کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8319174 | 1539296 | 2014 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effects of the lampricide 3-trifluoromethyl-4-nitrophenol (TFM) on fuel stores and ion balance in a non-target fish, the rainbow trout (Oncorhynchus mykiss)
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کلمات کلیدی
Hard water - آب سختATP - آدنوزین تری فسفات یا ATPGreat Lakes - دریاچه های بزرگBiotransformation - زیستدگرگونیPhosphocreatine - فسفریکراتینOxidative phosphorylation - فسفوریلاسیون اکسیداتیوRainbow trout - قزل آلای رنگین کمانLampricide - لیزر لیزرSea lamprey control - کنترل نهنگ دریاییGlucuronidation - گلوکورونید شدنGlycogen - گلیکوژنInvasive species - گونه های مهاجمGill - گیل
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
The pesticide 3-trifluoromethyl-4-nitrophenol (TFM) is used to control sea lamprey (Petromyzon marinus) populations in the Great Lakes through its application to nursery streams containing larval sea lampreys. TFM uncouples oxidative phosphorylation, impairing mitochondrial ATP production in sea lampreys and rainbow trout (Oncorhynchus mykiss). However, little else is known about its sub-lethal effects on non-target aquatic species. The present study tested the hypotheses that TFM exposure in hard water leads to (i) marked depletion of energy stores in metabolically active tissues (brain, muscle, kidney, liver) and (ii) disruption of active ion transport across the gill, adversely affecting electrolyte homeostasis in trout. Exposure of trout to 11.0 mg lâ 1 TFM (12-h LC50) led to increases in muscle TFM and TFM-glucuronide concentrations, peaking at 9 h and 12 h, respectively. Muscle and brain glycogen was reduced by 50%, while kidney and muscle lactate increased with TFM exposure. Kidney ATP and phosphocreatine decreased by 50% and 70%, respectively. TFM exposure caused no changes in whole body ion (Na+, Clâ, Ca2 +, K+) concentrations, gill Na+/K+ ATPase activity, or unidirectional Na+ movements across the gills. We conclude that TFM causes a mismatch between ATP supply and demand in trout, leading to increased reliance on glycolysis, but it does not have physiologically relevant effects on ion balance in hard water.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology - Volume 160, March 2014, Pages 30-41
Journal: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology - Volume 160, March 2014, Pages 30-41
نویسندگان
Oana Birceanu, Lisa A. Sorensen, Matthew Henry, Grant B. McClelland, Yuxiang S. Wang, Michael P. Wilkie,