
Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors
Keywords: گلیکوژن فسفریلاس; Glycogen phosphorylase; Glycogen phosphorylase inhibitor; 3,4-Dihydro-2-quinolone; Allosteric inhibitor; Dimer interface; X-ray crystallography; Physical properties; DMPK properties; Solubility; Plasma protein binding; Oxidative cyclisation; Thienopyrrole