhead box protein O1; GCK;
Vitamin K1 inversely correlates with glycemia and insulin resistance in patients with type 2 diabetes (T2D) and positively regulates SIRT1/AMPK pathway of glucose metabolism in liver of T2D mice and hepatocytes cultured in high glucose
Keywords: AMPK; AMP-activated protein kinase; CPT1A; carnitine palmitoyltransferase 1A; GK; glucokinase; G6P; glucose 6 phosphate; G6Pase; glucose 6 phosphatase; GGCX; gamma glutamyl carboxylase; GHb; glycated hemoglobin; GLUT2; glucose transporter 2; IL-6; interle
Baicalin regulates SirT1/STAT3 pathway and restrains excessive hepatic glucose production
Keywords: ECL; enhanced chemiluminescence; FOXO1; forkhead transcription factor1; G6Pase; glucose-6-phosphatase; HFD; high-fat diet; HGP; hepatic glucose production; MPC; mitochondrial pyruvate carrier; NAD; nicotinamide adenine dinucleotide; NEFAs; nonesterified f
Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway
Keywords: HFD; high fat-diet; STZ; streptozotocin; IRS-1; insulin receptor substrate-1; PI3K; phosphatidylinositol 3-kinase; PEPCK; phosphoenolpyruvate carboxykinase; G6pase; glucose 6-phosphatase; FOXO1; forkhead box O1; GSK3β; glycogen synthase kinase-3β; GS; g
STAT3: The art of multi-tasking of metabolic and immune functions in obesity
Keywords: Signal transducer and activator of transcription 3; Obesity; Metabolism; Lipid; Immune; AgRP; Agouti-related peptide; AMPK; AMP-activated protein kinase; AOX; acyl-CoA oxidase; ARC; arcuate nucleus; ATGL; adipose triglyceride lipase; BAT; brown adipose ti
Suppression of gluconeogenic gene transcription by SIK1-induced ubiquitination and degradation of CRTC1
Keywords: AMPK; AMP-activated protein kinase; cAMP; cyclic adenosine monophosphate; CRE; cAMP response element; CREB; CRE-binding protein; CRTC; CREB-regulated transcription coactivator; G6Pase; glucose 6-phosphatase; GAPDH; glyceraldehyde-3-phosphate dehydrogenase
Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR
Keywords: Natural products; Nuclear receptors; Liver X receptor; Farnesoid X receptor; Retinoid X receptor; Metabolic syndrome; Precision medicine; 6-ECDCA; 6α-ethyl-chenodeoxycholic acid (obeticholic acid); AA; arachidonic acid; ABC; ATP-binding cassette transpor
Oral administration of Nigella sativa oil ameliorates the effect of cisplatin on brush border membrane enzymes, carbohydrate metabolism and antioxidant system in rat intestine
Keywords: ACPase; acid phosphatase; ALP; alkaline phosphatase; BBM; brush border membrane; BBMV; BBM vesicles; CAT; catalase; CP; cisplatin; FBPase; fructose 1,6-bisphosphatase; G6Pase; glucose 6-phosphatase; G6PDH; glucose 6-phosphate dehydrogenase; GGTase; γ-glu
Red paprika (Capsicum annuum L.) and its main carotenoid capsanthin ameliorate impaired lipid metabolism in the liver and adipose tissue of high-fat diet-induced obese mice
Keywords: NAFLD; non-alcoholic fatty liver disease; WAT; white adipose tissue; ND; normal diet; HD; high-fat diet; RP; red paprika-supplemented diet; CS; capsanthin-supplemented diet; TG; triacylglycerol; TC; total cholesterol; HDL; high-density lipoprotein; NEFA;
Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases
Keywords: ALP; alkaline phosphatase; AMPK; AMP-activated protein kinase; Ang II; angiotensin II; BER; base excision repair; cAMP; cyclic adenosine monophosphate; CDK; cyclin-dependent kinase; CHIP; carboxyl terminus of Hsp70-interacting protein; CLL; chronic lympho
Cellular adaptation to xenobiotics: Interplay between xenosensors, reactive oxygen species and FOXO transcription factors
Keywords: AhR; arylhydrocarbon receptor; AIP; AhR interacting protein; ARE; antioxidant response element; ARNT; AhR nuclear translocator; bHLH; basic helix-loop-helix (DNA binding and dimerisation domain); CAR; constitutive androstane receptor; CBP; CREB-binding pr
The transcription factor Prep1 controls hepatic insulin sensitivity and gluconeogenesis by targeting nuclear localization of FOXO1
Keywords: Hepatocytes; Gluconeogenesis; Prep1; Insulin sensitivity; T2DM; type 2 diabetes; G6Pase; glucose-6-phosphatase; PEPCK; phosphoenolpyruvate carboxykinase;
Involvement of pregnane X receptor in the impaired glucose utilization induced by atorvastatin in hepatocytes
Keywords: HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; PCN; pregnenolone-16α-carbonitrile; PXR; pregnane X receptor; GLUT2; glucose transporter 2; GCK; glucokinase; PDK2; pyruvate dehydrogenase kinase isoenzyme 2; PEPCK1; phosphoenolpyruvate carboxykinase 1; G6
DHEA-induced modulation of renal gluconeogenesis, insulin sensitivity and plasma lipid profile in the control- and dexamethasone-treated rabbits. Metabolic studies
Keywords: Dexamethasone phosphate (dexP); Dehydroepiandrosterone (DHEA); Glucocorticoids (GCs); Cortisol; Renal gluconeogenesis; G6Pase; FBPase