Hedgehog pathway inhibitors of the acylthiourea and acylguanidine class show antitumor activity on colon cancer in vitro and in vivo
Keywords: انکوژن مرتبط با گلیوم; Hedgehog inhibitor; In vivo pharmacokinetics; Gram-scale synthesis; ADME-Tox; LS180 xenograft; Acylguanidine; Hh; Hedgehog; Shh; Sonic Hedgehog; Ptch; Patched; Smo; Smoothened; BCC; basal cell carcinoma; PE; petroleum ether; SRB; sulforhodamine B; Shh-CM