Hidradenitis Suppurativa-Like Lesions Associated with Pharmacologic Inhibition of Gamma-Secretase
Keywords: گاما دگرساز; GS; gamma-secretase;
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Review of the advances in treatment for Alzheimer disease: strategies for combating β-amyloid protein
Keywords: گاما دگرساز; Alzheimer disease; Beta-amyloid; Beta-secretase; Gamma-secretase; Amyloid hypotheses; Alzheimer; Beta-amiloide; Beta-secretasa; Gamma-secretasa; Hipótesis amiloidea;
Una revisión de los avances en la terapéutica de la enfermedad de Alzheimer: estrategia frente a la proteÃna β-amiloide
Keywords: گاما دگرساز; Alzheimer; Beta-amiloide; Beta-secretasa; Gamma-secretasa; Hipótesis amiloidea; Alzheimer disease; Beta-amyloid; Beta-secretase; Gamma-secretase; Amyloid hypotheses;
Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome
Keywords: گاما دگرساز; Interleukin-11; Interleukin-11 receptor; Proteolysis; Proteasome; Gamma-secretase;
NGP 555, a γ-secretase modulator, lowers the amyloid biomarker, Aβ42, in cerebrospinal fluid while preventing Alzheimer's disease cognitive decline in rodents
Keywords: گاما دگرساز; Alzheimer's; Amyloid; Modulator; Biomarkers; Pathology; Prevention; Cognition; Cerebrospinal fluid; Dementia; Gamma-secretase;
Long-term effect of neonatal inhibition of APP gamma-secretase on hippocampal development in the Ts65Dn mouse model of Down syndrome
Keywords: گاما دگرساز; Down syndrome; Neonatal pharmacotherapy; APP; Gamma-secretase; Hippocampal development;
NeuronRead, an open source semi-automated tool for morphometric analysis of phase contrast and fluorescence neuronal images
Keywords: گاما دگرساز; Semi-automated analysis; ImageJ macro; PhC microphotographs; Neuronal differentiation and regeneration; Gamma-secretase; Alzheimer's amyloid precursor protein (APP);
Physiological and pathological roles of the γ-secretase complex
Keywords: گاما دگرساز; Alzheimer's disease; Gamma-secretase; Amyloid-beta
Transient gamma-secretase inhibition accelerates and enhances fracture repair likely via Notch signaling modulation
Keywords: گاما دگرساز; Fracture repair; Notch signaling; Gamma-secretase; BMSC; Cartilage; Bone;
Hyaluronan nanoparticles bearing γ-secretase inhibitor: In vivo therapeutic effects on rheumatoid arthritis
Keywords: گاما دگرساز; Gamma-secretase; Hyaluronan; Nanoparticle; Rheumatoid arthritis
Monomeric C-reactive protein and Notch-3 co-operatively increase angiogenesis through PI3K signalling pathway
Keywords: گاما دگرساز; C-reactive protein; Notch; Angiogenesis; PI3K/Akt pathway; Gamma-secretase
Phlorotannin-rich Ecklonia cava reduces the production of beta-amyloid by modulating alpha- and gamma-secretase expression and activity
Keywords: گاما دگرساز; Ecklonia; Alzheimer's disease; Beta-amyloid; Alpha-secretase; Gamma-secretase; APP processing;
Expression and processing of fluorescent fusion proteins of amyloid precursor protein (APP)
Keywords: گاما دگرساز; APP106; truncated last 106 amino acids of APP; GappR; GFP-APP106-DsRed; RappG; DsRed-APP106-GFP; sGapp; soluble GFP-APP; sRapp; soluble DsRed-APP; sGappα; soluble GFP-APP alpha; sGappβ; soluble GFP-APP beta; Amyloid precursor protein; Amyloid-beta; Gree
Presenilins are novel substrates for TRAF6-mediated ubiquitination
Keywords: گاما دگرساز; AD; Alzheimer's disease; AICD; APP intracellular domain; APH-1; anterior pharynx-defective-1; APP; Amyloid precursor protein; Aβ; Amyloid β; C99; 99-amino acid APP C-terminal fragment; ER; Endoplasmic reticulum; FAD; Familial Alzheimer's disease; HEK293
CD46 processing: A means of expression
Keywords: گاما دگرساز; MS; multiple sclerosis; DCs; dendritic cells; MMP; matrix metalloproteinases; P/γS; presenilin/gamma secretase; RA; rheumatoid arthritis; PBMC; peripheral blood mononuclear cells; CD46; Enzymatic processing; Gamma-secretase; Matrix metalloproteinases; T
Basic NeuroscienceCisterna magna cannulated repeated CSF sampling rat model - effects of a gamma-secretase inhibitor on Aβ levels
Keywords: گاما دگرساز; Aβ; amyloid beta; CNS; central nervous system; CSF; cerebrospinal fluid; GSI; gamma-secretase inhibitor; PD; pharmacodynamic; PK; pharmacokinetic; Cerebrospinal fluid; Cisterna magna cannulation; Repeated CSF sampling; Alzheimer's; gamma-secretase; Amylo
Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis
Keywords: گاما دگرساز; Presenilin; Gamma-secretase; Calcium; Structure-function; SCAM; Amyloid; Cotton wool plaques; Alzheimer's disease
Notch-ing from T-cell to B-cell lymphoid malignancies
Keywords: گاما دگرساز; Notch; Lymphoid malignancies; Multiple myeloma; Gamma-secretase; Drug resistance
Jagged/Notch signalling is required for a subset of TGFβ1 responses in human kidney epithelial cells
Keywords: گاما دگرساز; Kidney epithelial cell; Jagged Notch pathway; gamma-Secretase; Transforming growth factor beta
Signal peptide peptidases: A family of intramembrane-cleaving proteases that cleave type 2 transmembrane proteins
Keywords: گاما دگرساز; Intramembrane-cleaving proteases (I-CLiPs); Signal peptide peptidase (SPP); Gamma-secretase; Presenilin; Signal peptide peptidase-like (SPPL)
Design and synthesis of benzoazepinone-derived cyclic malonamides and aminoamides as potent γ-secretase inhibitors
Keywords: گاما دگرساز; Gamma-secretase; Benzoazepinone; Inhibitors
Intracellular pH regulates amyloid precursor protein intracellular domain accumulation
Keywords: گاما دگرساز; APP, amyloid precursor protein; AICD, amyloid precursor protein intracellular domain; Abeta, Amyloid-beta peptide; CTF, carboxy-terminal fragment.Amyloid precursor protein; APP intracellular domain; Alzheimer’s disease; Lysosome; Gamma-secretase; Alkalizi
Presenilin-1 is an unprimed glycogen synthase kinase-3β substrate
Keywords: گاما دگرساز; PS-1, presenilin-1; NTF, N-terminal fragment; CTF, C-terminal fragment; APP, β-amyloid precursor protein; GSK-3β, glycogen synthase kinase-3βAlzheimer’s disease; Glycogen synthase kinase 3β; Presenilin-1; Phosphorylation; Gamma-secretase
Loss of nicastrin elicits an apoptotic phenotype in mouse embryos
Keywords: گاما دگرساز; Nicastrin; Presenilin; Gamma-secretase; Notch; Apoptosis; Mouse embryo; Heart; Brain; Development; Alzheimer's disease
Overexpression of calsenilin enhances γ-secretase activity
Keywords: گاما دگرساز; Calsenilin; Presenilin; Alzheimer's disease; Gamma-secretase; Calcium;