Keywords: گلوکورونید شدن; Nonsteroidal anti-inflammatory drug; Glucuronidation; Acyl glucuronide; Protein binding; Stereoselectivity;
مقالات ISI گلوکورونید شدن (ترجمه نشده)
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Keywords: گلوکورونید شدن; Herbacetin; Pharmacokinetics; Biotransformation; Glucuronidation; Hepatic metabolism; Colonic degradation;
Keywords: گلوکورونید شدن; Naringenin; Glucuronidation; UDP-Glucuronosyltransferase (UGT); Liver microsome; Intestine microsome; UGT; UDP-glucuronosyltransferase;
Keywords: گلوکورونید شدن; Bisphenol A; Parkinson disease; Glucuronidation;
Keywords: گلوکورونید شدن; Thyroid hormone; Thyroid hormone metabolism; Thyroid hormone degradation; Deiodination; Sulfation; Glucuronidation;
Keywords: گلوکورونید شدن; UGT-dependent resistance; Glucuronidation; ABC transporters; Antitumor drug resistance; UGT-modulated pharmacokineticsABC, ATP-binding cassette; ADME, absorption, distribution, metabolism, excretion; AED, antiepileptic drug; AhR, aryl hydrocarbon receptor
Keywords: گلوکورونید شدن; Diazepam; Cats; Glucuronidation; Bile salt export pump (Bsep); Liver injury
Keywords: گلوکورونید شدن; Dosing; glucuronidation; metabolism; neonate; paracetamol; sulfation
Keywords: گلوکورونید شدن; UDP-glucuronosyltransferase; Glucuronidation; In vitro–in vivo extrapolation; Liver; Intestine; Availability; Clearance; Prediction
Keywords: گلوکورونید شدن; Rhubarb; Anthraquinones; Glucuronidation; UGTs; Regioselectivity
Keywords: گلوکورونید شدن; Cytochrome; Drug-drug interactions; Glucuronidation; Pharmacogenetics; Pharmacokinetics; Statins
Keywords: گلوکورونید شدن; Triphenyl phosphate; Flame retardant; Metabolism; Hydroxylation; Glucuronidation; Human urine; Biomarker
Keywords: گلوکورونید شدن; TBBPA; Estrogen sulfotransferases; Glucuronidation; Uterus; Liver
Species differences in drug glucuronidation: Humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in humans
Keywords: گلوکورونید شدن; UDP-glucuronosyltransferase; Glucuronidation; Species difference; Humanized mice; Drug metabolism; Toxicity;
In vitro inhibitory effects of major bioactive constituents of Andrographis paniculata, Curcuma longa and Silybum marianum on human liver microsomal morphine glucuronidation: A prediction of potential herb-drug interactions arising from andrographolide,
Keywords: گلوکورونید شدن; Andrographolide; Curcumin; Glucuronidation; Herb-drug interactions; Morphine; Silybin;
Inhibition of UDP-glucose dehydrogenase by 6-thiopurine and its oxidative metabolites: Possible mechanism for its interaction within the bilirubin excretion pathway and 6TP associated liver toxicity
Keywords: گلوکورونید شدن; 6-Thiopurine; UDP-glucuronic acid; Glucuronidation; Drug metabolism; Jaundice;
The roles of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated proteins (MRPs/ABCCs) in the excretion of cycloicaritin-3-O-glucoronide in UGT1A1-overexpressing HeLa cells
Keywords: گلوکورونید شدن; Cycloicaritin; UGT1A1; Glucuronidation; HeLa cells; Efflux transporters;
UGT-mediated metabolism plays a dominant role in the pharmacokinetic behavior and the disposition of morusin in vivo and in vitro
Keywords: گلوکورونید شدن; Morusin; Glucuronidation; First-pass metabolism; Pharmacokinetics; UGTs; CYPs;
Piperine potentiates curcumin-mediated repression of mTORC1 signaling in human intestinal epithelial cells: implications for the inhibition of protein synthesis and TNFα signaling
Keywords: گلوکورونید شدن; Akt; AKT serine/threonine kinase 1; BCA; bicinchoninic acid; BRAF; B-Raf proto-oncogene, serine/threonine kinas; COX-2; cyclooxygenase-2; CUR; curcumin; CYP3A4; cytochrome P450 3A4; DMSO; dimethyl sulfoxide; DTT; dithiothreitol; eEF2; eukaryotic translati
Drug-drug interaction potential of antitumor acridine agent C-1748: The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7
Keywords: گلوکورونید شدن; Antitumor agent C-1748; Drug-drug interactions; II phase metabolism; Glucuronidation; Enzyme inhibition; UGT;
Nano liquid chromatography-high-resolution mass spectrometry for the identification of metabolites of the two new psychoactive substances N-(ortho-methoxybenzyl)-3,4-dimethoxyamphetamine and N-(ortho-methoxybenzyl)-4-methylmethamphetamine
Keywords: گلوکورونید شدن; NPS; new psychoactive substances; NBOMe; N-ortho-methoxybenzyl; 25B-NBOMe; 2-(4-bromo-2,5-dimethoxyphenyl)-N-(ortho-methoxybenzyl) ethanamine; 25C-NBOMe; 2-(4-chloro-2,5-dimethoxyphenyl)-N-(ortho-methoxybenzyl) ethanamine; 25I-NBOMe; 2-(4-iodo-2,5-dimetho
Quantitative characterization of UDP-glucuronosyltransferase 2B17 in human liver and intestine and its role in testosterone first-pass metabolism
Keywords: گلوکورونید شدن; UGT2B17; Glucuronidation; Testosterone; First-pass metabolism; Metabolomics; Inter-individual variability;
Stereoselective glucuronidation metabolism, pharmacokinetics, anti-amnesic pharmacodynamics, and toxic properties of vasicine enantiomers in vitro and in vivo
Keywords: گلوکورونید شدن; Vasicine enantiomers; Anti-amnesic; Glucuronidation; Pharmacokinetics; Stereoselective;
Inhibition of UDP-glucuronosyltransferase (UGT)-mediated glycyrrhetinic acid 3-O-glucuronidation by polyphenols and triterpenoids
Keywords: گلوکورونید شدن; UDP-Glucuronosyltransferase; UGT; Licorice; Glycyrrhetinic acid; Glycyrrhizin; Glucuronidation; Glucuronide; Natural medicine; Adverse reaction; Pseudohyperaldosteronism; DMSO; dimethyl sulfoxide; GA; Glycyrrhetinic acid; HPLC; high-performance liquid chr
Prevalence of UDP-glucuronosyltransferase polymorphisms (UGT1A6â2, 1A7â12, 1A8â3, 1A9â3, 2B7â2, and 2B15â2) in a Saudi population
Keywords: گلوکورونید شدن; Glucuronidation; UDP-glucuronosyltransferase; UGT1A; UGT2B; Saudi gene polymorphism;
Involvement of UDP-glucuronosyltransferases in higenamine glucuronidation and the gender and species differences in liver
Keywords: گلوکورونید شدن; Higenamine; UGT1A9; Liver microsomes; Glucuronidation; Species;
Structure-activity relationship studies on 1-(2-oxopropyl)indole-5-carboxylic acids acting as inhibitors of cytosolic phospholipase A2α: Effect of substituents at the indole 3-position on activity, solubility, and metabolic stability
Keywords: گلوکورونید شدن; Cytosolic phospholipase A2α; Inhibitors; Indole derivatives; Metabolic stability; Ketone reduction; Glucuronidation; Aqueous solubility;
The story of Indian yellow - excreting a solution
Keywords: گلوکورونید شدن; Indian yellow; Peori; Piuri; Purree; T.N. Mukharji; Glucuronidation; Euxanthone; Euxanthic acid;
Biomagnification of endocrine disrupting chemicals (EDCs) by Pleuronectes yokohamae: Does P. yokohamae accumulate dietary EDCs?
Keywords: گلوکورونید شدن; Assimilation efficiency; BMF; EDC; Glucuronidation;
Quantitatively metabolic profiles of salvianolic acids in rats after gastric-administration of Salvia miltiorrhiza extract
Keywords: گلوکورونید شدن; Salvianolic acid; Protocatechuic aldehyde; Protocatechuic acid; Stability; Metabolism; Glucuronidation
Homodimerization of UDP-glucuronosyltransferase 2B7 (UGT2B7) and identification of a putative dimerization domain by protein homology modeling
Keywords: گلوکورونید شدن; UDP-glucuronosyltransferase; UGT2B7; Homology model; Dimerization; Enzyme kinetics; Glucuronidation
Methylation, Glucuronidation, and Sulfonation of Daphnetin in Human Hepatic Preparations In Vitro: Metabolic Profiling, Pathway Comparison, and Bioactivity Analysis
Keywords: گلوکورونید شدن; daphnetin; methylation; glucuronidation; sulfonation; 8-O-methyldaphnetin; anti-inflammatory activity;
In vitro glucuronidation of methyl gallate and pentagalloyl glucopyranose by liver microsomes
Keywords: گلوکورونید شدن; Methyl gallate; Pentagalloyl glucopyranose; Glucuronidation; Liver microsomes; β-glucuronidases; Methyl gallate (PubChem CID: 7428); Pentagalloyl glucopyranose (PubChem CID: 65238);
Bisphenol A and its analogs: Do their metabolites have endocrine activity?
Keywords: گلوکورونید شدن; BPA; bisphenol A (4,4â²-(propane-2,2-diyl)diphenol); BPAF; bisphenol AF (1,1,1,3,3,3-hexafluoro-2,2-bis (4-hydroxyphenyl)propane); BPB; bisphenol B, (2,2-bis(4-hydroxyphenyl)butane); BPF; bisphenol F (bis(4-hydroxyphenyl)methane); BPS; bisphenol S (bis[4
Tissue and species differences in the glucuronidation of glabridin with UDP-glucuronosyltransferases
Keywords: گلوکورونید شدن; GA; glabridin; UGT; UDP-glucuronosyltransferases; HLM and HIM; liver and intestinal microsomes from humans, respectively; RLM and RIM; liver and intestinal microsomes from rats, respectively; CyLM and DLM; liver microsomes from cynomolgus monkeys and beag
In vitro glucuronidation of the primary metabolite of 10-chloromethyl-11-demethyl-12-oxo-calanolide A by human liver microsomes and its interactions with UDP-glucuronosyltransferase substrates
Keywords: گلوکورونید شدن; F18; Glucuronidation; Recombinant human UGTs; Human liver microsomes; Enzyme kinetics; Inhibition
Glucuronidation of bavachinin by human tissues and expressed UGT enzymes: Identification of UGT1A1 and UGT1A8 as the major contributing enzymes
Keywords: گلوکورونید شدن; Bavachinin; UDP-glucuronosyltransferases; UGT1A1; UGT1A8; Glucuronidation; Human tissues
In Vitro Evaluation of the Effect of 7-Methyl Substitution on Glucuronidation of Daphnetin: Metabolic Stability, Isoform Selectivity, and Bioactivity Analysis
Keywords: گلوکورونید شدن; daphnetin; glucuronidation; methyl substitution; structural modification; metabolic stability; phase II enzymes; glucuronosyl-transferases; human liver microsomes; enzyme kinetics; metabolic clearance;
The effect of glucuronidation on isoflavone induced estrogen receptor (ER)α and ERβ mediated coregulator interactions
Keywords: گلوکورونید شدن; Isoflavone; Glucuronidation; Estrogen receptor alpha; Estrogen receptor beta; Ligand binding domain; Coregulator binding
Regio- and Isoform-Specific Glucuronidation of Psoralidin: Evaluation of 3-O-Glucuronidation as a Functional Marker for UGT1A9
Keywords: گلوکورونید شدن; glucuronidation; UGTs; psoralidin; functional marker; reaction phenotyping;
Role of cytochrome P450 and UDP-glucuronosyltransferases in metabolic pathway of homoegonol in human liver microsomes
Keywords: گلوکورونید شدن; Homoegonol; 4-O-demethylation; Glucuronidation; Human liver microsomes; Cytochrome P450s; UDP-Glucuronosyltransferases
Preparation of silybin phase II metabolites: Streptomyces catalyzed glucuronidation
Keywords: گلوکورونید شدن; Silybin diastereomers; Silibinin; Silymarin; Glucuronidation; Glucuronyl transferase
Strategies for the modulation of phase II metabolism in a series of PKCε inhibitors
Keywords: گلوکورونید شدن; PKCε; Phase II; Metabolism; Glucuronidation; Polarity;
Steviol glucuronidation and its potential interaction with UDP-glucuronosyltransferase 2B7 substrates
Keywords: گلوکورونید شدن; HLM; human liver microsomes; IS; internal standard; SVG; steviol glucuronide; UGT; UDP glucuronosyltransferase; Steviol; Glucuronidation; UGT2B7; Inhibition; Botanical-drug interaction;
Multiple UDP-glucuronosyltransferases in human liver microsomes glucuronidate both R- and S-7-hydroxywarfarin into two metabolites
Keywords: گلوکورونید شدن; Glucuronidation; UGT (UDP-glucuronosyltransferase); Metabolism; Warfarin; 7-Hydroxywarfarin; In vitro;
Regioselective glucuronidation of the isoflavone calycosin by human liver microsomes and recombinant human UDP-glucuronosyltransferases
Keywords: گلوکورونید شدن; HLMs; human liver microsomes; UGTs; UDP-glucuronosyltransferases; SGR; Structure-glucuronidation relationship; HPLC; high performance liquid chromatography; NADPH; nicotinamide adenine dinucleotide phosphate reduced; CYP450s; cytochrome P450s; PAPS; 3â
Absolute quantification of UGT1A1 in various tissues and cell lines using isotope label-free UPLC-MS/MS method determines its turnover number and correlates with its glucuronidation activities
Keywords: گلوکورونید شدن; UGT; uridine 5â²-diphospho-glucuronosyltransferase (UDP-glucuronosyltransferase); CYP; cytochrome P450; UPLC; ultra performance liquid chromatography; MRM; multiple reaction monitoring; DP; declustering potential; CE; collision energy; CXP; collision cel
The effects of the lampricide 3-trifluoromethyl-4-nitrophenol (TFM) on fuel stores and ion balance in a non-target fish, the rainbow trout (Oncorhynchus mykiss)
Keywords: گلوکورونید شدن; Invasive species; Sea lamprey control; Lampricide; Great Lakes; Glucuronidation; Biotransformation; 3-trifluoromethyl-4-nitrophenol; Rainbow trout; Glycogen; Gill; Hard water; ATP; Phosphocreatine; Oxidative phosphorylation;
Effect of UDP-glucuronosyltransferase 1A8 polymorphism on raloxifene glucuronidation
Keywords: گلوکورونید شدن; 7-HFC; 7-hydroxy-4-trifluoromethylcoumarin; PCR; polymerase chain reaction; UGT; UDP-glucuronosyltransferase; UDP-glucuronosyltransferase 1A8 (UGT1A8); Genetic polymorphism; Raloxifene; Glucuronidation;
Pivaloylcodeine, a new codeine derivative, for the inhibition of morphine glucuronidation. An in vitro study in the rat
Keywords: گلوکورونید شدن; Codeine; Acetylcodeine; Pivaloylcodeine; Morphine-3-glucuronide; Liver microsomes; Glucuronidation;