Keywords: Intrahepatic cholestasis of pregnancy; Serum bile acid; Pseudo-targeted method; Metabolomics; UPLC-triple TOF-MS/MS; Diagnostic and therapeutic profiles; ICP; Intrahepatic cholestasis of pregnancy; TBA; total bile acids; UDCA; ursodeoxycholic acid; LCA; l
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Keywords: ASBT; apical sodium-dependent bile acid transporter; BMI; body mass index; CA; cholic acid; CA-D4; cholic acidâ2,2,4,4âD4; CARB; Carbohydrate and Related Biomarkers; CDCA; chenodeoxycholic acid; CRP; C-reactive protein; CV; coefficient of variation; D
Keywords: ASBT; apical sodium-dependent bile acid transporter; ASDs; amorphous solid dispersions; BACS; bile acid-CoA synthase; BAT; bile acid-amino acid transferase; BCS; biopharmaceutics classification system; BSH; bile salt hydrolase; C4; 7α-hydroxy-4-cholesten
Keywords: ABCB; ATP-binding cassette sub-family B; Apo; apolipoprotein; ASBT; apical sodium dependent bile acid transporter; BDL; bile duct ligation; BSEP; bile salt export pump; CA; cholic acid; CDCA; chenodeoxycholic acid; C/EBP; CCAAT-enhancer-binding protein; C
Keywords: ANT; adenine nucleotide translocator; Cyt C; cytochrome C; Cys A; cyclosporine A; FCCP; carbonylcyanide-p-(trifluoromethoxy) phenyl-hydrazone; GCDCA; glycochenodeoxycholic acid; IM; inner membrane; MβCD; methyl-β-cyclodextrin; MMP; mitochondrial membran
Bile acid receptors in the biliary tree: TGR5 in physiology and disease
Keywords: AC; adenylate cyclase; BS; bile salt; BSEP; bile salt export pump (ABCB11); CA; cholic acid/cholate; cAMP; cyclic AMP; CBDL; common bile duct ligation; CCA; cholangiocarcinoma; CDCA; chenodeoxycholic acid/chenodeoxycholate; CD95L; CD95 ligand; CFTR; cysti
Glycochenodeoxycholic Acid Does Not Increase Transforming Growth Factor-Beta Expression in Bile Duct Epithelial Cells or Collagen Synthesis in Myofibroblasts
Keywords: DMEM; Dulbecco's modified Eagle medium; FBS; fetal bovine serum; GCDCA; glycochenodeoxycholic acid; PCR; Polymerase chain reaction; TGF-β; transforming growth factor-beta; bile acids; primary sclerosing cholangitis; bile duct epithelial cells; phosphatyl
Deletion of liver-specific STAT5 gene alters the expression of bile acid metabolism genes and reduces liver damage in lithogenic diet-fed mice
Keywords: STAT5; signal transducer and activator of transcription 5; GH; growth hormone; IGF-1; insulin-like growth factor-1; LDLR; low-density lipoprotein receptor; STAT5 LKO; liver-specific STAT5 knock-out; STAT5 fl/fl; STAT5 flox/flox; TG; triacylglycerol; ChMCs
Promotion of classic neutral bile acids synthesis pathway is responsible for cholesterol-lowing effect of Si-miao-yong-an decoction: Application of LC-MS/MS method to determine 6 major bile acids in rat liver and plasma
Keywords: SMYAD; Si-miao-yong-an decoction; TCM; traditional Chinese medicine; TC; total cholesterol; TG; total triglyceride; LDL-c; low-density lipoprotein cholesterol; HDL-c; high-density lipoprotein cholesterol; CA; cholic acid; CDCA; chenodeoxycholic acid; TCA;
Improved synthesis of glycine, taurine and sulfate conjugated bile acids as reference compounds and internal standards for ESI-MS/MS urinary profiling of inborn errors of bile acid synthesis
Keywords: EEDQ; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; DEPC; diethyl phosphorocyanidate; DPPA; diphenyl phosphoryl azide; SO3-TEA; sulfur trioxide-triethylamine complex; SO3-TMA; sulfur trioxide-trimethylamine complex; SO3-DMA; sulfur trioxide-N,N-dimethyl
GCDCA down-regulates gene expression by increasing Sp1 binding to the NOS-3 promoter in an oxidative stress dependent manner
Keywords: Cholestatic liver disease; Endothelial nitric oxide synthase; Oxidative stress; Transcription factor Sp1; Glycochenodeoxycholic acid; ADHP; 0-acetyl-3, 7-dihydroxyphenoxazine; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BDL; bile duct
UPLC-MS-based serum metabonomics for identifying acute liver injury biomarkers in Chinese miniature pigs
Keywords: ALB; albumin; ALT; alanine aminotransferase; AST; aspartate aminotransferase; ATP; adenosine triphosphate; BPI; base peak intensity; CDP-choline; cytidine diphosphate choline; CHO; cholesterol; Cr; creatinine; ESI; electrospray ionization; FAAH; fatty aci
Hepatocyte-based in vitro model for assessment of drug-induced cholestasis
Keywords: ALT; alanine aminotransferase; ALP; aspartate aminotransferase; BAs; bile acids; BSEP/Bsep; bile salt export pump (human/rat); DICI; drug-induced cholestasis index; DMSO; dimethyl sulfoxide; TCA; taurocholic acid; CA; cholic acid; FBS; fetal bovine serum;
Disruption of Stard10 gene alters the PPARα-mediated bile acid homeostasis
Keywords: StAR; steroidogenic acute regulatory protein; START; StAR-related lipid transfer; STARD10/Stard10; START domain containing 10; WT; wild type; ASBT/Asbt; apical sodium dependent bile acid transporter; STARD2/Stard2; START domain containing 2; CA; cholic ac
Mitochondrial genome depletion in human liver cells abolishes bile acid-induced apoptosis: Role of the Akt/mTOR survival pathway and Bcl-2 family proteins
Keywords: ABC; ATP-binding cassette; Akt; protein kinase B; BCRP; Breast cancer resistance protein; BSEP; Bile salt export pump; DCA; Deoxycholic acid; DCFH-DA; 2â²,7â²-dichlorofluorescein diacetate; ERK; Extracellular regulated kinase; EtBr; Ethidium bromide; GC
Differential activation of the human farnesoid X receptor depends on the pattern of expressed isoforms and the bile acid pool composition
Keywords: Glycoconjugated bile acids; Tauroconjugated bile acids; Ileum; Liver; Nuclear receptor; ACA; allocholic acid; BA; bile acid; BSEP; bile salt export pump; CDCA; chenodeoxycholic acid; CA; cholic acid; DCA; deoxycholic acid; FGF; fibroblast growth factor; F
Bile acid profiling in human biological samples: Comparison of extraction procedures and application to normal and cholestatic patients
Keywords: CA; cholic acid; CDCA; chenodeoxycholic acid; CV; coefficient of variation; DCA; deoxycholic acid; GCA; glycocholic acid; GCDCA; glycochenodeoxycholic acid; GC-MS; gas chromatography coupled to mass spectrometry; GDCA; glycodeoxycholic acid; GLCA; glyco
Calcium-dependent nitric oxide production is involved in the cytoprotective properties of n-acetylcysteine in glycochenodeoxycholic acid-induced cell death in hepatocytes
Keywords: Activator protein 1; AP-1; Anion superoxide; O2â; 2,7- dichlorofluorescein diacetate; DCFDA; (Z)-1-[2-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate; NONOate; dihydroethidium; DHE; glycochenodeoxycholic acid; GCDCA; reduced glutathione;
Bile acid toxicity structure-activity relationships: Correlations between cell viability and lipophilicity in a panel of new and known bile acids using an oesophageal cell line (HET-1A)
Keywords: GCA; glcyocholic acid; GCDCA; glycochenodeoxycholic acid; GDCA; glycodeoxycholic acid; GUDCA; glycoursodeoxycholic acid; HSA; hydrophobic surface area; HCA; hyocholic acid; NCA; nutriacholic acid; UCA; ursocholic acid; PSA; polar surface area; TCA; tauroc
Bile acids induce hepatic stellate cell proliferation via activation of the epidermal growth factor receptor
Keywords: BrdU; bromodeoxyuridine; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; ERK; extracellular signal-regulated kinase; GCDCA; glycochenodeoxycholic acid; HSC; hepatic stellate cell; JNK; c-Jun N-terminal kinase; MEK; mitogen-activated