دانلود مقالات ISI درباره پروتئین فعال GAP، GTPase + ترجمه فارسی

p190RhoGAP has cellular RacGAP activity regulated by a polybasic region

Keywords: پروتئین فعال GAP، GTPase; GAP, GTPase activating protein; EGF, epidermal growth factor; LPA, lysophosphatidic acid; MEF, mouse embryonic fibroblast; PBR, polybasic region; PAK, p21-activated kinasep190RhoGAP; Rho; Rac; Polybasic region

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Vesicle-mediated export from the ER: COPII coat function and regulation

Keywords: پروتئین فعال GAP، GTPase; COPII, coat protein II complex; ER, endoplasmic reticulum; GEF, guanine nucleotide exchange factor; GAP, GTPase activating protein; CLSD, cranio–lentinculo–sutural dysplasia; TANGO1, transport and Golgi organization 1; ERES, ER exit sites; TFG-1, TRK-fuse

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Semaphorin7A and its receptors: Pleiotropic regulators of immune cell function, bone homeostasis, and neural development

Keywords: پروتئین فعال GAP، GTPase; CDn, cluster of differentiation n; CNS, central nervous system; EAE, experimental autoimmune encephalomyelitis; ECM, extracellular matrix; ERF, Ets2-repressor factor; FAK, focal adhesion kinase; GAP, GTPase activating protein; GPI, glycosylphosphatidylino

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

RGS19 inhibits Ras signaling through Nm23H1/2-mediated phosphorylation of the kinase suppressor of Ras

Keywords: پروتئین فعال GAP، GTPase; ERK, extracellular signal-regulated kinase; GAIP, Gα-interacting protein; GAP, GTPase activating protein; GIPC, GAIP interacting protein C terminus; GPCRs, G protein-coupled receptors; HEK293, human embryonic kidney 293; KSR, kinase suppressor of Ras; MAP

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Feedback regulation of Ran gene expression by Ran protein

Keywords: پروتئین فعال GAP، GTPase; Ran, Ras-related nuclear protein; RCC1, guanine nucleotide- exchange factor; GAP, GTPase activating protein; NPCs, nuclear pore complexes; GFP, green fluorescent protein; EMSA, electrophoretic mobility shift assay; Fluc, firefly luciferase; GST, glutathio

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

The tumor suppressor protein DLC1 is regulated by PKD-mediated GAP domain phosphorylation

Keywords: پروتئین فعال GAP، GTPase; Deleted in liver cancer 1 (DLC1); Protein kinase D (PKD); GTPase activating protein; Rho signaling; Serine phosphorylation; Tumor suppressorDLC1, deleted in liver cancer 1; GAP, GTPase activating protein; GEF, guanine nucleotide exchange factor; PDBu, pho

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Signaling networks regulating leukocyte podosome dynamics and function

Keywords: پروتئین فعال GAP، GTPase; BMM, bone marrow-derived macrophage; DC, dendritic cell; CIP4, Cdc42 interacting protein 4; CSF-1(R), colony stimulating factor-1(receptor); GAP, GTPase activating protein; GDI, guanine nucleotide dissociation inhibitor; LPS, lipopolysaccharide; mDia, mam

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Genetic deletion of regulator of G-protein signaling 4 (RGS4) rescues a subset of fragile X related phenotypes in the FMR1 knockout mouse

Keywords: پروتئین فعال GAP، GTPase; dKO, double knockout; FMRP, fragile X mental retardation protein; FXS, fragile X syndrome; GAP, GTPase activating protein; GIRK, G-protein coupled inwardly rectifying K+ channel; GPCR, G-protein coupled receptor; KO, knockout; mGluR, metabotropic glutamat

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 β-cells and rat islets

Keywords: پروتئین فعال GAP، GTPase; Arf6, ADP-ribosylation factor 6; ARNO, Arf nucleotide binding site opener; GAP, GTPase activating protein; GDI, GDP-dissociation inhibitor; GEF, guanine nucleotide-exchange factor; GGA3, Golgi-localized c-ear homology domain Arf-binding protein-3; GSIS, g

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Rac1 modulation of the apical domain is negatively regulated by βHeavy-spectrin

Keywords: پروتئین فعال GAP، GTPase; βH, βHeavy-spectrin; aPKC, atypical PKC; Dlg, Discs Large; Pak, p21 activated kinase; ZA, zonula adherens; MVB, multivesicular body; GEF, guanine nucleotide exchanging factor; GAP, GTPase activating protein; kst, karst; SBMS, spectrin based membrane skele

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Comparative genomics uncovers novel structural and functional features of the heterotrimeric GTPase signaling system

Keywords: پروتئین فعال GAP، GTPase; GPCRs, G-protein coupled receptors; 7TM, 7-transmembrane receptor; GAP, GTPase activating protein; PBP-I, periplasmic-binding protein type-I domain; TRAFAC GTPase, translation factor class; GAP, GTPase-activating protein; RGS, regulator of G-protein signa

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2011 سفارش ترجمه

The myriad roles of Anillin during cytokinesis

Keywords: پروتئین فعال GAP، GTPase; F-actin, filamentous actin; GEF, guanine nucleotide exchange factor; GAP, GTPase activating protein; PH, pleckstrin homology; AH, Anillin homology; SH3, Src homology 3; TCA, trichloroacetic acid; FRET, fluorescence/Förster resonance energy transfer; NLS,

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Phosphatidic acid potentiates Gαq stimulation of phospholipase C-β1 signaling

Keywords: پروتئین فعال GAP، GTPase; Gαq; GPCR; Phosphatidic acid; Phospholipase C-β; Phospholipase DDGK, diacylglycerol kinase; GAP, GTPase activating protein; GPCR, G protein coupled receptor; PA, phosphatidic acid; PLC-β, phospholipase C-β; PLD, phospholipase D; PMA, 4β-phorbol 12-myrista

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Phosphatidic acid regulates signal output by G protein coupled receptors through direct interaction with phospholipase C-β1

Keywords: پروتئین فعال GAP، GTPase; DGK, diacylglycerol kinase; GAP, GTPase activating protein; PA, phosphatidic acid; PLC-β, phospholipase C β; PLD, phospholipase DPhosphatidic acid; Phospholipase C-β; Gαq; GPCR; Phospholipase D; Diacylglycerol kinase

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Screening the secretion machinery: High throughput imaging approaches to elucidate the secretory pathway

Keywords: پروتئین فعال GAP، GTPase; ER, endoplasmic reticulum; FP, fluorescent protein; GAP, GTPase activating protein; HCS, high content screening; ORF, open reading frame; RNAi, RNA interferenceMembrane traffic; Secretory pathway; Cell-based assays; RNA interference; High content screenin

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Toward a model for Arf GTPases as regulators of traffic at the Golgi

Keywords: پروتئین فعال GAP، GTPase; AP1–4, Adaptin proteins; Arf, ADP-ribosylation factor; Arl, Arf-like; GAP, GTPase activating protein; GEF, guanine nucleotide exchange factor; GGA, Golgi localized, γ-ear-containing, Arf binding proteins; Mint, Munc18-interacting proteinsADP-ribosylation

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Simultaneous loss of the DLC1 and PTEN tumor suppressors enhances breast cancer cell migration

Keywords: پروتئین فعال GAP، GTPase; DLC1, deleted in liver cancer 1; GAP, GTPase activating protein; GEF, guanine nucleotide exchange factor; LOH, loss of heterozygosity; PI3K, phosphatidylinositol 3-kinase; PIP3, phosphatidylinositol 3,4,5-trisphosphate; PTEN, phosphatase and tensin homolo

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Decreased Expression of the RAS-GTPase Activating Protein RASAL1 Is Associated With Colorectal Tumor Progression

Keywords: پروتئین فعال GAP، GTPase; 5-aza, 5-aza-2′-deoxycytidine; CRC, colorectal cancer; GAP, GTPase activating protein; MAPK, mitogen-activated protein kinase; RASAL1, Ras protein activator like 1

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Semaphorins and their receptors in lung cancer

Keywords: پروتئین فعال GAP، GTPase; CRMP, collapsin response mediator protein; EC, endothelial cell; ECD, extracellular domain; EGFR, epidermal growth factor receptor; FHIT, fragile histidine triad; GAP, GTPase activating protein; GEF, guanine nucleotide exchange factor; GRP, gastrin-releas

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2009 سفارش ترجمه

Systems biology of the cell cycle of Saccharomyces cerevisiae: From network mining to system-level properties

Keywords: پروتئین فعال GAP، GTPase; APC, Anaphase Promoting Complex; Cdk1, Cyclin dependent kinase1 (Cdc28); CK2, Casein Kinase 2; FEAR, Cdc Fourteen Early Anaphase Release; GAP, GTPase activating protein; GEF, Guanine Exchange Factor; MBF, MCB, MluI Cell Cycle Box, Binding Factor; MCC, Mit

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2009 سفارش ترجمه

Plexin B1 is downregulated in renal cell carcinomas and modulates cell growth

Keywords: پروتئین فعال GAP، GTPase; GAP, GTPase activating protein; GAPDH, glyceraldehyde-3-phosphate-dehydrogenase; MTT, methylthiazoltetrazolium; RT-PCR, reverse transcription-polymerase chain reaction; RhoGEF, Rho-specific guanine nucleotide exchange factor; Sema4D, semaphorin 4D.

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Ric-8B interacts with Gαolf and Gγ13 and co-localizes with Gαolf, Gβ1 and Gγ13 in the cilia of olfactory sensory neurons

Keywords: پروتئین فعال GAP، GTPase; GEF, guanine nucleotide exchange factor; GPCRs, G protein coupled receptors; OR, odorant receptor; VNO, vomeronasal organ; Ric-8B, resistance to inhibitors of cholinesterase 8B; RGS, regulator of G protein signaling; GAP, GTPase activating protein; OMP, o

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Kap95p Binding Induces the Switch Loops of RanGDP to Adopt the GTP-Bound Conformation: Implications for Nuclear Import Complex Assembly Dynamics

Keywords: پروتئین فعال GAP، GTPase; GTP, guanosine 5′-triphosphate; GDP, guanosine 5′-diphosphate; GTPase, guanosine 5′-triphosphatase; GAP, GTPase activating protein; IBB, importin-β-binding; NCS, non-crystallographic symmetry; GST, glutathione-S-transferase; TLS, translation-libration-scr

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

Characterization of a Novel Prokaryotic GDP Dissociation Inhibitor Domain from the G Protein Coupled Membrane Protein FeoB

Keywords: پروتئین فعال GAP، GTPase; GEF, guanine nucleotide exchange factor; GAP, GTPase activating protein; GDI, guanine nucleotide dissociation inhibitor; mant, N-methylanthraniloyl; GMPPNP, guanosine-5′[(β,γ)-imido]triphosphate; MBP, maltose binding protein; LB, Luria brothbacterial prot

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه

Role of TGF-β1-independent changes in protein neosynthesis, p38αMAPK, and cdc42 in hydrogen peroxide-induced senescence-like morphogenesis

Keywords: پروتئین فعال GAP، GTPase; 2DGE, two-dimensional gel electrophoresis; CaD, caldesmon; CXM, cycloheximide; EGF, epidermal growth factor; FBS, fetal bovine serum; GAP, GTPase activating protein; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; HDF, human diploid fibroblast; HSP, heat

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2008 سفارش ترجمه

RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling

Keywords: پروتئین فعال GAP، GTPase; GAP, GTPase activating protein; RGS, Regulator of G protein signaling; PKCI-1, Protein kinase C interacting protein; PKC, Protein kinase C.RGSZ1; PKCI-1; Yeast two hybrid; 14-3-3; Phosphorylation; cAMP

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Coated vesicles in plant cells

Keywords: پروتئین فعال GAP، GTPase; CCV, clathrin-coated vesicles; CHC, clathrin heavy chain; CLC, clathrin light chain; ER, endoplasmic reticulum; ERES, endoplasmic reticulum export sites; GAP, GTPase activating protein; GEF, guanosine nucleotide exchange factor; LV, lytic vacuole; MVB, mu

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Redox signalling in anchorage-dependent cell growth

Keywords: پروتئین فعال GAP، GTPase; DCF-DA, 2′,7′-dichlorofluorescein diacetate; ECM, Extracellular matrix; ERK, Extracellular signal regulated kinase; GAP, GTPase activating protein; GF, Growth factor; GPCRs, G-protein coupled receptors; HGFR, Hepatocyte growth factor receptor; PI3K, Phosp

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

Molecular mechanisms of COPII vesicle formation

Keywords: پروتئین فعال GAP، GTPase; COPII, coat protein complex II; ER, endoplasmic reticulum; tER, transitional ER; GEF, guanine nucleotide exchange factor; GAP, GTPase activating protein; PI4P, phosphatidylinositol-4-phosphate; SNARE, soluble N-ethylmaleimide sensitive factor attachment p

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2

Keywords: پروتئین فعال GAP، GTPase; VEGF, vascular endothelial growth factor; VEGFR, vascular endothelial growth factor receptor; GEF, guanine nucleotide exchange factor; GAP, GTPase activating protein; HUVECs, human umbilical vein endothelial cells; HMVEC-d, human microvascular endothelial

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2007 سفارش ترجمه

The Parkinson’s disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase thatstimulates kinase activity

Keywords: پروتئین فعال GAP، GTPase; PD, Parkinson’s disease; LRRK2, leucine-rich repeat kinase 2; GEF, guanine nucleotide exchange factor; GAP, GTPase activating protein; GDI, guanine nucleotide dissociation inhibitor; GST, glutathione-S-transferase; IPTG, isopropyl β-d-thiogalactoside; SDS

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2007 سفارش ترجمه

The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation

Keywords: پروتئین فعال GAP، GTPase; GAP, GTPase activating protein; GDI, guanine nucleotide dissociation inhibitor; GEF, guanine nucleotide exchange factor; DH, Dbl-homology; PH, pleckstrin-homology; GST, glutathione-S-transferase; mant, N-methylanthraniloylTrio; Dbl-family GEF; pleckstrin-

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2007 سفارش ترجمه

Change in Nutritional Status Modulates the Abundance of Critical Pre-initiation Intermediate Complexes During Translation Initiation in Vivo

Keywords: پروتئین فعال GAP، GTPase; eIF, eukaryotic initiation factor; TC, ternary complex; GAP, GTPase activating protein; G protein, guanine nucleotide binding protein; GEF, guanine nucleotide exchange factor; CTD, carboxyl-terminal domain; NTD, amino-terminal domain; YPD, yeast-extract p

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2007 سفارش ترجمه

The budding yeast Pichia pastoris has a novel Sec23p homolog

Keywords: پروتئین فعال GAP، GTPase; COPII, coat protein complex II; DIC, differential interference contrast; ER, endoplasmic reticulum; GAP, GTPase activating protein; tER, transitional ERCOPII; Sec23; Lst1; Transitional ER; ER exit sites; Pichia pastoris

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

Adipocytes contain a novel complex similar to the tuberous sclerosis complex

Keywords: پروتئین فعال GAP، GTPase; EST, expressed sequence tag; GAP, GTPase activating protein; MS, mass spectrometry; TSC, tuberous sclerosis complexAdipocyte; Akt; GTPase activating protein; Insulin; KIAA1219; Tuberous sclerosis complex

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

The multiple function of Grb2 associated binder (Gab) adaptor/scaffolding protein in immune cell signaling

Keywords: پروتئین فعال GAP، GTPase; BCR, B cell receptor complex; Dok, downstream of kinase; EGFR, epidermal growth factor receptor; FcR, Fc receptors; Gab, Grb2 associated binder; GAP, GTPase activating protein; HGF, hepatocyte growth factor; ITAM, immunoreceptor tyrosine based activation

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

Mitochondrial targeting of growth suppressor protein DLC2 through the START domain

Keywords: پروتئین فعال GAP، GTPase; DLC2, deleted in liver cancer 2; GAP, GTPase activating protein; HCC, hepatocellular carcinoma; PBS, phosphate buffered saline; SAM, sterile α-motif; SRE, serum response element; StAR, steroidogenic acute regulatory protein; START, steroidogenic acute reg

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

Differential mechanisms of glutamate receptor regulation of SynGAP in cortical neurones

Keywords: پروتئین فعال GAP، GTPase; PBS, phosphate-buffered saline; GAP, GTPase activating protein; NMDA, N-methyl-d-aspartate; AMPA, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid; APV, d(−)-2-amino-5-phosphono-pentanoic acid; SDS, sodium dodecylsulphate; PSD, post synaptic densityNM

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

Molecular targets for emerging anti-tumor therapies for neurofibromatosis type 1

Keywords: پروتئین فعال GAP، GTPase; EGFR, epidermal growth factor receptor; FTI, farnesyl transferase inhibitor; GGTI, geranylgeranyl transferase inhibitor; GAP, GTPase activating protein; MPNST, malignant peripheral nerve sheath tumor; NF1, type 1 neurofibromatosis; PAK, p21-activated kina

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

Thy-1, a versatile modulator of signaling affecting cellular adhesion, proliferation, survival, and cytokine/growth factor responses

Keywords: پروتئین فعال GAP، GTPase; COX, cyclooxygenase; FAK, focal adhesion kinase; Gadd 45 γ, DNA-damage-inducible protein 45 gamma; GAP, GTPase activating protein; GPI, glycosylphosphatidylinositol; LAT, linker for activation of T cells; MAPK, mitogen-activated protein kinase; NCAM, neur

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Peroxisome biogenesis: Where Arf and coatomer might be involved

Keywords: پروتئین فعال GAP، GTPase; Arf, ADP ribosylation factor; BFA, brefeldin A; COP, coat protein; ER, endoplasmic reticulum; GAP, GTPase activating protein; GEF, guanine nucleotide exchange factor; GDPβS, Guanosine 5′-[β-thio]diphosphate; GMP-PNP, Guanosine 5′-[β,γ-imido]triphosphate;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

C1 domains exposed: From diacylglycerol binding to protein–protein interactions

Keywords: پروتئین فعال GAP، GTPase; PDBu, phorbol 12,13-dibutyrate; DAG, diacylglycerol; DGK, diacylglycerol kinase; DOG, dioctanylglycerol; EGF, epidermal growth factor; GAP, GTPase activating protein; GEF, guanine nucleotide exchange factor; GFP, green fluorescent protein; KSR, kinase sup

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1

Keywords: پروتئین فعال GAP، GTPase; Ec, constitutive effector; DMEM, Dulbecco’s modified Eagle medium; 4E-BP1, eIF4E-binding protein 1; GAP, GTPase activating protein; HEK, human embryonic kidney; mTOR, mammalian target of rapamycin; PI3K, phosphoinositide-3-kinase; Rheb, Ras homologue enri

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه