Screening the secretion machinery: High throughput imaging approaches to elucidate the secretory pathway

Increasing our knowledge of the secretory pathway remains fundamental to a greater understanding of cell health and disease. High throughput cell biology approaches provide a new opportunity to study this important process at a truly genome-wide scale. This review highlights how techniques such as high throughput subcellular localisation, RNA interference screening and automated microscopy are now being harnessed to provide new information about secretory pathway function.