Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; BD, bipolar disorder; BDNF, brain derived neurotrophic factor; CNS, central nervous system; ERK, extracellular signal-regulated kinase; GDNF, glial cell line-derived neurotrophic factor; GFRalpha-1, GDNF family receptor alpha 1; GSK3, glycogen synthase ki
مقالات ISI GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی (ترجمه نشده)
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Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; BDNF, brain-derived neurotrophic factor; CB, carotid body; GDNF, glial cell line-derived neurotrophic factor; GFRα1, GDNF family receptor alpha-1; NGF, nerve growth factor; NT-3, neurotrophin-3; NT-4, neurotrophin-4; NWR, normotensive Wistar rats; p75NTR,
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; HAT, histone acetyltransferases; HSP70, heat shock protein 70; GDNF, glial cell line-derived neurotrophic factor; BDNF, brain derived neurotrophic factor; SMN, survival motor neuron; FMR, fragile X mental retardation; iNOS, inducible nitric oxide synthase
Genetic variation in the GDNF promoter affects its expression and modifies the severity of Hirschsprung's disease (HSCR) in rats carrying Ednrbsl mutations
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; HSCR, Hirschsprung’s disease; GDNF, glial cell line-derived neurotrophic factor; ENS, enteric nervous system; RET, Ret proto-oncogene; LEF1, lymphoid enhancing factor-1HSCR; Gdnf; Promoter; Genetic variation; Dual-luciferase assay
GPER: A new tool to protect dopaminergic neurons?
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; BDNF, brain-derived neurotrophic factor; DA, dopamine; E2, 17β-estradiol; ER, estrogen receptor; FBS, fetal bovine serum; G1, GPER agonist; G15, GPER antagonist; GFAP, glial fibrilar acidic protein; GDNF, glial cell line-derived neurotrophic factor; GPER,
Improvement in the neural stem cell proliferation in rats treated with modified “Shengyu” decoction may contribute to the neurorestoration
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; BrdU, 5-Bromo-2׳-deoxy-uridine; GDNF, glial cell line-derived neurotrophic factor; GFAP, glial fibrillary acidic protein; MSD, modified “Shengyu” decoction; NCAM, neural cell adhesion molecule; NeuN, neuron-specific nuclear protein; NGF, nerve growth fact
Lactoferrin up-regulates intestinal gene expression of brain-derived neurotrophic factors BDNF, UCHL1 and alkaline phosphatase activity to alleviate early weaning diarrhea in postnatal piglets
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; BDNF, brain-derived neurotrophic factor; GDNF, glial cell line-derived neurotrophic factor; IAP, intestinal alkaline phosphatase; Lf, lactoferrin; UCHL1, ubiquitin carboxy-terminal hydrolase L1 (ubiquitin thiolesterase)BDNF; Neurotrophins; Lactoferrin; UC
GDNF is important for striatal organization and maintenance of dopamine neurons grown in the presence of the striatum
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; DARPP-32, dopamine and cyclic AMP-regulated phosphoprotein-relative molecular mass 32,000; GDNF, glial cell line-derived neurotrophic factor; LGE, lateral ganglionic eminence; MRI, magnetic resonance imaging; PBS, phosphate-buffered saline; PCR, Polymeras
Effects of intravenous administration of umbilical cord blood CD34+ cells in a mouse model of neonatal stroke
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; ANOVA, analysis of variance; CBF, cerebral blood flow; GDNF, glial cell line-derived neurotrophic factor; HIE, hypoxic–ischemic encephalopathy; hUCB, human umbilical cord blood; HuNu, anti-human nuclei antibody; MCAO, middle cerebral artery occlusion; MNC
Neurotrophic and neuroprotective efficacy of intranasal GDNF in a rat model of Parkinson’s disease
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; 6-OHDA, 6-hydroxydopamine; BBB, blood–brain barrier; BSA, bovine serum albumin; GDNF, glial cell line-derived neurotrophic factor; IOD, integrated optical density; MFB, median forebrain bundle; OVAL, ovalbumin; PBS, phosphate-buffered saline; PD, Parkinso
Expression patterns of CXCR4 in different colon tissue segments of patients with Hirschsprung's disease
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; CXCR4, C-X-C chemokine receptor type 4; ENCCs, enteric neural crest cells; ENS, enteric nervous system; GDNF, glial cell line-derived neurotrophic factor; HSCR, Hirschsprung's disease; NCCs, neural crest cells; NCDCs, neural crest-derived cells; SDF-1, st
The protective effects of resveratrol on Schwann cells with toxicity induced by ethanol in vitro
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; AMPK, AMP-activated protein kinase; BDNF, brain-derived neurotrophic factor; CC, Compound C; DMEM/F-12, Dulbecco’s Modified Eagle Medium with the F-12 supplement; EtOH, ethanol; GDNF, glial cell line-derived neurotrophic factor; NAD, nicotinamide adenine
Glial cell line-derived neurotrophic factor (GDNF) induces neuritogenesis in the cochlear spiral ganglion via neural cell adhesion molecule (NCAM)
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; DMEM, Dulbecco's modified Eagle medium; DMSO, dimethylsulfoxid; Fc, fragment crystallizeable region; FITC, fluorescein isothiocyanate; GDNF, glial cell line-derived neurotrophic factor; GFRα1, glial cell line-derived neurotrophic factor receptor alpha 1;
Absence of SHATI/Nat8l reduces social interaction in mice
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; ANOVA, analysis of variance; BDNF, brain-derived neurotrophic factor; GDNF, glial cell line-derived neurotrophic factor; LITAF, lipopolysaccharides-induced tumor necrosis factor-α factor; RT-PCR, reverse transcription polymerase chain reaction; TNF-α, tum
Increased cellular distribution of vimentin and Ret in the cingulum induced by developmental hypothyroidism in rat offspring maternally exposed to anti-thyroid agents
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; CC, corpus callosum; Cld11, claudin 11; CNS, central nervous system; DCC, deleted in colorectal cancer protein; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; GD, gestation day; GDNF, glial cell line-derived neurotrophic factor; GFAP, glial fibrillary a
Involvement of phosphatidylinositol 3-kinase/Akt on basic fibroblast growth factor-induced glial cell line-derived neurotrophic factor release from rat glioma cells
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; DMEM, Dulbecco's modified Eagle's medium; Egr-1, early growth response-1; ELISA, enzyme-linked immunosorbent assay; FGF, fibroblast growth factor; FGF-2, basic fibroblast growth factor; GDNF, glial cell line-derived neurotrophic factor; GSK3β, glycogen sy
PI3K signaling in the regulation of branching morphogenesis
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; BAD, Bcl-2-associated death promoter; ECM, extracellular matrix; EGF, epidermal growth factor; FGF, fibroblast growth factor; GDNF, glial cell line-derived neurotrophic factor; GPCR, G protein-coupled receptor; HGF, hepatocyte growth factor; MAPK, mitogen
Overexpression of serum response factor in astrocytes improves neuronal plasticity in a model of early alcohol exposure
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; CBI, contralateral bias index; CREB, cAMP response element binding protein; EDTA, ethylene diamine tetra acetic acid; FASD, fetal alcohol spectrum disorders; GDNF, glial cell line-derived neurotrophic factor; GFAP, Glial fibrillary acidic protein; GFP, Gr
Ethyl pyruvate-mediated Nrf2 activation and hemeoxygenase 1 induction in astrocytes confer protective effects via autocrine and paracrine mechanisms
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; EP, ethyl pyruvate; Nrf2, nuclear factor E2-related factor 2; HO-1, hemeoxygenase 1; ARE, antioxidant response element; ZnPP, zinc protoporphyrin; GDNF, glial cell line-derived neurotrophic factor; GSH, glutathione; bZIP, basic-region leucine zipper; NQO1
A new alternative NF-ΚB Pathway mediated the neuroprotection of GDNF on 6-OHDA-induced DA neurons neurotoxicity
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; GDNF, glial cell line-derived neurotrophic factor; DA, dopaminergic; SNc, substantia nigra pars compacta; NIK, NF-κB-inducing kinase; I B, inhibitor of B; IKK, I B kinase; TH, tyrosine hydroxylaseGDNF; DA neurons; NIK; IKKα; NF-κB
Genetics of human enteric neuropathies
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; AAAS, Allgrove syndrome; CIPO, chronic intestinal pseudo obstruction; EDNRB, endothelin receptor type B; ENS, enteric nervous system; FLNA, filamin A; FVN, familial visceral neuropathy; GDNF, glial cell line-derived neurotrophic factor; HOX11L1, T-cell le
Transgene expression in the striatum following intracerebral injections of DNA nanoparticles encoding for human glial cell line-derived neurotrophic factor
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; plasmid optimization; Parkinson's disease; gene therapy; splice variantANOVA, analysis of variance; DNP, DNA nanoparticle; GDNF, glial cell line-derived neurotrophic factor; hGDNF, human GDNF; PEG, polyethylene glycol; s.e.m., standard error of the mean;
Histone deacetylase inhibition alters histone methylation associated with heat shock protein 70 promoter modifications in astrocytes and neurons
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; Valproic acid; Histone methylation; Heat shock protein 70; MS-275; NF-Y; p300BDNF, brain-derived neurotrophic factor; CNS, central nervous system; GDNF, glial cell line-derived neurotrophic factor; H3K4Me2, histone 3 lysine 4 dimethylation; H3K4Me3, histo
Lentiviral delivery of Meteorin protects striatal neurons against excitotoxicity and reverses motor deficits in the quinolinic acid rat model
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; CDNF, cerebral dopamine neurotrophic factor; CNTF, ciliary neurotrophic factor; GDNF, Glial Cell Line-derived Neurotrophic Factor; GFP, green fluorescent protein; HD, Huntington's Disease; MANF, mesencephalic astrocyte-derived neurotrophic factor; PD, Par
Constitutive Ret signaling is protective for dopaminergic cell bodies but not for axonal terminals
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; DA, dopamine; DOPAC, dihydroxyphenylacetic acid; HVA, homovanilic acid; TH, tyrosine hydroxylase; DAT, dopamine transporter; VMAT2, vesicular monoamine transporter 2; RTK, receptor tyrosine kinase; GDNF, glial cell line-derived neurotrophic factor; MEN2B,
Neurofilament dot blot assays: Novel means of assessing axon viability in culture
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; GDNF, glial cell line-derived neurotrophic factor; Min, minimal serum free media; NF, neurofilament; NO, nitric oxide; SOD, superoxide dismutase; ROS, reactive oxygen speciesAxon viability; Dot blot assay; Neurodegenerative disease; Neurofilament; Phospho
Distribution of acid sphingomyelinase in rodent and non-human primate brain after intracerebroventricular infusion
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; BSA, bovine serum albumin; CSF, cerebrospinal fluid; ELISA, enzyme-linked immunosorbent assay; ERT, enzyme replacement therapy; Gd, gadoteridol; GDNF, glial cell line-derived neurotrophic factor; HRP, horseradish peroxidase; ICP, intracranial pressure; IC
Reconstruction and quantitative evaluation of dopaminergic innervation of striatal neurons in dissociated primary cultures
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; GAP43, growth-associated protein-43; DIV, days in vitro; GDNF, glial cell line-derived neurotrophic factor; GIRK-2, G-protein-activated inwardly rectifying potassium channel 2; MAP2, microtubule-associated protein 2; pNF, phosphorylated neurofilaments; St
Exercise exerts neuroprotective effects on Parkinson's disease model of rats
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; BDNF, brain-derived neurotrophic factor; BrdU, 5-bromo-2′-deoxy-uridine; DA, dopamine; Dcx, doublecortin; GDNF, glial cell line-derived neurotrophic factor; HPF, high-power field; PD, Parkinson's disease; SNc, substantia nigra pars compacta; SVZ, subventr
Differential effects of riluzole on subpopulations of adult rat dorsal root ganglion neurons in vitro
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; cell culture; sensory neuron; neuritogenesis; regenerationBDNF, brain-derived neurotrophic factor; CGRP, calcitonin gene related peptide; DRG, dorsal root ganglion; FITC, fluoroscein-isothiocyanate; GDNF, glial cell line-derived neurotrophic factor; GFR1,
Group II metabotropic glutamate receptor activation by agonist LY379268 treatment increases the expression of brain derived neurotrophic factor in the mouse brain
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; LY379268; mGlu2/3 receptors; BDNF; neurotrophic factors; hippocampus; cerebral cortexBDNF, brain-derived neurotrophic factor; GDNF, glial cell line-derived neurotrophic factor; LY379268, (−)-2-Oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylic acid; mGlu, m
Potential of rat bone marrow-derived mesenchymal stem cells as vehicles for delivery of neurotrophins to the Parkinsonian rat brain
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; DAPI, 4',6-diamidino-2-phenylindole; ELISA, enzyme linked immunosorbent assay; GDNF, glial cell line-derived neurotrophic factor; GFP, green fluorescent protein; MSCs, mesenchymal stem cells; PD, Parkinson's disease; SN, substantia nigra; TH, tyrosine hyd
A dual-hit animal model for age-related parkinsonism
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; PD, Parkinson's disease; PS, Parkinsonian syndrome; DA, dopamine; NE, norepinephrine; SN, substantia nigra; GDNF, glial cell line-derived neurotrophic factor; NGF, nerve growth factor; METH, methamphetamine; TH, tyrosine hydroxylaseMonoamines; Dopamine; A
Orphan nuclear receptor Nurr1 induces neuron differentiation from embryonic cortical precursor cells via an extrinsic paracrine mechanism
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; BDNF, brain-derived neurotrophic factor; CM, conditioned medium; CNTF, ciliary neurotrophic factor; GDNF, glial cell line-derived neurotrophic factor; GFAP, glial fibrillary acidic protein; MAP2, microtubule-associated protein 2; LIF, leukemia inhibitory
Erythropoietin exerts anti-epileptic effects with the suppression of aberrant new cell formation in the dentate gyrus and upregulation of neuropeptide Y in seizure model of rats
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; 6-OHDA, 6-hydroxydopamine; BDNF, brain-derived neurotrophic factor; BrdU, bromodeoxyuridine; CNS, central nervous system; EPO, erythropoietin; EPO-R, erythropoietin receptor; GDNF, glial cell line-derived neurotrophic factor; KA, kainic acid; NeuN, neuron
GDNF-induced cell signaling and neurite outgrowths are differentially mediated by GFRalpha1 isoforms
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; GDNF, glial cell line-derived neurotrophic factor; GFRα1, GDNF family receptor alpha-1; NRTN, neurturin; RA, retinoic acid; FK, forskolin; LIMK, LIM kinase; MLC, myosin light chainGDNF; GFRα1; Rho family GTPase; ROCK; Inhibitory splice isoforms; Neurite o
GDNF — A potential target to treat addiction
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; ERK1/2, extracellular signal-regulated kinase 1/2; GDNF, glial cell line-derived neurotrophic factor; GFRα1, GDNF family receptor α1; HET, heterozygote; HSP90, heat shock protein 90; MAPK, mitogen-activated protein kinase; Nac, Nucleus accumbens; 18-MC, 1
Astrocyte-secreted GDNF and glutathione antioxidant system protect neurons against 6OHDA cytotoxicity
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; 6OHDA, 6 hydroxydopamine; GFP, green fluorescent protein; GDNF, glial cell line-derived neurotrophic factor; GSH, glutathioneNeuroprotection; Neuro-regeneration; Neurotrophic factor; Signal transduction; Thiol antioxidant; Coculture; Viral vectors; Lentiv
Mechanisms of interleukin-1β-induced GDNF release from rat glioma cells
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; CNS, central nervous system; DMEM, Dulbecco's modified Eagle's medium; ELISA, enzyme-linked immunosolvent assay; GDNF, glial cell line-derived neurotrophic factor; IκB, inhibitor kappa B; IKK, IκB kinase; IL, interleukin; JAK, Janus family of tyrosine kin
Neuroprotective effect of grafting GDNF gene-modified neural stem cells on cerebral ischemia in rats
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; GDNF, Glial cell line-derived neurotrophic factor; NSCs, neural stem cells; GFP, green fluorescent protein; BrdU, 5′-bromo-2′-deoxyuridine; mNSS, modified Neurological Severity Scores; Syp, synaptophysin; PSD-95, postsynaptic density-95; MAP-2, microtubul
Effect of treatment on serum glial cell line-derived neurotrophic factor in depressed patients
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; ELISA, enzyme linked immunosorbent assay; GDNF, glial cell line-derived neurotrophic factor; HDRS, Hamilton Depression Rating Scale; MDD, major depressive disorder; SPSS, Statistical Package for Social Sciences; SD, Standard deviationAntidepressants; GDNF
Inhibition of astrocytes promotes long-distance growing nerve fibers in ventral mesencephalic cultures
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; Ara-C, cytosine β-d-arabinofuranoside; CRL, crown-rump length; DIV, days in vitro; E, embryonic days; GDNF, glial cell line-derived neurotrophic factor; TH, tyrosine hydroxylase; GLAST, glia glutamate transporterVentral mesencephalon; Astrocyte; Ara-C; Ax
The ibogaine medical subculture
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; 18-MC, 18-methoxycoronaridine; AC, adenylyl cyclase; EKG, electrocardiogram; FDA, United States Food and Drug Administration; GDNF, glial cell line-derived neurotrophic factor; GPCRs, G protein-coupled receptors; Ibogaine HCl, ibogaine hydrochloride; LSD,
Involvement of glial cell line-derived neurotrophic factor in inhibitory effects of a hydrophobic dipeptide Leu-Ile on morphine-induced sensitization and rewarding effects
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; CPP, conditioned place preference; DA, dopamine; EIA, enzyme immunoassay; GDNF, glial cell line-derived neurotrophic factor; METH, methamphetamine; MOR, morphine; NAc, nucleus accumbens; TNF-α, tumor necrosis factor-α; TH, tyrosine hydroxylase; VTA, ventr
Purification of bioactive glycosylated recombinant glial cell line-derived neurotrophic factor
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; GDNF, glial cell line-derived neurotrophic factor; GFRα1, GDNF receptor α 1; BSA, bovine serum albumin; RT-PCR, reverse transcription-polymerase chain reaction; CM, conditioned medium; PBS, phosphate-buffered saline; PD, Parkinson's disease; SNpc, substan
Differential effects of glial cell line-derived neurotrophic factor on A9 and A10 dopamine neuron survival in vitro
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; GDNF; VM tissue; substantia nigra; VTA; dopamine; transplantationCB, calbindin; CR, calretinin; DA, dopamine; DMEM, Dulbecco’s modified essential medium; E, embryonic day; GDNF, glial cell line-derived neurotrophic factor; GDNF H, ventral mesencephalon wi
Adenosine induces expression of glial cell line-derived neurotrophic factor (GDNF) in primary rat astrocytes
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; CPA, N6-cyclopentyladenosine; CGS 21680, 2-p-(2-carboxyethyl) phenethylamino-5′-N-ethylcarboxamindo-adenosine hydrochloride; CNS, central nervous system; GDNF, glial cell line-derived neurotrophic factor; GFRα-1, GDNF receptor-1; IL-6, interleukin-6; RET,
Administration of amitriptyline attenuates noise-induced hearing loss via glial cell line-derived neurotrophic factor (GDNF) induction
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; AT, amitriptyline; HC, hair cells; IHCs, inner hair cells; OHCs, outer hair cells; NTFs, neurotrophic factors; NTF, neurotrophic factor; ABR, auditory brainstem response; GDNF, glial cell line-derived neurotrophic factor; BDNF, brain-derived neurotrophic
Activation of tyrosine kinase receptor signaling pathway by rasagiline facilitates neurorescue and restoration of nigrostriatal dopamine neurons in post-MPTP-induced parkinsonism
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; BDNF, brain-derived neurotrophic factor; DA, dopamine; DAVID, Database for Visualization Annotation and Integrated Discovery; DOPAC, dihydroxyphenyl acetic acid; Fasl, Fas ligand; GDNF, glial cell line-derived neurotrophic factor; GSK, glycogen synthase k
Distribution and immunohistochemical localization of GDNF protein in selected neural and non-neural tissues of rats during development and changes in unilateral 6-hydroxydopamine lesions
Keywords: GDNF، فاکتور نوروپاتی مشتق از سلولهای گلایلی; BDNF, brain-derived neurotrophic factor; BSA, bovine serum albumin; DRG, dorsal root ganglion; GDNF, glial cell line-derived neurotrophic factor; 6-OHDA, 6-Hydroxydopamine; NGF, nerve growth factor; NT-3, neurotrophin-3; NT-4, neurotrophin-4; PBS, phospha