Phlorotannin-rich Ecklonia cava reduces the production of beta-amyloid by modulating alpha- and gamma-secretase expression and activity

► Ecklonia cava reduces beta-amyloids. ► Ecklonia cava reduces gamma-secretase processing via lowering presenilin-1 mRNA. ► Ecklonia cava additionally increases non-amyloidogenic alpha-secretase processing.