کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8260485 | 1534663 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Elevated tissue omega-3 fatty acid status prevents age-related glucose intolerance in fat-1 transgenic mice
ترجمه فارسی عنوان
افزایش سطح بافت اسید چرب امگا -3 مانع از عدم تحمل گلوکز مرتبط با سن در موش های ترانسژنیک چربی 1
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کلمات کلیدی
ACCGlucose 6 phosphataseG6PasePAI-1PEPCKIKKPPARαACOX1n-6n-3MCP-1GTTJnkNF-κBPTTFASc-Jun Kinase - C-Jun KinaseIκB kinase - IkB kinasepyruvate tolerance test - آزمون تحمل پیرواتacetyl-CoA carboxylase - استیل کروکسی سیلازPolyunsaturated fatty acids - اسید چرب اشباع نشدهOmega-3 fatty acid - اسید چرب امگا 3fatty acid synthase - اسید چرب سنتازPUFA - اسید چرب چند غیراشباعinflammation - التهاب( توروم) Omega-3 - امگا 3omega-6 - امگا 6triglyceride - تریگلیسریدglucose tolerance test - تست تحمل گلوکزtumor necrosis factor α - تومور نکروز عامل αAging - سالخوردگیTNF-α - فاکتور نکروز توموری آلفاnuclear factor-κB - فاکتور هسته ای κBphosphoenolpyruvate carboxykinase - فسفوآنولپیرود کربوکسیکینازLipogenesis - لیپوژنزPlasminogen activator inhibitor-1 - مهار کننده فعال کننده پلاسمینوژن-1wild-type - نوع وحشیGlucose homeostasis - هوموستاز گلوکزperoxisome proliferator-activated receptor-α - پراکسیزوم پرولیفراتور فعال گیرنده -αmonocyte chemoattractant protein - پروتئین شیمیایی monocyte chemoattractantGas chromatography - کروماتوگرافی گازیGluconeogenesis - گلوکونوژنز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
The objective of this study was to investigate the impact of elevated tissue omega-3 (n-3) polyunsaturated fatty acids (PUFA) status on age-related glucose intolerance utilizing the fat-1 transgenic mouse model, which can endogenously synthesize n-3 PUFA from omega-6 (n-6) PUFA. Fat-1 and wild-type mice, maintained on the same dietary regime of a 10% corn oil diet, were tested at two different ages (2 months old and 8 months old) for various glucose homeostasis parameters and related gene expression. The older wild-type mice exhibited significantly increased levels of blood insulin, fasting blood glucose, liver triglycerides, and glucose intolerance, compared to the younger mice, indicating an age-related impairment of glucose homeostasis. In contrast, these age-related changes in glucose metabolism were largely prevented in the older fat-1 mice. Compared to the older wild-type mice, the older fat-1 mice also displayed a lower capacity for gluconeogenesis, as measured by pyruvate tolerance testing (PTT) and hepatic gene expression of phosphoenolpyruvate carboxykinase (PEPCK) and glucose 6 phosphatase (G6Pase). Furthermore, the older fat-1 mice showed a significant decrease in body weight, epididymal fat mass, inflammatory activity (NFκ-B and p-IκB expression), and hepatic lipogenesis (acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS) expression), as well as increased peroxisomal activity (70-kDa peroxisomal membrane protein (PMP70) and acyl-CoA oxidase1 (ACOX1) expression). Altogether, the older fat-1 mice exhibit improved glucose homeostasis in comparison to the older wild-type mice. These findings support the beneficial effects of elevated tissue n-3 fatty acid status in the prevention and treatment of age-related chronic metabolic diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1842, Issue 2, February 2014, Pages 186-191
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1842, Issue 2, February 2014, Pages 186-191
نویسندگان
Talita Romanatto, Jarlei Fiamoncini, Bin Wang, Rui Curi, Jing X. Kang,