دانلود مقالات ISI درباره GAP، پروتئین فعال GTPase + ترجمه فارسی

مجاهدین خلق در سرطان و درمان سرطان

MEK in cancer and cancer therapy

Keywords: GAP، پروتئین فعال GTPase; MAP kinases; ERK inhibitors; Targeted therapy; Resistance; Predictive biomarker; CombinationCRC, colorectal cancer; EMT, epithelial-to-mesenchymal transition; ERK, extracellular signal-regulated kinase; GAP, GTPase-activating protein; GEF, guanine nucleot

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

ARAP2 promotes GLUT1-mediated basal glucose uptake through regulation of sphingolipid metabolism

Keywords: GAP، پروتئین فعال GTPase; ARAP2, ARFGAP with RhoGAP domain, ankyrin repeat and PH domain 2; ARF, ADP-ribosylation factor; ASAP2, ARFGAP with SH3 domain, ankyrin repeat and PH domain 2; GAP, GTPase-activating protein; GCS, glucosylceramide synthase; GLUT1, glucose transporter 1; PH

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

The yeast Arf-GAP Glo3p is required for the endocytic recycling of cell surface proteins

Keywords: GAP، پروتئین فعال GTPase; GAP, GTPase-activating protein; GFP, green fluorescent protein; mCherry, monomeric Cherry; GEF, guanine nucleotide exchange factor; VPS, vacuolar protein sorting; TGN, trans-Golgi network; ER, endoplasmic reticulumArf-GAP; Small GTPase; Vesicular traffick

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Targeting RAS-MAPK-ERK and PI3K-AKT-mTOR signal transduction pathways to chemosensitize anaplastic thyroid carcinoma

Keywords: GAP، پروتئین فعال GTPase; ATC, anaplastic thyroid carcinoma; ATP, adenosine triphosphate; CPt, cisplatin; DOX, doxorubicin; DTC, differentiated thyroid carcinoma; FBS, fetal bovine serum; FTI, farnesyltransferase inhibitor; GAP, GTPase-Activating Protein; GTP, Guanosine-5′-triphos

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Dynamic and Thermodynamic Response of the Ras Protein Cdc42Hs upon Association with the Effector Domain of PAK3

Keywords: GAP، پروتئین فعال GTPase; ASA, accessible surface area; CRIB, Cdc42/Rac interactive binding; CSA, chemical shift anisotropy; GAP, GTPase-activating protein; GDI, guanine nucleotide dissociation inhibitor; GDP, guanosine diphosphate; GEF, guanine nucleotide exchange factor; GTP, gu

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2014 سفارش ترجمه

Ephexin4-mediated promotion of cell migration and anoikis resistance is regulated by serine 897 phosphorylation of EphA2

Keywords: GAP، پروتئین فعال GTPase; RhoG; Cell migration; Anoikis resistance; EphA2; Ephexin; RhoGEFGEF, guanine nucleotide exchange factor; GAP, GTPase-activating protein; SAM, sterile-α-motif; poly-HEMA, poly-hydroxyethylmethacrylate.

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Phospholipase C-β in immune cells

Keywords: GAP، پروتئین فعال GTPase; BCR, B cell receptor; CT, C-terminal; DAG, diacylglycerol; dko, double knockout; GAP, GTPase-activating protein; GPCR, G-protein-coupled receptor; HSC, hematopoietic stem cell; IL, interleukin; IP3, inositol 1,4,5-trisphosphate; ITAM, immunoreceptor tyros

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Akt2 regulates Rac1 activity in the insulin-dependent signaling pathway leading to GLUT4 translocation to the plasma membrane in skeletal muscle cells

Keywords: GAP، پروتئین فعال GTPase; GAP, GTPase-activating protein; GEF, guanine nucleotide exchange factor; GFP, green fluorescent protein; GST, glutathione S-transferase; HA, hemagglutinin; Myr-p110, myristoylated p110; PI3K, phosphoinositide 3-kinase; siRNA, small interfering RNAAkt2; Gl

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Archaeal Translation Initiation Factor aIF2 Can Substitute for Eukaryotic eIF2 in Ribosomal Scanning during Mammalian 48S Complex Formation

Keywords: GAP، پروتئین فعال GTPase; IF, initiation factor; HCV, hepatitis C virus; IRES, internal ribosome entry site; GAP, GTPase-activating protein; 5′ UTR, 5′ untranslated regionArchaea; aIF2; eIF2; Met-tRNA binding; ribosomal scanning

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Control of synapse development and plasticity by Rho GTPase regulatory proteins

Keywords: GAP، پروتئین فعال GTPase; GEF, guanine nucleotide exchange factor; GAP, GTPase-activating protein; LTP, long-term potentiation; LTD, long-term depression; F-actin, filamentous actin; CNS, central nervous system; PH, pleckstrin homology domain; CC-Ex, coiled coil-extended region; R

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2011 سفارش ترجمه

Comparative genomics uncovers novel structural and functional features of the heterotrimeric GTPase signaling system

Keywords: GAP، پروتئین فعال GTPase; GPCRs, G-protein coupled receptors; 7TM, 7-transmembrane receptor; GAP, GTPase activating protein; PBP-I, periplasmic-binding protein type-I domain; TRAFAC GTPase, translation factor class; GAP, GTPase-activating protein; RGS, regulator of G-protein signa

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2011 سفارش ترجمه

Structural and Functional Impact of Cancer-Related Missense Somatic Mutations

Keywords: GAP، پروتئین فعال GTPase; SNP, single-nucleotide polymorphism; SVM, support vector machine; GEF, guanine nucleotide exchange factor; GAP, GTPase-activating protein; PDB, Protein Data Bank; HC, high confidence; XDH, xanthine dehydrogenase; TGFBR2, transforming growth factor β recep

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2011 سفارش ترجمه

Tyr39 of Ran Preserves the Ran·GTP Gradient by Inhibiting GTP Hydrolysis

Keywords: GAP، پروتئین فعال GTPase; GAP, GTPase-activating protein; RanBP1, Ran-binding protein 1; trFTIR, time-resolved Fourier transform infrared spectroscopy; pdb, protein data bankRan; GTPase; FTIR; protein dynamics; nucleocytoplasmatic transport

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Specific motifs of the V-ATPase a2-subunit isoform interact with catalytic and regulatory domains of ARNO

Keywords: GAP، پروتئین فعال GTPase; V-ATPase, vacuolar-type H+-ATPase; a2N, N-terminal cytosolic tail of V-ATPase a2-subunit isoform; ARNO, ADP-ribosylation factor nucleotide site opener; Arf6, ADP-ribosylation factor 6; GEF, GDP/GTP-exchange factor; GAP, GTPase-activating protein; GST, glu

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

Cytokinesis and cancer: Polo loves ROCK‘n’ Rho(A)

Keywords: GAP، پروتئین فعال GTPase; Polo-like kinase 1; RhoA GTPase; Rho kinase; cytokinesisPlk1, Polo-like kinase 1; GEF, guanine nucleotide-exchange factor; GAP, GTPase-activating protein; ROCK, Rho-associated coiled- coil-forming kinase; MLC, myosin light chain

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2010 سفارش ترجمه

A Bacterial GAP-Like Protein, YihI, Regulating the GTPase of Der, an Essential GTP-Binding Protein in Escherichia coli

Keywords: GAP، پروتئین فعال GTPase; Der, double era-like GTPase; GAP, GTPase-activating protein; NTA, nitrilotriacetic acid; BSA, bovine serum albumin; RGS, regulators of G-protein signalingDer; GTPase; E. coli; ribosome; yeast two-hybrid

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2010 سفارش ترجمه

Mitofusin-2 regulates mitochondrial and endoplasmic reticulum morphology and tethering: The role of Ras

Keywords: GAP، پروتئین فعال GTPase; BAP31, B-lymphocyte receptor-associated protein 31; CMT2A, Charcot-Marie-Tooth type 2A neuropathy; Drp1, dynamin-related protein 1; ER, endoplasmic reticulum; ERK, extracellular regulated kinase; GAP, GTPase-activating protein; GEF, guanine exchange facto

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

β2-Chimaerin binds to EphA receptors and regulates cell migration

Keywords: GAP، پروتئین فعال GTPase; GAP, GTPase-activating protein; DAG, diacylglycerol; SH2, Src-homology 2; RT, reverse transcriptase; EYFP, enhanced yellow fluorescent protein; shRNA, short hairpin RNA; GAPDH, glyceraldehyde-3-phosphate dehydrogenaseβ2-Chimaerin; RacGAP; EphA receptor; E

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis

Keywords: GAP، پروتئین فعال GTPase; APC, adenomatous polyposis coli; CK1, casein kinase 1; ECM, extracellular matrix; EGF, epidermal growth factor; ERK, extracellular signal-regulated kinase; FGF, fibroblast growth factor; GAP, GTPase-activating protein; GSK-3β, glycogen synthase kinase-3β;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

IQGAP1 regulation and roles in cancer

Keywords: GAP، پروتئین فعال GTPase; APC, adenomatous polyposis coli; Arp2/3, actin related protein; EGF, epidermal growth factor; EMT, epithelial-to-mesenchymal transition; ERK, extracellular signal-regulated kinase; GBM, glioblastoma multiforme; GAP, GTPase-activating protein; HCC, hepatoc

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Evolution of specificity in the eukaryotic endomembrane system

Keywords: GAP، پروتئین فعال GTPase; LCEA, last Common Eukaryotic Ancestor; SM, Sec1/Munc18; GAP, GTPase-activating protein; GEF, guanine exchange factor; TGN, trans-Golgi network; AP, adaptin; NPC, nuclear pore complex; MVB, multivesicular body; ENTH, epsin N-terminal homology; REP, Rab esc

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Arf GAP2 is positively regulated by coatomer and cargo

Keywords: GAP، پروتئین فعال GTPase; ALPS, Arf GAP lipid packing sensor; Arf, ADP-ribosylation factor; GAP, GTPase-activating protein; PI4P, phosphatidylinositol 4-phosphate; PIP2, phosphatidylinositol 4,5-bisphosphateADP-ribosylation factor; GTPase-activating protein; COPI; Golgi; p24 Cargo

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Role of Individual Domains and Identification of Internal Gap in Human Guanylate Binding Protein-1

Keywords: GAP، پروتئین فعال GTPase; hGBP-1, human guanylate binding protein-1; IFN-γ, interferon-gamma; VSV, vesicular stomatitis virus; EMCV, encephalomyocarditis virus; GAP, GTPase-activating protein; EDTA, ethylenediaminetetraacetic acidhuman guanylate binding protein-1; GTP hydrolysis;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2009 سفارش ترجمه

The DH-PH Region of the Giant Protein UNC-89 Activates RHO-1 GTPase in Caenorhabditis elegans Body Wall Muscle

Keywords: GAP، پروتئین فعال GTPase; GEF, guanine nucleotide exchange factor; GAP, GTPase-activating protein; MBP, maltose-binding protein; MHC, myosin heavy chain; GFP, green fluorescent proteinC. elegans; muscle; GEF; rho; UNC-89

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Effects of lovastatin on Rho isoform expression, activity, and association with guanine nucleotide dissociation inhibitors

Keywords: GAP، پروتئین فعال GTPase; GAP, GTPase-activating protein; GDI, guanine nucleotide dissociation inhibitor; GEF, guanine nucleotide exchange factor; GFP, green fluorescent protein; GST, glutathione-S-transferase; HEL cells, human erythroleukemia cells; HMG-CoA, 3-hydroxy-3-methylglu

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

The Role of the Conserved Switch II Glutamate in Guanine Nucleotide Exchange Factor-Mediated Nucleotide Exchange of GTP-Binding Proteins

Keywords: GAP، پروتئین فعال GTPase; GEF, guanine nucleotide exchange factor; GAP, GTPase-activating protein; wt, wild type; DH, dibble homology; PH, pleckstrin homology; GST, glutathione S-transferase; GDI, GDP-dissociation inhibitor; mGDP, 2′,3′-bis(O)-N-methylanthraniloyl-GDPG protein; GE

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2008 سفارش ترجمه

Compensatory and Long-Range Changes in Picosecond–Nanosecond Main-Chain Dynamics upon Complex Formation: 15N Relaxation Analysis of the Free and Bound States of the Ubiquitin-like Domain of Human Plexin-B1 and the Small GTPase Rac1

Keywords: GAP، پروتئین فعال GTPase; GAP, GTPase-activating protein; GEF, guanine exchange factor; GDI, GDP dissociation inhibitor; GDP, guanosine diphosphate; GMPPNP, guanosine-5′-[(β,γ)-imido]triphosphate triethylammonium salt; GTP, guanosine triphosphate; GTPase, guanosine 5′-triphosphata

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2008 سفارش ترجمه

Structural organization of the tight junctions

Keywords: GAP، پروتئین فعال GTPase; aPKC, atypical protein kinase C; GAP, GTPase-activating protein; GST, glutathione-S-transferase; JAM, junctional adhesion molecule; LLGL1, lethal giant larvae-1; MAGI, membrane-associated guanylate kinase with inverted orientation; MAGUK, membrane-associa

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2008 سفارش ترجمه

Postnatal induction and localization of R7BP, a membrane-anchoring protein for regulator of G protein signaling 7 family-Gβ5 complexes in brain

Keywords: GAP، پروتئین فعال GTPase; postnatal brain development; signal transduction; palmitoylation; lipid raft; G protein-coupled receptors; immunohistochemistryAra-c, cytosine arabinoside; DIV, days in vitro; DRM, detergent-resistant membrane; GAP, GTPase-activating protein; GFAP, glial

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2008 سفارش ترجمه

Diacylglycerol kinase γ interacts with and activates β2-chimaerin, a Rac-specific GAP, in response to epidermal growth factor

Keywords: GAP، پروتئین فعال GTPase; DGK, diacylglycerol kinase; DAG, diacylglycerol; PA, phosphatidic acid; PKC, protein kinase C; PIP5K, phosphatidylinositol-4-phosphate 5-kinase; EGF, epidermal growth factor; GAP, GTPase-activating protein; GFP, green fluorescent protein; EGFP, enhanced G

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

Subsequent events to GTP binding by the plant PsbO protein: Structural changes, GTP hydrolysis and dissociation from the photosystem II complex

Keywords: GAP، پروتئین فعال GTPase; CD, circular dichroism; Chl, chlorophyll; DCBQ, 2,6-dichloro-p-benzoquinone; G domain, guanine nucleotide-binding domain; GAP, GTPase-activating protein; GDI, guanine nucleotide dissociation inhibitor; GEF, guanine nucleotide exchange factor; HEPES, 4-(2-

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

GIT1 utilizes a focal adhesion targeting-homology domain to bind paxillin

Keywords: GAP، پروتئین فعال GTPase; ARF, ADP-ribosylation factor; FAK, focal adhesion kinase; FAT, focal adhesion targeting; GAP, GTPase-activating protein; GRK, G protein-coupled receptor kinase; GIT, GRK-interacting ARF GAP; PAK, p21-activated protein kinase; PIX, PAK-interacting exchange

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2007 سفارش ترجمه

Dynamic phospholipid signaling by G protein-coupled receptors

Keywords: GAP، پروتئین فعال GTPase; DAG, diacylglycerol; EGF, epidermal growth factor; ERK, extracellular signal-regulated kinase; GAP, GTPase-activating protein; GEF, guanine nucleotide exchange factor; GPCR, G protein-coupled receptor; GTPγS, guanosine 5′-0-(3-thio)-triphosphate; IP3, ino

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2007 سفارش ترجمه

Selective interactions between Giα1 and Giα3 and the GoLoco/GPR domain of RGS14 influence its dynamic subcellular localization

Keywords: GAP، پروتئین فعال GTPase; RGS, regulators of G-protein signaling; RBD, Ras-binding domain; GoLoco, Gαi/o-Loco interaction domain; GAP, GTPase-activating protein; GDI, guanine nucleotide dissociation inhibitor; GEF, guanine nucleotide exchange factor; GTPase, guanosine triphosphata

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2007 سفارش ترجمه

How Regulators of G Protein Signaling Achieve Selective Regulation

Keywords: GAP، پروتئین فعال GTPase; cAMP, cyclic AMP; GAIP, G alpha interacting protein, also named RGS19; GAP, GTPase-activating protein; GIRK, G protein-gated inwardly rectifying K+ channels; GPCR, G protein-coupled receptor; GRK, G protein-coupled receptor kinase; GTPase, guanosine triph

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2007 سفارش ترجمه

DBC2 is Essential for Transporting Vesicular Stomatitis Virus Glycoprotein

Keywords: GAP، پروتئین فعال GTPase; BTB, broad-complex tramtrack bric a brac; POZ, poxvirus zinc finger; G-proteins, GTP-binding proteins; GEF, guanine nucleotide exchange factor; GAP, GTPase-activating protein; GDI, guanine nucleotide dissociation inhibitor; NSF, N-ethylmaleimide-sensitive

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

RIG1 inhibits the Ras/mitogen-activated protein kinase pathway by suppressing the activation of Ras

Keywords: GAP، پروتئین فعال GTPase; EGF, epidermal growth factor; ER, endoplasmic reticulum; ERK, extracellular-signal-regulated protein kinase; FBS, fetal bovine serum; GAP, GTPase-activating protein; GEF, guanidine nucleotide exchange factor; HRASLS2, HRAS-like suppressor 2; JNK, c-jun N-

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

Rap1: A turnabout for the crosstalk between cadherins and integrins

Keywords: GAP، پروتئین فعال GTPase; Cadherins; Integrins; Rap1; Molecular crosstalk; Endosome signalling; Vesicle traffickingAJ, adherens junction; GAP, GTPase-activating protein; GEF, guanine nucleotide exchange factor; ECM, extracellular matrix; RTK, receptor tyrosine kinase

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Characterization of the endogenous GIT1–βPIX complex, and identification of its association to membranes

Keywords: GAP، پروتئین فعال GTPase; ARF–GAP; PIX; Cell fractionation; GTPases; Endogenous complexARF, ADP-ribosylating factor; CEF, chicken embryo fibroblast; CyF, cytosolic fraction; GAP, GTPase-activating protein; GIT, G protein-coupled receptor kinase interactor; MeF membrane fraction; P

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

Structure of a GDP:AlF4 Complex of the SRP GTPases Ffh and FtsY, and Identification of a Peripheral Nucleotide Interaction Site

Keywords: GAP، پروتئین فعال GTPase; SRP, signal recognition particle; GAP, GTPase-activating protein; 1,5-IAEDANS, 5-((((2-iodoacetyl)amino)ethyl)amino)naphthalene-1-sulfonic acid; FRET, fluorescence resonance energy transferSRP; GTPase; GDP aluminum fluoride; RNA; regulation

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2006 سفارش ترجمه